Intravenous morphine versus intravenous paracetamol after cardiac surgery in neonates and infants: a study protocol for a randomized controlled trial by Gerdien A. Zeilmaker-Roest, Joost van Rosmalen, Monique van Dijk, Erik Koomen, Nicolaas J. G. Jansen, Martin C. J. Kneyber, Sofie Maebe, Greet van den Berghe, Dirk Vlasselaers, Ad J. J. C. Bogers, Dick Tibboel, Enno D. Wildschut

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Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO): study protocol for a randomiz... by Janine B. Kastelijn, Yorick L. van de Pavert, Marc G. Besselink, Paul Fockens, Rogier P. Voermans, Roy L. J. van Wanrooij, Thomas R. de Wijkerslooth, Wouter L. Curvers, Ignace H. J. T. de Hingh, Marco J. Bruno, Bas Groot Koerkamp, Gijs A. Patijn, Alexander C. Poen, Jeanin E. van Hooft, Akin Inderson, J. Sven D. Mieog, Jan-Werner Poley, Alderina Bijlsma, Daan J. Lips, Niels G. Venneman, Robert C. Verdonk, Hendrik M. van Dullemen, Frederik J. H. Hoogwater, Geert W. J. Frederix, I. Quintus Molenaar, Paco M. J. Welsing, Leon M. G. Moons, Hjalmar C. van Santvoort, Frank P. Vleggaar, for the Dutch Pancreatic Cancer Group

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Prevention of Morbidity in Sickle Cell Disease (POMS2a)—overnight auto-adjusting continuous positive airway pressure compared with nocturnal oxygen therapy: a randomised crossover... by Jo Howard, Sophie A. Lee, Baba Inusa, Man Ying Edith Cheng, Cheema Bavenjit, Isabel C. Reading, Sally Ann Wakeford, Johanna C. Gavlak, Patrick B. Murphy, Nicholas Hart, Atul Gupta, Sati Sahota, Eufemia Jacob, Maria Chorozoglou, Carol Ossai, Maureen Gwam, Fenella J. Kirkham, Angela M. Wade, Christina Liossi

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The With Or Without Olecranon K-wire (WOW OK) Trial of tension band wire fixation versus cerclage fixation without K-wires in displaced stable olecranon fractures: study protocol f... by Gustav Cornefjord, Ioannis Kostogiannis, Cecilia Rogmark, Daniel Jerrhag, Daniel Wenger

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Effects of an 8-week multimodal exercise program on ground reaction forces and plantar pressure during walking in boys with autism spectrum disorder by Mahrokh Dehghani, Amir Ali Jafarnezhadgero, Mohamad Abdollahpour Darvishani, Shirin Aali, Urs Granacher

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Acupuncture for primary fibromyalgia: Study protocol of a randomized controlled trial by Man Han, Jiakang Cui, Yuya Xiao, Donghong Xiao, Juan Jiao, Qiuwei Peng, Feng Tian, Xiaopo Tang, Jianyong Zhang, Quan Jiang

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Self-injury: Treatment, Assessment, Recovery (STAR): online intervention for adolescent non-suicidal self-injury - study protocol for a randomized controlled trial by Michael Kaess, Julian Koenig, Stephanie Bauer, Markus Moessner, Gloria Fischer-Waldschmidt, Margarete Mattern, Sabine C. Herpertz, Franz Resch, Rebecca Brown, Tina In-Albon, Michael Koelch, Paul L. Plener, Christian Schmahl, Alexandra Edinger, the STAR Consortium

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Double blind, randomized controlled trial, to evaluate the effectiveness of a controlled nitric oxide releasing patch versus meglumine antimoniate in the treatment of cutaneous lei... by Silva Federico A, Mosquera Hernando, Muñoz Gerardo, Smith Daniel J, Rueda-Clausen Christian F, Vélez Iván D, López Marcos, Rueda Ligia C, Silva Sandra Y, Buitrago Adriana, Díaz Holger, López-Jaramillo Patricio

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The efficacy of Narrative Exposure Therapy for Children (KIDNET) as a treatment for traumatized young refugees versus treatment as usual: update to the study protocol for the multi... by Jasmin Wittmann, Melissa Groß, Claudia Catani, Telja Schmidt, Sina Neldner, Sarah Wilker, Theodor May, Verena Ertl, Rita Rosner, Areej Zindler, Michael Odenwald, Frank Neuner

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Statistical analyses of ordinal outcomes in randomised controlled trials: protocol for a scoping review by Chris J. Selman, Katherine J. Lee, Clare L. Whitehead, Brett J. Manley, Robert K. Mahar

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Recruiting hard-to-reach pregnant women at high psychosocial risk: strategies and costs from a randomised controlled trial by Alice MacLachlan, Karen Crawford, Shona Shinwell, Catherine Nixon, Marion Henderson

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Evaluation of the protective efficacy of a spatial repellent to reduce malaria incidence in children in Mali compared to placebo: study protocol for a cluster-randomized double-bli... by Suzanne Van Hulle, Issaka Sagara, Momar Mbodji, Ghislain Ismael Nana, Mamadou Coulibaly, Alassane Dicko, Mamady Kone, Ismaila Thera, Daman Sylla, Mamadou Diango Traore, Fang Liu, John P. Grieco, Nicole L. Achee

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Optimal@NRW: optimized acute care of nursing home residents using an intersectoral telemedical cooperation network — study protocol for a stepped-wedge trial by David Brücken, Jenny Unterkofler, Sophie Pauge, Jonas Bienzeisler, Christian Hübel, Sebastian Zechbauer, Rolf Rossaint, Wolfgang Greiner, Birthe Aufenberg, Rainer Röhrig, Leo Cornelius Bollheimer, Optimal@NRW Research Group, Jörg Christian Brokmann

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ELECtric Tibial nerve stimulation to Reduce Incontinence in Care homes: protocol for the ELECTRIC randomised trial by J. Booth, L. Aucott, S. Cotton, C. Goodman, S. Hagen, D. Harari, M. Lawrence, A. Lowndes, L. Macaulay, G. MacLennan, H. Mason, D. McClurg, J. Norrie, C. Norton, C. O’Dolan, D. A. Skelton, C. Surr, S. Treweek

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Sinako, a study on HIV competent households in South Africa: a cluster-randomised controlled trial protocol by Caroline Masquillier, Lucia Knight, Linda Campbell, Neo Sematlane, Anton Delport, Tanyaradzwa Dube, Edwin Wouters

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Single dose of intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of postoperative anaemia in colorectal can... by María Jesús Laso-Morales, Roser Vives, Andrea Vallejo-Tarrat, Novella Caló, Anna Valle-Beltran, Caridad Pontes

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Protocol of the process evaluation of cluster randomised control trial for estimating the effectiveness and cost-effectiveness of a complex intervention to increase care home staff... by Linda Birt, Thando Katangwe-Chigamba, Sion Scott, David J Wright, Adam P. Wagner, Erika Sims, Veronica Bion, Carys Seeley, Faisal Alsaif, Allan Clarke, Alys Griffiths, Liz Jones, Alison Bryant, Amrish Patel

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Single-session intervention on growth mindset on negative emotions for university student mental health (U-SIGMA): a protocol of two-armed randomized controlled trial by Shimin Zhu, Yuxi Hu, Di Qi, Nan Qin, Xinli Chi, Jiawen Luo, Jie Wu, Hua Huang, Qiaobing Wu, Lu Yu, Shiguang Ni, Kyra Hamilton, Samson Tse

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The importance of clinical importance when determining the target difference in sample size calculations by Richard A. Parker, Jonathan A. Cook

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Efficacy of intraoperative irrigation with artificial cerebrospinal fluid in chronic subdural hematoma surgery: study protocol for a multicenter randomized controlled trial by Yoshitaka Nagashima, Yoshio Araki, Kazuki Nishida, Shunichiro Kuramitsu, Kenichi Wakabayashi, Shinji Shimato, Takeshi Kinkori, Toshihisa Nishizawa, Takahisa Kano, Toshinori Hasegawa, Atsushi Noda, Kenko Maeda, Yu Yamamoto, Osamu Suzuki, Naoki Koketsu, Takeshi Okada, Masashige Iwasaki, Kiyo Nakabayashi, Shigeru Fujitani, Hideki Maki, Yachiyo Kuwatsuka, Masahiro Nishihori, Takafumi Tanei, Tomohide Nishikawa, Yusuke Nishimura, Ryuta Saito, Tokai Neurosurgical disorder Research Group CSDH Study investigators

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