CHARACTERIZATION AND ANTIPARASITIC ACTIVITY OF BENZOPHENONE THIOSEMICARBAZONES ON Trypanosoma brucei brucei by Georges C. Accrombessi, Jacques Poupaert, Raymond H. Fatondji, Salomé D. S. Kpoviessi, Fernand A. Gbaguidi, Bienvenu Glinma

“…Their anti-trypanosomal activities were evaluated on Trypanosoma brucei brucei. Among these compounds, benzophenone 4 phenyl-3-thiosemicarbazone 4 has the highest activity with the half-inhibitory concentration (IC50) = 8.48 micromolar (µM). …”
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The Role of the Trypanosoma cruzi TcNRBD1 Protein in Translation. by Camila Oliveira, Paulo Costa Carvalho, Lysangela Ronalte Alves, Samuel Goldenberg

“…Despite the importance of this type of control in Trypanosoma cruzi, few RNA binding proteins have been characterized. …”
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In vitro evaluation of the activity of aromatic nitrocompounds against Trypanosoma cruzi by Renata B Oliveira, Ana Paula F Passos, Rosana O Alves, Alvaro J Romanha, Maria Auxiliadora F Prado, José Dias de Souza Filho, Ricardo J Alves

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An updated map of Trypanosoma cruzi histone post-translational modifications by Rafael Fogaça de Almeida, Matheus Fernandes, Lyris Martins Franco de Godoy

“…Measurement(s) histone_modification Technology Type(s) mass spectrometry • nanoflow liquid chromatography-tandem mass spectrometry • Data-Dependent Acquisition Sample Characteristic - Organism Trypanosoma cruzi Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.13491165…”
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Exoproteome profiling of Trypanosoma cruzi during amastigogenesis early stages. by Samuel C Mandacaru, Rayner M L Queiroz, Marcos R Alborghetti, Lucas S de Oliveira, Consuelo M R de Lima, Izabela M D Bastos, Jaime M Santana, Peter Roepstorff, Carlos André O Ricart, Sébastien Charneau

“…Chagas disease is caused by the protozoan Trypanosoma cruzi, affecting around 8 million people worldwide. …”
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Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi. by Carolina Furtado, Marianna Kunrath-Lima, Matheus Andrade Rajão, Isabela Cecília Mendes, Michelle Barbi de Moura, Priscila Carneiro Campos, Andrea Mara Macedo, Glória Regina Franco, Sérgio Danilo Junho Pena, Santuza Maria Ribeiro Teixeira, Bennett Van Houten, Carlos Renato Machado

“…In this report, we identified and characterized Ogg1 from the protozoan parasite Trypanosoma cruzi (TcOgg1), the causative agent of Chagas disease. …”
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An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei. by Juan P de Macêdo, Gabriela Schumann Burkard, Moritz Niemann, Michael P Barrett, Henri Vial, Pascal Mäser, Isabel Roditi, André Schneider, Peter Bütikofer

“…Elucidating the mechanism of action of trypanocidal compounds is an important step in the development of more efficient drugs against Trypanosoma brucei. In a screening approach using an RNAi library in T. brucei bloodstream forms, we identified a member of the mitochondrial carrier family, TbMCP14, as a prime candidate mediating the action of a group of anti-parasitic choline analogs. …”
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Host Genetics Background Influence in the Intragastric Trypanosoma cruzi Infection by Carolina Salles Domingues, Flávia de Oliveira Cardoso, Daiana de Jesus Hardoim, Marcelo Pelajo-Machado, Alvaro Luiz Bertho, Alvaro Luiz Bertho, Kátia da Silva Calabrese

Subjects: “…Trypanosoma cruzi…”
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Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents by Antonia Efstathiou, Cássio Santana Meira, Nicolas Gaboriaud-Kolar, Tanira Matutino Bastos, Vinícius Pinto Costa Rocha, Konstantina Vougogiannopoulou, Alexios-Leandros Skaltsounis, Despina Smirlis, Milena Botelho Pereira Soares

“…Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. …”
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A Mother's Gift: Congenital Transmission of Trypanosoma and Leishmania Species. by Tara Grinnage-Pulley, Benjamin Scott, Christine A Petersen

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Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi by Araya Jorge E, Neira Iván, Silva Solange da, Mortara Renato A, Manque Patricio, Cordero Esteban, Sagua Hernán, Loyola Alberto, Bórquez Jorge, Morales Glauco, González Jorge

Subjects: “…Trypanosoma cruzi…”
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Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. by Shamila S Gunatilleke, Claudia M Calvet, Jonathan B Johnston, Chiung-Kuang Chen, Grigori Erenburg, Jiri Gut, Juan C Engel, Kenny K H Ang, Joseph Mulvaney, Steven Chen, Michelle R Arkin, James H McKerrow, Larissa M Podust

“…METHODOLOGY/PRINCIPAL FINDINGS:The similarity between the membrane sterol requirements of pathogenic fungi and those of the parasitic protozoon Trypanosoma cruzi, the causative agent of Chagas human cardiopathy, has led to repurposing anti-fungal azole inhibitors of sterol 14α-demethylase (CYP51) for the treatment of Chagas Disease. …”
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Surface electrical charge of bloodstream trypomastigotes of Trypanosoma cruzi strains by Maria Auxiliadora de Sousa

“…Bloodstream trypomastigotes of some Trypanosoma cruzi strains were processed through DEAE-cellulose columns under standardized conditions. …”
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Proximity-Dependent Biotinylation and Identification of Flagellar Proteins in Trypanosoma cruzi by Madalyn M. Won, Aaron Baublis, Barbara A. Burleigh

Subjects: “…Trypanosoma cruzi…”
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Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice by Sonia G. Andrade

Subjects: “…Trypanosoma cruzi…”
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Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics. by Andrea Trochine, Darren J Creek, Paula Faral-Tello, Michael P Barrett, Carlos Robello

“…The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). …”
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Trypanosoma cruzi: genetic group with peculiar biochemical and biological behavior by Mônica Lúcia Gomes, Max Jean de Ornelas Toledo, Celso Vataru Nakamura, Nilza de Lucas Rodrigues Bittencourt, Egler Chiari, Silvana Marques de Araújo

Subjects: “…Trypanosoma cruzi…”
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Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity by Estefanía Dibello, Natalia Oddone, Jaime Franco, Tünde-Zita Illyés, Andrea Medeiros, Attila Kiss, Fanni Hőgye, Katalin E. Kövér, László Szilágyi, Marcelo A. Comini

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Active transcription and ultrastructural changes during Trypanosoma cruzi metacyclogenesis by Ludmila R.P. Ferreira, Fernando de M. Dossin, Thiago C. Ramos, Edna Freymüller, Sergio Schenkman

Subjects: “…Trypanosoma cruzi…”
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Chronic experimental infection by Trypanosoma cruzi in Cebus apella monkeys by A. Riarte, A. Sinagra, M. Lauricella, N. Bolomo, M. Moreno, P. Cossio, R. Arana, E. L. Segura

Subjects: “…Trypanosoma cruzi…”
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