Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppressor gene by Zhou Zhiwei, Wang Qijing, Sun Jiancong, Wang Hui, Pan Ke, Huang Wei, Chen Yibing, Weng Desheng, Ma Haiqing, Wang Huiyun, Xia Jianchuan

“…This study was aimed to determine what genes were affected by the LOH and served as tumor suppressor genes (TSGs) in this region. Here, a high-throughput single nucleotide polymorphisms (SNPs) microarray fabricated in-house was used to analyze the LOH status around D7S486 on 7q31 in 75 patients with primary GC. …”
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Merkel Cell Polyomavirus in Merkel Cell Carcinoma: Integration Sites and Involvement of the KMT2D Tumor Suppressor Gene by Reety Arora, Jae Eun Choi, Paul W. Harms, Pratik Chandrani

“…Additionally, in one case we found, for the first time, integration involving the tumor suppressor gene <i>KMT2D</i>, adding to previous reports of rare MCPyV integration into host tumor suppressor genes in MCC.…”
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Molecular Analysis: Microsatellite Instability and Loss of Heterozygosity of Tumor Suppressor Gene in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) by Vesna Hadžiavdić, Nada Pavlović-Čalić, Izet Eminović

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Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes. by Naomi Ohta, Susumu Ishiguro, Atsushi Kawabata, Deepthi Uppalapati, Marla Pyle, Deryl Troyer, Supriyo De, Yongqing Zhang, Kevin G Becker, Masaaki Tamura

“…These results suggest that FST may play an important role in exhibiting stronger tumoricidal ability in rat UCMSC than human UCMSC and also implies that human UCMSC can be transformed into stronger tumoricidal cells by enhancing tumor suppressor gene expression.…”
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The allele frequency of two single nucleotide polymorphisms in the von Hippel-Lindau (VHL) tumor suppressor gene in the Taiwanese population by Wen-Chung Wang, Hui-Ju Chen, Wei-Pang Shu, Yi-Chang Tsai, Yen-Chein Lai

“…The von Hippel-Lindau (VHL) tumor suppressor gene located on chromosome 3p25-26 is implicated in VHL disease. …”
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Clinical Utility of promoter methylation of the tumor suppressor genes DKK3, and RASSF1A in breast cancer patients by Marwa H. Saied, Aya Samy Rady, Galal Mustafa Abo El Naga, Ola A. Sharaki

“…Background: DNA methylation is the commonest known epigenetic change that results in silencing of tumor suppressor genes. Promoter methylation of tumor suppressor genes has the potential for early detection of breast cancer. …”
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The Neurofibromatosis 2 Tumor Suppressor Gene Product, Merlin, Regulates Human Meningioma Cell Growth by Signaling through YAP by Katherine Striedinger, Scott R. VandenBerg, Gilson S. Baia, Michael W. McDermott, David H. Gutmann, Anita Lal

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Time dependent of epigenetic effect of disulfiram on tumor suppressor gene of RASSF1A in Hela cancer cell line by Seyedeh naghme Noorirad, Mohsen Pourghasem, Farideh Feizi, Zeinab Abedian, Masoumeh Ghasemi, Zahra Babazadeh, Navid Rabiee

“…In the process, inhibitors of DNA methyltransferase (DNMT) induce re-expression of tumor suppressor genes. Among these inhibitors, disulfiram (DSF) has been suggested as non-nucleoside analogous. …”
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Low expression of WWC1, a tumor suppressor gene, is associated with aggressive breast cancer and poor survival outcome by Zhanwei Wang, Dionyssios Katsaros, Nicoletta Biglia, Yi Shen, Yuanyuan Fu, Maarit Tiirikainen, Herbert Yu

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MicroRNA-375 Functions as a Tumor-Suppressor Gene in Gastric Cancer by Targeting Recepteur d’Origine Nantais by Sen Lian, Jung Sun Park, Yong Xia, Thi Thinh Nguyen, Young Eun Joo, Kyung Keun Kim, Hark Kyun Kim, Young Do Jung

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Correction to: Evidence that DNA repair genes, a family of tumor suppressor genes, are associated with evolution rate and size of genomes by Konstantinos Voskarides, Harsh Dweep, Charalambos Chrysostomou

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TUSC1, a putative tumor suppressor gene, reduces tumor cell growth in vitro and tumor growth in vivo. by Zhihong Shan, Abbas Shakoori, Sohrab Bodaghi, Paul Goldsmith, Jen Jin, Jonathan S Wiest

“…We also tested the functional activities and mechanisms of TUSC1 as a tumor suppressor gene through growth suppression in vitro and in vivo. …”
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Promoter Hypermethylation of Tumor Suppressor Genes Located on Short Arm of the Chromosome 3 as Potential Biomarker for the Diagnosis of Nasopharyngeal Carcinoma by Thuan Duc Lao, Toan Ngoc Nguyen, Thuy Ai Huyen Le

“…DNA methylation, the most common epigenetic alteration, has been proven to play important roles in nasopharyngeal carcinoma (NPC). Numerous tumor suppressor genes located on the chromosome 3p, particularly in the region of 3p21, are frequently methylated in NPC, thus suggesting great potential for diagnosis of NPC. …”
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Integrative Genomic and Transcriptomic Analyses of Tumor Suppressor Genes and Their Role on Tumor Microenvironment and Immunity in Lung Squamous Cell Carcinoma by Ahreum Kim, Ahreum Kim, Sun Min Lim, Joo-Hang Kim, Joo-Hang Kim, Jeong-Sun Seo, Jeong-Sun Seo

Subjects: “…tumor suppressor gene…”
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Retarding breast tumor growth with nanoparticle-facilitated intravenous delivery of BRCA1 and BRCA2 tumor suppressor genes by Nabilah Ibnat, Ezharul Hoque Chowdhury

“…Abstract Gene augmentation therapy entails replacement of the abnormal tumor suppressor genes in cancer cells. In this study, we performed gene augmentation for BRCA1/2 tumor suppressors in order to retard tumor development in breast cancer mouse model. …”
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In vivo genome‐editing screen identifies tumor suppressor genes that cooperate with Trp53 loss during mammary tumorigenesis by Luuk Heitink, James R. Whittle, François Vaillant, Bianca D. Capaldo, Johanna F. Dekkers, Caleb A. Dawson, Michael J. G. Milevskiy, Elliot Surgenor, Minhsuang Tsai, Huei‐Rong Chen, Michael Christie, Yunshun Chen, Gordon K. Smyth, Marco J. Herold, Andreas Strasser, Geoffrey J. Lindeman, Jane E. Visvader

“…To gain insight into mutations that drive breast tumorigenesis, we describe a pipeline for the identification and validation of tumor suppressor genes. Based on an in vivo genome‐wide CRISPR/Cas9 screen in Trp53+/– heterozygous mice, we identified tumor suppressor genes that included the scaffold protein Axin1, the protein kinase A regulatory subunit gene Prkar1a, as well as the proof‐of‐concept genes Pten, Nf1, and Trp53 itself. …”
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HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability by Jun-Wei Zhao, Fang Fang, Yi Guo, Tai-Lin Zhu, Yun-Yun Yu, Fan-Fei Kong, Ling-Fei Han, Dong-Sheng Chen, Fang Li

“…In particular, the well-studied tumor suppressor genes SCAI was found to be integrated by HPV16, which would likely disrupt its expression and therefore facilitate the migration of tumor. …”
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Significance of Hypermethylation of Tumor-Suppressor Genes PTGER4 and ZNF43 at CpG Sites in the Prognosis of Colorectal Cancer by Chao-Yang Chen, Jia-Jheng Wu, Yu-Jyun Lin, Chih-Hsiung Hsu, Je-Ming Hu, Pi-Kai Chang, Chien-An Sun, Tsan Yang, Jing-Quan Su, Yu-Ching Chou

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Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma by Rong Deng, Jun-Hao Huang, Yan Wang, Li-Huan Zhou, Zi-Feng Wang, Bing-Xin Hu, Yu-Hong Chen, Dong Yang, Jia Mai, Zhi-Ling Li, Hai-Liang Zhang, Yun Huang, Xiao-Dan Peng, Gong-Kan Feng, Xiao-Feng Zhu, Jun Tang

“…Individuals with Down syndrome exhibit a remarkably reduced incidence of breast cancer (BC), moving the search for tumor suppressor genes on human chromosome 21 (HSA21). In this study, we aim to identify and explore potential mechanisms by which SEs are established for tumor suppressor RCAN1.4 on HSA21 in BC. …”
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EFFECT OF PULSED MAGNETIC FIELDS ON THE EXPRESSION LEVELS OF TUMOR SUPPRESSOR GENES IN HUMAN T98G GLYOBLASTOMA CELL LINE by Yu. S. Sidorenko, O. I. Kit, I. A. Popov, A. I. Shikhlyarova, E. E. Rostorguev, N. N. Timoshkina, M. A. Gusareva, Yu. Yu. Arapova, D. S. Potemkin, A. A. Pushkin, V. V. Stasov

“…Aim: to study the effect of a pulsed magnetic field (PMF) on the expression of key tumor suppressor genes, such as aPc, MLH, and MGMt in human t98G glioblastoma cell line. material and methods. the PMF with the intensity of 15 and 300 mt was used alone and in combination with ionizing radiation at a single dose of 10 Gy. to perform ionizing radiation, theratron Equinox 60co unit Best theratronics Ltd., Ottawa, canada) was used. the source of the pulsed magnetic field was Neuro-Ms / D therapeutic advanced device of the Neurosoft company. …”
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