Hypermethylation of tumor suppressor genes involved in critical regulatory pathways for developing a blood-based test in breast cancer. by Ramin Radpour, Zeinab Barekati, Corina Kohler, Qing Lv, Nicole Bürki, Claude Diesch, Johannes Bitzer, Hong Zheng, Seraina Schmid, Xiao Yan Zhong

“…In the first cohort, circulating cell free methylated DNA of the 8 tumor suppressor genes (TSGs) was significantly higher in patients with breast cancer compared to normal controls (P<0.01). …”
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7.344 Tumor Suppressor Gene p53: How the Guardian of our Genome Prevents Cancer, Fall 2010 by Xue, Wen

Subjects: “…tumor suppressor gene…”
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The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. by Banham, A, Beasley, N, Campo, E, Fernandez, P, Fidler, C, Gatter, K, Jones, M, Mason, D, Prime, J, Trougouboff, P, Wood, K, Cordell, J

“…Our study identifies FOXP1 as a new candidate tumor suppressor gene localized to the chromosome 3p14.1 region.…”

Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells by Barkovskaya, A, Seip, K, Prasmickaite, L, Mills, IG, Moestue, SA, Itkonen, HM

Absence of p53 gene expression in selenium molecular prevention of chemically Induced hepatocarcinogenesis in rats by Nasar Y Alwahaibi, Siti B Budin, Jamaludin H Mohamed

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Semaphorin 6D as an independent predictor for better prognosis in clear cell renal cell carcinoma by Jiachen Duan, Mengyuan Jin, Baoping Qiao

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Candidate Tumor-Suppressor Gene DLEC1 Is Frequently Downregulated by Promoter Hypermethylation and Histone Hypoacetylation in Human Epithelial Ovarian Cancer by Joseph Kwong, Ji-Young Lee, Kwong-Kwok Wong, Xiaofeng Zhou, David T.W. Wong, Kwok-Wai Lo, William R. Welch, Ross S. Berkowitz, Samuel C. Mok

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The Role of Epstein-Barr Virus in Modulating Key Tumor Suppressor Genes in Associated Malignancies: Epigenetics, Transcriptional, and Post-Translational Modifications by Adelaide Ohui Fierti, Michael Bright Yakass, Ernest Adjei Okertchiri, Samuel Mawuli Adadey, Osbourne Quaye

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Two Single Nucleotide Polymorphisms in the Von Hippel-Lindau Tumor Suppressor Gene in Patients with Clear Cell Renal Cell Carcinoma by Magdalena Chrabańska, Nikola Szweda-Gandor, Bogna Drozdzowska

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Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis by Antonino Bruno, Douglas M. Noonan, Roberto Valli, Giovanni Porta, Roberto Taramelli, Lorenzo Mortara, Francesco Acquati

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PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. by Dariusz Pytel, Yan Gao, Katarzyna Mackiewicz, Yuliya V Katlinskaya, Kirk A Staschke, Maria C G Paredes, Akihiro Yoshida, Shuo Qie, Gao Zhang, Olga S Chajewski, Lawrence Wu, Ireneusz Majsterek, Meenhard Herlyn, Serge Y Fuchs, J Alan Diehl

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Solvent effects on structural and thermochemical properties of p53 tumor-suppressor gene: a molecular modeling approach in drug design by Irani S, Atyabi SM, Mivehchi H, Siadat SD, Aghasadeghi MR, Farhangi A

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The tumor suppressor gene <it>KCTD11</it>^{<it>REN </it>}is regulated by Sp1 and methylation and its expression is reduced in tumors by Rinaldi Christian, Di Camillo Raffaello, Murgo Simona, Po Agnese, Capece Daria, Ciccocioppo Lucia, Zazzeroni Francesca, Mancarelli M Michela, Ferretti Elisabetta, Gulino Alberto, Alesse Edoardo

“…Although loss of 17p13 has been often associated with <it>p53 </it>genetic alteration or Hypermethylated in Cancer 1 (<it>HIC1</it>) gene hypermethylation, other tumor suppressor genes (TSGs) located in this region have critical roles in tumorigenesis. …”
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A Novel Mutation in the Von Hippel-Lindau Tumor Suppressor Gene Identified in a Patient Presenting with Gestational Diabetes Mellitus by Yun Hyi Ku, Chang Ho Ahn, Chan-Hyeon Jung, Jie Eun Lee, Lee-Kyung Kim, Soo Heon Kwak, Hye Seung Jung, Kyong Soo Park, Young Min Cho

“…We present a novel mutation in the VHL tumor suppressor gene that presented with gestational diabetes mellitus.MethodsA 30-year-old woman presented with gestational diabetes mellitus. …”
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Genome-wide screening of tumor suppressor genes in oncogenic transformation of normal lung epithelial cells and preliminary validation in sample databases by ZHAO Binyu, ZHANG Junlei, WANG Jiaqi, RUAN Yan, ZHANG Yue, LIU Lianlian

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A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability. by Mahdieh Jadaliha, Omid Gholamalamdari, Wei Tang, Yang Zhang, Ana Petracovici, Qinyu Hao, Aamira Tariq, Tae Gyoon Kim, Sarah E Holton, Deepak K Singh, Xiao Ling Li, Susan M Freier, Stefan Ambs, Rohit Bhargava, Ashish Lal, Supriya G Prasanth, Jian Ma, Kannanganattu V Prasanth

“…Our studies demonstrate crucial roles played by NAT lncRNAs in regulating post-transcriptional gene expression of key oncogenic or tumor suppressor genes, thereby contributing to TNBC progression.…”
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Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers by He Fang, Hanyang Li, Hang Zhang, Shu Wang, Shuang Xu, Li Chang, Yongsheng Yang, Ranji Cui

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Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers by Yiting Chen, Yiting Chen, Jieling Ning, Wenjie Cao, Shuanglian Wang, Tao Du, Jiahui Jiang, Xueping Feng, Bin Zhang

“…In addition, we also summarize emerging insights on TXNIP expression and its functional role in different kinds of cancers, as well as clarify its participation in metabolic reprogramming and oxidative stress in cancer cells, wherein it acts as a putative tumor suppressor gene to inhibit the proliferation, invasion, and migration of different tumor cells as well as promote apoptosis in these cells. …”
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Analysis of the <it>Mitogen-activated protein kinase kinase 4 </it>(<it>MAP2K4</it>) tumor suppressor gene in ovarian cancer by Ryland Georgina L, Ramakrishna Manasa, Choong David YH, Davis Sally J, Campbell Ian G, Gorringe Kylie L

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The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis by Jenni Lahtela, Barun Pradhan, Katja Närhi, Annabrita Hemmes, Merja Särkioja, Panu E. Kovanen, Arthur Brown, Emmy W. Verschuren

“…Therapeutic responses are further defined by the landscape of passenger mutations, or loss of tumor suppressor genes. We report here a thorough study to address the physiological role of the putative lung cancer tumor suppressor EPH receptor A3 (EPHA3), a gene that is frequently mutated in human lung adenocarcinomas. …”
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