Epigenetic identification of mitogen-activated protein kinase 10 as a functional tumor suppressor and clinical significance for hepatocellular carcinoma by Liping Tang, Shasha Zhu, Weiyan Peng, Xuedong Yin, Cui Tan, Yaying Yang

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PTEN in hereditary and sporadic cancer by Ngeow, Joanne, Eng, Charis

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Globally invariant behavior of oncogenes and random genes at population but not at single cell level by Sirbu, Olga, Helmy, Mohamed, Giuliani, Alessandro, Selvarajoo, Kumar

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The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth. by Wendy M McKimpson, Ziqiang Yuan, Min Zheng, Judy S Crabtree, Steven K Libutti, Richard N Kitsis

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Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study. by Ishrat Mahjabeen, Mahmood Akhtar Kayani

“…In this study we aimed to test the association between reduced mitochondrial tumor suppressor genes' activities and enhancement in tissue oxidative stress and cell proliferation in HNSCC cases. …”
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Pilot RNAi Screen in <i>Drosophila</i> Neural Stem Cell Lineages to Identify Novel Tumor Suppressor Genes Involved in Asymmetric Cell Division by Sandra Manzanero-Ortiz, Ana de Torres-Jurado, Rubí Hernández-Rojas, Ana Carmena

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Evaluation of transcriptionally regulated genes identifies NCOR1 in hormone receptor negative breast tumors and lung adenocarcinomas as a potential tumor suppressor gene. by María Del Mar Noblejas-López, Sara Morcillo-García, Cristina Nieto-Jiménez, Miriam Nuncia-Cantarero, Balázs Győrffy, Eva M Galan-Moya, Atanasio Pandiella, Alberto Ocaña

“…In conclusion, hereby we describe the presence and prognostic role of mutations in the NCOR1 gene in hormone receptor negative breast and lung adenocarcinomas, and we also confirm that NCOR1 is a tumor suppressor gene. Further studies should be performed to explore therapeutic mechanisms to restore its function.…”
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Haploinsufficiency of Tumor Suppressor Genes is Driven by the Cumulative Effect of microRNAs, microRNA Binding Site Polymorphisms and microRNA Polymorphisms: An in silico Approach by Mayakannan Manikandan, Ganesh Raksha, Arasambattu Kannan Munirajan

“…Haploinsufficiency of tumor suppressor genes, wherein the reduced production and activity of proteins results in the inability of the cell to maintain normal cellular function, is one among the various causes of cancer. …”
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Appropriate Amounts and Activity of the Wilms’ Tumor Suppressor Gene, <i>wt1</i>, Are Required for Normal Pronephros Development of <i>Xenopus</i> Embryos by Taisei Shiraki, Takuma Hayashi, Jotaro Ozue, Minoru Watanabe

“…The Wilms’ tumor suppressor gene, <i>wt1</i>, encodes a zinc finger-containing transcription factor that binds to a GC-rich motif and regulates the transcription of target genes. …”
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Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties by Schini-Kerth Valérie B, Fuhrmann Guy, Etienne-Selloum Nelly, Mousli Marc, Sharif Tanveer, Alhosin Mahmoud, Bronner Christian

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Tumoral tissue specific promoter hypermethylation of distinct tumor suppressor genes in a case with non--small cell lung carcinoma: A case report by Arslan Sulhattin, Dogan Tamer, Koksal Binnur, Yildirim Malik, Gumus Cesur, Elagoz Sahenda, Akkurt Ibrahim, Ozdemir Ozturk

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A Potential Tumor Suppressor Gene Named miR-508-5p Inhibited the Proliferation and Invasion of Human Melanoma Cells by Targeting KIT by Lin Dang PhD, Yan Wang PhD, Cuiping Shi MM, Mengsi Liao PhD, Zhaojun Sun MM, Sining Fang MM

“…Taken together, we speculated that miR-508-5p functioned as an important suppressor in human melanoma by targeting KIT, suggesting miR-508-5p might be a promising tumor suppressor gene for further target therapies from bench to clinic.…”
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Comparison of the fertility of tumor suppressor gene-deficient C57BL/6 mouse strains reveals stable reproductive aging and novel pleiotropic gene by Masaoki Kohzaki, Akira Ootsuyama, Toshiyuki Umata, Ryuji Okazaki

“…Abstract Tumor suppressor genes are involved in maintaining genome integrity during reproduction (e.g., meiosis). …”
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Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype. by Mina Waraya, Keishi Yamashita, Akira Ema, Natsuya Katada, Shiro Kikuchi, Masahiko Watanabe

“…BACKGROUND:A comprehensive search for DNA methylated genes identified candidate tumor suppressor genes that have been proven to be involved in the apoptotic process of the p53 pathway. …”
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Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene. by Tale Barøy, Chandra S R Chilamakuri, Susanne Lorenz, Jinchang Sun, Øyvind S Bruland, Ola Myklebost, Leonardo A Meza-Zepeda

“…Together, these results suggest CHM as a candidate tumor suppressor gene that warrants further investigation.…”
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NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells by Maureen Keller, Fatéméh Dubois, Sylvain Teulier, Alexandre P. J. Martin, Jérôme Levallet, Elodie Maille, Solenn Brosseau, Nicolas Elie, Alexander Hergovich, Emmanuel Bergot, Jacques Camonis, Gérard Zalcman, Guénaëlle Levallet

“…Abstract Background RASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition (EMT). …”
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Haploinsufficiency of Tumor Suppressor Genes is Driven by the Cumulative Effect of microRNAs, microRNA Binding Site Polymorphisms and microRNA Polymorphisms: An In silico Approach by Mayakannan Manikandan, Ganesh Raksha, Arasambattu Kannan Munirajan

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miR-125b-5p functions as a tumor suppressor gene partially by regulating HMGA2 in esophageal squamous cell carcinoma. by Li-Li Mei, Wen-Jun Wang, Yun-Tan Qiu, Xiu-Feng Xie, Jie Bai, Zhi-Zhou Shi

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The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways. by Badgwell, D, Lu, Z, Le, K, Gao, F, Yang, M, Suh, G, Bao, J, Das, P, Andreeff, M, Chen, W, Yu, Y, Ahmed, A, S-L Liao, W, Bast, R

“…ARHI is an imprinted tumor-suppressor gene that is downregulated in &gt;60% of ovarian cancers, and its loss is associated with decreased progression-free survival. …”

Molecular Genetics of Esophageal Cancer : Indian Perspective by Suddhasattwa Ray, Mona Malekzadehmoghani, Sonia S Ray, Partha Sen, Sayan Chakraborty

Subjects: “…tumor-suppressor genes, riz1,methylation…”
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