Genetic Changes in Ovarian Cancer by Kar-San Ling, Gin-Den Chen, Horng-Jyh Tsai, Maw-Sheng Lee, Po-Hui Wang

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AIP mutations in Brazilian patients with sporadic pituitary adenomas: a single-center evaluation by Paula Bruna Araujo, Paula Bruna Araujo, Carlos Henrique de Azeredo Lima, Liana Ogino, Aline H S Camacho, Leila Chimelli, Márta Korbonits, Monica RGadelha

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NF2 alteration in mesothelioma by Yoshitaka Sekido, Yoshitaka Sekido, Tatsuhiro Sato

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Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers by Guzmán Leda, Depix María, Salinas Ana, Roldán Rosa, Aguayo Francisco, Silva Alejandra, Vinet Raul

“…Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in the development of LC. …”
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The role of oncogenes and tumor suppressor genes in determining survival rates of lung cancer patients in the population of North Sumatra, Indonesia [version 2; peer review: 2 approved] by Noni Novisari Soeroso, Noverita Sprinse Vinolina, Fannie Rizki Ananda, Johan Samuel Sitanggang

“…Several oncogenes and tumor suppressor genes have been identified and have different roles related to survival rates in lung cancer patients. …”
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The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens by Luke A. Wiley, Ramya Rajagopal, Lisa K. Dattilo, David C. Beebe

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PTC124 Rescues Nonsense Mutation of Two Tumor Suppressor Genes <i>NOTCH1</i> and <i>FAT1</i> to Repress HNSCC Cell Proliferation by Ming-Han Wu, Rui-Yu Lu, Si-Jie Yu, Yi-Zhen Tsai, Ying-Chen Lin, Zhi-Yu Bai, Ruo-Yu Liao, Yi-Chiang Hsu, Chia-Chi Chen, Bi-He Cai

“…With the exception of the <i>TP53</i> tumor suppressor gene, there has been little research on cancers with nonsense mutation. …”
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Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9 by Tao Guo, Guo-Qiao Chen, Xu-Fan Li, Meng Wang, Kun-Ming Liu, Xiao-Ying Yang, Si-Cheng Liu, Yi-Li Feng, Peng-Yuan Liu, Hui Lin, An-Yong Xie

“…Methods CRISPR/Cas9-based targeted somatic multiplex-mutagenesis was used to target 34 tumor suppressor genes (TSGs) for induction of primary liver tumors in mice. …”
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Androgen Receptors Act as a Tumor Suppressor Gene to Suppress Hepatocellular Carcinoma Cells Progression via miR-122-5p/RABL6 Signaling by Neng Tang, Xiaolin Dou, Xing You, Yixiong Li, Xi Li, Xi Li, Xi Li, Guodong Liu, Guodong Liu, Guodong Liu

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The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs by Roberto Stabile, Mario Román Cabezas, Mathijs P. Verhagen, Francesco A. Tucci, Thierry P. P. van den Bosch, Maria J. De Herdt, Berdine van der Steen, Alex L. Nigg, Meng Chen, Cristina Ivan, Masayoshi Shimizu, Senada Koljenović, Jose A. Hardillo, C. Peter Verrijzer, Robert J. Baatenburg de Jong, George A. Calin, Riccardo Fodde

“…Abstract Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1; also known as deleted in oral cancer or DOC1) is a tumor suppressor gene known to play functional roles in both cell cycle regulation and in the epigenetic control of embryonic stem cell differentiation, the latter as a core subunit of the nucleosome remodeling and histone deacetylation (NuRD) complex. …”
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Canine Mammary Carcinomas: A Comparative Analysis of Altered Gene Expression by Farruk M. Lutful Kabir, Carlos E. Alvarez, R. Curtis Bird

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Effect of Trichostatin A on Histone Deacetylases 1, 2 and 3, p21Cip1/Waf1/Sdi1, p27Kip1, and p57Kip2 Gene Expression in Breast Cancer SK-BR-3 Cell Line by Masumeh Sanaei, Fraidoon Kavoosi

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RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the Proton-Coupled Folate Carrier by Dzjemma Sarkisjan, Joris R. Julsing, Btissame El Hassouni, Richard J. Honeywell, Ietje Kathmann, Larry H. Matherly, Young B. Lee, Deog J. Kim, Godefridus J. Peters

“…From the increased protein expression of tumor-suppressor genes and functional activation of PCFT, we concluded that RX-3117 might have induced hypomethylation of the promotor.…”
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Immunohistochemical assessment of tumor suppressor gene Wwox in relation to proliferative marker KI67 proteins expression in giant cell lesions of the jaws and giant cell tumor of long bones by Muna S Merza

“…This study aimed to evaluate and compare immunohistochemical expression of tumor suppressor gene (WWOX) and proliferative marker (ki67) in giant cell lesions (GCLs) of the jaws and long bones. …”
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Combined effects of cigarette smoking, gene polymorphisms and methylations of tumor suppressor genes on non small cell lung cancer: a hospital-based case-control study in China by Jin Yongtang, Xu Heyun, zhang Chunye, Kong Yunming, Hou Yong, Xu Yingchun, Xue Shaoli

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The Histone Methyltransferase SETD8 Regulates the Expression of Tumor Suppressor Genes via H4K20 Methylation and the p53 Signaling Pathway in Endometrial Cancer Cells by Asako Kukita, Kenbun Sone, Syuzo Kaneko, Eiryo Kawakami, Shinya Oki, Machiko Kojima, Miku Wada, Yusuke Toyohara, Yu Takahashi, Futaba Inoue, Saki Tanimoto, Ayumi Taguchi, Tomohiko Fukuda, Yuichiro Miyamoto, Michihiro Tanikawa, Mayuyo Mori-Uchino, Tetsushi Tsuruga, Takayuki Iriyama, Yoko Matsumoto, Kazunori Nagasaka, Osamu Wada-Hiraike, Katsutoshi Oda, Ryuji Hamamoto, Yutaka Osuga

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Correction: Wu et al. Tumor-Suppressor Gene Transmembrane Protein 98 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer.... by San-Gang Wu, Jing-Ying Xu, Jian Lei, Min Hu, Juan Zhou

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Bioinformatics and Molecular Analysis of the Breast Cancer Susceptibility Gene BRCA1 in Breast Cancer by Inam Jasim Lafta

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The Effect of Different Anesthetic Techniques on Proliferation, Apoptosis, and Gene Expression in Colon Cancer Cells: A Pilot In Vitro Study by Alexandru Leonard Alexa, Ancuta Jurj, Ciprian Tomuleasa, Adrian Bogdan Tigu, Raluca-Miorita Hategan, Daniela Ionescu

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Novel homozygous mutation in the WWOX gene causes seizures and global developmental delay: Report and review by Ehaideb Salleh N., Al-Bu Ali Majed J., Al-obaid Jaafer J., Aljassim Kareemah M., Alfadhel Majid

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