Significance of promoter methylation of multiple tumor suppressor genes in hepatocellular carcinoma by Alaa Tahoon, Doaa El-Khateeb, Asmaa Mosbeh, Ibrahim Tantawy El Sayed, Ashraf Khalil

“…Abstract Background Methylation of the promoter at CpG islands is a mechanism of silencing tumor suppressor genes and therefore enhances cancer progression. …”
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Tumor suppressor gene methylation in follicular lymphoma: a comprehensive review by Montero Alberto, Hayslip John

“…<p>Abstract</p> <p>Transcriptional silencing of tumor suppressor genes, associated with DNA methylation, is a common epigenetic event in hematologic malignancies. …”
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Classical Oncogenes and Tumor Suppressor Genes: A Comparative Genomics Perspective by Oxana K. Pickeral, Jonathan Z. Li, Ian Barrow, Mark S. Boguski, Wojciech Makałowski, Jiong Zhang

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Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes by Pankaj Taneja, Sinan Zhu, Dejan Maglic, Eizabeth A. Fry, Robert D. Kendig, Kazushi Inoue

“…Malignant cells arise from a variety of genetic factors, such as mutations in tumor suppressor genes (TSGs) that are involved in regulating the cell cycle, apoptosis, or cell differentiation, or maintenance of genomic integrity. …”
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An Electrochemical DNA Sensor for p53 Tumor Suppressor Gene Detection by Zhang Jie, Wan Long, Fan Hao, Liao Fusheng

“…Introduction By using this new method, we demonstrate that this prototype sensor has been able to detect as low as picomolar p53 tumor suppressor gene with excellent differentiation ability for even single mismatches.…”
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Increased tumorigenesis associated with loss of the tumor suppressor gene <it>Cadm1</it> by van der Weyden Louise, Arends Mark J, Rust Alistair G, Poulogiannis George, McIntyre Rebecca E, Adams David J

“…</p> <p>Conclusion</p> <p>We confirm that <it>Cadm1</it> is indeed a bona fide tumor suppressor gene and provide new insights into genetic partners that co-operate in tumorigenesis when <it>Cadm1</it>-expression is lost.…”
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Clusterin in cancer: Dual role as a tumor suppressor gene and an oncogene by Rajashree Kadam, Tanuja Teni

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Looking at Thyroid Cancer from the Tumor-Suppressor Genes Point of View by Sadegh Rajabi, Catherine Alix-Panabières, Arshia Sharbatdar Alaei, Raziyeh Abooshahab, Heewa Shakib, Mohammad Reza Ashrafi

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BRD7 Acts as a Tumor Suppressor Gene in Lung Adenocarcinoma. by Yushun Gao, Bing Wang, Shugeng Gao

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Compensation by tumor suppressor genes during retinal development in mice and humans by Johnson Dianna, Martins Rodrigo, Schweers Brett, Donovan Stacy L, Dyer Michael A

“…<p>Abstract</p> <p>Background</p> <p>The <it>RB1 </it>gene was the first tumor suppressor gene cloned from humans by studying genetic lesions in families with retinoblastoma. …”
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Mutations in the P53 Tumor Suppressor Gene in Colorectal Cancer in Taiwan by Fu-Hsin Chang, Dong-Sheng Tzeng, For-Wey Lung

“…Mutations in the tumor suppressor gene p53 have been reported as occurring prevalently in a wide range of human tumors. …”
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Mutagenesis of the p̳53 tumor suppressor gene studied in Saccharomyces cerevisiae by Moshinsky, Deborah Jennie, 1970-

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A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions by Xue, Wen, Kitzing, Thomas, Roessler, Stephanie, Zuber, Johannes, Krasnitz, Alexander, Schultz, Nikolaus, Revill, Kate, Weissmueller, Susann, Rappaport, Amy R., Simon, Janelle, Zhang, Jack, Luo, Weijun, Hicks, James, Zender, Lars, Wang, Xin Wei, Powers, Scott, Wigler, Michael, Lowe, Scott W.

“…The large chromosomal deletions frequently observed in cancer genomes are often thought to arise as a “two-hit” mechanism in the process of tumor-suppressor gene (TSG) inactivation. Using a murine model system of hepatocellular carcinoma (HCC) and in vivo RNAi, we test an alternative hypothesis, that such deletions can arise from selective pressure to attenuate the activity of multiple genes. …”
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Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer by Venditti Julio, Gimenez Liliana, Puerta Patricia, Grau Laura, Castro Mónica, Quadrelli Silvia, Sánchez-Carbayo Marta

“…The objective of this study was to examine a multiplexed approach to assess the methylation of tumor suppressor genes as tumor stratification and clinical outcome prognostic biomarkers for lung cancer.…”
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Downregulation of tumor-suppressor gene LHX6 in cancer: a systematic review by Nathalia Evelyn, Theardy Madelaine Skolastika, Elvira Sharleen, Rosellinny Graciella, Liyanto Andrew Steven, Utama Michael Putra, Sumarpo Anton

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Tumor suppressor gene E-cadherin and its role in normal and malignant cells by Pećina-Šlaus Nives

“…<p>Abstract</p> <p>E-cadherin tumor suppressor genes are particularly active area of research in development and tumorigenesis. …”
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Hypermethylated promoters of tumor suppressor genes were identified in Crohn’s disease patients by Tae-Oh Kim, Yu Kyeong Han, Joo Mi Yi

“…In this study, we used 15 tumor suppressor genes (TSGs), originally identified in colon cancer, to detect promoter methylation in patients with Crohn’s disease (CD). …”
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Tumor suppressor genes are frequently methylated in lymph node metastases of breast cancers by Xu Jia, Tagliabue Elda, Carcangiu Maria, Zhao Naiqing, Orlandi Rosaria, Feng Weiwei, Bast Robert C, Yu Yinhua

“…</p> <p>Conclusions</p> <p>This study suggests that hypermethylation of tumor suppressor genes is extended from primary to metastatic tumors during tumor progression.…”
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Bona Fide Tumor Suppressor Genes Hypermethylated in Melanoma: A Narrative Review by Canan Güvenç, Fien Neckebroeck, Asier Antoranz, Marjan Garmyn, Joost van den Oord, Francesca Maria Bosisio

Subjects: “…tumor suppressor genes…”
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Integrated transcriptome interactome study of oncogenes and tumor suppressor genes in breast cancer by G. Pranavathiyani, Raja Rajeswary Thanmalagan, Naorem Leimarembi Devi, Amouda Venkatesan

“…Dysregulation of oncogenes and tumor suppressor genes is the major reason for the cause of cancer. …”
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