High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene by Jehnan Liu, Sadeesh K. Ramakrishnan, Saja S. Khuder, Meenakshi K. Kaw, Harrison T. Muturi, Sumona Ghosh Lester, Sang Jun Lee, Larisa V. Fedorova, Andrea J. Kim, Iman E. Mohamed, Cara Gatto-Weis, Kathryn M. Eisenmann, Philip B. Conran, Sonia M. Najjar

“…Allelic deletions of PTEN, a tumor suppressor gene, are common in prostate cancer in men. …”
Get full text

Epigenetic silencing and tumor suppressor gene of HAND2 by targeting ERK signaling in colorectal cancer by Zixu Yuan, Xihu Yu, Wenle Chen, Daici Chen, Jian Cai, Yingming Jiang, Xiaoxia Liu, Zhijie Wu, Lei Wang, William M. Grady, Hui Wang

Get full text

The tumor suppressor gene RBM5 inhibits lung adenocarcinoma cell growth and induces apoptosis by Shao Chen, Zhao Lijing, Wang Ke, Xu Wei, Zhang Jie, Yang Baoxue

“…<p>Abstract</p> <p>Background</p> <p>The loss of tumor suppressor gene (TSG) function is a critical step in the pathogenesis of human lung cancer. …”
Get full text

Reclassification of variants of tumor suppressor genes based on Sanger RNA sequencing without NMD inhibition by Changhee Ha, Ja-Hyun Jang, Young-gon Kim, Jong-Won Kim

Subjects: “…tumor suppressor gene…”
Get full text

The Frequency of Exon 2 Mutations of KLF6 Tumor Suppressor Gene in Prostate Cancer Specimens by Mehdi Nikbakht Dastjerdi, Javad Ramezani

Subjects: “…Tumor suppressor genes…”
Get full text

Analysis of loss of heterozygosity of the tumor suppressor genes p53 and BRCA1 in ovarial carcinomas by Luković Ljiljana, Popović Branka, Atanacković Jasmina, Novaković Ivana, Perović Milica, Petrović Bojana, Petković Spasoje

“…Background/aim: Among the genes involved in ovarian carcinogenesis, there has been increased interest in tumor-suppressor genes p53 and BRCA1. Both of the genes make control of cell cycle, DNA repair and apoptosis. …”
Get full text

Experiment of HNF4A as a Tumor Suppressor Gene Inhibiting Progression of Colorectal Cancer by SHAO Shengli, YANG Xi

Get full text

Mutation of the P53 Tumor Suppressor Gene in Transitional Cell Carcinoma of the Urinary Tract in Taiwan by Hung-Yu Lin

Get full text

Changes in Expression of Tumor Suppressor Gene RKIP Impact How Cancers Interact with Their Complex Environment by Christopher Figy, Anna Guo, Veani Roshale Fernando, Saori Furuta, Fahd Al-Mulla, Kam C. Yeung

“…Stepwise accumulation of mutations in oncogenes and tumor suppressor genes enables cancer cells to acquire the ability to reshape the microenvironment to advance their growth and metastasis. …”
Get full text

Splicing profile by capture RNA-seq identifies pathogenic germline variants in tumor suppressor genes by Tyler Landrith, Bing Li, Ashley A. Cass, Blair R. Conner, Holly LaDuca, Danielle B. McKenna, Kara N. Maxwell, Susan Domchek, Nichole A. Morman, Christopher Heinlen, Deborah Wham, Cathryn Koptiuch, Jennie Vagher, Ragene Rivera, Ann Bunnell, Gayle Patel, Jennifer L. Geurts, Morgan M. Depas, Shraddha Gaonkar, Sara Pirzadeh-Miller, Rebekah Krukenberg, Meredith Seidel, Robert Pilarski, Meagan Farmer, Khateriaa Pyrtel, Kara Milliron, John Lee, Elizabeth Hoodfar, Deepika Nathan, Amanda C. Ganzak, Sitao Wu, Huy Vuong, Dong Xu, Aarani Arulmoli, Melissa Parra, Lily Hoang, Bhuvan Molparia, Michele Fennessy, Susanne Fox, Sinead Charpentier, Julia Burdette, Tina Pesaran, Jessica Profato, Brandon Smith, Ginger Haynes, Emily Dalton, Joy Rae-Radecki Crandall, Ruth Baxter, Hsiao-Mei Lu, Brigette Tippin-Davis, Aaron Elliott, Elizabeth Chao, Rachid Karam

“…Abstract Germline variants in tumor suppressor genes (TSGs) can result in RNA mis-splicing and predisposition to cancer. …”
Get full text

Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study by Cantone Laura, Rizzo Giovanna, Marinelli Barbara, Angelici Laura, Bonzini Matteo, Nordio Francesco, Tarantini Letizia, Zhang Xiao, Hou Lifang, Apostoli Pietro, Bertazzi Pier, Baccarelli Andrea

“…<p>Abstract</p> <p>Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. …”
Get full text

The Role of the PTEN Tumor Suppressor Gene and Its Anti-Angiogenic Activity in Melanoma and Other Cancers by Jacqueline Maphutha, Danielle Twilley, Namrita Lall

“…Human malignant melanoma and other solid cancers are largely driven by the inactivation of tumor suppressor genes and angiogenesis. Conventional treatments for cancer (surgery, radiation therapy, and chemotherapy) are employed as first-line treatments for solid cancers but are often ineffective as monotherapies due to resistance and toxicity. …”
Get full text

Evolution and origin of merlin, the product of the <it>Neurofibromatosis type 2 </it>(<it>NF2</it>) tumor-suppressor gene by Omelyanchuk Leonid V, Chang Long-Sheng, Akhmametyeva Elena M, Blinov Alexander, Golovnina Kseniya

“…<p>Abstract</p> <p>Background</p> <p>Merlin, the product of the <it>Neurofibromatosis type 2 </it>(<it>NF2</it>) tumor suppressor gene, belongs to the ezrin-radixin-moesin (ERM) subgroup of the protein 4.1 superfamily, which links cell surface glycoproteins to the actin cytoskeleton. …”
Get full text

DNA methylation analysis of the tumor suppressor gene CDKN2B in Brazilian leukemia patients by Patrícia Santos Pereira Lima, Greice Andreoti Molffeta, Amélia Góes de Araujo, Marco Antônio Zago, Wilson Araújo da Silva Jr.

Get full text

The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision. by H Artee Luchman, Hallgrimur Benediktsson, Michelle L Villemaire, Alan C Peterson, Frank R Jirik

Get full text

CWH43 Is a Novel Tumor Suppressor Gene with Negative Regulation of TTK in Colorectal Cancer by Cheng-Chin Lee, Kuei-Yen Tsai, Ai-Wei Lee, Po-Li Wei, Chien-Yu Huang, Uyanga Batzorig, Yu-Jia Chang

Get full text

<it>ECRG4 </it>is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma by Kuhnen Cornelius, Tannapfel Andrea, Reifenberger Guido, Wolter Marietta, Traska Thilo, Feldhaus Valeska, Götze Silke, Martin Dirk, Müller Oliver, Sievers Sonja

“…<p>Abstract</p> <p>Background</p> <p>Cancer cells display widespread changes in DNA methylation that may lead to genetic instability by global hypomethylation and aberrant silencing of tumor suppressor genes by focal hypermethylation. In turn, altered DNA methylation patterns have been used to identify putative tumor suppressor genes.…”
Get full text

Tumor-Suppressor Gene Transmembrane Protein 98 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer by San-Gang Wu, Jing-Ying Xu, Jian Lei, Min Hu, Juan Zhou

Get full text

Transcriptional activation of the <it>Lats1 </it>tumor suppressor gene in tumors of CUX1 transgenic mice by Battat Robert, Cadieux Chantal, Harada Ryoko, Siam Rania, Vadnais Charles, Nepveu Alain

Get full text

Microsatellite Instability and Loss of Heterozygosity of Tumor Suppressor Genes in Bosnian Patients with Sporadic Colorectal Cancer by Vesna Hadžiavdić, Nada Pavlović-Čalić, Izet Eminović

“…We also analyzed genetic alterations of tumor suppressor genes as well as their relation with microsatellite instability. …”
Get full text