Permutation-based significance analysis reduces the type 1 error rate in bisulphite sequencing data analysis of human umbilical cord blood samples by Essi Laajala, Viivi Halla-aho, Toni Grönroos, Ubaid Ullah Kalim, Mari Vähä-Mäkilä, Mirja Nurmio, Henna Kallionpää, Niina Lietzén, Juha Mykkänen, Omid Rasool, Jorma Toppari, Matej Orešič, Mikael Knip, Riikka Lund, Riitta Lahesmaa, Harri Lähdesmäki

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Improved risk prediction of chemotherapy‐induced neutropenia—model development and validation with real‐world data by Mikko S. Venäläinen, Eetu Heervä, Outi Hirvonen, Sohrab Saraei, Tomi Suomi, Toni Mikkola, Maarit Bärlund, Sirkku Jyrkkiö, Tarja Laitinen, Laura L. Elo

“…Our study evaluates whether a machine learning‐based risk prediction model could outperform the previously introduced models, especially when validated against real‐world patient data from another institution not used for model training. Methods Using Turku University Hospital electronic medical records, we identified all patients who received chemotherapy for non‐hematological cancer between the years 2010 and 2017 (N = 5879). …”
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Does Glyphosate Affect the Human Microbiota? by Pere Puigbò, Lyydia I. Leino, Miia J. Rainio, Kari Saikkonen, Irma Saloniemi, Marjo Helander

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PET imaging of unruptured intracranial aneurysm inflammation (PET-IA) study: a feasibility study protocol by Riitta Parkkola, Antti Saraste, Jaakko Rinne, Dan Laukka, Jooa Paturi, Melissa Rahi, Juri Kivelev, Maria Gardberg, Johanna Kuhmonen

“…Secondary outcomes include estimating the correlations between uptake of 18F-FDG or 68Ga-DOTANOC and histological findings with blood and CSF miRNA-levels, arterial wall enhancement in gadolinium enhanced MRA, aneurysm size and shape, smoking, hypertension, and location of the aneurysm.Ethics and dissemination This study is approved by the Human Research Ethics Committee of the Hospital District of Southwest Finland, Finnish Medicines Agency Fimea, and Turku University Hospital. Findings will be disseminated through peer-reviewed journal articles and presentations at national and international conferences.Trial registration number NCT04715503…”
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Integrins are enriched on aberrantly fucosylated tumour‐derived urinary extracellular vesicles by Md. Khirul Islam, Bert Dhondt, Parvez Syed, Misba Khan, Kamlesh Gidwani, Jason Webber, An Hendrix, Guido Jenster, Tarja Lamminen, Peter J. Boström, Kim Pettersson, Urpo Lamminmäki, Janne Leivo

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Smoking is an Independent Marker of Poor Prognosis in Cutaneous Melanoma by Kalle Mattila, Helmi Vihinen, Antti Karlsson, Heikki Minn, Pia Vihinen, Eetu Heervä

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Indoor microbial exposure increases complement component C3a and C-reactive protein concentrations in serum by Outi Karhuvaara, Liisa Vilén, Jari Nuutila, Tuula Putus, Janne Atosuo

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Retrospective Analysis of Artifacts in Cone Beam Computed Tomography Images Used to Diagnose Chronic Rhinosinusitis by Niina Kuusisto, Jussi Hirvonen, Auli Suominen, Stina Syrjänen, Sisko Huumonen, Pekka Vallittu, Ilpo Kinnunen

“…Methods: All CBCT images of the patients referred to the Emergency Radiology unit, Turku University Hospital, with an indication of CRS in 2017 were re-examined. …”
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Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation by Maja Šolman, Alessio Ligabue, Olga Blaževitš, Alok Jaiswal, Yong Zhou, Hong Liang, Benoit Lectez, Kari Kopra, Camilo Guzmán, Harri Härmä, John F Hancock, Tero Aittokallio, Daniel Abankwa

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Brain Glucose Metabolism in Health, Obesity, and Cognitive Decline—Does Insulin Have Anything to Do with It? A Narrative Review by Eleni Rebelos, Juha O. Rinne, Pirjo Nuutila, Laura L. Ekblad

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Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma: Association with Metabolic Tumor Burden Determined with FDG-PET/CT by Antti Silvoniemi, Jukka Laine, Katri Aro, Linda Nissi, Leif Bäck, Jukka Schildt, Jussi Hirvonen, Jaana Hagström, Heikki Irjala, Leena-Maija Aaltonen, Marko Seppänen, Heikki Minn

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OP3: Cutaneous Melanoma in Children, Adolescents and Young Adults by Emma Rousi, Ilkka O. Koskivuo, Susanna Juteau, Lauri Talve, Veli-Matti Kähäri.

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Association of working hours with accelerometer-based sleep duration and sleep quality on the following night among older employees by Saana Myllyntausta, Anna Pulakka, Jaana Pentti, Jussi Vahtera, Marianna Virtanen, Sari Stenholm

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The impact of diabetes on the relationship of coronary artery disease and outcome: a study using multimodality imaging by Matias Mäenpää, Iida Kujala, Esa Harjulahti, Iida Stenström, Wail Nammas, Juhani Knuuti, Antti Saraste, Teemu Maaniitty

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Arpp19 Promotes Myc and Cip2a Expression and Associates with Patient Relapse in Acute Myeloid Leukemia by Eleonora Mäkelä, Eliisa Löyttyniemi, Urpu Salmenniemi, Otto Kauko, Taru Varila, Veli Kairisto, Maija Itälä-Remes, Jukka Westermarck

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Sex-specific associations between maternal pregnancy-specific anxiety and newborn amygdalar volumes - preliminary findings from the FinnBrain Birth Cohort Study by Satu J. Lehtola, Jetro J. Tuulari, Linnea Karlsson, John D. Lewis, Vladimir S. Fonov, D. Louis Collins, Riitta Parkkola, Jani Saunavaara, Niloofar Hashempour, Juho Pelto, Tuire Lähdesmäki, Noora M. Scheinin, Hasse Karlsson

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Discrepancies between Radiology Specialists and Residents in Fracture Detection from Musculoskeletal Radiographs by Jarno T. Huhtanen, Mikko Nyman, Roberto Blanco Sequeiros, Seppo K. Koskinen, Tomi K. Pudas, Sami Kajander, Pekka Niemi, Eliisa Löyttyniemi, Hannu J. Aronen, Jussi Hirvonen

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Biomarkers of viral and bacterial infection in rhinovirus pneumonia by Maria Hartiala, Elina Lahti, Elina Lahti, Laura Toivonen, Matti Waris, Olli Ruuskanen, Ville Peltola

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Vascular Adhesion Protein 1 Mediates Gut Microbial Flagellin-Induced Inflammation, Leukocyte Infiltration, and Hepatic Steatosis by Raine Toivonen, Sanja Vanhatalo, Maija Hollmén, Eveliina Munukka, Anniina Keskitalo, Sami Pietilä, Laura Elo, Pentti Huovinen, Sirpa Jalkanen, Satu Pekkala

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Localization in Unstructured Environments: Towards Autonomous Robots in Forests with Delaunay Triangulation by Qingqing Li, Paavo Nevalainen, Jorge Peña Queralta, Jukka Heikkonen, Tomi Westerlund

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