Incidence of rubella in a state in North-western Nigeria: a call for action by Semeeh Akinwale Omoleke, Henry Chukwuebuka Udenenwu

Get full text

Ulipristal acetate versus levonorgestrel-releasing intrauterine system for heavy menstrual bleeding (UCON): a randomised controlled phase III trialResearch in context by Lucy H.R. Whitaker, Lee J. Middleton, Jane P. Daniels, Alistair R.W. Williams, Lee Priest, Smita Odedra, Versha Cheed, Clive E. Stubbs, T. Justin Clark, Mary-Ann Lumsden, Dharani K. Hapangama, Siladitya Bhattacharya, Paul P. Smith, Elaine P. Nicholls, Neil Roberts, Scott I. Semple, Lucky Saraswat, Jane Walker, Rohan R. Chodankar, Hilary O.D. Critchley

Get full text

Procalcitonin testing to guide antibiotic therapy for the treatment of sepsis in intensive care settings and for suspected bacterial infection in emergency department settings: a s... by Marie Westwood, Bram Ramaekers, Penny Whiting, Florian Tomini, Manuela Joore, Nigel Armstrong, Steve Ryder, Lisa Stirk, Johan Severens, Jos Kleijnen

“…Study registration: This study is registered as PROSPERO CRD42014010822. Funding: The National Institute for Health Research Health Technology Assessment programme.…”
Get full text

The international effort: building the bridge for Translational Medicine: Report of the 1st International Conference of Translational Medicine (ICTM) by Xiaoming Chen, Roland Andersson, William CS Cho, David Christiani, Richard Coico, Jeffery Drazen, Markus Ege, Thomas Fehniger, Hongwei Gao, Kunlin Jin, Michael N Liebman, Elena Lopez, Giuseppe Marraro, Gyorgy Marko‐Varga, Francesco M Marincola, Laurentiu M Popescu, Claudio Spada, Aamir Shahzad, Ena Wang, Wei Wang, Xiangdong Wang, Yong‐Xiao Wang, Jinglin Xia, Jia Qu

Get full text

The South African Society of Psychiatrists (SASOP) and SASOP State Employed Special Interest Group (SESIG) position statements on psychiatric care in the public sector by Bernard Janse van Rensburg

“…HIV/AIDS in children: national HIV programmes have to promote awareness of the neurocognitive problems and psychiatric morbidity associated with HIV in children. …”
Get full text

Maternal and newborn health priority setting partnership in rural Uganda in association with the James Lind Alliance: a study protocol by James Ditai, Monicah Nakyazze, Deborah Andrinar Namutebi, Proscovia Auma, Martin Chebet, Cynthia Nalumansi, Grace Martha Nabulo, Kenneth Mugabe, Toto Anne Gronlund, Anthony Mbonye, Andrew D. Weeks

Get full text

Infant deaths in the UK community following successful cardiac surgery: building the evidence base for optimal surveillance, a mixed-methods study by Katherine L Brown, Jo Wray, Rachel L Knowles, Sonya Crowe, Jenifer Tregay, Deborah Ridout, David J Barron, David Cunningham, Roger Parslow, Rodney Franklin, Nick Barnes, Sally Hull, Catherine Bull

Get full text

Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study by Oriol Mitjà, DrMD, Camila González-Beiras, BSc, Charmie Godornes, BSc, Reman Kolmau, BSc, Wendy Houinei, HEO, Haina Abel, BSc, August Kapa, BSc, Raymond Paru, BSc, Sibauk V Bieb, MaHM, James Wangi, MPH, Sergi Sanz, MSc, Kingsley Asiedu, MPH, Sheila A Lukehart, ProfPhD, Quique Bassat, ProfMD

Get full text

Evaluation of efficacy, outcomes and safety of infant haemodialysis and ultrafiltration in clinical use: I-KID a stepped wedge cluster RCT by Heather Lambert, Shaun Hiu, Malcolm Coulthard, John N S Matthews, Ruth Wood, Jean Crosier, Rachel Agbeko, Thomas Brick, Heather Duncan, David Grant, Quen Mok, Andrew Gustaf Nyman, John Pappachan, Paul Wellman, Chris Boucher, Joe Bulmer, Denise Chisholm, Kirsten Cromie, Victoria Emmet, Richard Feltbower, Michael Grayling, Rebecca Harrison, Eva-Maria Holstein, Ciara A Kennedy, Elaine McColl, Kevin Morris, Lee Norman, Julie Office, Roger Parslow, Christine Pattinson, Shriya Sharma, Jonathan Smith, Alison Steel, Rachel Steel, Jayne Straker, Lamprini Vrana, Jenn Walker, Mike Whitaker, Jim Wightman, Nina Wilson, Lucy Wirz

“…Trial registration This trial is registered as ISRCTN 13787486. Funding This award was funded by the National Institute for Health and Care Research (NIHR) Efficacy and Mechanism Evaluation Programme (NIHR award ref: 14/23/26) and is published in full in Efficacy and Mechanism Evaluation; Vol. 11, No. 1. …”
Get full text

Death, bereavement and randomised controlled trials (BRACELET): a methodological study of policy and practice in neonatal and paediatric intensive care trials by Claire Snowdon, Peter Brocklehurst, Robert Tasker, Martin Ward Platt, Sheila Harvey, Diana Elbourne

“…Collectively they enrolled over 3000 children. Most enrolled small numbers, the majority of participants being enrolled by a small group of academic medical units. …”
Get full text

Evidence for retained spike-binding and neutralizing activity against emerging SARS-CoV-2 variants in serum of COVID-19 mRNA vaccine recipients by Juan Manuel Carreño, Hala Alshammary, Gagandeep Singh, Ariel Raskin, Fatima Amanat, Angela Amoako, Ana Silvia Gonzalez-Reiche, Adriana van de Guchte, PARIS study group, Komal Srivastava, Emilia Mia Sordillo, D. Noah Sather, Harm van Bakel, Florian Krammer, Viviana Simon

Get full text

Ten-year follow-up of a randomised trial of drainage, irrigation and fibrinolytic therapy (DRIFT) in infants with post-haemorrhagic ventricular dilatation by Karen Luyt, Sally Jary, Charlotte Lea, Grace J Young, David Odd, Helen Miller, Grazyna Kmita, Cathy Williams, Peter S Blair, Aída Moure Fernández, William Hollingworth, Michelle Morgan, Adam Smith-Collins, N Jade Thai, Steven Walker-Cox, Kristian Aquilina, Ian Pople, Andrew Whitelaw

“…A total of 52 children were assessed at 10 years of age (DRIFT, n = 28; standard treatment, n = 24). …”
Get full text

Reporting the whole story: Analysis of the ‘out‐of‐scope’ questions from the James Lind Alliance Teenage and Young Adult Cancer Priority Setting Partnership Survey by Faith Gibson, Lorna A. Fern, Bob Phillips, Helen Gravestock, Sonia Malik, Amy Callaghan, Karen Dyker, Mike Groszmann, Leila Hamrang, Rachael Hough, Demi McGeachy, Sue Morgan, Sam Smith, Sheela Upadhyaya, Helen Veitch, Max Williamson, Jeremy Whelan, Susie Aldiss

Get full text

Nature-based interventions to support mental health and well-being of young women in pregnancy: exploratory work for future feasibility RCT by Gina Sands, Holly Blake, Tim Carter, Helen Spiby

“…This can have long-term effects for them and their children. This also results in high costs for the National Health Service and social services. …”
Get full text

Interventions to reduce suicidal thoughts and behaviours among people in contact with the criminal justice system: A global systematic review by Annie Carter, Amanda Butler, Melissa Willoughby, Emilia Janca, Stuart A. Kinner, Louise Southalan, Seena Fazel, Rohan Borschmann

Get full text

Intravenous co-amoxiclav to prevent infection after operative vaginal delivery: the ANODE RCT by Marian Knight, Virginia Chiocchia, Christopher Partlett, Oliver Rivero-Arias, Xinyang Hua, Ursula Bowler, James Gray, Shan Gray, Kim Hinshaw, Aethele Khunda, Philip Moore, Linda Mottram, Nelly Owino, Dharmintra Pasupathy, Julia Sanders, Abdul H Sultan, Ranee Thakar, Derek Tuffnell, Louise Linsell, Edmund Juszczak

Get full text

Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study by Margaret N. Kosek, Tahmeed Ahmed, Zulfiquar Bhutta, Laura Caulfield, Richard Guerrant, Eric Houpt, Gagandeep Kang, Margaret Kosek, Gwenyth Lee, Aldo Lima, Benjamin J.J. McCormick, James Platts-Mills, Jessica Seidman, Laura Caulfield, Margaret Kosek, Gwenyth Lee, Benjamin J.J. McCormick, Jessica Seidman, Rebecca R. Blank, Michael Gottlieb, Stacey L. Knobler, Dennis R. Lang, Mark A. Miller, Karen H. Tountas, Zulfiqar A. Bhutta, Laura Caulfield, William Checkley, Richard L. Guerrant, Eric Houpt, Margaret N. Kosek, Dennis R. Lang, Carl J. Mason, Mark A. Miller, Laura E. Murray-Kolb, William A. Petri, Jr., Jessica C. Seidman, Tahmeed Ahmed, Pascal Bessong, Zulfiqar A. Bhutta, Rashidul Haque, Sushil John, Gagandeep Kang, Margaret N. Kosek, Aldo A.M. Lima, Estomih R. Mduma, Reinaldo B. Oriá, Prakash Sunder Shrestha, Sanjaya Kumar Shrestha, Erling Svensen, Anita K.M. Zaidi, Cláudia B. Abreu, Angel Mendez Acosta, Imran Ahmed, A.M. Shamsir Ahmed, Asad Ali, Ramya Ambikapathi, Leah Barrett, Aubrey Bauck, Eliwaza Bayyo, Ladaporn Bodhidatta, Anuradha Bose, J. Daniel Carreon, Ram Krishna Chandyo, Vivek Charu, Hilda Costa, Rebecca Dillingham, Alessandra Di Moura, Viyada Doan, Jose Quirino Filho, Jhanelle Graham, Christel Hoest, Iqbal Hossain, Munirul Islam, M. Steffi Jennifer, Shiny Kaki, Beena Koshy, Gwenyth Lee, Álvaro M. Leite, Noélia L. Lima, Bruna L.L. Maciel, Mustafa Mahfuz, Cloupas Mahopo, Angelina Maphula, Benjamin J.J. McCormick, Monica McGrath, Archana Mohale, Milena Moraes, Francisco S. Mota, Jayaprakash Muliyil, Regisiana Mvungi, Gaurvika Nayyar, Emanuel Nyathi, Maribel Paredes Olortegui, Reinaldo Oria, Angel Orbe Vasquez, William K. Pan, John Pascal, Crystal L. Patil, Laura Pendergast, Silvia Rengifo Pinedo, James Platts-Mills, Stephanie Psaki, Mohan Venkata Raghava, Karthikeyan Ramanujam, Muneera Rasheed, Zeba A. Rasmussen, Stephanie A. Richard, Anuradha Rose, Reeba Roshan, Barbara Schaefer, Rebecca Scharf, Jessica C. Seidman, Srujan L. Sharma, Binob Shrestha, Rita Shrestha, Suzanne Simons, Alberto M. Soares, Rosa M.S. Mota, Sajid Soofi, Tor Strand, Fahmida Tofail, Rahul J. Thomas, Ali Turab, Manjeswori Ulak, Vivian Wang, Ladislaus Yarrot, Pablo Peñataro Yori, Didar Alam, Ramya Ambikapathi, Caroline Amour, Cesar Banda Chavez, Sudhir Babji, Rosa Rios de Burga, Viyada Doan, Julian Torres Flores, Jean Gratz, Ajila T. George, Dinesh Hariraju, Alexandre Havt, Eric Houpt, Priyadarshani Karunakaran, Robin P. Lazarus, Ila F. Lima, Monica McGrath, Dinesh Mondal, Pedro H.Q.S. Medeiros, Rosemary Nshama, Josiane Quetz, Shahida Qureshi, Sophy Raju, Anup Ramachandran, Rakhi Ramadas, A. Catharine Ross, Mery Siguas Salas, Amidou Samie, Kerry Schulze, Jessica C. Seidman, E. Shanmuga Sundaram, Buliga Mujaga Swema, Dixner Rengifo Trigoso

Get full text

A framework for the definition and interpretation of the use of surrogate endpoints in interventional trialsResearch in context by Oriana Ciani, Anthony M. Manyara, Philippa Davies, Derek Stewart, Christopher J. Weir, Amber E. Young, Jane Blazeby, Nancy J. Butcher, Sylwia Bujkiewicz, An-Wen Chan, Dalia Dawoud, Martin Offringa, Mario Ouwens, Asbjørn Hróbjartssson, Alain Amstutz, Luca Bertolaccini, Vito Domenico Bruno, Declan Devane, Christina D.C.M. Faria, Peter B. Gilbert, Ray Harris, Marissa Lassere, Lucio Marinelli, Sarah Markham, John H. Powers, Yousef Rezaei, Laura Richert, Falk Schwendicke, Larisa G. Tereshchenko, Achilles Thoma, Alparslan Turan, Andrew Worrall, Robin Christensen, Gary S. Collins, Joseph S. Ross, Rod S. Taylor

Get full text

Ultrastructure for the diagnosis of primary ciliary dyskinesia in South Africa, a resource-limited setting by Monica Birkhead, Samuel Otido, Theodore Mabaso, Keketso Mopeli, Dorcas Tlhapi, Charl Verwey, Charl Verwey, Ziyaad Dangor, Ziyaad Dangor

Get full text

Statistical modeling based on structured surveys of Australian native possum excreta harboring Mycobacterium ulcerans predicts Buruli ulcer occurrence in humans by Koen Vandelannoote, Andrew H Buultjens, Jessica L Porter, Anita Velink, John R Wallace, Kim R Blasdell, Michael Dunn, Victoria Boyd, Janet AM Fyfe, Ee Laine Tay, Paul DR Johnson, Saras M Windecker, Nick Golding, Timothy P Stinear

Get full text