Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation by Zijun Chen, Zhengyang Li, Xiaojian Hu, Feiyan Xie, Siyun Kuang, Bowen Zhan, Wenqing Gao, Xiangjun Chen, Siqi Gao, Yang Li, Yongming Wang, Feng Qian, Chen Ding, Jianhua Gan, Chaoneng Ji, Xue‐Wei Xu, Zheng Zhou, Jinqing Huang, Housheng Hansen He, Jixi Li

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Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I) by Jennifer D. Brooks, Hermann Nabi, Irene L. Andrulis, Antonis C. Antoniou, Jocelyne Chiquette, Philippe Després, Peter Devilee, Michel Dorval, Arnaud Droit, Douglas F. Easton, Andrea Eisen, Laurence Eloy, Samantha Fienberg, David Goldgar, Eric Hahnen, Yann Joly, Bartha Maria Knoppers, Aisha Lofters, Jean-Yves Masson, Nicole Mittmann, Jean-Sébastien Paquette, Nora Pashayan, Rita Schmutzler, Tracy Stockley, Sean V. Tavtigian, Meghan J. Walker, Michael Wolfson, Anna Maria Chiarelli, Jacques Simard

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Timing of Lung Transplant Referral in Patients with Severe COVID-19 Lung Injury Supported by ECMO by Liran Levy, Ofir Deri, Ella Huszti, Eyal Nachum, Stephane Ledot, Nir Shimoni, Milton Saute, Leonid Sternik, Ran Kremer, Yigal Kassif, Nona Zeitlin, Jonathan Frogel, Ilya Lambrikov, Ilia Matskovski, Sumit Chatterji, Lior Seluk, Nadav Furie, Inbal Shafran, Ronen Mass, Amir Onn, Ehud Raanani, Amir Grinberg, Yuval Levy, Arnon Afek, Yitshak Kreiss, Alexander Kogan

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Effect of the COVID-19 pandemic on mental health visits in primary care: an interrupted time series analysis from nine INTRePID countriesResearch in context by Javier Silva-Valencia, Carla Lapadula, John M. Westfall, Gabriela Gaona, Simon de Lusignan, Robert Sarkadi Kristiansson, Zheng Jye Ling, Lay Hoon Goh, Percy Soto-Becerra, Maria Sofia Cuba-Fuentes, Knut-Arne Wensaas, Signe Flottorp, Valborg Baste, William Chi-Wai Wong, Amy Pui Pui Ng, Angela Ortigoza, Jo-Anne Manski-Nankervis, Christine Mary Hallinan, Paula Zingoni, Luciano Scattini, Adrian Heald, Karen Tu, Karen Tu, Angela Ortigoza, Carla Lapadula, Paula Zingoni, Luciano Scattini, Jo-Anne Manski-Nankervis, Christine Mary Hallinan, Adrian Laughlin, William Chi-Wai Wong, Amy Pui Pui Ng, Zhou Li, Knut-Arne Wensaas, Signe Agnes Flottorp, Valborg Baste, Maria Sofia Cuba-Fuentes, Javier Silva-Valencia, Percy Soto-Becerra, Zheng Jye Ling, Lay Hoon Goh, Robert Kristiansson, Mats Martinell, Simon de Lusignan, Uy Hoang, Adrian Heald, Wilson Pace, John M. Westfall, Gabriela Gaona, Michael Kidd

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Encourager les personnes âgées souffrant de préfragilité et de fragilité à participer au programme d’exercice et de nutrition « MoveStrong » : analyse des résultats secondaires d’u... by Isabel Rodrigues, Justin Wagler, Justin Wagler, Heather Keller, Lehana Thabane, Zachary Weston, Sharon Straus, Alexandra Papaioannou, Marina Mourtzakis, Jamie Milligan, Wanrudee Isaranuwatchai, Desmond Loong, Ravi Jain, Larry Funnell, Angela Cheung, Sheila Brien, Maureen Ashe, Lora Giangregorio

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Cardiopulmonary Exercise Testing in Repaired Tetralogy of Fallot: Multiparametric Overview and Correlation with Cardiac Magnetic Resonance and Physical Activity Level by Benedetta Leonardi, Federica Gentili, Marco Alfonso Perrone, Fabrizio Sollazzo, Lucia Cocomello, Stefani Silva Kikina, Rachel M. Wald, Vincenzo Palmieri, Aurelio Secinaro, Maria Giulia Gagliardi, Attilio Parisi, Attilio Turchetta, Lorenzo Galletti, Massimiliano Bianco, Fabrizio Drago

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Comparing biparametric to multiparametric MRI in the diagnosis of clinically significant prostate cancer in biopsy-naive men (PRIME): a prospective, international, multicentre, non... by Jonathan J Deeks, Chris Brew-Graves, Yemisi Takwoingi, Aiman Haider, Clare Allen, Alex Freeman, Mark Emberton, Antti Rannikko, John Wilkinson, Daniel Margolis, Enrique Gomez Gomez, Sangeet Ghai, Alex Kirkham, Veeru Kasivisvanathan, Caroline M Moore, Hazel McBain, Anders Bjartell, Paula Lorgelly, Pramit Khetrapal, Shonit Punwani, Nicola Muirhead, Ridhi Agarwal, Philip Ryan, Caroline S Clarke, Aqua Asif, Peter Albertsen, Alexander Ng, Francesco Giganti, Louise Dickinson, Jeremy Grummet, Vinson Wai-Shun Chan, Arjun Nathan, Marimo Rossiter, Réka Novotta, Tushar Narain, Antonette Andrews, Valeria Panebianco, Lance Mynderse, Adam Froemming, Naoki Takahasi, Tristan Barrett, Raphaële Renard-Penna, Vibeke Løgager, Lars Boesen, Lars Budäus, Tho Pham, Jing Yi Jessica Weng, Wim Witjes, Christien Caris, Joke Van Egmond

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The let-7b-5p, miR-326, and miR-125a-3p are associated with left ventricular systolic dysfunction in post-myocardial infarction by Raquel Costa Silva Dantas-Komatsu, Marina Sampaio Cruz, Marina Sampaio Cruz, Paula Paccielli Freire, Paula Paccielli Freire, Rosiane Viana Zuza Diniz, Raul Hernandes Bortolin, Raul Hernandes Bortolin, Otávio Cabral-Marques, Otávio Cabral-Marques, Otávio Cabral-Marques, Otávio Cabral-Marques, Otávio Cabral-Marques, Otávio Cabral-Marques, Kamilla Batista da Silva Souza, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata, Bruna Zavarize Reis, Igor Jurisica, Igor Jurisica, Igor Jurisica, Vivian Nogueira Silbiger, Vivian Nogueira Silbiger, Andre Ducati Luchessi, Andre Ducati Luchessi

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Medication self-management toolkits for adults with multiple sclerosis: A scoping review by Sara J.T. Guilcher, Lauren Cadel, Andrea He, Stephanie R. Cimino, Maham Ahmed, Chester H. Ho, Sander L. Hitzig, Lisa M. McCarthy, Tejal Patel, Shoshana Hahn-Goldberg, Aisha K. Lofters, Tanya L. Packer

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Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study by Bernhard Mlecnik, Toshihiko Torigoe, Gabriela Bindea, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Yoshihiko Hirohashi, Tomohisa Furuhata, Ichiro Takemasa, Prabhudas Patel, Hemangini Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Takayuki Yoshino, Hiroya Taniguchi, Carlo Bifulco, Alessandro Lugli, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T. Rau, Martin D. Berger, Iris D. Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol I. Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H. A. Roehrl, Pamela S. Ohashi, Linh T. Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradly G. Wouters, Giuseppe V. Masucci, Emilia Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Florence Marliot, Tessa Fredriksen, Bénédicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn Van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Francesco M. Marincola, Paolo A. Ascierto, Bernard A. Fox, Franck Pagès, Yutaka Kawakami, Jérôme Galon

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Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer by Bernhard Mlecnik, Alessandro Lugli, Gabriela Bindea, Florence Marliot, Carlo Bifulco, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T. Rau, Martin D. Berger, Iris D. Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol I. Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H. A. Roehrl, Pamela S. Ohashi, Linh T. Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradly G. Wouters, Giuseppe V. Masucci, Emilia K. Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Bénédicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Prabhu Patel, Hemangini H. Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M. Marincola, Paolo A. Ascierto, Bernard A. Fox, Franck Pagès, Jérôme Galon

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The Canadian Women’s Heart Health Alliance ATLAS on the Epidemiology, Diagnosis, and Management of Cardiovascular Disease in Women — Chapter 9: Summary of Current Status, Challenge... by Sharon L. Mulvagh, MD, FRCPC, FACC, FASE, FAHA, Tracey J.F. Colella, RN, PhD, Martha Gulati, MD, MS, Rebecca Crosier, MD, Saleema Allana, RN, PhD, Varinder Kaur Randhawa, MD, PhD, Jill Bruneau, PhD, RN, Christine Pacheco, MD, Shahin Jaffer, MD, MHSc, FRCPC, Lisa Cotie, PhD, Emma Mensour, Marie-Annick Clavel, PhD, Braeden Hill, Amy A. Kirkham, PhD, Heather Foulds, PhD, Kiera Liblik, Andrea Van Damme, BN, MN, Sherry L. Grace, PhD, Karen Bouchard, PhD, Heather Tulloch, PhD, Helen Robert, April Pike, PhD, RN, Jamie L. Benham, MD, PhD, Nicole Tegg, MN, RN, BScN, Nazli Parast, PhD, APN, Najah Adreak, MD, Laurie-Anne Boivin-Proulx, MD, MSc, Monica Parry, PhD, RN, Zoya Gomes, BSc, MSc, Hope Sarfi, Chinelo Iwegim, MD, MHPM, Harriette G.C. Van Spall, MD, MPH, Kara A. Nerenberg, MD, MSc, Stephen P. Wright, PhD, Jayneelkumar A. Limbachia, MSc, Kerri-Anne Mullen, PhD, Colleen M. Norris, PhD, MScN, BScN, RN

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Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune re... by Anna Spreafico, Eva Muñoz Couselo, Anja Irmisch, Juliana Bessa, George Au-Yeung, Oliver Bechter, Inge Marie Svane, Miguel F. Sanmamed, Miguel F. Sanmamed, Valentina Gambardella, Valentina Gambardella, Meredith McKean, Margaret Callahan, Reinhard Dummer, Christian Klein, Pablo Umaña, Nicole Justies, Florian Heil, Linda Fahrni, Eugenia Opolka-Hoffmann, Inja Waldhauer, Conrad Bleul, Roland F. Staack, Vaios Karanikas, Stephen Fowler

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Integrative analysis of clinicopathological features defines novel prognostic models for mantle cell lymphoma in the immunochemotherapy era: a report from The North American Mantle... by Julie M. Vose, Kai Fu, Lu Wang, Adnan Mansoor, Douglas Stewart, Hongxia Cheng, Lynette Smith, Ji Yuan, Hina Naushad Qureishi, Brian K. Link, Melissa H. Cessna, Paul M. Barr, Brad S. Kahl, Matthew S. Mckinney, Nadia Khan, Ranjana H. Advani, Peter Martin, Andre H. Goy, Tycel J. Phillips, Amitkumar Mehta, Manali Kamdar, Michael Crump, Barbara Pro, Christopher R. Flowers, Caron A. Jacobson, Sonali M. Smith, Deborah M. Stephens, Veronika Bachanova, Zhaohui Jin, Shishou Wu, Francisco Hernandez-Ilizaliturri, Pallawi Torka, Andrea Anampa-Guzmán, Farshid Kashef, Xing Li, Sunandini Sharma, Timothy C. Greiner, James O. Armitage, Matthew Lunning, Dennis D. Weisenburger, Robert G. Bociek, Javeed Iqbal, Guohua Yu, Chengfeng Bi, the North American Mantle Cell Lymphoma Consortium

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Proposal for an Ambulatory Heart Failure Management Curriculum for Cardiology Residency Training Programs by Aws Almufleh, MBBS, MPH, FRCPC, Ricky D. Turgeon, BSc (Pharm), ACPR, PharmD, Anique Ducharme, MD, MSc, FRCPC, Filio Billia, MD, PhD, FRCPC, Justin Ezekowitz, MD, MBBCh, MSc, FRCPC

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Validation of the Use of Discharge Diagnostic Codes for the Verification of Secondary Atrial Fibrillation in Administrative Databases by Erika Nakajima, BSc, Bisan ShweikiAlrefaee, MD, Peter C. Austin, PhD, Dennis T. Ko, MD, MSc, Husam Abdel-Qadir, MD, PhD

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First-in-human phase I study of the OX40 agonist GSK3174998 with or without pembrolizumab in patients with selected advanced solid tumors (ENGAGE-1) by Stephane Champiat, Aurélien Marabelle, Anna Spreafico, Mehmet Altan, Todd M Bauer, Osama Rahma, Karen A Autio, Neeta Somaiah, Meredith McKean, Aaron R Hansen, Jan H M Schellens, Willeke Ros, F Stephen Hodi, Jeffrey S Weber, John V Heymach, Herbert Struemper, Sandrine Aspeslagh, Daniel C Cho, Jennifer K Litton, Axel Hoos, Vincent K Lam, Emmett V Schmidt, Sophie Postel-Vinay, Frans L Opdam, Elaine M Paul, Christoph M Ahlers, Helen Zhou, Shelby A Gorman, Maura Watmuff, Kaitlin M Yablonski, Niranjan Yanamandra, Michael J Chisamore

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Transitions of care for older adults discharged home from the emergency department: an inductive thematic content analysis of patient comments by Vanessa Couture, Nathalie Germain, Émilie Côté, Lise Lavoie, Joanie Robitaille, Michèle Morin, Josée Chouinard, Yves Couturier, France Légaré, Marie-Soleil Hardy, Lucas B. Chartier, Audrey-Anne Brousseau, Nadia Sourial, Éric Mercier, Clémence Dallaire, Richard Fleet, Annie Leblanc, Don Melady, Denis Roy, Samir Sinha, Marie-Josée Sirois, Holly O. Witteman, Marcel Émond, Josée Rivard, Isabelle Pelletier, Stéphane Turcotte, Rawane Samb, Raphaëlle Giguère, Lyna Abrougui, Pascal Y. Smith, Patrick M. Archambault, on behalf of  the Network of Canadian Emergency Researchers

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Immunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection by Desirée Rodrigues Plaça, Dennyson Leandro M. Fonseca, Alexandre H. C. Marques, Shahab Zaki Pour, Júlia Nakanishi Usuda, Gabriela Crispim Baiocchi, Caroline Aliane de Souza Prado, Ranieri Coelho Salgado, Igor Salerno Filgueiras, Paula Paccielli Freire, Paula Paccielli Freire, Vanderson Rocha, Vanderson Rocha, Vanderson Rocha, Vanderson Rocha, Niels Olsen Saraiva Camara, Rusan Catar, Guido Moll, Guido Moll, Igor Jurisica, Igor Jurisica, Igor Jurisica, Vera Lúcia Garcia Calich, Lasse M. Giil, Laura Rivino, Laura Rivino, Hans D. Ochs, Gustavo Cabral-Miranda, Lena F. Schimke, Lena F. Schimke, Lena F. Schimke, Otavio Cabral-Marques, Otavio Cabral-Marques, Otavio Cabral-Marques, Otavio Cabral-Marques, Otavio Cabral-Marques, Otavio Cabral-Marques

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Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease by Dhanya Ramachandran, Jonathan P. Tyrer, Stefan Kommoss, Anna DeFazio, Marjorie J. Riggan, AOCS Group, Penelope M. Webb, Peter A. Fasching, Diether Lambrechts, María J. García, Cristina Rodríguez-Antona, Marc T. Goodman, Francesmary Modugno, Kirsten B. Moysich, Beth Y. Karlan, Jenny Lester, Susanne K. Kjaer, Allan Jensen, Estrid Høgdall, Ellen L. Goode, William A. Cliby, Amanika Kumar, Chen Wang, Julie M. Cunningham, Stacey J. Winham, Alvaro N. Monteiro, Joellen M. Schildkraut, Daniel W. Cramer, Kathryn L. Terry, Linda Titus, Line Bjorge, Liv Cecilie Vestrheim Thomsen, OPAL Study Group, Tanja Pejovic, Claus K. Høgdall, Iain A. McNeish, Taymaa May, David G. Huntsman, Jacobus Pfisterer, Ulrich Canzler, Tjoung-Won Park-Simon, Willibald Schröder, Antje Belau, Lars Hanker, Philipp Harter, Jalid Sehouli, Rainer Kimmig, Nikolaus de Gregorio, Barbara Schmalfeldt, Klaus Baumann, Felix Hilpert, Alexander Burges, Boris Winterhoff, Peter Schürmann, Lisa-Marie Speith, Peter Hillemanns, Andrew Berchuck, Sharon E. Johnatty, Susan J. Ramus, Georgia Chenevix-Trench, Paul D. P. Pharoah, Thilo Dörk, Florian Heitz

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