Immunohistochemical Analysis of Lymphocyte Populations in Acute Skin Rejection: The University Health Network Addition to the Banff Classification by Siba Haykal, MD, PhD, FRCSC, FACS, Natasha Barone, MSc, Sara Rostami, DVM, Sajad Moshkelgosha, PhD, Stephen Juvet, MD, PhD, FRCPC, Shaf Keshavjee, MD, MSc, FRCSC, FACS, Danny Ghazarian, MD, PhD, FRCPC, FCAP

“…Our findings led to the establishment of the University Health Network addition of skin rejection. Conclusions:. …”
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Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience. by Evans, A, Chetty, R, Clarke, B, Croul, S, Ghazarian, D, Kiehl, T, Ordonez, B, Ilaalagan, S, Asa, S

“…Although telepathology (TP) has not been widely implemented for primary frozen section diagnoses, interest in its use is growing as we move into an age of increasing sub-specialization and centralization of pathology services. University Health Network (UHN) is a 3-site academic institution in downtown Toronto. …”

Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience. by Evans, A, Chetty, R, Clarke, B, Croul, S, Ghazarian, D, Kiehl, T, Perez Ordonez, B, Ilaalagan, S, Asa, S

“…Although telepathology (TP) has not been widely implemented for primary frozen section diagnoses, interest in its use is growing as we move into an age of increasing subspecialization and centralization of pathology services. University Health Network is a 3-site academic institution in downtown Toronto. …”

Perioperative Hypertension Etiologies in Patients Undergoing Noncardiac Surgery in University Health Network Hospitals–Canada from 2015–2020 by Mohseni S, Behnam-Roudsari S, Tarbiat M, Shaker P, Shivaie S, Shafiee MA

“…Identifying reasons associated with hypertension in each period is of great help in preventing and better managing perioperative hypertension.Objective: The aim of the study was to explore common etiologies of hypertension during the perioperative period (pre, intra, and post-operation) in patients who underwent noncardiac surgeries in University Health Network (UHN) hospitals, Canada, from 2015 to 2020.Patients and Methods: We retrospectively analyzed the medical records of 174 patients undergoing noncardiac surgeries who experienced perioperative hypertension. …”
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Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience (Reprinted from Hum Pathol, vol 40, pg 1070-1091, 2009) by Evans, A, Chetty, R, Clarke, B, Croul, S, Ghazarian, D, Kiehl, T, Ordonez, B, Ilaalagan, S, Asa, S

The potential for diversion of prescribed opioids among orthopaedic patients: Results of an anonymous patient survey. by Kala Sundararajan, Prabjit Ajrawat, Mayilee Canizares, J Denise Power, Anthony V Perruccio, Angela Sarro, Luis Montoya, Y Raja Rampersaud, University Health Network Division of Orthopaedic Surgery

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P084: Clinical integration of potential germline findings from a tumor testing precision medicine program by Maria Carolina Sanabria-Salas, Nina Anggala, Brittany Gillies, Helia Purnaghshband, Kirsten Farncombe, Larissa Peck, Laura Redondo, Peter Sabatini, Renee Hofstedter, Philippe Bedard, Raymond Kim

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An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE) by Derek L. Clouthier, Scott C. Lien, S. Y. Cindy Yang, Linh T. Nguyen, Venkata S. K. Manem, Diana Gray, Michael Ryczko, Albiruni R. A. Razak, Jeremy Lewin, Stephanie Lheureux, Ilaria Colombo, Philippe L. Bedard, David Cescon, Anna Spreafico, Marcus O. Butler, Aaron R. Hansen, Raymond W. Jang, Sangeet Ghai, Ilan Weinreb, Valentin Sotov, Ramy Gadalla, Babak Noamani, Mengdi Guo, Sawako Elston, Amanda Giesler, Sevan Hakgor, Haiyan Jiang, Tracy McGaha, David G. Brooks, Benjamin Haibe-Kains, Trevor J. Pugh, Pamela S. Ohashi, Lillian L. Siu

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Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes by Oliver A. Kent, Manipa Saha, Etienne Coyaud, Helen E. Burston, Napoleon Law, Keith Dadson, Sujun Chen, Estelle M. Laurent, Jonathan St-Germain, Ren X. Sun, Yoshinori Matsumoto, Justin Cowen, Aaryn Montgomery-Song, Kevin R. Brown, Charles Ishak, Jose La Rose, Daniel D. De Carvalho, Housheng Hansen He, Brian Raught, Filio Billia, Peter Kannu, Robert Rottapel

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Salvage Radiotherapy Following Partial Gland Ablation for Prostate Cancer: Functional and Oncological Outcomes by Yazan Qaoud, Piero Bettoli, Noelia Sanmamed-Salgado, Jaime O. Herrera-Caceres, Mohamad Baker Berjaoui, Katherine Lajkosz, Hanan Goldberg, Dixon T.S. Woon, Zoe Glase, Sangeet Ghai, Antonio Finelli, Peter Chung, Nathan Perlis, Neil Fleshner, Alejandro Berlin

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Integrating comprehensive genomic sequencing of non-small cell lung cancer into a public healthcare system by Kirstin Perdrizet, Tracy L. Stockley, Jennifer H. Law, Adam Smith, Tong Zhang, Roxanne Fernandes, Muqdas Shabir, Peter Sabatini, Nadia Al Youssef, Christine Ishu, Janice JN Li, Ming-Sound Tsao, Prodipto Pal, Michael Cabanero, Joerg Schwock, Hyang Mi Ko, Scott Boerner, Heather Ruff, Frances A. Shepherd, Penelope A. Bradbury, Geoffrey Liu, Adrian G. Sacher, Natasha B. Leighl

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Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer by Stanley Zhou, James R. Hawley, Fraser Soares, Giacomo Grillo, Mona Teng, Seyed Ali Madani Tonekaboni, Junjie Tony Hua, Ken J. Kron, Parisa Mazrooei, Musaddeque Ahmed, Christopher Arlidge, Hwa Young Yun, Julie Livingstone, Vincent Huang, Takafumi N. Yamaguchi, Shadrielle M. G. Espiritu, Yanyun Zhu, Tesa M. Severson, Alex Murison, Sarina Cameron, Wilbert Zwart, Theodorus van der Kwast, Trevor J. Pugh, Michael Fraser, Paul C. Boutros, Robert G. Bristow, Housheng Hansen He, Mathieu Lupien

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K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression by Zhenyue Hao, Yi Sheng, Gordon S. Duncan, Wanda Y. Li, Carmen Dominguez, Jennifer Sylvester, Yu-Wen Su, Gloria H.Y. Lin, Bryan E. Snow, Dirk Brenner, Annick You-Ten, Jillian Haight, Satoshi Inoue, Andrew Wakeham, Alisha Elford, Sara Hamilton, Yi Liang, Juan C. Zúñiga-Pflücker, Housheng Hansen He, Pamela S. Ohashi, Tak W. Mak

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Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity by Caitriona M. McEvoy, Julia M. Murphy, Lin Zhang, Sergi Clotet-Freixas, Jessica A. Mathews, James An, Mehran Karimzadeh, Delaram Pouyabahar, Shenghui Su, Olga Zaslaver, Hannes Röst, Rangi Arambewela, Lewis Y. Liu, Sally Zhang, Keith A. Lawson, Antonio Finelli, Bo Wang, Sonya A. MacParland, Gary D. Bader, Ana Konvalinka, Sarah Q. Crome

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Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity by S. Y. Cindy Yang, Scott C. Lien, Ben X. Wang, Derek L. Clouthier, Youstina Hanna, Iulia Cirlan, Kelsey Zhu, Jeffrey P. Bruce, Samah El Ghamrasni, Marco A. J. Iafolla, Marc Oliva, Aaron R. Hansen, Anna Spreafico, Philippe L. Bedard, Stephanie Lheureux, Albiruni Razak, Vanessa Speers, Hal K. Berman, Alexey Aleshin, Benjamin Haibe-Kains, David G. Brooks, Tracy L. McGaha, Marcus O. Butler, Scott V. Bratman, Pamela S. Ohashi, Lillian L. Siu, Trevor J. Pugh

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Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes by Shideh Mirhadi, Shirley Tam, Quan Li, Nadeem Moghal, Nhu-An Pham, Jiefei Tong, Brian J. Golbourn, Jonathan R. Krieger, Paul Taylor, Ming Li, Jessica Weiss, Sebastiao N. Martins-Filho, Vibha Raghavan, Yasin Mamatjan, Aafaque A. Khan, Michael Cabanero, Shingo Sakashita, Kugeng Huo, Sameer Agnihotri, Kota Ishizawa, Thomas K. Waddell, Gelareh Zadeh, Kazuhiro Yasufuku, Geoffrey Liu, Frances A. Shepherd, Michael F. Moran, Ming-Sound Tsao

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Intraoperative fluorescence imaging with aminolevulinic acid detects grossly occult breast cancer: a phase II randomized controlled trial by Kathryn Ottolino-Perry, Anam Shahid, Stephanie DeLuca, Viktor Son, Mayleen Sukhram, Fannong Meng, Zhihui ( Amy) Liu, Sara Rapic, Nayana Thalanki Anantha, Shirley C. Wang, Emilie Chamma, Christopher Gibson, Philip J. Medeiros, Safa Majeed, Ashley Chu, Olivia Wignall, Alessandra Pizzolato, Cheryl F. Rosen, Liis Lindvere Teene, Danielle Starr-Dunham, Iris Kulbatski, Tony Panzarella, Susan J. Done, Alexandra M. Easson, Wey L. Leong, Ralph S. DaCosta

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CDC25 as a common therapeutic target for triple-negative breast cancer - the challenges ahead by Eldad Zacksenhaus, Jeff C. Liu, Letizia Granieri, Ioulia Vorobieva, Dong-Yu Wang, Ronak Ghanbari-Azarnier, Huiqin Li, Amjad Ali, Philip E.D. Chung, YoungJun Ju, Zhe Jiang, Mariusz Shrestha

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ONECUT2 is a driver of neuroendocrine prostate cancer by Haiyang Guo, Xinpei Ci, Musaddeque Ahmed, Junjie Tony Hua, Fraser Soares, Dong Lin, Loredana Puca, Aram Vosoughi, Hui Xue, Estelle Li, Peiran Su, Sujun Chen, Tran Nguyen, Yi Liang, Yuzhe Zhang, Xin Xu, Jing Xu, Anjali V. Sheahan, Wail Ba-Alawi, Si Zhang, Osman Mahamud, Ravi N. Vellanki, Martin Gleave, Robert G. Bristow, Benjamin Haibe-Kains, John T. Poirier, Charles M. Rudin, Ming-Sound Tsao, Bradly G. Wouters, Ladan Fazli, Felix Y. Feng, Leigh Ellis, Theo van der Kwast, Alejandro Berlin, Marianne Koritzinsky, Paul C. Boutros, Amina Zoubeidi, Himisha Beltran, Yuzhuo Wang, Housheng Hansen He

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Biological and therapeutic implications of a unique subtype of NPM1 mutated AML by Arvind Singh Mer, Emily M. Heath, Seyed Ali Madani Tonekaboni, Nergiz Dogan-Artun, Sisira Kadambat Nair, Alex Murison, Laura Garcia-Prat, Liran Shlush, Rose Hurren, Veronique Voisin, Gary D. Bader, Corey Nislow, Mattias Rantalainen, Soren Lehmann, Mark Gower, Cynthia J. Guidos, Mathieu Lupien, John E. Dick, Mark D. Minden, Aaron D. Schimmer, Benjamin Haibe-Kains

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