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    Graphene Oxide Decreases Pro-Inflammatory Proteins Production in Skeletal Muscle Cells Exposed to SARS-CoV-2 Spike Protein by Bałaban J, Wierzbicki M, Zielińska-Górska M, Sosnowska M, Daniluk K, Jaworski S, Koczoń P, Cysewski D, Chwalibog A, Sawosz E

    Published 2023-01-01
    “…Jaśmina Bałaban,1 Mateusz Wierzbicki,1 Marlena Zielińska-Górska,1 Malwina Sosnowska,1 Karolina Daniluk,1 Sławomir Jaworski,1 Piotr Koczoń,2 Dominik Cysewski,3 André Chwalibog,4 Ewa Sawosz1 1Department of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Chemistry, Institute of Food Sciences, Warsaw University of Life Sciences, Warsaw, Poland; 3Clinical Research Centre, Medical University of Bialystok, Białystok, Poland; 4Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, DenmarkCorrespondence: André Chwalibog, University of Copenhagen, Groennegaardsvej 3, Frederiksberg, 1870, Denmark, Tel +45 40963573, Email ach@sund.ku.dkAim: The experiments aimed to document the presence of the ACE2 receptor on human muscle cells and the effects of the interaction of these cells with the spike protein of the SARS-CoV-2 virus in terms of induction of pro-inflammatory proteins, as well as to assess the possibility of reducing the pool of these proteins with the use of graphene oxide (GO) flakes.Methods: Human Skeletal Myoblast (HSkM), purchased from Gibco were maintained in standard condition according to the manufacturer’s instruction. …”
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