Published 2020-08-01
“…Christopher B Cooper,1 Robert Paine,2 Jeffrey L Curtis,3,4 Richard E Kanner,2 Carlos H Martinez,3 Catherine A Meldrum,3 Russell Bowler,5 Wanda O’Neal,6 Eric A Hoffman,7 David Couper,6 Miguel Quibrera,6 Gerald Criner,8 Mark T Dransfield,9 MeiLan K Han,3 Nadia N Hansel,10 Jerry A Krishnan,11 Stephen C Lazarus,12 Stephen P Peters,13 R Graham Barr,14 Fernando J Martinez,15 Prescott G Woodruff12 On behalf of the SPIROMICS investigators1Departments of Medicine and Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; 2Section of Pulmonary and Critical Care Medicine, Department of Veterans Affairs Medical Center, University of Utah, Salt Lake City, UT, USA; 3Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA; 4Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA; 5National Jewish Health, University of Colorado School of Medicine, Denver, CO, USA; 6University of North Carolina Marisco Lung Institute, Chapel Hill, NC, USA; 7Department of Radiology, University of Iowa, Iowa City, IA, USA; 8Department of Pulmonary and Critical Care Medicine, Temple University, Philadelphia, PA, USA; 9Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; 10Johns Hopkins University School of Medicine, Baltimore, MD, USA; 11Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA; 12Division of Pulmonary and Critical Care Medicine, Department of Medicine,
University of California San Francisco, San Francisco, CA, USA; 13Wake Forest School of Medicine, Winston-Salem, NC, USA; 14Department of Medicine, Columbia University Medical Center, New York, NY, USA; 15Joan and Sanford I Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USACorrespondence: Christopher B CooperDepartments of Medicine and Physiology,David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, 37-131 CHS, Los Angeles, CA 90095, USAEmail ccooper@mednet.ucla.eduRationale: Some COPD patients develop extreme breathlessness, decreased exercise capacity and poor health status yet respiratory disability is poorly characterized as a distinct phenotype.Objective: To define respiratory disability in COPD based on available functional measures and to determine associations with risk for exacerbations and death.Methods: We analyzed baseline data from a multi-center observational study (SPIROMICS). …”
Get full text
Article