Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy in co-cultured cancer cells by Serkan Sayin, Brittany Rosener, Carmen G Li, Bao Ho, Olga Ponomarova, Doyle V Ward, Albertha JM Walhout, Amir Mitchell

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Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming by Emmanouela Tsagkaraki, Adilson Guilherme, Sarah M. Nicoloro, Mark Kelly, Lawrence M. Lifshitz, Hui Wang, Kyounghee Min, Leslie A. Rowland, Kaltinaitis B. Santos, Nicole Wetoska, Randall H. Friedline, Stacy A. Maitland, Min Chen, Lee S. Weinstein, Scot A. Wolfe, Jason K. Kim, Michael P. Czech

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Spontaneous Near-Resolution of a Rathke’s Cleft Cyst by Cagney Cristancho, MD, Jhansi Maradana, MD, Vaishali D. Kapare, MBBS, David Choi, MD, PhD, Mira S. Torres, MD

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Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration by Kevin MingJie Gao, Kristy Chiang, Zhaozhao Jiang, Filiz T. Korkmaz, Harish P. Janardhan, Chinmay M. Trivedi, Lee J. Quinton, Sebastien Gingras, Katherine A. Fitzgerald, Ann Marshak-Rothstein

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Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis by Kyounghee Min, Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M Lifshitz, Naideline Raymond, Emmanouela Tsagkaraki, Shauna M Harney, Chloe DiMarzio, Hui Wang, Nicholas McHugh, Brianna Bramato, Brett Morrison, Jeffery D Rothstein, Anastasia Khvorova, Michael P Czech

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A folliculocentric variant of extragenital lichen sclerosus presenting in a 29-year-old man by Rachel Wetstone, MPH, Mary Awad, MD, Kaitlyn Yim, MD, Zendee Elaba, MD, Nikki A. Levin, MD, PhD

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Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer by Alok K. Mishra, Tianyi Ye, Shahid Banday, Ritesh P. Thakare, Chinh Tran-To Su, Ngoc N.H. Pham, Amjad Ali, Ankur Kulshreshtha, Shreya Roy Chowdhury, Tessa M. Simone, Kai Hu, Lihua Julie Zhu, Birgit Eisenhaber, Sara K. Deibler, Karl Simin, Paul R. Thompson, Michelle A. Kelliher, Frank Eisenhaber, Sunil K. Malonia, Michael R. Green

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Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity by Hassan H. Fakih, Qi Tang, Ashley Summers, Minwook Shin, Julianna E. Buchwald, Rosemary Gagnon, Vignesh N. Hariharan, Dimas Echeverria, David A. Cooper, Jonathan K. Watts, Anastasia Khvorova, Hanadi F. Sleiman

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Non-canonical amino acid incorporation into AAV5 capsid enhances lung transduction in mice by Hao Chang, Ailing Du, Jun Jiang, Lingzhi Ren, Nan Liu, Xuntao Zhou, Jialing Liang, Guangping Gao, Dan Wang

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Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants by Qi Li, Fiachra Humphries, Roxie C. Girardin, Aaron Wallace, Monir Ejemel, Alla Amcheslavsky, Conor T. McMahon, Zachary A. Schiller, Zepei Ma, John Cruz, Alan P. Dupuis, Anne F. Payne, Arooma Maryam, Nese Kurt Yilmaz, Kathleen A. McDonough, Brian G. Pierce, Celia A. Schiffer, Andrew C. Kruse, Mark S. Klempner, Lisa A. Cavacini, Katherine A. Fitzgerald, Yang Wang

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Phosphosite Scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1 by Michelle M. Conti, Rui Li, Michelle A. Narváez Ramos, Lihua Julie Zhu, Thomas G. Fazzio, Jennifer A. Benanti

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Technology engagement is associated with higher perceived physical well-being in stroke patients prescribed smartwatches for atrial fibrillation detection by Edith Mensah Otabil, Qiying Dai, Paula Anzenberg, Andreas Filippaios, Eric Ding, Jordy Mehawej, Joanne E. Mathew, Darleen Lessard, Ziyue Wang, Kamran Noorishirazi, Alexander Hamel, Tenes Paul, Danielle DiMezza, Dong Han, Fahimeh Mohagheghian, Apurv Soni, Honghuang Lin, Bruce Barton, Jane Saczynski, Ki H. Chon, Khanh-Van Tran, David D. McManus

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Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike by Marco A Díaz-Salinas, Qi Li, Monir Ejemel, Leonid Yurkovetskiy, Jeremy Luban, Kuang Shen, Yang Wang, James B Munro

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The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin α6 mRNA splicing by Dimpi Mukhopadhyay, Hira Lal Goel, Choua Xiong, Shivam Goel, Ayush Kumar, Rui Li, Lihua Julie Zhu, Jennifer L. Clark, Michael A. Brehm, Arthur M. Mercurio

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Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons by Meenakshi Sundaram Kumar, Megan E. Fowler-Magaw, Daniel Kulick, Sivakumar Boopathy, Del Hayden Gadd, Melissa Rotunno, Catherine Douthwright, Diane Golebiowski, Issa Yusuf, Zuoshang Xu, Robert H. Brown, Miguel Sena-Esteves, Alison L. O'Neil, Daryl A. Bosco

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Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G by Molly Smullen, Meagan N. Olson, Liam F. Murray, Madhusoodhanan Suresh, Guang Yan, Pepper Dawes, Nathaniel J. Barton, Jivanna N. Mason, Yucheng Zhang, Aria A. Fernandez-Fontaine, George M. Church, Diego Mastroeni, Qi Wang, Elaine T. Lim, Yingleong Chan, Benjamin Readhead

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Cytotoxic CD4 development requires CD4 effectors to concurrently recognize local antigen and encounter type I IFN-induced IL-15 by Priyadharshini Devarajan, Allen M. Vong, Catherine H. Castonguay, Noah J. Silverstein, Olivia Kugler-Umana, Bianca L. Bautista, Karen A. Kelly, Jeremy Luban, Susan L. Swain

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A metabolic regulatory network for the Caenorhabditis elegans intestine by Sushila Bhattacharya, Brent B. Horowitz, Jingyan Zhang, Xuhang Li, Hefei Zhang, Gabrielle E. Giese, Amy D. Holdorf, Albertha J.M. Walhout

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Ocular Drug Delivery: Advancements and Innovations by Bo Tian, Evan Bilsbury, Sean Doherty, Sean Teebagy, Emma Wood, Wenqi Su, Guangping Gao, Haijiang Lin

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The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias by Yongping Chen, Gopinath Krishnan, Sepideh Parsi, Marine Pons, Veroniki Nikolaki, Lu Cao, Zuoshang Xu, Fen-Biao Gao

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