Maralixibat for the treatment of PFIC: Long‐term, IBAT inhibition in an open‐label, Phase 2 study by Kathleen M. Loomes, Robert H. Squires, Deirdre Kelly, Sanjay Rajwal, Nisreen Soufi, Alain Lachaux, Irena Jankowska, Cara Mack, Kenneth D. R. Setchell, Palaniswamy Karthikeyan, Ciara Kennedy, Alejandro Dorenbaum, Nirav K. Desai, Will Garner, Thomas Jaecklin, Pamela Vig, Alexander Miethke, Richard J. Thompson

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Polygenic risk for mental disorders as predictors of posttraumatic stress disorder after mild traumatic brain injury by Murray B. Stein, Sonia Jain, Livia Parodi, Karmel W. Choi, Adam X. Maihofer, Lindsay D. Nelson, Pratik Mukherjee, Xiaoying Sun, Feng He, David O. Okonkwo, Joseph T. Giacino, Frederick K. Korley, Mary J. Vassar, Claudia S. Robertson, Michael A. McCrea, Nancy Temkin, Amy J. Markowitz, Ramon Diaz-Arrastia, Jonathan Rosand, Geoffrey T. Manley, TRACK-TBI Investigators

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The association between altered intestinal microbiome, impaired systemic and ocular surface immunity, and impaired wound healing response after corneal alkaline-chemical injury in... by Yashan Bu, Kendrick Co Shih, Ho Lam Wong, Sum Sum Kwok, Amy Cheuk-Yin Lo, Joseph Yau-Kei Chan, Alex Lap-Ki Ng, Tommy Chung-Yan Chan, Vishal Jhanji, Louis Tong, Louis Tong

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Real-world treatment patterns and effectiveness of palbociclib plus an aromatase inhibitor in patients with metastatic breast cancer aged 75 years or older by Adam Brufsky, Xianchen Liu, Benjamin Li, Lynn McRoy, Connie Chen, Rachel M. Layman, Hope S. Rugo

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Associations between cumulative social risk, psychosocial risk, and ideal cardiovascular health: Insights from the HeartSCORE study by Julia Berkowitz, Vishal Khetpal, Justin B Echouffo-Tcheugui, Claudia E Bambs, Aryan Aiyer, Kevin E. Kip, Steven E. Reis, Sebhat Erqou

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Pancreatic quantitative sensory testing to predict treatment response of endoscopic therapy or surgery for painful chronic pancreatitis with pancreatic duct obstruction: study prot... by Adam Slivka, Rohit Das, Asbjørn Mohr Drewes, Søren Schou Olesen, Mouen A Khashab, Vikesh K Singh, Dhiraj Yadav, Mahya Faghih, Anna Evans Phillips, Elham Afghani, Venkata Sandeep Akshintala, Panayiotis Y Benos, Jeffrey Easler, Charles Gabbert, Vivek Halappa, Jami L Saloman, Biatta Sholosh, Tianxiu Wang

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p53 promotes peroxisomal fatty acid β-oxidation to repress purine biosynthesis and mediate tumor suppression by Jianhong Zhao, Xiaojun Zhou, Baoxiang Chen, Mingzhu Lu, Genxin Wang, Nagarajan Elumalai, Chenhui Tian, Jinmiao Zhang, Yanliang Liu, Zhiqiang Chen, Xinyi Zhou, Mingzhi Wu, Mengjiao Li, Edward V. Prochownik, Ali Tavassoli, Congqing Jiang, Youjun Li

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Mechanical Thrombectomy in the Late Presentation of Anterior Circulation Large Vessel Occlusion Stroke: A Guideline From the Society of Vascular and Interventional Neurology Guidel... by Thanh N. Nguyen, Alicia C. Castonguay, James E. Siegler, Simon Nagel, Maarten G. Lansberg, Adam de Havenon, Sunil A. Sheth, Mohamad Abdalkader, Jenny P. Tsai, Gregory W. Albers, Hesham E. Masoud, Tudor G. Jovin, Sheila O. Martins, Raul G. Nogueira, Osama O. Zaidat

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Core components of a rehabilitation program in pediatric cardiac disease by Ana Ubeda Tikkanen, Ana Ubeda Tikkanen, Ana Ubeda Tikkanen, Ana Ubeda Tikkanen, Joshua Vova, Lainie Holman, Maddie Chrisman, Kristin Clarkson, Rachel Santiago, Lisa Schonberger, Kelsey White, Daryaneh Badaly, Naomi Gauthier, Tam Dan N. Pham, Jolie J. Britt, Scott E. Crouter, Maeve Giangregorio, Meena Nathan, Unoma O. Akamagwuna, Unoma O. Akamagwuna

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A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part I: System Planning and Care Teams by Sagar Dave, Aakash Shah, Samuel Galvagno, Kristen George, Ashley R. Menne, Daniel J. Haase, Brian McCormick, Raymond Rector, Siamak Dahi, Ronson J. Madathil, Kristopher B. Deatrick, Mehrdad Ghoreishi, James S. Gammie, David J. Kaczorowski, Thomas M. Scalea, Jay Menaker, Daniel Herr, Eric Krause, Ali Tabatabai

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Intravenous Thrombolysis for Acute Ischemic Stroke in Patients With Recent Direct Oral Anticoagulant Use: A Systematic Review and Meta‐Analysis by Malik Ghannam, Mohammad AlMajali, Milagros Galecio‐Castillo, Abdullah Al Qudah, Farid Khasiyev, Mahmoud Dibas, Dana Ghazaleh, Juan Vivanco‐Suarez, Cristian Morán‐Mariños, Mudassir Farooqui, Aaron Rodriguez‐Calienes, Prateeka Koul, Hannah Roeder, HyungSub Shim, Edgar Samaniego, Enrique C. Leira, Harold P. Adams, Santiago Ortega‐Gutierrez

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Tumors Involving the Infratemporal Fossa: A Systematic Review of Clinical Characteristics and Treatment Outcomes by Othman Bin-Alamer, Lokeshwar S. Bhenderu, Paolo Palmisciano, Kishore Balasubramanian, Prashant Upadhyay, Gianluca Ferini, Anna Viola, Valentina Zagardo, Kenny Yu, Aaron A. Cohen-Gadol, Tarek Y. El Ahmadieh, Ali S. Haider

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Survey of the extracellular matrix architecture across the rat arterial tree by Dylan D. McCreary, MS, Nolan F. Skirtich, BS, Elizabeth A. Andraska, MD, MS, Edith Tzeng, MD, Ryan M. McEnaney, MD

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A Novel Nomogram for Prediction of Post-Hepatectomy Liver Failure in Patients with Resectable Hepatocellular Carcinoma: A Multicenter Study by Wang J, Zhang Z, Shang D, Liao Y, Yu P, Li J, Chen S, Liu D, Miao H, Li S, Zhang B, Huang A, Liu H, Zhang Y, Qi X

“…Jitao Wang,1,2,* Zhanguo Zhang,3,* Dong Shang,4,* Yong Liao,2,* Peng Yu,5,* Jinling Li,2 Shubo Chen,2 Dengxiang Liu,2 Hongrui Miao,3 Shuang Li,4 Biao Zhang,4 Anliang Huang,4 Hao Liu,6 Yewei Zhang,7 Xiaolong Qi1 1Center of Portal Hypertension, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People’s Republic of China; 2Xingtai Key Laboratory of Precision Medicine for Liver Cirrhosis and Portal Hypertension, Xingtai People’s Hospital of Hebei Medical University, Xingtai, People’s Republic of China; 3Hepatic Surgery Center, Tongji Hospital, Tongji Hospital Affiliated to Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 4Department of Hepatobiliary Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China; 5Department of Hepatobiliary Surgery, Fifth Medical Center of PLA General Hospital, Beijing, People’s Republic of China; 6Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 7Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaolong Qi, Center of Portal Hypertension, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People’s Republic of China, Email qixiaolong@vip.163.com Jitao Wang, Xingtai Key Laboratory of Precision Medicine for Liver Cirrhosis and Portal Hypertension, Xingtai People’s Hospital of Hebei Medical University, Xingtai, Hebei, People’s Republic of China, Email wangjt302@163.comObjective: To develop a nomogram for predicting post-hepatectomy liver failure (PHLF) in patients with resectable hepatocellular carcinoma (HCC) based on portal hypertension, the extent of resection, ALT, total bilirubin, and platelet count.Methods: Patients with HCC hospitalized from January 2015 to December 2020 were included in a retrospective cohort study. 595 HCC patients were divided into a training cohort (n=416) and a validation cohort (n=179) by random sampling. …”
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Loneliness in adults awaiting liver transplantation at 7 U.S. transplant centers by Kacey A. Berry, Dorothea Kent, Srilakshmi Seetharaman, Randi Wong, Yara Mohamad, Frederick Yao, Maria Nunez-Duarte, Sharad I. Wadhwani, Brian J. Boyarsky, Robert S. Rahimi, Andres Duarte-Rojo, Matthew R. Kappus, Michael L. Volk, Daniela P. Ladner, Dorry L. Segev, Mara McAdams-DeMarco, Elizabeth C. Verna, Daniel R. Ganger, Jennifer C. Lai

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Extracellular vesicle PD-L1 dynamics predict durable response to immune-checkpoint inhibitors and survival in patients with non-small cell lung cancer by Diego de Miguel-Perez, Alessandro Russo, Oscar Arrieta, Murat Ak, Feliciano Barron, Muthukumar Gunasekaran, Priyadarshini Mamindla, Luis Lara-Mejia, Christine B. Peterson, Mehmet E. Er, Vishal Peddagangireddy, Francesco Buemi, Brandon Cooper, Paolo Manca, Rena G. Lapidus, Ru-Ching Hsia, Andres F. Cardona, Aung Naing, Sunjay Kaushal, Fred R. Hirsch, Philip C. Mack, Maria Jose Serrano, Vincenzo Adamo, Rivka R. Colen, Christian Rolfo

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A phase II study of perioperative pembrolizumab plus mFOLFOX in patients with potentially resectable esophagus, gastroesophageal junction (GEJ), and stomach adenocarcinoma by Weijing Sun, Nirmal Veeramachaneni, Raed Al‐Rajabi, Rashna Madan, Anup Kasi, Mazin Al‐Kasspooles, Joaquina Baranda, Anwaar Saeed, Milind A. Phadnis, Andrew K. Godwin, Mojtaba Olyaee, Natalie Streeter, Alykhan Nagji, Junqiang Dai, Stephen Williamson

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Plasma glycoproteomic biomarkers identify metastatic melanoma patients with reduced clinical benefit from immune checkpoint inhibitor therapy by Chad Pickering, Paul Aiyetan, Gege Xu, Alan Mitchell, Rachel Rice, Yana G. Najjar, Joseph Markowitz, Joseph Markowitz, Lisa M. Ebert, Lisa M. Ebert, Lisa M. Ebert, Michael P. Brown, Michael P. Brown, Michael P. Brown, Gonzalo Tapia-Rico, Dennie Frederick, Xin Cong, Daniel Serie, Klaus Lindpaintner, Flavio Schwarz, Genevieve M. Boland

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Evaluation of the efficacy and safety of amustaline/glutathione pathogen-reduced RBCs in complex cardiac surgery: the Red Cell Pathogen Inactivation (ReCePI) study—protocol for a p... by Edward L. Snyder, Michael E. Sekela, Ian J. Welsby, Yoshiya Toyoda, Mohamed Alsammak, Neel R. Sodha, Thomas M. Beaver, J. Peter R. Pelletier, James D. Gorham, John S. McNeil, Roman M. Sniecinski, Ronald G. Pearl, Gregory A. Nuttall, Ravi Sarode, T. Brett Reece, Alesia Kaplan, Robertson D. Davenport, Tina S. Ipe, Peyman Benharash, Ileana Lopez-Plaza, Richard R. Gammon, Patrick Sadler, John P. Pitman, Kathy Liu, Stanley Bentow, Laurence Corash, Nina Mufti, Jeanne Varrone, Richard J. Benjamin, for the ReCePI study group

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Prognostic utility and characterization of left ventricular hypertrophy using global thickness by Magnus Lundin, Einar Heiberg, David Nordlund, Tom Gyllenhammar, Katarina Steding-Ehrenborg, Henrik Engblom, Marcus Carlsson, Dan Atar, Jesper van der Pals, David Erlinge, Rasmus Borgquist, Ardavan Khoshnood, Ulf Ekelund, Jannike Nickander, Raquel Themudo, Sabrina Nordin, Rebecca Kozor, Anish N. Bhuva, James C. Moon, Eva Maret, Kenneth Caidahl, Andreas Sigfridsson, Peder Sörensson, Erik B. Schelbert, Håkan Arheden, Martin Ugander

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