SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity by Fan Yao, Zhicheng Zhou, Jongchan Kim, Qinglei Hang, Zhenna Xiao, Baochau N. Ton, Liang Chang, Na Liu, Liyong Zeng, Wenqi Wang, Yumeng Wang, Peijing Zhang, Xiaoyu Hu, Xiaohua Su, Han Liang, Yutong Sun, Li Ma

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Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy by Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Jun Yao, Hui Li, Meisi Yan, Wei-Chao Chang, Jung-Mao Hsu, Jong-Ho Cha, Jennifer L. Hsu, Cheng-Wei Chou, Xian Sun, Yalan Deng, Chao-Kai Chou, Dihua Yu, Mien-Chie Hung

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Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma by Xin Hu, Junya Fujimoto, Lisha Ying, Junya Fukuoka, Kazuto Ashizawa, Wenyong Sun, Alexandre Reuben, Chi-Wan Chow, Nicholas McGranahan, Runzhe Chen, Jinlin Hu, Myrna C. Godoy, Kazuhiro Tabata, Kishio Kuroda, Lei Shi, Jun Li, Carmen Behrens, Edwin Roger Parra, Latasha D. Little, Curtis Gumbs, Xizeng Mao, Xingzhi Song, Samantha Tippen, Rebecca L. Thornton, Humam Kadara, Paul Scheet, Emily Roarty, Edwin Justin Ostrin, Xu Wang, Brett W. Carter, Mara B. Antonoff, Jianhua Zhang, Ara A. Vaporciyan, Harvey Pass, Stephen G. Swisher, John V. Heymach, J. Jack Lee, Ignacio I. Wistuba, Waun Ki Hong, P. Andrew Futreal, Dan Su, Jianjun Zhang

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Author Correction: FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation by Jun Yan, Qingnan Zhao, Konrad Gabrusiewicz, Ling-Yuan Kong, Xueqing Xia, Jian Wang, Martina Ott, Jingda Xu, R. Eric Davis, Longfei Huo, Ganesh Rao, Shao-Cong Sun, Stephanie S. Watowich, Amy B. Heimberger, Shulin Li

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FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation by Jun Yan, Qingnan Zhao, Konrad Gabrusiewicz, Ling-Yuan Kong, Xueqing Xia, Jian Wang, Martina Ott, Jingda Xu, R. Eric Davis, Longfei Huo, Ganesh Rao, Shao-Cong Sun, Stephanie S. Watowich, Amy B. Heimberger, Shulin Li

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174 Combined IL-2, agonistic CD3 and 4–1BB stimulation preserve clonotype hierarchy in propagated non-small cell lung cancer tumor-infiltrating lymphocytes by Alexandre Reuben, Cara Haymaker, Chantale Bernatchez, John Heymach, Tina Cascone, Jianjun Zhang, Ara Vaporciyan, Boris Sepesi, Ignacio Wistuba, Lorenzo Federico, Junya Fujimoto, Parin Shah, Jack Roth, Don Gibbons, Marie Andree Forget, Marcelo Negrao, Meredith Frank, Peixin Jiang, Roohussaba Khairullah, Chi-Wan Chow, Yan Long, Shiaw-Yih Lin, Kyle Mitchell, Annika Weissferdt, Daniel McGrail

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy by Meenu Sharma, Hiep Khong, Faisal Fa’ak, Salah-Eddine Bentebibel, Louise M. E. Janssen, Brent C. Chesson, Caitlin A. Creasy, Marie-Andrée Forget, Laura Maria S. Kahn, Barbara Pazdrak, Binisha Karki, Yared Hailemichael, Manisha Singh, Christina Vianden, Srinivas Vennam, Uddalak Bharadwaj, David J. Tweardy, Cara Haymaker, Chantale Bernatchez, Shixia Huang, Kimal Rajapakshe, Cristian Coarfa, Michael E. Hurwitz, Mario Sznol, Patrick Hwu, Ute Hoch, Murali Addepalli, Deborah H. Charych, Jonathan Zalevsky, Adi Diab, Willem W. Overwijk

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Metabolic Reprogramming of GMP Grade Cord Tissue Derived Mesenchymal Stem Cells Enhances Their Suppressive Potential in GVHD by Mayela Mendt, May Daher, Rafet Basar, Mayra Shanley, Bijender Kumar, Francesca Lim Wei Inng, Sunil Acharya, Hila Shaim, Natalie Fowlkes, Jamie P. Tran, Elif Gokdemir, Nadima Uprety, Ana K. Nunez-Cortes, Emily Ensley, Thao Mai, Lucila N. Kerbauy, Lucila N. Kerbauy, Lucila N. Kerbauy, Luciana Melo-Garcia, Paul Lin, Yifei Shen, Vakul Mohanty, JunJun Lu, Sufang Li, Vandana Nandivada, Jing Wang, Pinaki Banerjee, Francia Reyes-Silva, Enli Liu, Sonny Ang, April Gilbert, Ye Li, Xinhai Wan, Jun Gu, Ming Zhao, Natalia Baran, Luis Muniz-Feliciano, Jeffrey Wilson, Indreshpal Kaur, Mihai Gagea, Marina Konopleva, David Marin, Guilin Tang, Ken Chen, Richard Champlin, Katayoun Rezvani, Elizabeth J. Shpall

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P672: CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH CHRONIC MYELOID LEUKEMIA AND T315I MUTATION AFTER FAILURE OF PRIOR THERAPIES by Aram Bidikian, Fadi Haddad, Koji Sasaki, Ghayas Issa, Tapan Kadia, Nitin Jain, Yesid Alvarado, Nicholas Short, Musa Yilmaz, Lucia Masarova, Elias Jabbour, Hagop Kantarjian

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Pooled library screening with multiplexed Cpf1 library by Jintan Liu, Sanjana Srinivasan, Chieh-Yuan Li, I-Lin Ho, Johnathon Rose, MennatAllah Shaheen, Gang Wang, Wantong Yao, Angela Deem, Chris Bristow, Traver Hart, Giulio Draetta

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Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases by Yun Zhang, Shunbin Xiong, Bin Liu, Vinod Pant, Francis Celii, Gilda Chau, Ana C. Elizondo-Fraire, Peirong Yang, Mingjian James You, Adel K. El-Naggar, Nicholas E. Navin, Guillermina Lozano

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Transient CA19-9 Elevation Post-COVID-19 Vaccine and Infection: A Case Series by S. Baydogan, R. Wright, R.T. Kottoor, M. Kim, M.S. Bhutani, F. McAllister

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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine by Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri, Florian L. Muller

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P372: DISMAL OUTCOMES OF PATIENTS WITH RELAPSED/REFRACTORY B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA AFTER FAILURE OF BOTH INOTUZUMAB OZOGAMICIN AND BLINATUMOMAB by W. Macaron, E. Jabbour, M. Konopleva, F. Ravandi, N. Jain, G. Issa, T. Kadia, K. Sasaki, P. Kebriaei, M. Yilmaz, P. Thompson, K. Takahashi, H. Abbas, W. Wierda, R. Garris, H. Kantarjian, N. Short

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Hematopoiesis under telomere attrition at the single-cell resolution by Natthakan Thongon, Feiyang Ma, Andrea Santoni, Matteo Marchesini, Elena Fiorini, Ashley Rose, Vera Adema, Irene Ganan-Gomez, Emma M. Groarke, Fernanda Gutierrez-Rodrigues, Shuaitong Chen, Pamela Lockyer, Sarah Schneider, Carlos Bueso-Ramos, Guillermo Montalban-Bravo, Caleb A. Class, Kelly A. Soltysiak, Matteo Pellegrini, Ergun Sahin, Alison A. Bertuch, Courtney D. DiNardo, Guillermo Garcia-Manero, Neal S. Young, Karen Dwyer, Simona Colla

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FABP4 as a key determinant of metastatic potential of ovarian cancer by Kshipra M. Gharpure, Sunila Pradeep, Marta Sans, Rajesha Rupaimoole, Cristina Ivan, Sherry Y. Wu, Emine Bayraktar, Archana S. Nagaraja, Lingegowda S. Mangala, Xinna Zhang, Monika Haemmerle, Wei Hu, Cristian Rodriguez-Aguayo, Michael McGuire, Celia Sze Ling Mak, Xiuhui Chen, Michelle A. Tran, Alejandro Villar-Prados, Guillermo Armaiz Pena, Ragini Kondetimmanahalli, Ryan Nini, Pranavi Koppula, Prahlad Ram, Jinsong Liu, Gabriel Lopez-Berestein, Keith Baggerly, Livia S. Eberlin, Anil K. Sood

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852 Differential expression of surface protein-encoding genes highlights therapeutic vulnerabilities of four SCLC subtypes by Jing Wang, Qi Wang, John Heymach, Lixia Diao, Robert Cardnell, Lauren Byers, Elizabeth Park, Carl Gay, C Allison Stewart, Kasey Cargill

379 Immune infiltrates are associated with clinical outcomes in patients with resectable soft tissue sarcoma (STS) treated with neoadjuvant immune checkpoint blockade (ICB) by Heather Lin, Wei-Lien Wang, Jennifer Wargo, Neeta Somaiah, Ignacio Wistuba, Edwin Parra, Elise Nassif, Grace Mathew, Alexander Lazar, Andrew Bishop, Emily Keung, Cibelle Lima, Ashleigh Guadagnolo, Valerae Lewis, Keila Torres, Kelly Hunt, Barry Feig, Christopher Scally, Ahmed Al Rawi, Shadarra Crosby, Davis Ingram, Khalida Wani, Christina Roland

Metagenomes of rectal swabs in larger, advanced stage cervical cancers have enhanced mucus degrading functionalities and distinct taxonomic structure by Tatiana V. Karpinets, Xiaogang Wu, Travis Solley, Molly B. El Alam, Travis T. Sims, Kyoko Yoshida-Court, Erica Lynn, Mustapha Ahmed-Kaddar, Greyson Biegert, Jingyan Yue, Xingzhi Song, Huandong Sun, Joseph F. Petrosino, Melissa P. Mezzari, Pablo Okhuysen, Patricia J. Eifel, Anuja Jhingran, Lilie L. Lin, Kathleen M. Schmeler, Lois Ramondetta, Nadim Ajami, Robert R. Jenq, Andrew Futreal, Jianhua Zhang, Ann H. Klopp, Lauren E. Colbert

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962 Integrative immunomics highlight the immunomodulatory impact of neoadjuvant chemotherapy and immune-based treatments in resected non-small-cell lung cancer by Heather Lin, Alexandre Reuben, Cara Haymaker, Chantale Bernatchez, John Heymach, Apar Pataer, Jack Lee, Tina Cascone, Annikka Weissferdt, Jianjun Zhang, Ara Vaporciyan, Boris Sepesi, Ignacio Wistuba, Lorenzo Federico, Hitoshi Dejima, Alejandro Francisco-Cruz, Stephen Swisher, Don Gibbons, Edwin Parra, Luisa Solis, Stephanie Schmidt, Younghee Lee, Cheuk Leung, Frank Rojas, Monika Pradhan, Haiping Guo, William William, Humam Kadara, Marcelo Negrao, Christopher Bristow, Timothy Heffernan