Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma by Runzhe Chen, Jun Li, Junya Fujimoto, Lingzhi Hong, Xin Hu, Kelly Quek, Ming Tang, Akash Mitra, Carmen Behrens, Chi-Wan Chow, Peixin Jiang, Latasha D. Little, Curtis Gumbs, Xingzhi Song, Jianhua Zhang, Dongfeng Tan, John V. Heymach, Ignacio Wistuba, P. Andrew Futreal, Don L. Gibbons, Lauren A. Byers, Jianjun Zhang, Alexandre Reuben

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Identification of MicroRNA–mRNA Networks in Melanoma and Their Association with PD-1 Checkpoint Blockade Outcomes by Robert A. Szczepaniak Sloane, Michael G. White, Russell G. Witt, Anik Banerjee, Michael A. Davies, Guangchun Han, Elizabeth Burton, Nadim Ajami, Julie M. Simon, Chantale Bernatchez, Lauren E. Haydu, Hussein A. Tawbi, Jeffrey E. Gershenwald, Emily Keung, Merrick Ross, Jennifer McQuade, Rodabe N. Amaria, Khalida Wani, Alexander J. Lazar, Scott E. Woodman, Linghua Wang, Miles C. Andrews, Jennifer A. Wargo

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Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia by Natalia Baran, Alessia Lodi, Yogesh Dhungana, Shelley Herbrich, Meghan Collins, Shannon Sweeney, Renu Pandey, Anna Skwarska, Shraddha Patel, Mathieu Tremblay, Vinitha Mary Kuruvilla, Antonio Cavazos, Mecit Kaplan, Marc O. Warmoes, Diogo Troggian Veiga, Ken Furudate, Shanti Rojas-Sutterin, Andre Haman, Yves Gareau, Anne Marinier, Helen Ma, Karine Harutyunyan, May Daher, Luciana Melo Garcia, Gheath Al-Atrash, Sujan Piya, Vivian Ruvolo, Wentao Yang, Sriram Saravanan Shanmugavelandy, Ningping Feng, Jason Gay, Di Du, Jun J. Yang, Fieke W. Hoff, Marcin Kaminski, Katarzyna Tomczak, R. Eric Davis, Daniel Herranz, Adolfo Ferrando, Elias J. Jabbour, M. Emilia Di Francesco, David T. Teachey, Terzah M. Horton, Steven Kornblau, Katayoun Rezvani, Guy Sauvageau, Mihai Gagea, Michael Andreeff, Koichi Takahashi, Joseph R. Marszalek, Philip L. Lorenzi, Jiyang Yu, Stefano Tiziani, Trang Hoang, Marina Konopleva

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Germline DNMT3A mutation in familial acute myeloid leukaemia by Courtney D. DiNardo, Hannah C. Beird, Marcos Estecio, Swanand Hardikar, Koichi Takahashi, Sarah A. Bannon, Gautam Borthakur, Elias Jabbour, Curtis Gumbs, Joseph D. Khoury, Mark Routbort, Ting Gong, Kimie Kondo, Hagop Kantarjian, Guillermo Garcia-Manero, Taiping Chen, P. Andrew Futreal

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Predictors of success in establishing orthotopic patient-derived xenograft models of triple negative breast cancer by Gloria V. Echeverria, Shirong Cai, Yizheng Tu, Jiansu Shao, Emily Powell, Abena B. Redwood, Yan Jiang, Aaron McCoy, Amanda L. Rinkenbaugh, Rosanna Lau, Alexander J. Trevarton, Chunxiao Fu, Rebekah Gould, Elizabeth E. Ravenberg, Lei Huo, Rosalind Candelaria, Lumarie Santiago, Beatriz E. Adrada, Deanna L. Lane, Gaiane M. Rauch, Wei T. Yang, Jason B. White, Jeffrey T. Chang, Stacy L. Moulder, W. Fraser Symmans, Susan G. Hilsenbeck, Helen Piwnica-Worms

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Outcomes with sequential FLT3-inhibitor-based therapies in patients with AML by Musa Yilmaz, Mansour Alfayez, Courtney D. DiNardo, Gautam Borthakur, Tapan M. Kadia, Marina Y. Konopleva, Sanam Loghavi, Rashmi Kanagal-Shamanna, Keyur P. Patel, Elias J. Jabbour, Guillermo Garcia-Manero, Naveen Pemmaraju, Sherry A. Pierce, Issa Ghayas, Nicholas J. Short, Guillermo Montalban-Bravo, Koichi Takahashi, Rita Assi, Ahmad S. Alotaibi, Maro Ohanian, Michael Andreeff, Jorge E. Cortes, Hagop M. Kantarjian, Farhad Ravandi, Naval G. Daver

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Distinct Immunophenotypes of T Cells in Bronchoalveolar Lavage Fluid From Leukemia Patients With Immune Checkpoint Inhibitors-Related Pulmonary Complications by Sang T. Kim, Ajay Sheshadri, Vickie Shannon, Dimitrios P. Kontoyiannis, Hagop Kantarjian, Guillermo Garcia-Manero, Farhad Ravandi, Jin S. Im, Prajwal Boddu, Lara Bashoura, Diwakar D. Balachandran, Scott E. Evans, Saadia Faiz, Wilfredo Ruiz Vazquez, Margarita Divenko, Rohit Mathur, Samantha P. Tippen, Curtis Gumbs, Sattva S. Neelapu, Aung Naing, Linghua Wang, Adi Diab, Andrew Futreal, Roza Nurieva, Naval Daver

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P1279: OUTCOMES OF AUTOLOGOUS STEM CELL TRANSPLANT IN PATIENTS WITH MULTIPLE MYELOMA WITH TWO OR MORE HIGH-RISK CYTOGENETIC ABNORMALITIES by Oren Pasvolsky, Sassine Ghanem, Denái R. Milton, Adeel Masood, Mark R. Tanner, Qaiser Bashir, Samer Srour, Neeraj Saini, Jeremy L. Ramdial, Yago Nieto, Hans C. Lee, Krina K. Patel, Partow Kebriaei, Sheeba K. Thomas, Donna M. Weber, Robert Z. Orlowski, Elizabeth J. Shpall, Richard E. Champlin, Muzaffar H. Qazilbash

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Actionability classification of variants of unknown significance correlates with functional effect by Amber Johnson, Patrick Kwok-Shing Ng, Michael Kahle, Julia Castillo, Bianca Amador, Yujia Wang, Jia Zeng, Vijaykumar Holla, Thuy Vu, Fei Su, Sun-Hee Kim, Tara Conway, Xianli Jiang, Ken Chen, Kenna R. Mills Shaw, Timothy A. Yap, Jordi Rodon, Gordon B. Mills, Funda Meric-Bernstam

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199 Quantitative and spatial characteristics of TIL in inflammatory neighborhoods of advanced melanoma tumors by Adi Diab, Suhendan Ekmekcioglu, Noha Abdel-Wahab, Michael A Davies, Julie M Simon, Alexander J Lazar, Jared K Burks, Salah-Eddine Bentebibel, Sungnam Cho, Javier A Gomez, Reham Abdel-Wahab, Jeffrey E Gershenwald

P509: THE IMPACT OF THE NUMBER OF RAS MUTATIONS IN THE OUTCOMES OF PATIENTS WITH ACUTE MYELOID LEUKEMIA TREATED FRONTLINE AT A SINGLE INSTITUTION. by Mahesh Swaminathan, Rashmi Kanagal-Shamanna, Farhad Ravandi, Tapan Kadia, Courtney Dinardo, Naval Daver, Naveen Pemmaraju, Elias Jabbour, Sherry Pierce, John Matthew Villareal, Gautam Borthakur

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S160: MOLECULAR DETERMINANTS OF DISEASE PROGRESSION AFTER HYPOMETHYLATING AGENT THERAPY IN RAS PATHWAY MUTANT CHRONIC MYELOMONOCYTIC LEUKEMIA AT THE SINGLE-CELL LEVEL by G. Montalban-Bravo, F. Ma, I. Ganan-Gomez, R. Kanagal-Shamana, V. Adema, N. Thongon, H. Yang, K. A. Soltysiak, C. Bueso-Ramos, H. Kantarjian, G. Garcia-Manero, S. Colla

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PC15. 14-year Experience with Complex Abdominal Wall Reconstruction after Cancer Resection by Abbas M. Hassan, MD, Camila M. Franco, MD, Nikhil Shah, MD, Tucker Netherton, PhD, Alexander F. Mericli, MD, Patrick Garvey, MD, Mark V. Schaverien, MD, Edward I. Chang, MD, Matthew Hanasono, MD, Jesse C. Selber, MD, Charles E. Butler, MD

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P585: IMPACT OF MYELOID MUTATION PROFILE ON PCR RESPONSES AND SURVIVAL IN PATIENTS WITH CORE-BINDING FACTOR AML TREATED WITH FLAG BASED REGIMES by Jayastu Senapati, Aram Bidikian, Farhad Ravandi, Tapan Kadia, Courtney Dinardo, Guillermo Garcia-Manero, Naval Daver, Naveen Pemmaraju, Elias Jabbour, Mark Brandt, Gautam Borthakur

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TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival by Lele Zhu, Xiaoping Xie, Lingyun Zhang, Hui Wang, Zuliang Jie, Xiaofei Zhou, Jianhong Shi, Shuli Zhao, Boxiang Zhang, Xuhong Cheng, Shao-Cong Sun

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The immune landscape of undifferentiated pleomorphic sarcoma by Rossana Lazcano, Carmelia M. Barreto, Ruth Salazar, Fernando Carapeto, Raymond S. Traweek, Cheuk H. Leung, Swati Gite, Jay Mehta, Davis R. Ingram, Khalida M. Wani, Kim-Anh T. Vu, Edwin R. Parra, Wei Lu, Jianling Zhou, Russell G. Witt, Brandon Cope, Prapassorn Thirasastr, Heather Y. Lin, Christopher P. Scally, Anthony P. Conley, Ravin Ratan, J. Andrew Livingston, Alexandra M. Zarzour, Joseph Ludwig, Dejka Araujo, Vinod Ravi, Shreyaskumar Patel, Robert Benjamin, Jennifer Wargo, Ignacio I. Wistuba, Ignacio I. Wistuba, Ignacio I. Wistuba, Neeta Somaiah, Christina L. Roland, Emily Z. Keung, Luisa Solis, Wei-Lien Wang, Alexander J. Lazar, Alexander J. Lazar, Alexander J. Lazar, Elise F. Nassif

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Proteogenomic landscape of gastric adenocarcinoma peritoneal metastases by Shuangtao Zhao, Ruiping Wang, Shumei Song, Dapeng Hao, Guangchun Han, Xingzhi Song, Jianhua Zhang, Melissa Pool Pizzi, Namita Shanbhag, Andrew Futreal, Brian Badgwell, Kazuto Harada, George Calin, Jody Vykoukal, Chuan-Yih Yu, Hiroyuki Katayama, Samir M. Hanash, Linghua Wang, Jaffer A. Ajani

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Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): matchi... by Sweet Ping Ng, Houda Bahig, Jihong Wang, Carlos E. Cardenas, Anthony Lucci, Carolyn S. Hall, Salyna Meas, Vanessa N. Sarli, Ying Yuan, Diana L. Urbauer, Yao Ding, Shane Ikner, Vi Dinh, Baher A. Elgohari, Jason M. Johnson, Heath D. Skinner, G. Brandon Gunn, Adam S. Garden, Jack Phan, David I. Rosenthal, William H. Morrison, Steven J. Frank, Katherine A. Hutcheson, Abdallah S. R. Mohamed, Stephen Y. Lai, Renata Ferrarotto, Michael P. MacManus, Clifton D. Fuller

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Nivolumab and ipilimumab with concurrent stereotactic radiosurgery for intracranial metastases from non-small cell lung cancer: analysis of the safety cohort for non-randomized, op... by Jing Li, Yan Wang, Chad Tang, James Welsh, Renata Ferrarotto, Mehmet Altan, Tina Cascone, Juhee Song, Marcelo V Negrao, John V Heymach, Brett W Carter, Ferdinandos Skoulidis, Yasir Y Elamin, Xiuning Le, Caroline Chung, George R Blumenschein, Nandita Guha-Thakurta, Jeffrey S Wefel, Amol J Ghia, Debra N Yeboa, Mary Frances McAleer, Kristina D Woodhouse, Susan L McGovern, Chenyang Wang, Betty Y S Kim, Jeffrey S Weinberg, Tina M Briere

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P103: Comparison of PET-derived parameters in program cell death-1 inhibitor and CD30 antibody drug conjugate-based therapies in patients with advanced stage cHL: A single center e... by Serageldin Kamel, Lucia Martiniova, Eslam Aboismail, Joo Schmidt, Sairah Ahmed, Ranjit Nair, Raphael E. Steiner, Michael L. Wang, Sarita Soebianto, Gregory Ravizzini, Tinsu Pan, Hun Ju Lee

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