Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans by PingHsun Hsieh, Vy Dang, Mitchell R. Vollger, Yafei Mao, Tzu-Hsueh Huang, Philip C. Dishuck, Carl Baker, Stuart Cantsilieris, Alexandra P. Lewis, Katherine M. Munson, Melanie Sorensen, AnneMarie E. Welch, Jason G. Underwood, Evan E. Eichler

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Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease by Sienna R. Li, Ramila E. Gulieva, Louisa Helms, Nelly M. Cruz, Thomas Vincent, Hongxia Fu, Jonathan Himmelfarb, Benjamin S. Freedman

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Preclinical Ultra-High Dose Rate (FLASH) Proton Radiation Therapy System for Small Animal Studies by Ning Cao, PhD, Danielle P. Johnson Erickson, PhD, Eric C. Ford, PhD, Robert C. Emery, MS, Marissa Kranz, MS, Peter Goff, MD, PhD, Marco Schwarz, PhD, Juergen Meyer, PhD, Tony Wong, PhD, Jatinder Saini, PhD, MBA, Charles Bloch, PhD, Robert D. Stewart, PhD, George A. Sandison, PhD, Alec Morimoto, BS, Ava DeLonais-Dick, BS, Ben A. Shaver, BS, Ramesh Rengan, MD, PhD, Jing Zeng, MD

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Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism by See-Yeun Ting, Kaitlyn D LaCourse, Hannah E Ledvina, Rutan Zhang, Matthew C Radey, Hemantha D Kulasekara, Rahul Somavanshi, Savannah K Bertolli, Larry A Gallagher, Jennifer Kim, Kelsi M Penewit, Stephen J Salipante, Libin Xu, S Brook Peterson, Joseph D Mougous

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Host–pathogen dynamics in longitudinal clinical specimens from patients with COVID-19 by Michelle J. Lin, Victoria M. Rachleff, Hong Xie, Lasata Shrestha, Nicole A. P. Lieberman, Vikas Peddu, Amin Addetia, Amanda M. Casto, Nathan Breit, Patrick C. Mathias, Meei-Li Huang, Keith R. Jerome, Alexander L. Greninger, Pavitra Roychoudhury

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Dietary cholesterol increases paraoxonase 1 enzyme activity by Daniel S. Kim, Amber A. Burt, Jane E. Ranchalis, Rebecca J. Richter, Julieann K. Marshall, Karen S. Nakayama, Ella R. Jarvik, Jason F. Eintracht, Elisabeth A. Rosenthal, Clement E. Furlong, Gail P. Jarvik

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Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson’s disease pathogenesis by Lifu Sheng, Tessandra Stewart, Dishun Yang, Eric Thorland, David Soltys, Patrick Aro, Tarek Khrisat, Zhiying Xie, Na Li, Zongran Liu, Chen Tian, Matthew Bercow, Junichi Matsumoto, Cyrus P. Zabetian, Elaine Peskind, Joseph F. Quinn, Min Shi, Jing Zhang

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Amino acid primed mTOR activity is essential for heart regeneration by Jason W. Miklas, Shiri Levy, Peter Hofsteen, Diego Ic Mex, Elisa Clark, Jeanot Muster, Aaron M. Robitaille, Gargi Sivaram, Lauren Abell, Jamie M. Goodson, Inez Pranoto, Anup Madan, Michael T. Chin, Rong Tian, Charles E. Murry, Randall T. Moon, Yuliang Wang, Hannele Ruohola-Baker

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PLTP activity inversely correlates with CAAD: effects of PON1 enzyme activity and genetic variants on PLTP activity1[S] by Daniel Seung Kim, Amber A. Burt, Jane E. Ranchalis, Simona Vuletic, Tomas Vaisar, Wan-Fen Li, Elisabeth A. Rosenthal, Weijiang Dong, Jason F. Eintracht, Arno G. Motulsky, John D. Brunzell, John J. Albers, Clement E. Furlong, Gail P. Jarvik

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Efficacy and muscle safety assessment of fukutin-related protein gene therapy by Halli Benasutti, Joseph W. Maricelli, Jane Seto, John Hall, Christine Halbert, Jacqueline Wicki, Lydia Heusgen, Nicholas Purvis, Michael Regnier, David C. Lin, Buel D. Rodgers, Jeffrey S. Chamberlain

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Senataxin, the yeast Sen1p orthologue: Characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease by Ying-Zhang Chen, Sayed H. Hashemi, Susan K. Anderson, Yongzhao Huang, Maria-Ceu Moreira, David R. Lynch, Ian A. Glass, Phillip F. Chance, Craig L. Bennett

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Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling by Justin A. Roby, Katharina Esser-Nobis, Elyse C. Dewey-Verstelle, Marian R. Fairgrieve, Johannes Schwerk, Amy Y. Lu, Frank W. Soveg, Emily A. Hemann, Lauren D. Hatfield, Brian C. Keller, Alexander Shapiro, Adriana Forero, Jennifer E. Stencel-Baerenwald, Ram Savan, Michael Gale

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Reversing immunosuppression in the tumor microenvironment of fibrolamellar carcinoma via PD-1 and IL-10 blockade by S. K. Daniel, K. M. Sullivan, L. K. Dickerson, R. J. E. van den Bijgaart, A. F. Utria, K. P. Labadie, H. L. Kenerson, X. Jiang, K. S. Smythe, J. S. Campbell, R. H. Pierce, T. S. Kim, K. J. Riehle, R. S. Yeung, J. A. Carter, K. C. Barry, V. G. Pillarisetty

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Somatic Mosaicism of a PDGFRB Activating Variant in Aneurysms of the Intracranial, Coronary, Aortic, and Radial Artery Vascular Beds by Carolina A. Parada, Fatima M. El‐Ghazali, Daphne Toglia, Jacob Ruzevick, Malia McAvoy, Samuel Emerson, Yigit Karasozen, Tina Busald, Ahmad A. Nazem, Shaun M. Suranowitz, Sherene Shalhub, Desiree A. Marshall, Luis F. Gonzalez‐Cuyar, Michael O. Dorschner, Manuel Ferreira

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Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs by Tommy H. Taslim, Abdiasis M. Hussein, Riya Keshri, Julien R. Ishibashi, Tung C. Chan, Bich N. Nguyen, Shuozhi Liu, Daniel Brewer, Stuart Harper, Scott Lyons, Ben Garver, Jimmy Dang, Nanditaa Balachandar, Samriddhi Jhajharia, Debra del Castillo, Julie Mathieu, Hannele Ruohola-Baker

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Treatment of ocular tumors through a novel applicator on a conventional proton pencil beam scanning beamline by Rajesh Regmi, Dominic Maes, Alexander Nevitt, Allison Toltz, Erick Leuro, Jonathan Chen, Lia Halasz, Ramesh Rengan, Charles Bloch, Jatinder Saini

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Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL[S] by Daniel S. Kim, Amber A. Burt, David R. Crosslin, Peggy D. Robertson, Jane E. Ranchalis, Edward J. Boyko, Deborah A. Nickerson, Clement E. Furlong, Gail P. Jarvik

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In Regard to Barker by Peter H. Goff, MD, PhD, Stephanie K. Schaub, MD, Maclean M. Cook, BS, Paul N. Nghiem, MD, PhD, Upendra Parvathaneni, MBBS, FRANZCR

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The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample by Nadia Postupna, Shannon E. Rose, Laura E. Gibbons, Natalie M. Coleman, Leanne L. Hellstern, Kayla Ritchie, Angela M. Wilson, Eiron Cudaback, Xianwu Li, Erica J. Melief, Allison E. Beller, Jeremy A. Miller, Amber L. Nolan, Desiree A. Marshall, Rod Walker, Thomas J. Montine, Eric B. Larson, Paul K. Crane, Richard G. Ellenbogen, Edward S. Lein, Edward S. Lein, Kristen Dams-O'Connor, C. Dirk Keene, C. Dirk Keene

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Novel gene-by-environment interactions: APOB and NPC1L1 variants affect the relationship between dietary and total plasma cholesterol[S] by Daniel S. Kim, Amber A. Burt, Jane E. Ranchalis, Ella R. Jarvik, Elisabeth A. Rosenthal, Thomas S. Hatsukami, Clement E. Furlong, Gail P. Jarvik

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