The genomic landscape of tuberous sclerosis complex by Katie R. Martin, Wanding Zhou, Megan J. Bowman, Juliann Shih, Kit Sing Au, Kristin E. Dittenhafer-Reed, Kellie A. Sisson, Julie Koeman, Daniel J. Weisenberger, Sandra L. Cottingham, Steven T. DeRoos, Orrin Devinsky, Mary E. Winn, Andrew D. Cherniack, Hui Shen, Hope Northrup, Darcy A. Krueger, Jeffrey P. MacKeigan

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Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis by Shraddha Pai, Peipei Li, Bryan Killinger, Lee Marshall, Peixin Jia, Ji Liao, Arturas Petronis, Piroska E. Szabó, Viviane Labrie

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Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p by Lin Bai, Amanda Kovach, Qinglong You, Hao-Chi Hsu, Gongpu Zhao, Huilin Li

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Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease by Sonia George, Nolwen L. Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, Emily Schulz, Steven Pierce, Amanda R. Burmeister, Zachary Madaj, Jennifer A. Steiner, Martha L. Escobar Galvis, Lena Brundin, Patrik Brundin

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Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway by Jianshuang Li, Di Lu, Hong Dou, Huadie Liu, Kevin Weaver, Wenjun Wang, Jiada Li, Edward T.H. Yeh, Bart O. Williams, Ling Zheng, Tao Yang

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PGC-1β maintains mitochondrial metabolism and restrains inflammatory gene expression by Hannah Guak, Ryan D. Sheldon, Ian Beddows, Alexandra Vander Ark, Matthew J. Weiland, Hui Shen, Russell G. Jones, Julie St-Pierre, Eric H. Ma, Connie M. Krawczyk

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Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling by Youwen Zhuang, Heng Liu, X. Edward Zhou, Ravi Kumar Verma, Parker W. de Waal, Wonjo Jang, Ting-Hai Xu, Lei Wang, Xing Meng, Gongpu Zhao, Yanyong Kang, Karsten Melcher, Hao Fan, Nevin A. Lambert, H. Eric Xu, Cheng Zhang

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NF1 deficiency drives metabolic reprogramming in ER+ breast cancer by Rachel (Rae) J. House, Elizabeth A. Tovar, Luke N. Redlon, Curt J. Essenburg, Patrick S. Dischinger, Abigail E. Ellis, Ian Beddows, Ryan D. Sheldon, Evan C. Lien, Carrie R. Graveel, Matthew R. Steensma

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Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank by Catarina Gouveia, Elizabeth Gibbons, Nadia Dehghani, James Eapen, Rita Guerreiro, Jose Bras

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Cdc7-Dbf4 Kinase Overexpression in Multiple Cancers and Tumor Cell Lines Is Correlated with p53 Inactivation by Dorine Bonte, Charlotta Lindvall, Hongyu Liu, Karl Dykema, Kyle Furge, Michael Weinreich

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The CA19-9 and Sialyl-TRA Antigens Define Separate Subpopulations of Pancreatic Cancer Cells by Daniel Barnett, Ying Liu, Katie Partyka, Ying Huang, Huiyuan Tang, Galen Hostetter, Randall E. Brand, Aatur D. Singhi, Richard R. Drake, Brian B. Haab

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Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling by Jamie L. Grit, Benjamin K. Johnson, Patrick S. Dischinger, Curt J. Essenburg, Marie Adams, Stacy Campbell, Kai Pollard, Christine A. Pratilas, Tim J. Triche, Carrie R. Graveel, Matthew R. Steensma

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Integrated Epigenome, Exome, and Transcriptome Analyses Reveal Molecular Subtypes and Homeotic Transformation in Uterine Fibroids by Jitu Wilson George, Huihui Fan, Benjamin Johnson, Tyler James Carpenter, Kelly Katherine Foy, Anindita Chatterjee, Amanda Lynn Patterson, Julie Koeman, Marie Adams, Zachary Brian Madaj, David Chesla, Erica Elizabeth Marsh, Timothy Junius Triche, Hui Shen, Jose Manuel Teixeira

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Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways by Ziyun Wu, Megan M. Senchuk, Dylan J. Dues, Benjamin K. Johnson, Jason F. Cooper, Leira Lew, Emily Machiela, Claire E. Schaar, Heather DeJonge, T. Keith Blackwell, Jeremy M. Van Raamsdonk

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Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease by Stewart F. Graham, Nolwen L. Rey, Zafer Ugur, Ali Yilmaz, Eric Sherman, Michael Maddens, Ray O. Bahado-Singh, Katelyn Becker, Emily Schulz, Lindsay K. Meyerdirk, Jennifer A. Steiner, Jiyan Ma, Patrik Brundin

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Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration by Xinhe Wang, Katelyn Becker, Nathan Levine, Michelle Zhang, Andrew P. Lieberman, Darren J. Moore, Jiyan Ma

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Chemical Biology Screening Identifies a Vulnerability to Checkpoint Kinase Inhibitors in TSC2-Deficient Renal Angiomyolipomas by Robert M. Vaughan, Jennifer J. Kordich, Chun-Yuan Chan, Nanda K. Sasi, Stephanie L. Celano, Stephanie L. Celano, Kellie A. Sisson, Megan Van Baren, Matthew G. Kortus, Dean J. Aguiar, Katie R. Martin, Katie R. Martin, Jeffrey P. MacKeigan, Jeffrey P. MacKeigan, Jeffrey P. MacKeigan

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Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta by Mike R. Wilson, Jeanne Holladay, Rachael Sheridan, Galen Hostetter, Bree Berghuis, Carrie Graveel, Curt Essenburg, Anderson Peck, Thai H. Ho, Melissa Stanton, Ronald L. Chandler

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Parkinson's disease genetic risk in a midbrain neuronal cell line by Steven E. Pierce, Trevor Tyson, Alix Booms, Jordan Prahl, Gerhard A. Coetzee

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3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression by Pamela Himadewi, Xue Qing David Wang, Fan Feng, Haley Gore, Yushuai Liu, Lei Yu, Ryo Kurita, Yukio Nakamura, Gerd P Pfeifer, Jie Liu, Xiaotian Zhang

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