Therapeutic Efficacy of Variable Biological Effectiveness of Proton Therapy in U-CH2 and MUG-Chor1 Human Chordoma Cell Death by Prerna Singh, John Eley, Nayab Mahmood, Binny Bhandary, Tijana Dukic, Kevin J. Tu, Jerimy Polf, Narottam Lamichhane, Javed Mahmood, Zeljko Vujaskovic, Hem D. Shukla

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Impact of Persistent Anemia on Systemic Inflammation and Tuberculosis Outcomes in Persons Living With HIV by Fernanda O. Demitto, Mariana Araújo-Pereira, Mariana Araújo-Pereira, Mariana Araújo-Pereira, Carolina A. Schmaltz, Flávia M. Sant’Anna, María B. Arriaga, María B. Arriaga, María B. Arriaga, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Valeria C. Rolla, Valeria C. Rolla

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2450 Delirium and catatonia: Age matters by Jo E. Wilson, Richard Carlson, Maria C. Duggan, Pratik Pandharipande, Timothy D. Girard, Li Wang, Jennifer L. Thompson, Rameela Chandrasekhar, Andrew Francis, Stephen E. Nicolson, Robert S. Dittus, Stephan Heckers, E. W. Ely

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Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer by Evan B. Glass, Alyssa A. Hoover, Kennady K. Bullock, Matthew Z. Madden, Bradley I. Reinfeld, Whitney Harris, Dominique Parker, Demetra H. Hufnagel, Marta A. Crispens, Dineo Khabele, W. Kimryn Rathmell, Jeffrey C. Rathmell, Andrew J. Wilson, Todd D. Giorgio, Fiona E. Yull

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Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus by Kailun Zhang, Robert F. Potter, Jamie Marino, Carol E. Muenks, Matthew G. Lammers, Jennifer Dien Bard, Tanis C. Dingle, Romney Humphries, Lars F. Westblade, Carey-Ann D. Burnham, Gautam Dantas

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Aspirin Attenuates Hyperoxia-Induced Acute Respiratory Distress Syndrome (ARDS) by Suppressing Pulmonary Inflammation via the NF-κB Signaling Pathway by Yu-Tang Tung, Yu-Tang Tung, Yu-Tang Tung, Yu-Tang Tung, Chi-Hsuan Wei, Chi-Hsuan Wei, Chih-Ching Yen, Po-Ying Lee, Lorraine B. Ware, Hao-En Huang, Wei Chen, Chuan-Mu Chen, Chuan-Mu Chen, Chuan-Mu Chen

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Plasma Metabolomics Reveals Dysregulated Metabolic Signatures in HIV-Associated Immune Reconstitution Inflammatory Syndrome by Luxin Pei, Luxin Pei, Kiyoshi F. Fukutani, Kiyoshi F. Fukutani, Kiyoshi F. Fukutani, Rafael Tibúrcio, Rafael Tibúrcio, Rafael Tibúrcio, Adam Rupert, Eric W. Dahlstrom, Frances Galindo, Elizabeth Laidlaw, Andrea Lisco, Maura Manion, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Irini Sereti

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An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradationResearch in context by Bin Zhang, Haijun Han, Xinyi Zhao, Andria N. Li, Yan Wang, Wenji Yuan, Zhongli Yang, Ming D. Li

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Protocol and statistical analysis plan for the Antibiotic Choice On ReNal outcomes (ACORN) randomised clinical trial by Sunil Kripalani, Li Wang, Ruth Kleinpell, Wesley H Self, Todd W Rice, Matthew W Semler, Edward D Siew, Paul Harris, Jonathan D Casey, Adam Wright, Tina Hartert, Gordon Bernard, Joanna Stollings, Russell Rothman, Jay Morrison, Christopher Lindsell, Todd Rice, Robert Freundlich, Edward Tang Qian, Justin Siemann, Mary Lynn Dear, Bradley Daniel Lloyd, Kevin Seitz, George Nelson, Patty Wright, Bradley Dennis, Jesse Wrenn, Jonathan Andereck, Bob Dittus, Shon Dwyer, Cheryl Gatto, Frank Harrell, Jim Hayman, Catherine Ivory, Lee Ann Liska, Patrick Luther, Thomas Nantais, Jill Pulley, Kris Rehm, Matt Semler, Robin Steaban, Philip Walker, Consuelo Wilkins, Autumn Zuckerman

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Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning by Fubiao Shi, Flaviane de Fatima Silva, Dianxin Liu, Hari U. Patel, Jonathan Xu, Wei Zhang, Clara Türk, Marcus Krüger, Sheila Collins

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Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis by Sheng Zhong, Wenzhuo Yang, Zhiyun Zhang, Yangyiran Xie, Lin Pan, Jiaxin Ren, Fei Ren, Yifan Li, Haoqun Xie, Hongyu Chen, Davy Deng, Jie Lu, Hui Li, Bo Wu, Youqi Chen, Fei Peng, Vinay K. Puduvalli, Ke Sai, Yunqian Li, Ye Cheng, Yonggao Mou

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Single nucleotide polymorphisms rs148582811 regulates its host gene ARVCF expression to affect nicotine-associated hippocampus-dependent memory by Zhongli Yang, Jiali Chen, Haijun Han, Yan Wang, Xiaoqiang Shi, Bin Zhang, Ying Mao, Andria N. Li, Wenji Yuan, Jianhua Yao, Ming D. Li

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Epigenome-Wide Meta-Analysis Reveals Differential DNA Methylation Associated With Estimated Glomerular Filtration Rate Among African American Men With HIV by Junyu Chen, Qin Hui, Zeyuan Wang, Francis P. Wilson, Kaku So-Armah, Matthew S. Freiberg, Amy C. Justice, Ke Xu, Wei Zhao, Farah Ammous, Jennifer A. Smith, Sharon L.R. Kardia, Marta Gwinn, Vincent C. Marconi, Yan V. Sun

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Proton Beam Therapy for Head and Neck Carcinoma of Unknown Primary: Toxicity and Quality of Life by Alexander D. Sherry, BS, Dario Pasalic, MD, G. Brandon Gunn, MD, C. David Fuller, MD, PhD, Jack Phan, MD, PhD, David I. Rosenthal, MD, William H. Morrison, MD, Erich M. Sturgis, MD, Neil D. Gross, MD, Maura L. Gillison, MD, PhD, Renata Ferrarotto, MD, Adel K. El-Naggar, MD, Adam S. Garden, MD, Frank MDSteven J.

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Obesity and Overweight: Probing Causes, Consequences, and Novel Therapeutic Approaches Through the American Heart Association's Strategically Focused Research Network by Jeanne M. Clark, W. Timothy Garvey, Kevin D. Niswender, Ann Marie Schmidt, Rexford S. Ahima, Jose O. Aleman, Ashley N. Battarbee, Joshua Beckman, Wendy L. Bennett, Nancy J. Brown, Paula Chandler‐Laney, Nancy Cox, Ira J. Goldberg, Kirk M. Habegger, Lorie M. Harper, Alyssa H. Hasty, Bertha A. Hidalgo, Sangwon F. Kim, Julie L. Locher, James M. Luther, Nisa M. Maruthur, Edgar R. Miller, Mary Ann Sevick, Quinn Wells

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Host perspectives on short-term experiences in global health: a survey by William Cherniak, MD, Emily Latham, MPH, Barbara Astle, PhD, Geoffrey Anguyo, ChB, Tessa Beaunoir, RN, Joel H Buenaventura, MD, Matthew DeCamp, MD, Karla Diaz, PhD, Quentin Eichbaum, MD, Marius Hedimbi, PhD, Cat Myser, PhD, Charles Nwobu, ChB, Katherine Standish, MD, Jessica Evert, MD

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The Association Between Brain Volumes and Posttraumatic Stress Disorder in Intensive Care Unit Survivors: A Preliminary Study by Kristina Stepanovic, Kristina Stepanovic, Baxter Rogers, Baxter Rogers, Baxter Rogers, Baxter Rogers, Amy L. Kiehl, Amy L. Kiehl, Amy L. Kiehl, E. Wesley Ely, E. Wesley Ely, E. Wesley Ely, E. Wesley Ely, James Jackson, James Jackson, James Jackson, James Jackson, Jo Ellen Wilson, Jo Ellen Wilson, for the VISIONS Investigators and VISualizing Icu SurvivOrs Neuroradiological Sequelae Cohort Study

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Enhancement of CD4+ T Cell Function as a Strategy for Improving Antibiotic Therapy Efficacy in Tuberculosis: Does It Work? by Diego L. Costa, Diego L. Costa, Diego L. Costa, Eduardo P. Amaral, Sivaranjani Namasivayam, Lara R. Mittereder, Lara R. Mittereder, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Alan Sher

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Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines by Susanna Esposito, Paola Stefanelli, Norman K. Fry, Giorgio Fedele, Qiushui He, Qiushui He, Pauline Paterson, Tina Tan, Markus Knuf, Markus Knuf, Carlos Rodrigo, Carlos Rodrigo, Catherine Weil Olivier, Katie L. Flanagan, Katie L. Flanagan, Katie L. Flanagan, Ivan Hung, Iria Lutsar, Kathryn Edwards, Miguel O'Ryan, Nicola Principi, World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Vaccine Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EVASG)

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Eicosanoids in the Pancreatic Tumor Microenvironment—A Multicellular, Multifaceted Progression by Vikas B. Gubbala, Nidhi Jytosana, Vincent Q. Trinh, H. Carlo Maurer, Razia F. Naeem, Nikki K. Lytle, Zhibo Ma, Steven Zhao, Wei Lin, Haiyong Han, Yu Shi, Tony Hunter, Pankaj K. Singh, Kenneth P. Olive, Marcus C.B. Tan, Susan M. Kaech, Geoffrey M. Wahl, Kathleen E. DelGiorno

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