The unrestricted global effort to complete the COOL trial by Andrew W. Kirkpatrick, Federico Coccolini, Matti Tolonen, Samuel Minor, Fausto Catena, Emanuel Gois, Christopher J. Doig, Michael D. Hill, Luca Ansaloni, Massimo Chiarugi, Dario Tartaglia, Orestis Ioannidis, Michael Sugrue, Elif Colak, S. Morad Hameed, Hanna Lampela, Vanni Agnoletti, Jessica L. McKee, Naisan Garraway, Massimo Sartelli, Chad G. Ball, Neil G. Parry, Kelly Voght, Lisa Julien, Jenna Kroeker, Derek J. Roberts, Peter Faris, Corina Tiruta, Ernest E. Moore, Lee Anne Ammons, Elissavet Anestiadou, Cino Bendinelli, Konstantinos Bouliaris, Rosemarry Carroll, Marco Ceresoli, Francesco Favi, Angela Gurrado, Joao Rezende-Neto, Arda Isik, Camilla Cremonini, Silivia Strambi, Georgios Koukoulis, Mario Testini, Sandy Trpcic, Alessandro Pasculli, Erika Picariello, Fikri Abu-Zidan, Ademola Adeyeye, Goran Augustin, Felipe Alconchel, Yuksel Altinel, Luz Adriana Hernandez Amin, José Manuel Aranda-Narváez, Oussama Baraket, Walter L. Biffl, Gian Luca Baiocchi, Luigi Bonavina, Giuseppe Brisinda, Luca Cardinali, Andrea Celotti, Mohamed Chaouch, Maria Chiarello, Gianluca Costa, Nicola de’Angelis, Nicolo De Manzini, Samir Delibegovic, Salomone Di Saverio, Belinda De Simone, Vincent Dubuisson, Pietro Fransvea, Gianluca Garulli, Alessio Giordano, Carlos Gomes, Firdaus Hayati, Jinjian Huang, Aini Fahriza Ibrahim, Tan Jih Huei, Ruhi Fadzlyana Jailani, Mansoor Khan, Alfonso Palmieri Luna, Manu L. N. G. Malbrain, Sanjay Marwah, Paul McBeth, Andrei Mihailescu, Alessia Morello, Francesk Mulita, Valentina Murzi, Ahmad Tarmizi Mohammad, Simran Parmar, Ajay Pak, Michael Pak-Kai Wong, Desire Pantalone, Mauro Podda, Caterina Puccioni, Kemal Rasa, Jianan Ren, Francesco Roscio, Antonio Gonzalez-Sanchez, Gabriele Sganga, Maximilian Scheiterle, Mihail Slavchev, Dmitry Smirnov, Lorenzo Tosi, Anand Trivedi, Jaime Andres Gonzalez Vega, Maciej Waledziak, Sofia Xenaki, Desmond Winter, Xiuwen Wu, Andee Dzulkarnean Zakaria, Zaidi Zakaria

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Oncoplastic and reconstructive surgery in SENONETWORK Italian breast centers: lights and shadows by Matteo Ghilli, Andrea Vittorio Emanuele Lisa, Marzia Salgarello, Giovanni Papa, Mario Rietjens, Secondo Folli, Annalisa Curcio, Guglielmo Ferrari, Francesco Caruso, Vittorio Altomare, Daniele Friedman, Maria Carmen De Santis, Fiorenza De Rose, Bruno Meduri, Francesca De Felice, Lorenza Marino, Francesca Cucciarelli, Stefania Montemezzi, Pietro Panizza, Paolo Belli, Francesca Caumo, Valeriano Vinci, Giorgio De Santis, Marco Klinger, Manuela Roncella, Francesco Abbonante, Ginevra Lamanna, Augusto Lombardi, Silvio Vischi, Lorenzo Orzalesi, Giovanni Angiolucci, Samantha Bozzo, Laura Pizzorno, Bettina Ballardini, Maggiorino Barbero, Leonardo Barellini, Claudio Battaglia, Luisa Reggiani, Caterina Santi, Nicoletta Biglio, Marina Bortul, Paolo Burelli, Massimo Busani, Roberta Cabula, Katia Cagossi, Vito Maria Fontanarosa, Francesca Catalano, Carla Cedolini, Luigi Ciuffreda, Fabio Corsi, Olindo Custodero, Stefano Mori, Roy De Vita, Loredana Defilippi, Samantha Marcuzzi, Stefano Drago, Giovanni Battista, Loredana Burgoa, Paolo Cristofolini, Giovanna Romanucci, Andrea Loreti, Valerio Prosperi, Paolo Carcoforo, Patrizia Fulvia Franzini, Patrizia Frittelli, Giuseppe Perniciaro, Daniele Generali, Monica Giordano, Giovanazzi Riccardo, Simona Grossi, Alessandra Huscher, Giuseppe La Torre, Gianfranco Lolli, Carla Magni, Stefano Mancini, Lorenzo Galli, Alba Di Leone, Samuele Massarut, Alberto Massocco, Monica Cramarossa, Graziano Meneghini, Luca Fabiocchi, Anna Maria Miglietta, Francesco Millo, Antonella Ciabattoni, Francesca Pellini, Marco Moschetta, Antonino Musolino, Dante Palli, Giulia Pagura, Mariagrazia Pieraccini, Davide Marenco, Romano Polato, Maria Renne, Cosmo Maurizio Ressa, Fabio Ricci, Raffaella Ridolfo, Francesca Angela Rovera, Francesco Barberini, Marina Vinciguerra, Marco Furci, Maria Sciamannini, Daniela Gianquinto, Silvia Petrucci, Angelica Della Valle, Pietra Stancampiano, Andrea Lippi, Giovanni Tazzioli, Davide Lombardi, Martino Trunfio, Luca Valieri, Carlo Vecchio, Paolo Veronesi, Gretha Grilz

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No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in <i>MLH1</i> and <i>MSH2</i>: A Prospective Lynch Syndrome Database Study by Mev Dominguez-Valentin, John-Paul Plazzer, Julian R. Sampson, Christoph Engel, Stefan Aretz, Mark A. Jenkins, Lone Sunde, Inge Bernstein, Gabriel Capella, Francesc Balaguer, Finlay Macrae, Ingrid M. Winship, Huw Thomas, Dafydd Gareth Evans, John Burn, Marc Greenblatt, Wouter H. de Vos tot Nederveen Cappel, Rolf H. Sijmons, Maartje Nielsen, Lucio Bertario, Bernardo Bonanni, Maria Grazia Tibiletti, Giulia Martina Cavestro, Annika Lindblom, Adriana Della Valle, Francisco Lopez-Kostner, Karin Alvarez, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Sigve Nakken, Eivind Hovig, Kate Green, Fiona Lalloo, James Hill, Hans F. A. Vasen, Claudia Perne, Reinhard Büttner, Heike Görgens, Elke Holinski-Feder, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Nils Rahner, Jürgen Weitz, Verena Steinke-Lange, Wolff Schmiegel, Deepak Vangala, Emma J. Crosbie, Marta Pineda, Matilde Navarro, Joan Brunet, Leticia Moreira, Ariadna Sánchez, Miquel Serra-Burriel, Miriam Mints, Revital Kariv, Guy Rosner, Tamara Alejandra Piñero, Walter Hernán Pavicic, Pablo Kalfayan, Sanne W. ten Broeke, Jukka-Pekka Mecklin, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, Päivi Peltomäki, John L. Hopper, Aung Ko Win, Daniel D. Buchanan, Noralane M. Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane C. Figueiredo, Stephen N. Thibodeau, Christina Therkildsen, Thomas V. O. Hansen, Lars Lindberg, Einar Andreas Rødland, Florencia Neffa, Patricia Esperon, Douglas Tjandra, Gabriela Möslein, Toni T. Seppälä, Pål Møller

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The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990–2019: Findings from the Global Burden of Disease Study 2019 by Giulio Castelpietra, Ann Kristin Skrindo Knudsen, Emilie E. Agardh, Benedetta Armocida, Massimiliano Beghi, Kim Moesgaard Iburg, Giancarlo Logroscino, Rui Ma, Fabrizio Starace, Nicholas Steel, Giovanni Addolorato, Catalina Liliana Andrei, Tudorel Andrei, Jose L Ayuso-Mateos, Maciej Banach, Till Winfried Bärnighausen, Francesco Barone-Adesi, Akshaya Srikanth Bhagavathula, Felix Carvalho, Márcia Carvalho, Joht Singh Chandan, Vijay Kumar Chattu, Rosa A.S. Couto, Natália Cruz-Martins, Paul I. Dargan, Keshab Deuba, Diana Dias da Silva, Adeniyi Francis Fagbamigbe, Eduarda Fernandes, Pietro Ferrara, Florian Fischer, Peter Andras Gaal, Alessandro Gialluisi, Juanita A. Haagsma, Josep Maria Haro, M. Tasdik Hasan, Syed Shahzad Hasan, Sorin Hostiuc, Licia Iacoviello, Ivo Iavicoli, Elham Jamshidi, Jost B. Jonas, Tamas Joo, Jacek Jerzy Jozwiak, Srinivasa Vittal Katikireddi, Joonas H. Kauppila, Moien A.B. Khan, Adnan Kisa, Sezer Kisa, Mika Kivimäki, Kamrun Nahar Koly, Ai Koyanagi, Manasi Kumar, Tea Lallukka, Berthold Langguth, Caterina Ledda, Paul H. Lee, Ilaria Lega, Christine Linehan, Joana A. Loureiro, Áurea M Madureira-Carvalho, Jose Martinez-Raga, Manu Raj Mathur, John J. McGrath, Enkeleint A. Mechili, Alexios-Fotios A. Mentis, Tomislav Mestrovic, Bartosz Miazgowski, Andreea Mirica, Antonio Mirijello, Babak Moazen, Shafiu Mohammed, Francesk Mulita, Gabriele Nagel, Ionut Negoi, Ruxandra Irina Negoi, Vincent Ebuka Nwatah, Alicia Padron-Monedero, Songhomitra Panda-Jonas, Shahina Pardhan, Maja Pasovic, Jay Patel, Ionela-Roxana Petcu, Marina Pinheiro, Richard Charles G. Pollok, Maarten J. Postma, David Laith Rawaf, Salman Rawaf, Esperanza Romero-Rodríguez, Luca Ronfani, Dominic Sagoe, Francesco Sanmarchi, Michael P Schaub, Nigussie Tadesse Sharew, Rahman Shiri, Farhad Shokraneh, Inga Dora Sigfusdottir, João Pedro Silva, Renata Silva, Bogdan Socea, Miklós Szócska, Rafael Tabarés-Seisdedos, Marco Torrado, Marcos Roberto Tovani-Palone, Tommi Juhani Vasankari, Massimiliano Veroux, Russell M. Viner, Andrea Werdecker, Andrea Sylvia Winkler, Simon I. Hay, Alize J. Ferrari, Mohsen Naghavi, Peter Allebeck, Lorenzo Monasta

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Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma by Celeste M. Porsbjerg, John Townend, John Townend, Celine Bergeron, Celine Bergeron, George C. Christoff, Gregory P. Katsoulotos, Gregory P. Katsoulotos, Désirée Larenas-Linnemann, Trung N. Tran, Riyad Al-Lehebi, Riyad Al-Lehebi, Sinthia Z. Bosnic-Anticevich, Sinthia Z. Bosnic-Anticevich, John Busby, Mark Hew, Mark Hew, Konstantinos Kostikas, Nikolaos G. Papadopoulos, Nikolaos G. Papadopoulos, Paul E. Pfeffer, Paul E. Pfeffer, Todor A. Popov, Chin Kook Rhee, Mohsen Sadatsafavi, Ming-Ju Tsai, Ming-Ju Tsai, Charlotte Suppli Ulrik, Mona Al-Ahmad, Mona Al-Ahmad, Alan Altraja, Aaron Beastall, Aaron Beastall, Lakmini Bulathsinhala, Lakmini Bulathsinhala, Victoria Carter, Victoria Carter, Borja G. Cosio, Kirsty Fletton, Kirsty Fletton, Susanne Hansen, Susanne Hansen, Liam G. Heaney, Richard B. Hubbard, Richard B. Hubbard, Richard B. Hubbard, Piotr Kuna, Ruth B. Murray, Tatsuya Nagano, Laura Pini, Diana Jimena Cano Rosales, Florence Schleich, Michael E. Wechsler, Rita Amaral, Rita Amaral, Arnaud Bourdin, Guy G. Brusselle, Guy G. Brusselle, Wenjia Chen, Li Ping Chung, Eve Denton, Eve Denton, Joao A. Fonseca, Flavia Hoyte, David J. Jackson, Rohit Katial, Bruce J. Kirenga, Mariko Siyue Koh, Agnieszka Ławkiedraj, Lauri Lehtimäki, Lauri Lehtimäki, Mei Fong Liew, Mei Fong Liew, Bassam Mahboub, Bassam Mahboub, Neil Martin, Neil Martin, Andrew N. Menzies-Gow, Andrew N. Menzies-Gow, Pee Hwee Pang, Andriana I. Papaioannou, Pujan H. Patel, Luis Perez-De-Llano, Matthew J. Peters, Matthew J. Peters, Luisa Ricciardi, Bellanid Rodríguez-Cáceres, Ivan Solarte, Ivan Solarte, Tunn Ren Tay, Carlos A. Torres-Duque, Carlos A. Torres-Duque, Eileen Wang, Eileen Wang, Martina Zappa, John Abisheganaden, John Abisheganaden, John Abisheganaden, Karin Dahl Assing, Richard W. Costello, Peter G. Gibson, Peter G. Gibson, Enrico Heffler, Enrico Heffler, Jorge Máspero, Jorge Máspero, Stefania Nicola, Diahn-Warng Perng (Steve), Diahn-Warng Perng (Steve), Francesca Puggioni, Sundeep Salvi, Chau-Chyun Sheu, Chau-Chyun Sheu, Concetta Sirena, Camille Taillé, Tze Lee Tan, Leif Bjermer, Giorgio Walter Canonica, Giorgio Walter Canonica, Takashi Iwanaga, Libardo Jiménez-Maldonado, Libardo Jiménez-Maldonado, Christian Taube, Luisa Brussino, David B. Price, David B. Price, David B. Price

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The Second International Asteroid Warning Network Timing Campaign: 2005 LW3 by Davide Farnocchia, Vishnu Reddy, James M. Bauer, Elizabeth M. Warner, Marco Micheli, Matthew J. Payne, Tony Farnham, Michael S. Kelley, Miguel R. Alarcon, Paolo Bacci, Roberto Bacci, Mauro Bachini, Kevin Baillié, Giorgio Baj, Daniel Bamberger, Anatoly P. Barkov, Stefan Beck, Guido Betti, Enrico Biancalani, Bryce T. Bolin, David Briggs, Luca Buzzi, Haowen Cheng, Eric Christensen, Alessandro Coffano, Luca Conversi, Christophe Demeautis, Larry Denneau, Josselin Desmars, Anlaug A. Djupvik, Leonid Elenin, Paolo Fini, Tobias Felber, Randy Flynn, Gianni Galli, Mikael Granvik, Bill Gray, Zuri Gray, Luca Grazzini, Werner Hasubick, Tobias Hoffmann, Robert Holmes, Marco Iozzi, Alexander L. Ivanov, Viktor A. Ivanov, Natalya V. Ivanova, Cristóvão Jacques, Hai Jiang, Zheng Jinghui, Anni Kasikov, Myung-Jin Kim, Balaji Kumar, Hee-Jae Lee, Bin Li, Jing Liu, Javier Licandro, Tyler Linder, Vadim E. Lysenkov, Martina Maestripieri, Andrea Mantero, Vladimiro Marinello, Jennie McCormick, Darrel Moon, Alessandro Nastasi, James D. Neill, Guenther Neue, Artem O. Novichonok, Francisco Ocaña, Gianpaolo Pizzetti, Anton Pomazan, Josiah N. Purdum, Christophe Ratinaud, Dong-Goo Roh, Filipp D. Romanov, Nello Ruocco, Toni Santana-Ros, Toni Scarmato, Anastasia Schmalz, Sergei Schmalz, Miquel Serra-Ricart, Clay Sherrod, Nick Sioulas, Andrea Soffiantini, Giacomo Succi, David J. Tholen, Jeppe S. Thomsen, William Thuillot, Richard Wainscoat, Guy Wells, Robert Weryk, Nikolai A. Yakovenko, Hong-Suh Yim, Chengxing Zhai

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Short Communications by the Authors

“…Overwintering of Crane, Grus grus, within the Alpine arch Prima nidificazione accertata di assiolo Otus scops in provincia di Varese…”
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Consensus and Diversity in the Management of Varicocele for Male Infertility: Results of a Global Practice Survey and Comparison with Guidelines and Recommendations by Rupin Shah, Ashok Agarwal, Parviz Kavoussi, Amarnath Rambhatla, Ramadan Saleh, Rossella Cannarella, Ahmed M. Harraz, Florence Boitrelle, Shinnosuke Kuroda, Taha Abo-Almagd Abdel-Meguid Hamoda, Armand Zini, Edmund Ko, Gokhan Calik, Tuncay Toprak, Hussein Kandil, Murat Gül, Mustafa Emre Bakırcıoğlu, Neel Parekh, Giorgio Ivan Russo, Nicholas Tadros, Ates Kadioglu, Mohamed Arafa, Eric Chung, Osvaldo Rajmil, Fotios Dimitriadis, Vineet Malhotra, Gianmaria Salvio, Ralf Henkel, Tan V. Le, Emrullah Sogutdelen, Sarah Vij, Abdullah Alarbid, Ahmet Gudeloglu, Akira Tsujimura, Aldo E. Calogero, Amr El Meliegy, Andrea Crafa, Arif Kalkanli, Aykut Baser, Berk Hazir, Carlo Giulioni, Chak-Lam Cho, Christopher C.K. Ho, Ciro Salzano, Daniel Suslik Zylbersztejn, Dung Mai Ba Tien, Edoardo Pescatori, Edson Borges, Ege Can Serefoglu, Emine Saïs-Hamza, Eric Huyghe, Erman Ceyhan, Ettore Caroppo, Fabrizio Castiglioni, Fahmi Bahar, Fatih Gokalp, Francesco Lombardo, Franco Gadda, Gede Wirya Kusuma Duarsa, Germar-Michael Pinggera, Gian Maria Busetto, Giancarlo Balercia, Gianmartin Cito, Gideon Blecher, Giorgio Franco, Giovanni Liguori, Haitham Elbardisi, Hakan Keskin, Haocheng Lin, Hisanori Taniguchi, Hyun Jun Park, Imad Ziouziou, Jean de la Rosette, Jim Hotaling, Jonathan Ramsay, Juan Manuel Corral Molina, Ka Lun Lo, Kadir Bocu, Kareim Khalafalla, Kasonde Bowa, Keisuke Okada, Koichi Nagao, Koji Chiba, Lukman Hakim, Konstantinos Makarounis, Marah Hehemann, Marcelo Rodriguez Peña, Marco Falcone, Marion Bendayan, Marlon Martinez, Massimiliano Timpano, Mesut Altan, Mikkel Fode, Mohamed S. Al-Marhoon, Mohammad Ali Sadighi Gilani, Mohammad Ayodhia Soebadi, Nazim Gherabi, Nikolaos Sofikitis, Oğuzhan Kahraman, Ponco Birowo, Priyank Kothari, Puneet Sindhwani, Qaisar Javed, Rafael F. Ambar, Raghavender Kosgi, Ramy Abou Ghayda, Ricky Adriansjah, Rosita Angela Condorelli, Sandro La Vignera, Sava Micic, Shannon Hee Kyung Kim, Shinichiro Fukuhara, Sun Tae Ahn, Taymour Mostafa, Teng Aik Ong, Teppei Takeshima, Toshiyasu Amano, Trenton Barrett, Umut Arslan, Vilvapathy Senguttuvan Karthikeyan, Widi Atmoko, Yasushi Yumura, Yiming Yuan, Yuki Kato, Davor Jezek, Bryan Kwun-Chung Cheng, Georgios Hatzichristodoulou, Jun Dy, Eduard Ruiz Castañé, Ahmed I. El-Sakka, Quang Nguyen, Selcuk Sarikaya, Luca Boeri, Ronny Tan, Mohamad A. Moussa, Ahmed El-Assmy, Hamed Alali, Naif Alhathal, Yasser Osman, Dragoljub Perovic, Hesamoddin Sajadi, Hamed Akhavizadegan, Miroslav Vučinić, Said Kattan, Mohamed S. Kattan, Nasser Mogharabian, Nguyen Ho Vinh Phuoc, Kay Seong Ngoo, Mohammad H. Alkandari, Shaheed Alsuhaibani, Ioannis Sokolakis, Mehdi Babaei, Mak Siu King, Thorsten Diemer, Marcelo M. Gava, Raphael Henrique, Rodrigo Spinola e Silva, Gustavo Marquesine Paul, Tiago Cesar Mierzwa, Sidney Glina, Kashif Siddiqi, Han Wu, Jana Wurzacher, Ala’a Farkouh, Hwancheol Son, Suks Minhas, Joe Lee, Nikko Magsanoc, Paolo Capogrosso, German Jose Albano, Sheena E. M. Lewis, Channa N. Jayasena, Juan G. Alvarez, Colin Teo, Ryan P. Smith, Jo Ben M. Chua, Christian Fuglesang S. Jensen, Sijo Parekattil, Renata Finelli, Damayanthi Durairajanayagam, Keshab Kumar Karna, Abdelkareem Ahmed, Don Evenson, Yukihiro Umemoto, Ana Puigvert, Gökhan Çeker, Giovanni M Colpi

STUDIO PRELIMINARE DI PERSISTENZA DI BATTERI NON FERMENTANTI IN UN REPARTO DI TERAPIA INTENSIVA E RIANIMAZIONE by A. Giordano, S. Gerardi, A. Vanzetta, P. Varesi, C. Mancini

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STUDIO DELLA PREVALENZA DI CEPPI DI E.COLI E KLEBSIELLA SPP CON FENOTIPO ESBL DI RECENTE ISOLAMENTO CLINICO by A. Giordano, A. Carattoli, S. Gerardi, A. Garcia, M. Venditti, P. Varesi, C. Mancini

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