1006 High doses of MHC-II neoantigens in peptide cancer vaccines induce tumor-specific inhibitory cytolytic CD4+ T cells by Naveen Sharma, James Allison, Andres Salazar, Hussein Sultan, Ton Schumacher, Ivana Djuretic, Yik Andy Yeung, Jeffrey Ward, Marco Colonna, Yuang Song, Samuel Ameh, Robert Schreiber, Kenneth Murphy, Yoshiko Takeuchi, Corazon Arthur, Kathleen Sheehan, Kelly D Moynihan, Vladimir Sukhov, Maria Firulyova, Tian-Tian Liu, Maxim Artyomov

Glutamine metabolism modulates chondrocyte inflammatory response by Manoj Arra, Gaurav Swarnkar, Naga Suresh Adapala, Syeda Kanwal Naqvi, Lei Cai, Muhammad Farooq Rai, Srikanth Singamaneni, Gabriel Mbalaviele, Robert Brophy, Yousef Abu-Amer

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Prenatal exposure to maternal disadvantage-related inflammatory biomarkers: associations with neonatal white matter microstructure by Ashley F. P. Sanders, Brian Tirado, Nicole A. Seider, Regina L. Triplett, Rachel E. Lean, Jeffrey J. Neil, J. Philip Miller, Rebecca Tillman, Tara A. Smyser, Deanna M. Barch, Joan L. Luby, Cynthia E. Rogers, Christopher D. Smyser, Barbara B. Warner, Edith Chen, Gregory E. Miller

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Blocking the functional domain of TIP1 by antibodies sensitizes cancer to radiation therapy by Abhay K. Singh, David YA Dadey, Michael J. Rau, James Fitzpatrick, Harendra K. Shah, Minakshi Saikia, Reid Townsend, Dinesh Thotala, Dennis E. Hallahan, Vaishali Kapoor

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P667: Single gene deletion of FGF3 in a patient with features of 11q13 microdeletion syndrome by Hamed Rahi, Patricia Dickson, Tomi Toler, Meagan Corliss, Yang Cao

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SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration by Yo Sasaki, Hiroki Kakita, Shunsuke Kubota, Abdoulaye Sene, Tae Jun Lee, Norimitsu Ban, Zhenyu Dong, Joseph B Lin, Sanford L Boye, Aaron DiAntonio, Shannon E Boye, Rajendra S Apte, Jeffrey Milbrandt

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Profiling PIK3CA variants in disorders of somatic mosaicism by Bahareh A. Mojarad, Patricia V. Hernandez, Michael J. Evenson, Meagan M. Corliss, Sarah L. Stein, Amy Theos, Carrie C. Coughlin, Bryan Sisk, Maithilee Menezes, Molly C. Schroeder, Jonathan W. Heusel, Julie A. Neidich, Yang Cao

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Expanding telehealth through technology: Use of digital health technologies during pediatric electrophysiology telehealth visits by Lisa Roelle, PA, Juliana Ocasio, BA, Lauren Littell, MD, Eli Fredman, MD, Nathan Miller, RN, Tracy Conner, MD, George Van Hare, MD, FHRS, Jennifer N. Avari Silva, MD, FHRS

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Progressive, edematous plaques, mild pancytopenia, and inflammation by Leigh A. Compton, MD, PhD, Heather A. Jones, MD, Connor A. Vinyard, BS, Yi-Shan Lee, MD, PhD, Matthew J. Walter, MD, Christine C. Yokoyama, MD, PhD

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Sympathetic Ophthalmia Two Weeks After 23-Gauge Vitrectomy by Bahaeddin B.E. EL Khatib, Menka S.M.P. Patel, Alexander A.H. Hacopian, Monica M.D. Dalal, H. Nida H.N.S. Sen, Marena M.P. Patronas

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The association of center volume with transplant outcomes in selected high-risk groups in kidney transplantation by Massini Merzkani, Su-Hsin Chang, Haris Murad, Krista L. Lentine, Munis Mattu, Mei Wang, Vangie Hu, Bolin Wang, Yazen Al-Hosni, Obadah Alzahabi, Omar Alomar, Jason Wellen, Tarek Alhamad

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P460: Gene- and variant-specific calibration of in silico predictive models results in reclassification of 28% of missense VUS from ClinGen VCEPs by Shawn Fayer, Malvika Tejura, Abbye McEwen, Lea Starita, Douglas Fowler

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The Translational Landscape of SARS-CoV-2-infected Cells Reveals Suppression of Innate Immune Genes by Maritza Puray-Chavez, Nakyung Lee, Kasyap Tenneti, Yiqing Wang, Hung R. Vuong, Yating Liu, Amjad Horani, Tao Huang, Sean P. Gunsten, James B. Case, Wei Yang, Michael S. Diamond, Steven L. Brody, Joseph Dougherty, Sebla B. Kutluay

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Cognition and Brain System Segregation in Pediatric Brain Tumor Patients Treated with Proton Therapy by Anna V. Dowling, BS, Benjamin A. Seitzman, PhD, Timothy J. Mitchell, PhD, Michael Olufawo, BS, Donna L. Dierker, BS, Hari Anandarajah, BS, Ally Dworetsky, BS, Alana McMichael, MA, Catherine Jiang, BS, Dennis L. Barbour, MD, PhD, Bradley L. Schlaggar, MD, PhD, David D. Limbrick, MD, PhD, Jennifer M. Strahle, MD, Joshua B. Rubin, MD, PhD, Joshua S. Shimony, MD, PhD, Stephanie M. Perkins, MD

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Resting state network mapping in individuals using deep learning by Patrick H. Luckett, John J. Lee, Ki Yun Park, Ryan V. Raut, Ryan V. Raut, Karin L. Meeker, Evan M. Gordon, Abraham Z. Snyder, Abraham Z. Snyder, Beau M. Ances, Eric C. Leuthardt, Eric C. Leuthardt, Eric C. Leuthardt, Eric C. Leuthardt, Eric C. Leuthardt, Eric C. Leuthardt, Eric C. Leuthardt, Joshua S. Shimony

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Isolation of SARS-CoV-2 in Viral Cell Culture in Immunocompromised Patients With Persistently Positive RT-PCR Results by Abby Sung, Adam L. Bailey, Henry B. Stewart, David McDonald, Meghan A. Wallace, Kate Peacock, Candace Miller, Kimberly A. Reske, Caroline A. O’Neil, Victoria J. Fraser, Michael S. Diamond, Michael S. Diamond, Michael S. Diamond, Carey-Ann D. Burnham, Carey-Ann D. Burnham, Carey-Ann D. Burnham, Hilary M. Babcock, Jennie H. Kwon

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Genotype and clinical characteristics of patients with Wolfram syndrome and WFS1-related disorders by Evan M. Lee, Evan M. Lee, Evan M. Lee, Megha Verma, Megha Verma, Nila Palaniappan, Nila Palaniappan, Emiko M. Pope, Sammie Lee, Lindsey Blacher, Pooja Neerumalla, William An, Toko Campbell, Cris Brown, Stacy Hurst, Bess Marshall, Tamara Hershey, Virginia Nunes, Virginia Nunes, Miguel López de Heredia, Fumihiko Urano, Fumihiko Urano

“…We sought to elucidate the relationship between genotypic and phenotypic presentations of Wolfram syndrome which would assist clinicians in classifying the severity and prognosis of Wolfram syndrome more accurately.Approach: Patient data from the Washington University International Registry and Clinical Study for Wolfram Syndrome and patient case reports were analyzed to select for patients with two recessive mutations in the WFS1 gene. …”
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Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation by Natalia Jaeger, Ryan T. McDonough, Anne L. Rosen, Ariel Hernandez-Leyva, Naomi G. Wilson, Michael A. Lint, Emilie V. Russler-Germain, Jiani N. Chai, Leonard B. Bacharier, Chyi-Song Hsieh, Andrew L. Kau

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The association of caregiver attitudes, information sources, and trust with HPV vaccine initiation among adolescents by Akila Anandarajah, Thembekile Shato, Sarah Humble, Alan R. Barnette, Heather M. Brandt, Lisa M. Klesges, Vetta L. Sanders Thompson, Michelle I. Silver

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Perioperative mental health intervention bundle for older surgical patients: protocol for an intervention development and feasibility study by Michael Simon Avidan, Joanna Abraham, Katherine J Holzer, Eric Lenze, Ana A Baumann, Emily M Lenard, Kenneth E Freedland, Bethany R Tellor Pennington, Rachel C Wolfe, Theresa A Cordner, Mary Politi

“…A hybrid inductive–deductive thematic approach will be employed to analyse qualitative feedback from key stakeholders.Ethics and dissemination The study received approval from the Washington University Institutional Review Board. Results of this study will be presented in peer-reviewed journals, at professional conferences, and to our perioperative mental health advisory board.Trial registration number NCT05110690.…”
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