Curriculum renewal in the time of COVID‐19: The Washington University School of Medicine Story by Eva M. Aagaard, Timothy Yau, Carolyn Dufault

“…Abstract Washington University School of Medicine began a curriculum renewal process in 2017 with a goal of implementing the Gateway Curriculum in 2020. …”
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The Newberry Laboratory <subtitle>Washington University School of Medicine, St. Louis, MO, USA</subtitle>

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The Yan A. Su Laboratory <subtitle>Department of Biochemistry and Molecular Biology, Catherine Birch McCormick Genomics Center, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA</subtitle>

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Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center by Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John Budde, Pat Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Jen Gentsch, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Dan Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N. Do, Yun Ju Sung, Guoyan Zhao, John C. Morris, Krista Moulder, David M. Holtzman, Randall J. Bateman, Celeste Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E. Schindler, Joyce (Joy) Balls-Berry, Tammie L. S. Benzinger, Richard J. Perrin, Andrea Denny, B. Joy Snider, Susan L. Stark, Laura Ibanez, Carlos Cruchaga

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Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer by Nalinikanth Kotagiri, Matthew L. Cooper, Michael Rettig, Christopher Egbulefu, Julie Prior, Grace Cui, Partha Karmakar, Mingzhou Zhou, Xiaoxia Yang, Gail Sudlow, Lynne Marsala, Chantiya Chanswangphuwana, Lan Lu, LeMoyne Habimana-Griffin, Monica Shokeen, Xinming Xu, Katherine Weilbaecher, Michael Tomasson, Gregory Lanza, John F. DiPersio, Samuel Achilefu

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#27. First-in-human evaluation of safety and dosimetry of 64Cu-LLP2A for PET imaging by Richard Laforest, Anchal Ghai, Tyler J. Fraum, Reiko Oyama, Jennifer Frye, Helen Kaemmerer, Greg Gaehle, Tom Voller, Cedric Mpoy, Buck E. Rogers, Mark Fiala, Kooresh I. Shoghi, Samuel Achilefu, Michael Rettig, Ravi Vij, John F. DiPersio, Sally Schwarz, Monica Shokeen, Farrokh Dehdashti

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Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential by Terrence N. Wong, Christopher A. Miller, Matthew R. M. Jotte, Nusayba Bagegni, Jack D. Baty, Amy P. Schmidt, Amanda F. Cashen, Eric J. Duncavage, Nichole M. Helton, Mark Fiala, Robert S. Fulton, Sharon E. Heath, Megan Janke, Kierstin Luber, Peter Westervelt, Ravi Vij, John F. DiPersio, John S. Welch, Timothy A. Graubert, Matthew J. Walter, Timothy J. Ley, Daniel C. Link

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Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG by Yan Zhou, Wanjiang Zhang, Rachael Easton, James W. Ray, Patricia Lampe, Zhihong Jiang, Anne L. Brunkan, Alison Goate, Eugene M. Johnson, Jane Y. Wu

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Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer by Kelsy C. Cotto, Yang-Yang Feng, Avinash Ramu, Megan Richters, Sharon L. Freshour, Zachary L. Skidmore, Huiming Xia, Joshua F. McMichael, Jason Kunisaki, Katie M. Campbell, Timothy Hung-Po Chen, Emily B. Rozycki, Douglas Adkins, Siddhartha Devarakonda, Sumithra Sankararaman, Yiing Lin, William C. Chapman, Christopher A. Maher, Vivek Arora, Gavin P. Dunn, Ravindra Uppaluri, Ramaswamy Govindan, Obi L. Griffith, Malachi Griffith

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BDNF Blocks Caspase-3 Activation in Neonatal Hypoxia–Ischemia by Byung Hee Han, Anselm D'Costa, Stephen A. Back, Maia Parsadanian, Shilen Patel, Aarti R. Shah, Jeffrey M. Gidday, Anu Srinivasan, Mohanish Deshmukh, David M. Holtzman

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Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma by Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim

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Neoantigen DNA vaccines are safe, feasible, and induce neoantigen-specific immune responses in triple-negative breast cancer patients by Xiuli Zhang, S. Peter Goedegebuure, Michael Y. Chen, Rashmi Mishra, Felicia Zhang, Yik Yeung Yu, Kartik Singhal, Lijin Li, Feng Gao, Nancy B. Myers, Tammi Vickery, Jasreet Hundal, Michael D. McLellan, Mark A. Sturmoski, Samuel W. Kim, Ina Chen, Jesse T. Davidson, Narendra V. Sankpal, Stephanie Myles, Rama Suresh, Cynthia X. Ma, Ademuyiwa Foluso, Andrea Wang-Gillam, Sherri Davies, Ian S. Hagemann, Elaine R. Mardis, Obi Griffith, Malachi Griffith, Christopher A. Miller, Ted H. Hansen, Timothy P. Fleming, Robert D. Schreiber, William E. Gillanders

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Selinexor combined with cladribine, cytarabine, and filgrastim in relapsed or refractory acute myeloid leukemia by Ramzi Abboud, Ezhilarasi Chendamarai, Michael P. Rettig, Kathryn M. Trinkaus, Peter A. Riedell, Camille N. Abboud, Armin Ghobadi, Iskra Pusic, Keith Stockerl-Goldstein, Mark A. Schroeder, Ravi Vij, Peter Westervelt, John F. DiPersio, Geoffrey L. Uy

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Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer by Alex H. Wagner, Siddhartha Devarakonda, Zachary L. Skidmore, Kilannin Krysiak, Avinash Ramu, Lee Trani, Jason Kunisaki, Ashiq Masood, Saiama N. Waqar, Nicholas C. Spies, Daniel Morgensztern, Jason Waligorski, Jennifer Ponce, Robert S. Fulton, Leonard B. Maggi, Jason D. Weber, Mark A. Watson, Christopher J. O’Conor, Jon H. Ritter, Rachelle R. Olsen, Haixia Cheng, Anandaroop Mukhopadhyay, Ismail Can, Melissa H. Cessna, Trudy G. Oliver, Elaine R. Mardis, Richard K. Wilson, Malachi Griffith, Obi L. Griffith, Ramaswamy Govindan

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Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis by Ismail Sergin, Trent D. Evans, Xiangyu Zhang, Somashubhra Bhattacharya, Carl J. Stokes, Eric Song, Sahl Ali, Babak Dehestani, Karyn B. Holloway, Paul S. Micevych, Ali Javaheri, Jan R. Crowley, Andrea Ballabio, Joel D. Schilling, Slava Epelman, Conrad C. Weihl, Abhinav Diwan, Daping Fan, Mohamed A. Zayed, Babak Razani

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Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma by Lauren Broestl, Nicole M. Warrington, Lucia Grandison, Tamara Abou-Antoun, Olivia Tung, Saraswati Shenoy, Miranda M. Tallman, Gina Rhee, Wei Yang, Jasmin Sponagel, Lihua Yang, Najla Kfoury-Beaumont, Cameron M. Hill, Sulaiman A. Qanni, Diane D. Mao, Albert H. Kim, Sheila A. Stewart, Monica Venere, Jingqin Luo, Joshua B. Rubin

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SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation by Songyan Wang, Cliff J. Luke, Stephen C. Pak, Victoria Shi, Liyun Chen, Jonathan Moore, Arlise P. Andress, Kay Jayachandran, Jin Zhang, Yi Huang, Marina Platik, Anthony A. Apicelli, Julie K. Schwarz, Perry W. Grigsby, Gary A. Silverman, Stephanie Markovina

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Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers by Christopher A. Miller, Yevgeniy Gindin, Charles Lu, Obi L Griffith, Malachi Griffith, Dong Shen, Jeremy Hoog, Tiandao Li, David E. Larson, Mark Watson, Sherri R Davies, Kelly Hunt, Vera J. Suman, Jacqueline Snider, Thomas Walsh, Graham A. Colditz, Katherine DeSchryver, Richard K. Wilson, Elaine R. Mardis, Matthew J. Ellis

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#46. cAMP-mediated acid signaling regulates tumor-myeloid-bone cell crosstalk in the bone-tumor microenvironment by Kaylee O'Donnell, Xinming Su, Yalin Xu, Kristin A. Kwakwa, Deborah J. Veis, David G. DeNardo, Gregory M. Lanza, Katherine N. Weilbaecher

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#22. Investigating the TGF-β/integrin β3 signaling axis as a mediator of chemoresistance in breast cancer bone metastasis by Kristin A. Kwakwa, Gregory C. Fox, Michael H. Ross, Xinming Su, Yalin Xu, Netra Navadkar, Gregory M. Lanza, Christopher A. Maher, Katherine N. Weilbaecher

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