StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells by Céline Labouesse, Bao Xiu Tan, Chibeza C. Agley, Moritz Hofer, Alexander K. Winkel, Giuliano G. Stirparo, Hannah T. Stuart, Christophe M. Verstreken, Carla Mulas, William Mansfield, Paul Bertone, Kristian Franze, José C. R. Silva, Kevin J. Chalut

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Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis by Claire Fielding, Andrés García-García, Claudia Korn, Stephen Gadomski, Zijian Fang, Juan L. Reguera, José A. Pérez-Simón, Berthold Göttgens, Simón Méndez-Ferrer

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Genetic modification of primary human B cells to model high-grade lymphoma by Rebecca Caeser, Miriam Di Re, Joanna A. Krupka, Jie Gao, Maribel Lara-Chica, João M. L. Dias, Susanna L. Cooke, Rachel Fenner, Zelvera Usheva, Hendrik F. P. Runge, Philip A. Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S. Vassiliou, Brian J. P. Huntly, Annalisa Mupo, Rachael J. M. Bashford-Rogers, Daniel J. Hodson

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Convergent somatic evolution commences in utero in a germline ribosomopathy by Heather E. Machado, Nina F. Øbro, Nicholas Williams, Shengjiang Tan, Ahmed Z. Boukerrou, Megan Davies, Miriam Belmonte, Emily Mitchell, E. Joanna Baxter, Nicole Mende, Anna Clay, Philip Ancliff, Jutta Köglmeier, Sally B. Killick, Austin Kulasekararaj, Stefan Meyer, Elisa Laurenti, Peter J. Campbell, David G. Kent, Jyoti Nangalia, Alan J. Warren

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Generation of functional hepatocytes by forward programming with nuclear receptors by Rute A Tomaz, Ekaterini D Zacharis, Fabian Bachinger, Annabelle Wurmser, Daniel Yamamoto, Sandra Petrus-Reurer, Carola M Morell, Dominika Dziedzicka, Brandon T Wesley, Imbisaat Geti, Charis-Patricia Segeritz, Miguel C de Brito, Mariya Chhatriwala, Daniel Ortmann, Kourosh Saeb-Parsy, Ludovic Vallier

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P1416: DNA DAMAGE TRIGGERS A P53 INDUCED AGEING RESPONSE IN HAEMATOPOIETIC STEM CELLS by M. Wang, L. Brandt, X. Wang, J. Garaycoechea, N. Wilson, B. Göttgens, K. J. Patel

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Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape by Maurizio Mangolini, Alba Maiques-Diaz, Stella Charalampopoulou, Elena Gerhard-Hartmann, Johannes Bloehdorn, Andrew Moore, Giorgia Giachetti, Junyan Lu, Valar Nila Roamio Franklin, Chandra Sekkar Reddy Chilamakuri, Ilias Moutsopoulos, Andreas Rosenwald, Stephan Stilgenbauer, Thorsten Zenz, Irina Mohorianu, Clive D’Santos, Silvia Deaglio, Daniel J. Hodson, Jose I. Martin-Subero, Ingo Ringshausen

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TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells by Anna Osnato, Stephanie Brown, Christel Krueger, Simon Andrews, Amanda J Collier, Shota Nakanoh, Mariana Quiroga Londoño, Brandon T Wesley, Daniele Muraro, A Sophie Brumm, Kathy K Niakan, Ludovic Vallier, Daniel Ortmann, Peter J Rugg-Gunn

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insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology by Stanley E. Strawbridge, Agata Kurowski, Elena Corujo-Simon, Alastair N. Fletcher, Jennifer Nichols, Alexander G. Fletcher

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P442: DDX41 GERMLINE VARIANTS: POPULATION PREVALENCE, SIGNIFICANCE AND LEUKEMIC EVOLUTION by Sruthi Cheloor Kovilakam, Muxin Gu, William G. Dunn, Ludovica Marando, Clea Barcena, Serena Nik Zainal, Irina Mohorianu, Siddhartha P. Kar, Margarete A. Fabre, Pedro M. Quiros, George S. Vassiliou

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P1329: REGIONAL COMPARTMENTALIZATION OF THE BONE MARROW STROMA IS IMPORTANT FOR RESPONSES TO INFLAMMATION AND CANCER by James Swann, Ruiyuan Zhang, Evgenia Verovskaya, Fernando Calero-Nieto, Xiaonan Wang, Melissa Proven, Berthold Göttgens, Emmanuelle Passegué

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Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death by Keith Woodley, Laura S. Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M. Rattigan, Céline Philippe, Vilma Dembitz, Aoife M. S. Magee, Ryan Asby, Louie N. van de Lagemaat, Christopher Mapperley, Sophie C. James, Jochen H. M. Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S. Vassiliou, Kamil R. Kranc, G. Vignir Helgason, Brian J. P. Huntly, Paolo Gallipoli

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The proneural transcription factor ASCL1 regulates cell proliferation and primes for differentiation in neuroblastoma by Lydia M. Parkinson, Lydia M. Parkinson, Sarah L. Gillen, Laura M. Woods, Laura M. Woods, Lewis Chaytor, Lewis Chaytor, Daniel Marcos, Daniel Marcos, Fahad R. Ali, Fahad R. Ali, Fahad R. Ali, Jason S. Carroll, Anna Philpott, Anna Philpott

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Corrigendum: Electrochemically induced in vitro focal hypoxia in human neurons by Joseph J. Y. Wong, Balazs V. Varga, Ragnhildur Thóra Káradóttir, Elizabeth A. H. Hall

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GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells by Loriana Vitillo, Catherine Durance, Zoe Hewitt, Harry Moore, Austin Smith, Ludovic Vallier

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Multiomics data integration to reveal chromatin remodeling and reorganization induced by gene mutational synergy by Haiyang Yun, Shabana Vohra, David Lara-Astiaso, Brian J.P. Huntly

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Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPR by Nefeli Skoufou-Papoutsaki, Sam Adler, Paula D'Santos, Liz Mannion, Shenay Mehmed, Richard Kemp, Amy Smith, Francesca Perrone, Komal Nayak, Alasdair Russell, Matthias Zilbauer, Douglas J. Winton

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Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis by Zijian Fang, Giuditta Corbizi Fattori, Thomas McKerrell, Rebecca H. Boucher, Aimee Jackson, Rachel S. Fletcher, Dorian Forte, Jose-Ezequiel Martin, Sonia Fox, James Roberts, Rachel Glover, Erica Harris, Hannah R. Bridges, Luigi Grassi, Alba Rodriguez-Meira, Adam J. Mead, Steven Knapper, Joanne Ewing, Nauman M. Butt, Manish Jain, Sebastian Francis, Fiona J. Clark, Jason Coppell, Mary F. McMullin, Frances Wadelin, Srinivasan Narayanan, Dragana Milojkovic, Mark W. Drummond, Mallika Sekhar, Hesham ElDaly, Judy Hirst, Maike Paramor, E. Joanna Baxter, Anna L. Godfrey, Claire N. Harrison, Simón Méndez-Ferrer

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Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency by Nicholas Bredenkamp, Jian Yang, James Clarke, Giuliano Giuseppe Stirparo, Ferdinand von Meyenn, Sabine Dietmann, Duncan Baker, Rosalind Drummond, Yongming Ren, Dongwei Li, Chuman Wu, Maria Rostovskaya, Sarah Eminli-Meissner, Austin Smith, Ge Guo

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Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids by Roberta Azzarelli, Michela Ori, Anna Philpott, Benjamin D. Simons

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