Whole Blood Holding Time Prior to Plasma Processing Alters microRNA Expression Profile by Sung Hye Kim, Sung Hye Kim, David A. MacIntyre, David A. MacIntyre, Lynne Sykes, Lynne Sykes, Maria Arianoglou, Maria Arianoglou, Phillip R. Bennett, Phillip R. Bennett, Vasso Terzidou, Vasso Terzidou, Vasso Terzidou

Get full text

From IB2 to IIIB locally advanced cervical cancers: report of a ten-year experience by Sophie Espenel, Max-Adrien Garcia, Jane-Chloé Trone, Elodie Guillaume, Annabelle Harris, Amel Rehailia-Blanchard, Ming Yuan He, Sarra Ouni, Alexis Vallard, Chloé Rancoule, Majed Ben Mrad, Céline Chauleur, Guy De Laroche, Jean-Baptiste Guy, Pablo Moreno-Acosta, Nicolas Magné

Get full text

Prevention of atherosclerosis in patients living with HIV by Ferruccio De Lorenzo, Marta Boffito, Sophie Collot-Teixeira, Brian Gazzard, John L McGregor, Kevin Shotliff, Han Xiao

“…Ferruccio De Lorenzo1, Marta Boffito1, Sophie Collot-Teixeira2, Brian Gazzard1, John L McGregor2,3, Kevin Shotliff2, Han Xiao41General Medicine and Prevention of Vascular Disorders, Beta Cell Diabetes Centre and St Stephen’s AIDS Trust, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK; 2Kings College London, Cardiovascular Division, London, UK; 3INSERM U970, PARC Hôpital Européen George Pompidou, Paris, France; 4Cardiology Department, Homerton University Hospital NHS, London, UKInvestigational product: Rosuvastatin (Crestor®; Astra Zeneca).Active ingredients: Rosuvastatin (5 mg).Study title: Prevention of Atherosclerosis in Patients Living with HIV.Phase of study: Phase III.Aims: Primary aim:• To assess whether rosuvastatin therapy could slow the progression of the carotid intima-media thickness (C-IMT; as measured by the change in the mean IMT of the near and far walls of the distal common carotid arteries) over 2 years in HIV-infected patients (HIV-IP).Secondary aims:• To assess whether rosuvastatin therapy could reduce highly sensitive C reactive protein (hs-CRP) inflammatory marker that is increased in HIV-IP.…”
Get full text

Availability, scope and quality of monkeypox clinical management guidelines globally: a systematic review by Helen Groves, Dania Dahmash, Shevin T Jacob, Peter W Horby, Louise Sigfrid, Andrew Dagens, Erhui Cai, Ishmeala Rigby, Tom Fletcher, Lucille Blumberg, Alice Norton, Muge Cevik, Keerti Gedela, Melina Michelen, Vincent Cheng, Eli Harriss, Eika Webb, Amanda M Rojek, Susan Khader, Samuel Lipworth, Robert Nartowski, Peter Hart

Get full text

A Tumor-Infiltration CD8+ T Cell-Based Gene Signature for Facilitating the Prognosis and Estimation of Immunization Responses in HPV+ Head and Neck Squamous Cell Cancer by Yingning Wu, Yingning Wu, Yingning Wu, Lingzhang Meng, Kai Cai, Jingjie Zhao, Siyuan He, Jiajia Shen, Qiuju Wei, Qiuju Wei, Zechen Wang, Suren Sooranna, Hengguo Li, Jian Song, Jian Song

Get full text

The practicalities of adapting UK maternity clinical information systems for observational research: Experiences of the POOL study by Fiona Lugg-Widger, Christian Barlow, Rebecca Cannings-John, Chris Gale, Nicola Houlding, Rebecca Milton, Rachel Plachcinski, Michael Robling, Julia Sanders

Get full text

Intraoperative Hypotension and Related Risk Factors for Postoperative Mortality After Noncardiac Surgery in Elderly Patients: A Retrospective Analysis Report by Zhao B, Chen X, Chen Q, Li G, Chen Z, Yang Z, Gu L, Xiao X, Wang Z, Ning J, Yi B, Lu K, Zhang H, Gu J

“…Benhui Zhao,1,* Xingtong Chen,1,* Qian Chen,1,2 Gaoming Li,3 Zhe Chen,4 Ziheng Yang,1 Li Gu,1 Xudong Xiao,5 Zhen Wang,6 Jiaolin Ning,1 Bin Yi,1 Kaizhi Lu,1 Hongyan Zhang,7 Jianteng Gu1 1Department of Anesthesiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China; 2Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK; 3Department of Health Statistics, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China; 4Quality Management and Control Department, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China; 5Department of Anesthesiology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China; 6Department of Anesthesiology; 7Hospital Office, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianteng Gu; Hongyan Zhang Email jiantenggu@hotmail.com; etengyan@163.comBackground: Blood pressure fluctuation is very common during non-cardiac surgery in elderly. …”
Get full text

The Challenge of Home Allergen Re-introductions Using the Ladder Approach in Children With Non-IgE Mediated Gastrointestinal Food Allergy by Rosan Meyer, Claire De Koker, Robert Dziubak, Heather Godwin, Kate Reeve, Adriana Chebar-Lozinsky, Ru-Xin Foong, Ru-Xin Foong, Ana-Kristina Skrapac, Marlene Ellmer, Neil Shah

Get full text

Logistic regression analysis of risk factors for pediatric burns: a case–control study in underdeveloped minority areas in China by Ziren Lin, Ziren Lin, Petchi Iyappan, Zhiqun Huang, Suren Rao Sooranna, Suren Rao Sooranna, Yongfang Wu, Liuting Lan, Cheng Huang, Feiteng Liang, Daji Zhao, Dingjin Huang

Get full text

Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia: study protocol for a randomised controlled trial (PARROT-... by Alice Hurrell, Jenie Sparkes, Kate Duhig, Paul T. Seed, Jenny Myers, Cheryl Battersby, Katherine Clark, Marcus Green, Rachael M. Hunter, Andrew H. Shennan, Lucy C. Chappell, Louise Webster

Get full text

Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients by Christine B. Sieberg, Caitlin Taras, Aya Gomaa, Chelsea Nickerson, Cindy Wong, Catherine Ward, Georgios Baskozos, David L.H. Bennett, Juan D. Ramirez, Andreas C. Themistocleous, Andrew S.C. Rice, Pallai R. Shillo, Solomon Tesfaye, Robert R. Edwards, Nick A. Andrews, Charles Berde, Michael Costigan

Get full text

Teaching and Assessment of Medical Students During Complex Multifactorial Team-Based Tasks: The “Virtual on Call” Case Study by Emin EI, Emin E, Bimpis A, Pierides M, Dedeilia A, Javed Z, Rallis KS, Saeed F, Theophilou G, Karkanevatos A, Kitapcioglu D, Aksoy ME, Papalois A, Sideris M

“…Elif Iliria Emin,1 Ece Emin,2 Alexios Bimpis,3 Michael Pierides,4 Aikaterini Dedeilia,5 Zibad Javed,6 Kathrine-Sofia Rallis,6 Ferha Saeed,6 Georgios Theophilou,7 Apostolos Karkanevatos,8 Dilek Kitapcioglu,9 Mehmet Emin Aksoy,9 Apostolos Papalois,10 Michail Sideris6 1Department of Acute Medicine, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK; 2EGA Institute for Women’s Health, University College London, London, UK; 3Department of Neurosurgery, Tzaneio General Hospital, Piraeus, Greece; 4Department of Acute Medicine, Kettering General Hospital NHS Trust, Northamptonshire, UK; 5School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; 6Faculty of Medicine and Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK; 7Department of Gynaecological Oncology, St James Institute of Oncology, Leeds, UK; 8Department of ENT Surgery, Mid Cheshire Hospitals NHS Foundation Trust, Crewe, UK; 9Center of Advanced Simulation and Education, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey; 10Special Unit for Biomedical Research and Education, Aristotle University of Thessaloniki, Thessaloniki, GreeceCorrespondence: Michail Sideris, Faculty of Medicine and Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary university of London, London, UK, Email m.sideris@qmul.ac.ukAbstract: Although considerable efforts have been made to incorporate simulation-based learning (SBL) in undergraduate medical education, to date, most of the medical school curricula still focus on pure knowledge or individual assessment of objective structured clinical examination skills (OSCE). …”
Get full text

Inhaled 45–50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia by Kevin D. Broad, Igor Fierens, Bobbi Fleiss, Eridan Rocha-Ferreira, Mojgan Ezzati, Jane Hassell, Daniel Alonso-Alconada, Alan Bainbridge, Go Kawano, Daqing Ma, Ilias Tachtsidis, Pierre Gressens, Xavier Golay, Robert D. Sanders, Nicola J. Robertson

Get full text

Risk factors and outcomes of intraoperative hypothermia in neonatal and infant patients undergoing general anesthesia and surgery by Jialian Zhao, Zhenkai Le, Lihua Chu, Yi Gao, Manqing Zhang, Jiabin Fan, Daqing Ma, Yaoqin Hu, Dengming Lai

Get full text

Changes in Cardiovascular Disease Risk Factors With Immediate Versus Deferred Antiretroviral Therapy Initiation Among HIV‐Positive Participants in the START (Strategic Timing of An... by Jason V. Baker, Shweta Sharma, Amit C. Achhra, Jose Ignacio Bernardino, Johannes R. Bogner, Daniel Duprez, Sean Emery, Brian Gazzard, Jonathan Gordin, Greg Grandits, Andrew N. Phillips, Siegfried Schwarze, Elsayed Z. Soliman, Stephen A. Spector, Giuseppe Tambussi, Jens Lundgren

Get full text

Bictegravir/emtricitabine/tenofovir alafenamide as initial treatment for HIV-1: five-year follow-up from two randomized trialsResearch in context by Paul E. Sax, José R. Arribas, Chloe Orkin, Adriano Lazzarin, Anton Pozniak, Edwin DeJesus, Franco Maggiolo, Hans-Jürgen Stellbrink, Yazdan Yazdanpanah, Rima Acosta, Hailin Huang, Jason T. Hindman, Hal Martin, Jared M. Baeten, David Wohl

Get full text

Protocol of a two arm randomised, multi-centre, 12-month controlled trial: evaluating the impact of a Cognitive Behavioural Therapy (CBT)-based intervention Supporting UPtake and A... by R. Horne, E. Glendinning, K. King, T. Chalder, C. Sabin, A. S. Walker, L. J. Campbell, I. Mosweu, J. Anderson, S. Collins, R. Jopling, P. McCrone, H. Leake Date, S. Michie, M. Nelson, N. Perry, J. A. Smith, W. Sseruma, V. Cooper, On behalf of the SUPA Group

Get full text

How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence by Patrice Forget, Jose A. Aguirre, Ivanka Bencic, Alain Borgeat, Allessandro Cama, Claire Condron, Christina Eintrei, Pilar Eroles, Anil Gupta, Tim G. Hales, Daniela Ionescu, Mark Johnson, Pawel Kabata, Iva Kirac, Daqing Ma, Zhirajr Mokini, Jose Luis Guerrero Orriach, Michael Retsky, Sergio Sandrucci, Wiebke Siekmann, Ljilja Štefančić, Gina Votta-Vellis, Cara Connolly, Donal Buggy

Get full text

Transcriptome Profiling Reveals B-Lineage Cells Contribute to the Poor Prognosis and Metastasis of Clear Cell Renal Cell Carcinoma by Fafen Yang, Fafen Yang, Jingjie Zhao, Xiuzhuang Luo, Tong Li, Tong Li, Zechen Wang, Qiuju Wei, Qiuju Wei, Heming Lu, Yiliang Meng, Kai Cai, Liuying Lu, Yushi Lu, Lifen Chen, Suren Rao Sooranna, Linxue Luo, Linxue Luo, Jian Song, Jian Song, Lingzhang Meng

Get full text

Piloting an online telecoaching community-based exercise intervention with adults living with HIV: protocol for a mixed-methods implementation science study by Ahmed M Bayoumi, Darren A Brown, Kelly K O'Brien, Patricia Solomon, Ada Tang, Mehdi Zobeiry, Mona R Loutfy, Lisa Avery, Soo Chan Carusone, Brittany Torres, Francisco Ibáñez-Carrasco, Kiera McDuff, Tizneem Jiancaro, George Da Silva, Shaz Islam, Joanne Lindsay, Colleen Price, Zoran Pandovski, Ivan Illic, Puja Ahluwalia

Get full text