Copanlisib population pharmacokinetics from phase I–III studies and exposure–response relationships in combination with rituximab by Peter N. Morcos, Jonathan Moss, Rupert Austin, Florian Hiemeyer, Pier Luigi Zinzani, Vita Beckert, Lidia Mongay Soler, Barrett H. Childs, Dirk Garmann

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Model‐informed approach to support pediatric dosing for the pan‐PI3K inhibitor copanlisib in children and adolescents with relapsed/refractory solid tumors by Peter N. Morcos, Jan Schlender, Rolf Burghaus, Jonathan Moss, Adam Lloyd, Barrett H. Childs, Margaret E. Macy, Joel M. Reid, John Chung, Dirk Garmann

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Extended Thromboprophylaxis in Hospitalized Patients with Heart Failure: A Post Hoc Analysis of the MAGELLAN Study by Alex C. Spyropoulos, Gary E. Raskob, Theodore E. Spiro, Wentao Lu, Yoriko De Sanctis, John Albanese, Alexandre Mebazaa, Elliot S. Barnathan

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Enhancing the Quality of Rivaroxaban Exposure Estimates Using Prothrombin Time in the Absence of Pharmacokinetic Sampling by Alexander Solms, Matthias Frede, Scott D. Berkowitz, Anne Hermanowski‐Vosatka, Dagmar Kubitza, Wolfgang Mueck, Theodore E. Spiro, Stefan Willmann, Xiaoyu Yan, Liping Zhang, Dirk Garmann

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Albuminuria Screening in People With Type 2 Diabetes in a Managed Care Organization by Farrah Keong, MPH, Jennifer Gander, PhD, Daniel Wilson, MD, Jeffrey Durthaler, DPh, Belkis Pimentel, MD, Joshua I. Barzilay, MD

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Modified IMPROVE VTE Risk Score and Elevated D-Dimer Identify a High Venous Thromboembolism Risk in Acutely Ill Medical Population for Extended Thromboprophylaxis by Alex C. Spyropoulos, Concetta Lipardi, Jianfeng Xu, Colleen Peluso, Theodore E. Spiro, Yoriko De Sanctis, Elliot S. Barnathan, Gary E. Raskob

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Understanding what matters to metastatic castration‐resistant prostate cancer (mCRPC) patients when considering treatment options: A US patient preference survey by Daniel J. George, Ateesha F. Mohamed, Jui‐Hua Tsai, Milad Karimi, Ning Ning, Sayeli Jayade, Marc Botteman

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Pharmacologic activity and pharmacokinetics of metabolites of regorafenib in preclinical models by Dieter Zopf, Iduna Fichtner, Ajay Bhargava, Wolfram Steinke, Karl‐Heinz Thierauch, Konstanze Diefenbach, Scott Wilhelm, Frank‐Thorsten Hafner, Michael Gerisch

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To blind or not to blind first in human and exploratory clinical trials: Acceleration of development vs. risk of bias by Sebastian Haertter, Jitendar Kanodia, Jack Cook, Jeanette Alicea, Bonnie J. Brennan, Amit Desai, Bela Patel, Lin Pan, Kosalaram Goteti

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Real-world practice patterns and outcomes for RAI-refractory differentiated thyroid cancer by Andrew G Gianoukakis, Jennifer H Choe, Daniel W Bowles, Marcia S Brose, Lori J Wirth, Taofeek Owonikoko, Svetlana Babajanyan, Francis P Worden

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BetaEval Global: Prospective, Multinational, Observational Cohort Study of Patients Using BETACONNECT® by Patti F, Martínez Ginés ML, Norenberg C, Duarte Caron F

“…Francesco Patti,1 María Luisa Martínez Ginés,2 Christiane Norenberg,3 Fernando Duarte Caron4 1Department of Medical and Surgical Sciences and Advanced Technologies, GF Ingrassia; Multiple Sclerosis Center, University of Catania, Catania, Italy; 2Department of Neurology, Hospital General Universitario Gregorio Marañon, Madrid, Spain; 3Bayer AG, Wuppertal, Germany; 4Bayer, Whippany, New Jersey, NY, USACorrespondence: Francesco PattiMultiple Sclerosis Center, University of Catania, Piazza Università, 2, Catania 95131, ItalyEmail patti@unict.itPurpose: Patients with multiple sclerosis (MS) would benefit from continued long-term treatment with disease-modifying therapies, and autoinjectors may help improve patients’ satisfaction with therapy, thereby increasing adherence rates. …”
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Prostate cancer with bone metastasis in Beijing: an observational study of prevalence, hospital visits and treatment costs using data from an administrative claims database by Yi Song, Lin Xu, Lin Zhuo, Yinchu Cheng, Yuting Pan, Jihong Zong, Wentao Sun, Montse Soriano-Gabarró, Jian Lu

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Rivaroxaban Plus Aspirin for Extended Thromboprophylaxis in Acutely Ill Medical Patients: Insights from the MARINER Trial by Alex C. Spyropoulos, Mark Goldin, Walter Ageno, Gregory W. Albers, C. Gregory Elliott, William R. Hiatt, Jonathan L. Halperin, Gregory Maynard, P. Gabriel Steg, Jeffrey I. Weitz, Theodore E. Spiro, Wentao Lu, Jessica Marsigliano, Gary E. Raskob, Elliot S. Barnathan

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