Toxic Megacolon: Background, Pathophysiology, Management Challenges and Solutions [Corrigendum] by Desai J, Elnaggar M, Hanfy AA, Doshi R

“…The new reference should have been cited throughout the paper in the following places: Page 205, left column, second paragraph, first sentence, the text should read “A complete colonoscopy is extremely risky in patients with TM because it can cause colonic perforation.60” Page 205, right column, line 6, the text should read “TPN provides no proven clinical benefit in terms of avoiding surgical intervention in patients with colitis due to UC.35,60” Page 205, Glucocorticoids section, third and fourth sentences, the text should read “Dexamethasone, by diminishing the expression of NO synthase, has been reported to decrease the colonic diameter.60 Most providers consider methylprednisolone because of its lower potassium wasting and sodium retaining properties, while others prefer prednisolone as the oral and parenteral doses are the same.60” Page 205, Infliximab or Cyclosporine section, first sentence, the text should read “Patients with IBD-related TM who are refractory to three days of intravenous glucocorticoid therapy should receive either Infliximab or Cyclosporine as the secondline therapy.60” Page 205, Infliximab or Cyclosporine section, last sentence, the text should read “Since these three conditions may not be readily distinguishable during an acute flare-up such as TM, many authors suggest treating all IBD-related TM with the same approach.60” Page 206, C. difficile colitis section, third paragraph, first and second sentences, the text should read “Surgery is indicated in patients with colonic perforation, necrosis, or full-thickness ischemia, intraabdominal hypertension or abdominal compartment syndrome, clinical signs of peritonitis, or worsening abdominal exam despite adequate medical therapy, and end-organ failure.60 Besides, white blood cell count >50,000 cell/mL and serum lactate level of >5 mmol/L are relative indications for surgical intervention.60” Page 207, Pregnant women section, second sentence, the text should read “Patients who are in remission at the conception are likely to remain in remission during pregnancy.60” Page 208, Prognosis section, first paragraph, last sentence, the text should read “Colonic perforation is associated with a significantly worse prognosis, with the mortality rate increased by three- to fivefold.6,8,60” Page 208, Prognosis section, fourth paragraph, first sentence, the text should read “The difference in mortality rates may also be due to the biases of medical or surgical providers.60” Page 208, Prognosis section, fourth paragraph, third sentence, the text should read “Surgical studies reveal up to a 50 percent rate of future surgical intervention, including colectomy in patients with TM who initially responded well to medical treatment alone.55,58,60” The authors acknowledge the missing reference as a source of information for their article and apologise for not including it in the original publication. …”
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Fibrinogen–Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma by Li Z, Zhou C, Peng Q, Wang SG, Qian G, Tang L, Zhou X, Yang Q, Shen Z, Huang GZ, Wang Y, Li H

“…Data on serum fibrinogen, albumin levels, white blood cell count, platelet count, and alkaline phosphatase (ALP) before and after NAC were collected. …”
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Complete Blood Count (CBC) and CBC derived Ratios in Early Diagnosis of COVID-19: A Retrospective Single-centre Study by Balamurugan Senthilnayagam, Afrin Fathima, Karthika Rajenderan, S Preethi, Khowsalya Subrajaa, S Manjani

“…Median values for haemoglobin, haematocrit, Red Blood Cell (RBC) count and Red cell Distribution Width (RDW) were significantly higher (p-value <0.05) and total White Blood Cell (WBC) count, eosinophil differential count, absolute eosinophil count, lymphocyte count, absolute lymphocyte count, immature granulocyte count were significantly lower in COVID-19 patients as compared to controls. …”
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A prediction rule for severe adverse events in all inpatients with community-acquired pneumonia: a multicenter observational study by Toshihiro Sakakibara, Yuichiro Shindo, Daisuke Kobayashi, Masahiro Sano, Junya Okumura, Yasushi Murakami, Kunihiko Takahashi, Shigeyuki Matsui, Tetsuya Yagi, Hideo Saka, Yoshinori Hasegawa

“…Results The ALL-COP SCORE rule included albumin (< 2 g/dL, 2 points; 2–3 g/dL, 1 point), white blood cell (< 4000 cells/μL, 3 points), chronic lung disease (1 point), confusion (2 points), PaO2/FIO2 ratio (< 200 mmHg, 3 points; 200–300 mmHg, 1 point), potassium (≥ 5.0 mEq/L, 2 points), arterial pH (< 7.35, 2 points), systolic blood pressure (< 90 mmHg, 2 points), PaCO2 (> 45 mmHg, 2 points), HCO3 − (< 20 mmol/L, 1 point), respiratory rate (≥ 30 breaths/min, 1 point), pleural effusion (1 point), and extent of chest radiographical infiltration in unilateral lung (> 2/3, 2 points; 1/2–2/3, 1 point). …”
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Anti-Inflammatory, Antinociceptive and Antipyretic Effects of Extracts from Snakehead Fish (Channa Striatus and C. Lucius). by Mohd Johari, Azlina

“…As for C. striatus and ketoprofen treated groups, the total white blood cell (WBC) count was reduced compared to the control group but was not significant different. …”
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Anti-inflammatory, antinociceptive and antipyretic effects of extracts from snakehead fish (Channa striatus and C. lucius) by Mohd Johari, Azlina

“…As for C. striatus and ketoprofen treated groups, the total white blood cell (WBC) count was reduced compared to the control group but was not significant different. …”
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Clinicopathological and Prognostic Characteristics of Esophageal Spindle Cell Squamous Cell Carcinoma: An Analysis of 43 Patients in a Single Center by Peng Li, Peng Li, Yang Li, Chao Zhang, Chao Zhang, Yi-Hong Ling, Yi-Hong Ling, Jie-Tian Jin, Jie-Tian Jin, Jing-Ping Yun, Jing-Ping Yun, Mu-Yan Cai, Mu-Yan Cai, Rong-Zhen Luo, Rong-Zhen Luo

“…In the univariate analysis, drinking abuse, tumor size, macroscopic type, perineural invasion, pT, preoperative blood white blood cell count, preoperative blood neutrophil count, and preoperative blood neutrophil to lymphocyte ratio were significantly correlated with the cancer-specific survival and disease-free survival of the ESCSCC patients. …”
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Chromogranin A provides additional prognostic information in children with severe hand, foot, and mouth disease: A prospective observational study by Hongxing Dang, Jing Li, Chengjun Liu, Feng Xu

“…Methods: Serum CHGA, creatine kinase myocardial band (CK-MB), serum D-dimer, norepinephrine, blood glucose, lactate, and C-reactive protein levels, white blood cell (WBC) counts, usage of vasopressors, pediatric risk of mortality Ⅲ (PRISM-Ⅲ) scores, and viral etiology were measured upon pediatric intensive care unit (PICU) admission. …”
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Characterization of total adenosine deaminase activity (ADA) and its isoenzymes in saliva and serum in health and inflammatory conditions in four different species: an analytical a... by María Dolores Contreras-Aguilar, Asta Tvarijonaviciute, Ingrida Monkeviciene, María Martín-Cuervo, Luis Guillermo González-Arostegui, Lorena Franco-Martínez, José Joaquín Cerón, Fernando Tecles, Damián Escribano

“…In cows, salivary tADA and ADA1 significantly increased after calving, correlating with total white blood cell count (r = 0.487, P < 0.05, for both tADA and ADA1). …”
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Pneumonia in patients with cirrhosis: risk factors associated with mortality and predictive value of prognostic models by Lichen Xu, Shuangwei Ying, Jianhua Hu, Yunyun Wang, Meifang Yang, Tiantian Ge, Chunhong Huang, Qiaomai Xu, Haihong Zhu, Zhi Chen, Weihang Ma

“…Age, inappropriate empirical antibiotic therapy (HR: 2.326 p = 0.018 for 30-day and HR: 3.126 p < 0.001 for 90-day), bacteremia (HR: 3.037 p = 0.002 for 30-day and HR: 2.651 p = 0.001 for 90-day), white blood cell count (WBC) (HR: 1.452 p < 0.001 for 30-day and HR: 1.551 p < 0.001 for 90-day) and total bilirubin (HR: 1.059 p = 0.002 for 90-day) were independent factors for mortality in current study. …”
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A study of clinical and serological correlation of early myocardial injury in elderly patients infected with the Omicron variant by Xueying Yu, Xiaoguang Li, Shuai Xia, Lu Lu, Jiahui Fan, Ying Wang, Yan Fu, Chen Suo, Qiuhong Man, Lize Xiong, Lize Xiong

“…By comparing myocardial injury patients with non-myocardial injury patients, notable differences were observed in age, pre-existing medical conditions (e.g., hypertension, coronary heart disease, cerebrovascular disease, arrhythmia, chronic kidney disease, and heart failure), and various laboratory biomarkers, including cycle threshold-ORF1ab gene (Ct-ORF1ab), cycle threshold-N gene (Ct-N), white blood cell count, neutrophil (NEUT) count, NEUT%, lymphocyte (LYM) count, LYM%, and D-dimer, interleukin-6, procalcitonin, C-reactive protein, serum amyloid A, total protein, lactate dehydrogenase, aspartate aminotransferase, glomerular filtration rate, blood urea nitrogen, and serum creatinine (sCr) levels (P &lt; 0.05). …”
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Yeast polysaccharide supplementation: impact on lactation, growth, immunity, and gut microbiota in Dezhou donkeys by Bingjian Huang, Bingjian Huang, Muhammad Zahoor Khan, Muhammad Zahoor Khan, Yinghui Chen, Yinghui Chen, Huili Liang, Xiyan Kou, Xinrui Wang, Wei Ren, Changfa Wang, Zhenwei Zhang

“…Additionally, YPS was associated with increased plasma glucose and creatinine concentrations in foals, while tending to decrease alkaline phosphatase, white blood cell count, red blood cell count, and hemoglobin levels (p &lt; 0.10). …”
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Anemia in Lymphoma Patients in Indonesia: The Prevalence and Predictive Factors by Mardiah Suci Hardianti, Salsabilla Hasna Mutiara Rizki, Hafidz Arkananda, Amira L. Dhyanti, Syahru Agung Setiawan, Indrawati -, Nugira Dinantia, Nungki Anggorowati

“…Clinical and laboratory parameters included were age, sex, nutritional status, Ann Arbor staging, extranodal involvement, number of extranodal sites, Lactate Dehydrogenase (LDH) level, Eastern Cooperative Oncology Group (ECOG) performance status, platelet count, absolute lymphocyte count (ALC), white blood cell count (WBC), and lymphoma prognostic score (Non-Hodgkin Lymphoma/NHL using Index Prognostic International (IPI), Hodgkin’s Lymphoma/HL using International Prognostic Score (IPS)). …”
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Correlation of DNA load, genotyping, and clinical phenotype of Mycoplasma pneumoniae infection in children by Wei Wang, Wei Wang, Lu Wang, Lu Wang, Zhaoqing Yin, Shujuan Zeng, Guohua Yao, Yuqiao Liu, Yulian Fang, Yulian Fang, Cuian Ma, Hualei Cui, Hualei Cui

“…We found that MP DNA load was positively correlated with length of hospitalization, maximum fever temperature, CRP, PCT, Interleukin-6 (IL-6), and AST levels, and negatively correlated with fever and cough durations, white blood cell count (WBC), and proportion of monocytes (MONO). …”
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Postoperative red blood cell distribution width predicts functional outcome in aneurysmal subarachnoid hemorrhage after surgical clipping: A single-center retrospective study by Long Zhao, Long Zhao, Long Zhao, Yi Zhang, Ping Lin, Weida Li, Xingyuan Huang, Hangyang Li, Mingkai Xia, Xinlong Chen, Xi Zhu, Xiaoping Tang, Xiaoping Tang

“…Multivariate logistic regression of admission parameters showed that World Federation of Neurosurgical Societies (WFNS) grade (odds ratio [95% CI]: 1.322 [1.023–1.707], p = 0.033) and white blood cell (WBC) (odds ratio [95% CI]: 1.136 [1.044–1.236], p = 0.003) were independently associated with poor functional outcome. …”
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Chinese herbal compound for multidrug-resistant or extensively drug-resistant bacterial pneumonia: a meta-analysis and trial sequential analysis with association rule mining to ide... by Shuman Zhao, Yanting Geng, Jiaheng Shi, Jing Qian, Yebeilei Yang, Dan Dai, Zimin Yan, Wensheng Qi, Daxing Yu, Xin Zhao

“…Meta-analysis indicated that CHC combined with antibiotics improved the response rate (RR = 1.24; 95% CI: 1.19–1.28; p &lt; 0.0001) and microbiological eradication (RR = 1.41; 95% CI: 1.27–1.57; p &lt; 0.0001), lowered the white blood cell count (MD = −2.09; 95% CI: −2.65 to −1.53; p &lt; 0.0001), procalcitonin levels (MD = −0.49; 95% CI: −0.59 to −0.40; p &lt; 0.0001), C-reactive protein levels (MD = −11.80; 95% CI: −15.22 to −8.39; p &lt; 0.0001), Clinical Pulmonary Infection Scores (CPIS) (MD = −1.97; 95% CI: −2.68 to −1.26; p &lt; 0.0001), and Acute Physiology and Chronic Health Evaluation (APACHE)-II score (MD = −4.08; 95% CI: −5.16 to −3.00; p &lt; 0.0001), shortened the length of hospitalization (MD = −4.79; 95% CI: −6.18 to −3.40; p &lt; 0.0001), and reduced the number of adverse events. …”
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Genomic regions and pathways associated with gastrointestinal parasites resistance in Santa Inês breed adapted to tropical climate by Mariana Piatto Berton, Rafael Medeiros de Oliveira Silva, Elisa Peripolli, Nedenia Bonvino Stafuzza, Jesús Fernández Martin, Maria Saura Álvarez, Beatriz Villanueva Gavinã, Miguel Angel Toro, Georgget Banchero, Priscila Silva Oliveira, Joanir Pereira Eler, Fernando Baldi, José Bento Sterman Ferraz

“…Phenotypes evaluations were performed to verify resistance to gastrointestinal parasites, and were divided into two categories: i) farm phenotypes, assessing body condition score (BCS), degree of anemia assessed by the famacha chart (FAM), fur score (FS) and feces consistency (FC); and ii) lab phenotypes, comprising blood analyses for hematocrit (HCT), white blood cell count (WBC), red blood cell count (RBC), hemoglobin (HGB), platelets (PLT) and transformed (log10) egg per gram of feces (EPGlog). …”
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A Phase I Clinical Study Comparing the Tolerance, Immunogenicity, and Pharmacokinetics of Proposed Biosimilar BAT1806 and Reference Tocilizumab in Healthy Chinese Men by Hong Zhang, Hong Wang, Haijing Wei, Hong Chen, Jingrui Liu, Cuiyun Li, Xiaoxue Zhu, Xiaojiao Li, Jinchen Yu, Yinbo Zhou, Xiaolei Yang, Zhaohe Wang, Min Wu, Yanhua Ding

“…The most common treatment-related adverse events observed were a decrease in neutrophil, and white blood cell counts.Conclusion: The PK characteristics of BAT1806 were similar to those of the reference products, RoActemra-EU and Actemra-US. …”
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Comparison of transabdominal wall specimen retrieval and natural orifice specimen extraction robotic surgery in the outcome of colorectal cancer treatment by Ju Houqiong, Ju Houqiong, Wan Ziwen, Wan Ziwen, Zhong Chonghan, Zhong Chonghan, He Penghui, He Penghui, Yu Hongxin, Yu Hongxin, Lu Weijie, Lu Weijie, Liu Dongning, Liu Dongning, Li Taiyuan, Li Taiyuan

“…The outcome measurement criteria included postoperative complications, inflammatory response, pelvic floor function, anal function, cosmetic outcome, quality of life, disease-free survival (DFS), and overall survival (OS).ResultsThe robotic NOSES group had faster recovery time from gastrointestinal function (P = 0.014), shorter abdominal incision length (P &lt; 0.001), less pain (P &lt; 0.001), less additional analgesia required (P &lt; 0.001), and lower postoperative indicators of white blood cell count (P &lt; 0.001) and C-reactive protein content compared to the robotic-assisted resection surgery (RARS) group (P = 0.035). …”
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Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies by Pierre-Antoine Dugué, Clara Bodelon, Felicia F. Chung, Hannah R. Brewer, Srikant Ambatipudi, Joshua N. Sampson, Cyrille Cuenin, Veronique Chajès, Isabelle Romieu, Giovanni Fiorito, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Paolo Vineis, Silvia Polidoro, Laura Baglietto, Dallas English, Gianluca Severi, Graham G. Giles, Roger L. Milne, Zdenko Herceg, Montserrat Garcia-Closas, James M. Flanagan, Melissa C. Southey

“…Results None of the measures of epigenetic aging were associated with risk of breast cancer in the pooled analysis: Horvath ‘age acceleration’ (AA): OR per SD = 1.02, 95%CI: 0.95–1.10; AA-Hannum: OR = 1.03, 95%CI:0.95–1.12; PhenoAge: OR = 1.01, 95%CI: 0.94–1.09 and GrimAge: OR = 1.03, 95%CI: 0.94–1.12, in models adjusting for white blood cell proportions, body mass index, smoking and alcohol consumption. …”
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