Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model by K. Walweel, A.C. Boon, L.E. See Hoe, N.G. Obonyo, S.E. Pedersen, S.D. Diab, M.R. Passmore, K. Hyslop, S.M. Colombo, N.J. Bartnikowski, M. Bouquet, M.A. Wells, D.M. Black, L.P. Pimenta, A.K. Stevenson, K. Bisht, K. Skeggs, L. Marshall, A. Prabhu, L.N. James, D.G. Platts, P.S. Macdonald, D.C. McGiffin, J.Y. Suen, J.F. Fraser

“…Plasma and BAL endothelin-1 and cytokines (IL-1β, 6, 8 and tumour necrosis factor alpha (TNF-α)) were assessed by ELISA. Differential white blood cell counts were performed. Cardiac function during BSD was also examined using echocardiography, and cardiac biomarkers (A-type natriuretic peptide and troponin I were measured in plasma. …”
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Network Association of Biochemical and Inflammatory Abnormalities With Psychiatric Symptoms in First-Episode Schizophrenia Patients by Junwei Yan, Junwei Yan, Junwei Yan, Junwei Yan, Yuanyuan Chen, Yuanyuan Chen, Yuanyuan Chen, Yuanyuan Chen, Peijun Ju, Peijun Ju, Peijun Ju, Jianliang Gao, Jianliang Gao, Jianliang Gao, Jianliang Gao, Loufeng Zhang, Loufeng Zhang, Loufeng Zhang, Loufeng Zhang, Jingwei Li, Jingwei Li, Jingwei Li, Jingwei Li, Keming Wang, Keming Wang, Keming Wang, Keming Wang, Jie Zhang, Jie Zhang, Jie Zhang, Jie Zhang, Chao Li, Chao Li, Chao Li, Chao Li, Qingrong Xia, Qingrong Xia, Qingrong Xia, Qingrong Xia, Cuizhen Zhu, Cuizhen Zhu, Cuizhen Zhu, Cuizhen Zhu, Xulai Zhang, Xulai Zhang, Xulai Zhang, Xulai Zhang

“…Plasma inflammatory cytokines were measured by a fully automated electrochemiluminescent immunoassay (Meso Scale Discovery).ResultsBlood routine, biochemical, and inflammation cytokine test results showed that the levels of white blood cell count, neutrophil count, natrium, CRP, IL-8, IL-6, IL-13, and IL-16 significantly increased in the case group than in the healthy controls (p < 0.05), whereas levels of red blood cell count, hemoglobin concentration, mean corpuscular hemoglobin concentration, total protein, albumin, total bile acid, high-density lipoprotein (HDL), apolipoprotein A1, blood urea nitrogen, kalium and IL-15 were lower than in the healthy controls (p < 0.05). …”
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Comparative Analysis of Microbial Species and Multidrug Resistance Patterns Associated with Lower Urinary Tract Infections in Preterm and Full-Term Births by Felix Bratosin, Roxana Folescu, Pavel Krupyshev, Zoran Laurentiu Popa, Cosmin Citu, Adrian Ratiu, Ovidiu Rosca, Adrian Cosmin Ilie

“…However, significant differences were observed in several infection and inflammation markers. The median white blood cell count was higher in the preterm group (12.3 vs. 9.1, <i>p</i> = 0.032), and the median C-reactive protein level was significantly higher in the preterm group (18 vs. 7, <i>p</i> < 0.001). …”
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Preoperative chemoradiation-induced hematological toxicity and related vertebral dosimetry evaluations in patients with locally advanced gastric cancer: data from a phase III clini... by Ji-jin Wang, Han Shao, Li Zhang, Ming Jing, Wen-jing Xu, Heng-wen Sun, Zhi-wei Zhou, Yu-jing Zhang

“…The Spearman correlation analysis identified a significant correlation of V5 with the white blood cell nadir (P = 0.0001) and platelet nadir (P = 0.0002). …”
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Analysis of Factors Influencing Outcomes in Preterm Infants With Necrotizing Enterocolitis by JinBao Han, JinBao Han, JinBao Han, Gang Liu, Gang Liu, Gang Liu, MengNan Yu, Guang Li, JianYing Cao, Lian Duan, LiuMing Huang, LiuMing Huang, LiuMing Huang

“…The preoperative factors, including gestational age, birth weight, intrauterine infection, cholestasis, platelet change, white blood cell count, and C-reactive protein level were compared between the two groups, along with postoperative factors including infection status, complications, enteral and parenteral nutrition time, ICU time, ventilator use time, and intestinal necrosis length. …”
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The Effect of Dietary Intervention With High-Oleocanthal and Oleacein Olive Oil in Patients With Early-Stage Chronic Lymphocytic Leukemia: A Pilot Randomized Trial by Andrea Paola Rojas Gil, Ioannis Kodonis, Anastasios Ioannidis, Tzortzis Nomikos, Ioannis Dimopoulos, Georgios Kosmidis, Maria Efthymia Katsa, Maria Efthymia Katsa, Eleni Melliou, Prokopios Magiatis

“…During the DI2, a decrease in the white blood cell and lymphocyte count was observed (p ≤0.05), comparing 3 months before the intervention and 6 months after it. …”
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Safety and efficacy of apatinib in patients with advanced gastric or gastroesophageal junction adenocarcinoma after the failure of two or more lines of chemotherapy (AHEAD): a pros... by Jin Li, Shukui Qin, Lu Wen, Junsheng Wang, Wenying Deng, Weijian Guo, Tongfu Jia, Da Jiang, Guifang Zhang, Yifu He, Yi Ba, Haijun Zhong, Lin Wang, Xiaoyan Lin, Jianwei Yang, Jun Zhao, Yuxian Bai, Xiangyuan Wu, Feng Gao, Guogui Sun, Yongjuan Wu, Feng Ye, Qiong Wang, Zhong Xie, Tienan Yi, Yong Huang, Guohua Yu, Lin Lu, Ying Yuan, Wei Li, Likun Liu, Yuping Sun, Ying Sun, Lifeng Yin, Zhiguo Hou

“…In the safety population, 87.9% of patients experienced treatment-related adverse events (TRAEs), with the most common hypertension (45.2%), proteinuria (26.5%), and white blood cell count decreased (25.3%). Additionally, 51% of patients experienced grade ≥ 3 TRAEs. …”
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Genetic and biomarker modulation of arterial stiffness change in the SardiNIA population cohort by Nigus G. Asefa, Osorio Meirelles, Edward Lakatta, Edoardo Fiorillo, Angelo Scuteri, Francesco Cucca, Michele Marongiu, Michele Marongiu, Alessandro Delitala, David Schlessinger, Lenore J. Launer

“…Subsequent analyses focused on these risk groups to assess their association to PWV with time.ResultsUsing the complete dataset, we found a significant longitudinal association of total cholesterol (TC), triglycerides (TG), fibrinogen (FGN), and total white blood cell count (TWBC) with PWV, all with p &lt; 3.33 × 10−3. …”
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Concurrent <i>Sphingomonas paucimobilis</i> and <i>Mycobacterium tuberculosis</i> Meningitis in an Immunocompromised Patient: A Rare Case Report and Comprehensive Review of Literat... by Iosif Marincu, Felix Bratosin, Iulia Bogdan, Catalin Dumitru, Carmen Nicoleta Stoica, Andrei Nicolae Csep, Narcisa Mederle, Roxana Manuela Fericean, Alexandru Ovidiu Mederle, Reshmanth Prathipati, Gratiana Nicoleta Chicin, Adelina Mavrea, Paula Irina Barata, Adrian Vasile Bota

“…It was observed among the 13 identified cases (including ours) that the CSF white blood cell count had an average of 178.9 × 10³/mm³, an average glucose level of 33.0 mg/dL, and an average protein count of 294.2 mg/dL. …”
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Blood transcriptome analysis and identification of genes associated with supernumerary teats in Chinese Holstein cows by Q.Z. Chen, M.Y. Yang, X.Q. Liu, J.N. Zhang, S.Y. Mi, Y.J. Wang, W. Xiao, Y. Yu

“…Correlation analysis showed that LOC104968484, SLC25A6, GADD45G, BAX, APAF1, ATM, XIAP, MDM4, BDP1, CEP350, MED13, TAOK1, SMG1, and RIF1 are associated with white blood cell count and absolute value of lymphocytes in SNT cows only, so they might be genes associated with SNT in Chinese Holstein cows. …”
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Plasma angiopoietin 2 as a novel prognostic biomarker in alcohol-related cirrhosis and hepatitis by Victoria Tatiana Kronsten, Josepmaria Argemi, Ada Sera Kurt, Godhev Mannakat Vijay, Jennifer Marie Ryan, Ramón Bataller, Debbie Lindsay Shawcross

“…ANG2 levels correlated positively with model for end-stage liver disease (MELD) score (r = 0.30, P = 0.020), Child-Pugh score (r = 0.38, P = 0.003), international normalized ratio (r = 0.41, P = 0.001) and white blood cell count (r = 0.28, P = 0.040) and inversely correlated with albumin (r = −0.26, P = 0.040).ANG1 gene expression from liver biopsies was higher in SAH than that in HC (P < 0.0001), and greater in severe disease (P < 0.0001). …”
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Effects of different load weights on the work performance and physiological and hematobiochemical responses in working water buffalo by Visoky Paján-Jiménez, Fernando David Pazmiño-Rodríguez, Patricia Roldán-Santiago, Anna Dutro-Aceves, Luis Alberto de la Cruz-Cruz, Cristian Larrondo

“…However, 500 kg loads resulted in slower average speed (2.4 km, p = 0.0164), shorter working period (2.39 h, p < 0.0001) and distance traveled (7.29 km, p < 0.0001), and less total number of trips (8.27 trips, p < 0.0001) compared to 350 and 200 kg load weights (3.45 and 3.52 km/h, 2.55 and 2.79 h, 8.71 and 9.75 km, 10.94 and 16.61 trips, respectively); and the heaviest loads resulted in significantly higher (p < 0.005) respiratory rate, pulse, heart rate, rectal temperature, glucose, lactate dehydrogenase, creatine kinase, total protein, white blood cell count, neutrophils, lymphocytes, monocytes, eosinophils, and basophils. …”
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Transabdominal amniocentesis in expectant management of preterm premature rupture of membranes: A single center prospective study by Veronika Fulova, Eliska Hostinska, Martina Studnickova, Karel Huml, Jana Zapletalova, Jan Halek, Radovan Pilka

“…Maternal temperature, maternal serum C-reactive protein (CRP) and white blood cell (WBC) counts were assayed every subsequent day until delivery. …”
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Indoleamine 2,3-dioxygenase 1 promotes osteosarcoma progression by regulating tumor-derived exosomal miRNA hsa-miR-23a-3p by Dan Yang, Dan Yang, Yinxian Chen, Zhen Ning Tony He, Yichen Wang, Chenghui Ke, Yi Luo, Sun Wang, Qichao Ma, Mengjie Chen, Qing Yang, Ziming Zhang

“…Laboratory test indexes including serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH), white blood cell (WBC) count and C-reactive protein (CRP) at diagnosis of OS patients were collected. …”
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True Bacteremia or Contamination? Predictive Factors for Contamination in Blood Cultures Obtained in the Pediatric Emergency Room by Emel Berksoy, Eda Karadağ Öncel, Şefika Bardak, Şule Demir, Sema Bozkaya Yılmaz, Gülşah Demir, Alper Çiçek, Nisel Yılmaz, Gamze Gökalp, Murat Anıl, Dilek Yılmaz Çiftdoğan

“…Patients with bacteremia had higher white blood cell counts (13,900 vs. 11,300, p<0.001), C-reactive protein (CRP) (38.5 vs. 6.3, p<0.001), and procalcitonin (1.04 vs. 0.18, p<0.001). …”
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Clinical Characteristics, Outcomes, and Risk Factors of Disease Severity in Patients With COVID-19 and With a History of Cerebrovascular Disease in Wuhan, China: A Retrospective St... by Mengzhen Li, Zehui He, Jiecong Yang, Qihua Guo, Heng Weng, Jielian Luo, Baoying Gong, Wanzhen Cui, Banghan Ding, Jianwen Guo, Jianwen Guo

“…Patients with CVD tend to be older and with more comorbidities, including hypertension, diabetes, coronary heart disease, and chronic obstructive pulmonary disease. The levels of white blood cell, neutrophil, C-reactive protein, creatine kinase isoenzymes, and lactate dehydrogenase were higher, whereas the levels of lymphocyte and albumin were lower in the CVD group. …”
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Characterization of cardiac involvement in patients with LMNA splice-site mutation–related dilated cardiomyopathy and sudden cardiac death by Xuebin Ling, Yanjun Hou, Xingyu Jia, Youling Lan, Xiaoping Wu, Julan Wu, Wei Jie, Hui Liu, Shan Huang, Zhenling Wan, Tianfa Li, Junli Guo, Tiebiao Liang

“…Finally, we comprehensively summarized the pathological characteristics of LMNA-related DCM, including hypertrophy, atrophy, fibrosis, white blood cell infiltration, intercalated disc remodeling, and downregulation of desmin and connexin 43 (Cx43) expression.Discussion: Above all, Cardiaccardiac involvement in patients with LMNA splice-site mutation presented with a high rate of SCD. …”
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Molecular residual disease detection in resected, muscle-invasive urothelial cancer with a tissue-based comprehensive genomic profiling–informed personalized monitoring assay by Thomas Powles, Amanda Young, Halla Nimeiri, Russell W. Madison, Alexander Fine, Daniel R. Zollinger, Yanmei Huang, Chang Xu, Ole V. Gjoerup, Vasily N. Aushev, Hsin-Ta Wu, Alexey Aleshin, Corey Carter, Nicole Davarpanah, Viraj Degaonkar, Pratyush Gupta, Sanjeev Mariathasan, Erica Schleifman, Zoe June Assaf, Geoffrey Oxnard, Priti S. Hegde

“…Rather than performing white blood cell sequencing to filter germline and clonal hematopoiesis (CH) variants, we applied a bioinformatic approach to select tumor (non-germline/CH) variants for molecular residual disease detection. …”
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The effect of a loading dose of meropenem on outcomes of patients with sepsis treated by continuous renal replacement: study protocol for a randomized controlled trial by Sui-Qing Ni, Wen-Bing Teng, Yong-Hong Fu, Wei Su, Zhi Yang, Jie Cai, Jin-Nuo Xu, Xiao-Ying Deng, Xiang-Fang Liu, Sheng-Nan Fu, Jun Zeng, Chen Zhang

“…Secondary objectives include clinical cure rate, bacterial clearance rate, sepsis-related mortality and all-cause mortality, the total dose of meropenem, duration of meropenem treatment, duration of CRRT, Sequential Organ Failure Assessment (SOFA), C-reactive protein levels, procalcitonin levels, white blood cell count, and safety. Discussion This trial will assess for the first time whether administration of a loading dose of meropenem results in a more likely achievement of the PK/PD target and better therapeutic results in the patients with sepsis receiving CRRT. …”
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Exploration of biomarkers for efficacy evaluation of traditional Chinese medicine syndromes of acute exacerbation of chronic obstructive pulmonary disease based on metabolomics by Zhang Hailong, Zhang Hailong, Si Yimei, Du Yan, Du Yan, Liu Xinguang, Liu Xinguang, Li Jiansheng, Li Jiansheng, Li Jiansheng

“…Data on clinical symptoms and sign scores, modified British Medical Research Council (mMRC), COPD assessment test (CAT), and inflammation indicators, including white blood cell (WBC) count, percentage of neutrophil count (NEU%), and C-reactive protein (CRP), were collected before and after treatment to evaluate the therapeutic effect. …”
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