Hematological and blood biochemistry parameters as prognostic indicators of survival in canine multicentric lymphoma treated with COP and L-COP protocols by Somchin Sutthigran, Phasamon Saisawart, Patharakrit Teewasutrakul, Sirintra Sirivisoot, Chutimon Thanaboonnipat, Anudep Rungsipipat, Nan Choisunirachon

“…Furthermore, dogs with leukocytosis at 4 weeks post-treatment had a significantly shorter MST than those with a normal total white blood cell count (p = 0.024). Conclusion: Serum albumin level can serve as a simple negative prognostic indicator of survival outcomes in dogs with high-grade multicentric lymphoma treated with the L-COP protocol. …”
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Biomarkers to Predict Multiorgan Distress Syndrome and Acute Kidney Injury in Critically Ill Surgical Patients by In Sik Shin, Da Kyung Kim, Sanghyun An, Sung Chan Gong, Moo Hyun Kim, Md Habibur Rahman, Cheol-Su Kim, Joon Hyeong Sohn, Kwangmin Kim, Hoon Ryu

“…Patient characteristics and laboratory parameters including white blood cell (WBC) count, neutrophil count, delta neutrophil index, urine and serum β2-microglobulin, and urine serum mitochondrial DNA copy number (mtDNAcn) were analyzed to determine the reliable biomarker to predict AKI and MODS. …”
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The prevalence and predictors of geriatric giants in community-dwelling older adults: a cross-sectional study from the Middle East by Seyedeh Zahra Badrkhahan, Moein Ala, Hossein Fakhrzadeh, Arash Yaghoobi, Sara Mirzamohamadi, Seyed Masoud Arzaghi, Sina Shahabi, Farshad Sharifi, Afshin Ostovar, Noushin Fahimfar, Iraj Nabipour, Bagher Larijani, Gita Shafiee, Ramin Heshmat

“…Considering 95% confidence interval (CI), multivariate logistic regression revealed that low physical activity [odds ratio (OR) 31.73 (18.44–54.60)], cancer (OR 3.28 (1.27–8.44)), depression [OR 2.42 (1.97–2.98)], age [OR 1.11 (1.08–1.14)], waist circumference [OR 1.03 (1.01–1.06)], BMI [OR 1.07 (1.01–1.14)], MNA score [OR 0.85 (0.79–0.92)], polypharmacy [OR 2.26 (1.30–3.95)] and male gender [OR 0.63 (0.42–0.93)] were independently associated with frailty. White blood cell count (WBC), smoking, marital status, and number of comorbidities were not independently associated with frailty. …”
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Human adenovirus type 7 infection causes a more severe disease than type 3 by Yangxi Fu, Zhengzhen Tang, Zhixu Ye, Shi Mo, Xingui Tian, Ke Ni, Luo Ren, Enmei Liu, Na Zang

“…Results Clinical characteristics revealed that HAdV-7 infection caused more severe pneumonia, toxic encephalopathy, respiratory failure, longer mean hospitalization, significantly lower white blood cell (WBC) and platelet counts, compared to those of HAdV-3. …”
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Laboratory Testing Implications of Risk-Stratification and Management of COVID-19 Patients by Caidong Liu, Ziyu Wang, Wei Wu, Changgang Xiang, Lingxiang Wu, Jie Li, Weiye Hou, Huiling Sun, Youli Wang, Zhenling Nie, Yingdong Gao, Ruisheng Zhang, Haixia Tang, Qianghu Wang, Qianghu Wang, Qianghu Wang, Kening Li, Kening Li, Kening Li, Xinyi Xia, Xinyi Xia, Xinyi Xia, Pengping Li, Shukui Wang

“…We identified six indicators with permutation p < 0.05, including eosinophil percentage (p = 0.007), white blood cell count (p = 0.045), albumin (p = 0.041), aspartate transaminase (p = 0.043), lactate dehydrogenase (p = 0.002), and hemoglobin (p = 0.031). …”
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Risk Stratification of Cytogenetically Normal Acute Myeloid Leukemia With Biallelic CEBPA Mutations Based on a Multi-Gene Panel and Nomogram Model by Li-Xin Wu, Hao Jiang, Ying-Jun Chang, Ya-Lan Zhou, Jing Wang, Zi-Long Wang, Lei-Ming Cao, Jin-Lan Li, Qiu-Yu Sun, Shan-Bo Cao, Feng Lou, Tao Zhou, Li-Xia Liu, Cheng-Cheng Wang, Yu Wang, Qian Jiang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang, Xiao-Jun Huang, Xiao-Jun Huang, Guo-Rui Ruan

“…Risk stratification was performed by the prognostic factors to investigate the risk-adapted post-remission therapy by Kaplan–Meier method.ResultsAt least 1 mutated gene other than CEBPA was identified in patients and mutation number was associated with LFS (61.6% vs. 39.0%, P =0.033), survival (85.6% vs. 62.9%, P =0.030) and cumulative incidence of relapse (CIR) (38.4% vs. 59.5%, P =0.0496). White blood cell count, mutations in CFS3R, KMT2A and DNA methylation related genes were weighted to construct a nomogram model and differentiate two risk subgroups. …”
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Distinguishing COVID-19 From Influenza Pneumonia in the Early Stage Through CT Imaging and Clinical Features by Zhiqi Yang, Daiying Lin, Xiaofeng Chen, Jinming Qiu, Shengkai Li, Ruibin Huang, Zhijian Yang, Hongfu Sun, Yuting Liao, Jianning Xiao, Yanyan Tang, Xiangguang Chen, Sheng Zhang, Zhuozhi Dai

“…Clinical data including course of disease, age, sex, body temperature, clinical symptoms, total white blood cell (WBC) count, lymphocyte count, lymphocyte ratio, neutrophil count, neutrophil ratio, and C-reactive protein, as well as 22 qualitative and 25 numerical imaging features from non-contrast-enhanced chest CT images were obtained and compared between the COVID-19 and influenza pneumonia groups. …”
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Predictive value of plasma soluble urokinase-type plasminogen activator receptor for post-severe traumatic multiple organ dysfunction syndrome by ZHAO Yinjie, LI Yang, SHEN Yajing, GUI Yongqing, ZHANG Jun, ZHANG Yuansong, LIU Minghua, XIANG Qiang

“…The general data and variables such as suPAR, white blood cell (WBC) count, and injury severity score (ISS) were compared between the 2 groups. …”
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Antioxidant and Immune Stimulating Effects of <i>Allium cepa</i> Skin in the RAW 264.7 Cells and in the C57BL/6 Mouse Immunosuppressed by Cyclophosphamide by Ji-Su Kim, Eun-Byeol Lee, Ji-Hye Choi, Jieun Jung, Un-Yul Jeong, Ui-Jin Bae, Hwan-Hee Jang, Shin-Young Park, Youn-Soo Cha, Sung-Hyen Lee

“…Immune-stimulating effects of OS were evaluated in immunosuppressed mice induced by cyclophosphamide. White blood cell count and the B cell proliferation of splenocytes were higher in OS100 (OS extract 100 mg/kg body weight) and OS200 (OS extract 200 mg/kg body weight) groups than in the negative control (NC) group. …”
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Neoadjuvant pyrotinib, trastuzumab, and docetaxel for HER2-positive breast cancer (PHEDRA): a double-blind, randomized phase 3 trial by Jiong Wu, Zefei Jiang, Zhenzhen Liu, Benlong Yang, Hongjian Yang, Jinhai Tang, Kun Wang, Yunjiang Liu, Haibo Wang, Peifen Fu, Shuqun Zhang, Qiang Liu, Shusen Wang, Jian Huang, Chuan Wang, Shu Wang, Yongsheng Wang, Linlin Zhen, Xiaoyu Zhu, Fei Wu, Xiang Lin, Jianjun Zou

“…The most common grade 3 or worse adverse events were diarrhea (79 [44.4%] in the pyrotinib group and nine [5.1%] in the placebo group), neutropenia (33 [18.5%] and 36 [20.3%]), and decreased white blood cell count (29 [16.3%] and 24 [13.6%]). No deaths were reported during neoadjuvant treatment. …”
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Monocyte dysfunction in decompensated cirrhosis is mediated by the prostaglandin E2-EP4 pathway by Alexander A. Maini, Natalia Becares, Louise China, Thais H. Tittanegro, Amit Patel, Roel P.H. De Maeyer, Nekisa Zakeri, Tu Vinh Long, Lucy Ly, Derek W. Gilroy, Alastair O’Brien

“…Lay summary: Patients with decompensated cirrhosis (jaundice, fluid build-up, confusion, and vomiting blood) have high infection rates that lead to high mortality rates. A white blood cell subset, monocytes, function poorly in these patients, which is a key factor underlying their sensitivity to infection. …”
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Malnutrition in acute heart failure with preserved ejection fraction: clinical correlates and prognostic implications by Shih‐Chieh Chien, Chi‐In Lo, Chao‐Feng Lin, Kuo‐Tzu Sung, Jui‐Peng Tsai, Wen‐Hung Huang, Chun‐Ho Yun, Ta‐Chuan Hung, Jiun‐Lu Lin, Chia‐Yuan Liu, Charles Jia‐Yin Hou, I‐Hsien Tsai, Cheng‐Huang Su, Hung‐I Yeh, Chung‐Lieh Hung

“…Lean body size, higher white blood cell counts and C‐reactive protein levels, anaemia, and lack of angiotensin blocker use were independently associated with malnutrition (defined by SA < 3.5 g/dL). …”
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COVID-19 Disease in Pediatric Solid Organ Transplantation from Alpha to Omicron: A High Monocyte Count in the Preceding Three Months Portends a Risk for Severe Disease by Yasmina Sirgi, Maja Stanojevic, Jaeil Ahn, Nada Yazigi, Stuart Kaufman, Khalid Khan, Bernadette Vitola, Cal Matsumoto, Alexander Kroemer, Thomas Fishbein, Udeme D. Ekong

“…Main outcome and measures: We hypothesized that children on the most immunosuppression, defined by the number of immunosuppressive medications and usage of steroids, would have the most severe disease course and that differential white blood cell count in the months preceding infection would be associated with likelihood of having severe disease. …”
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Single versus multiple hyperthermic intraperitoneal chemotherapy applications for T4 gastric cancer patients: Efficacy and safety profiles by Jing Zhang, Yuemin Sun, Xiaofeng Bai, Peng Wang, Liang Tian, Yantao Tian, Yuxin Zhong

“…Mild renal dysfunction, mild liver dysfunction, low platelet levels and low white blood cell levels were recorded in both groups, without significant differences between the two groups (P &gt; 0.05). …”
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Suppressor of variegation 3–9 homologue 1 impairment and neutrophil-skewed systemic inflammation are associated with comorbidities in COPD by Tzu-Tao Chen, Sheng-Ming Wu, Kuan-Yuan Chen, Chien-Hua Tseng, Shu-Chuan Ho, Hsiao-Chi Chuang, Po-Hao Feng, Wen-Te Liu, Chia-Li Han, Erick Wan-Chun Huang, Yun-Kai Yeh, Kang-Yun Lee

“…In the COPD cohort, the high comorbidity group (≥ 2 comorbidities) had higher counts of whole white blood cell (WBC) and neutrophil, and lower proportion of eosinophil and eosinophil/neutrophil, as compared with low comorbidity group (0 and 1 comorbidities). …”
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Cytokine and Adhesion Molecule Expression Induced by Different Strains of Staphylococcus aureus in Type 1 Diabetic Rats: Role of Insulin by Paula R. Knox de Souza, Paula R. Knox de Souza, Sabrina S. Ferreira, Fernanda P. B. Nunes, Felipe B. Casagrande, Fernando H. G. Tessaro, Mariana C. F. Silva, José Walber Miranda Costa Cruz, Elsa M. Mamizuka, Joilson O. Martins

“…The following measurements were performed: (a) number of cells in the peritoneal lavage fluid (PeLF), white blood cell count, and blood glucose; (b) serum insulin and corticosterone; (c) cytokine levels in the PeLF; (d) expression of adhesion molecules in the vascular endothelium; and (e) microbicidal activity.Results: Diabetic rats showed an increased number of polymorphonuclear leukocytes (PMNs) and increased concentrations of CINC-1, IL-4, and IFN-γ in the PeLF after infection with the ATCC 25923 or N315 αHL+ strain. …”
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The Predictive Role of Maternal Biological Markers and Inflammatory Scores NLR, PLR, MLR, SII, and SIRI for the Risk of Preterm Delivery by Ingrid Hrubaru, Andrei Motoc, Marius Liviu Moise, Bogdan Miutescu, Ioana Mihaela Citu, Raja Akshay Pingilati, Daniela-Eugenia Popescu, Catalin Dumitru, Florin Gorun, Flavius Olaru, Izabella Erdelean, Marius Forga, Nicoleta Nicolae, Cosmin Citu

“…Laboratory data showed that patients with a preterm birth had significantly higher white blood cell count and monocytes, but significantly lower lymphocytes, platelets, and hemoglobin. …”
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Clinical and laboratory characteristics of children with sickle cell disease on hydroxyurea treated with artemether-lumefantrine for acute uncomplicated malaria by Catherine Segbefia, Seth Kwabena Amponsah, Adwoa K. A. Afrane, Mame Yaa Nyarko, Yvonne Brew, Nihad Salifu, Samuel Yao Ahorhorlu, Abdul Malik Sulley, Lars Hviid, Lars Hviid, Michael Fokuo Ofori, George Obeng Adjei

“…Further, Plasmodium falciparum identification of rapid diagnostic test (RDT) positive samples was done using nested polymerase chain reaction (PCR).ResultsAmong SCD participants with UM, admission temperature, neutrophils, alanine-aminotransferase, gamma-glutamyl-transferase, and haemoglobin significantly differed between HU recipients (HU+) and steady state, while white blood cell, neutrophils, reticulocytes, bilirubin, urea, and temperature differed significantly between non-HU recipients (no-HU), and steady state. …”
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Effects of dietary supplementation of natural Spirulina on growth performance, hemato-biochemical indices, gut health, and disease resistance to Aeromonas hydrophila of Stinging ca... by Mobasshsirin Rahman, Md. Abdullah Al Mamun, Sanjay Singh Rathore, Shishir Kumar Nandi, Zulhisyam Abdul Kari, Lee Seong Wei, Albaris B. Tahiluddin, Md. Moshiur Rahman, Nesara Kadadakatte Manjappa, Arman Hossain, Shamima Nasren, M.M. Mahbub Alam, Walter G. Bottje, Guillermo Téllez-Isaías, Muhammad Anamul Kabir

“…Red blood cell, white blood cell, lymphocytes, neutrophil, monocytes, basophil, hemoglobin, red cell distribution width-standard deviation, and mean corpuscular hemoglobin were all substantially (p < 0.05) greater in 5% Spirulina diet-fed fish. …”
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Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis by Panagiotis Georgiadis, Irene Liampa, Dennie G. Hebels, Julian Krauskopf, Aristotelis Chatziioannou, Ioannis Valavanis, Theo M.C.M. de Kok, Jos C.S. Kleinjans, Ingvar A. Bergdahl, Beatrice Melin, Florentin Spaeth, Domenico Palli, R.C.H. Vermeulen, J. Vlaanderen, Marc Chadeau-Hyam, Paolo Vineis, Soterios A. Kyrtopoulos, on behalf of the EnviroGenomarkers consortium

“…After adjustment for white blood cell composition, we identified 722 differentially methylated CpG sites and 15 differentially expressed genes (Bonferroni-corrected p < 0.05) as well as 2 miRNAs (FDR < 0.05) which were associated with the risk of future CLL. …”
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