Comparison Between Early Appendicectomy and Delayed Appendicectomy in Treating Acute AppendicitisComparison Between Early Appendicectomy and Delayed Appendicectomy in Treating Acut... by Deaa Abdulkhalik Raheem m, Muqdad Fuad Abdulkareem, Humamalddin Edan Hussein

“…Results: Regarding the mean white blood cell count at the first postoperative day, it was lower for group B. than that for group A (p-value 0.0018). …”
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Clinical Features for Severely and Critically Ill Patients with COVID-19 in Shandong: A Retrospective Cohort Study by Zhou S, Xu J, Sun W, Zhang J, Zhang F, Zhao X, Wang X, Zhang W, Li Y, Ning K, Pan Y, Liu T, Zhao J, Yu J, Sun Y, Gao F, Zhang R, Fu C, Sun Y, Ouyang X, Zhang F, Hu Q, Teng H, Li Y, Zhang C, Tan W, Li J, Yin L, Dong L, Wang C

“…Compared to patients with severe disease, those with critical disease had distinctly higher white blood cell counts, procalcitonin levels, and D-dimer levels, and lower hemoglobin levels and lymphocyte counts. …”
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Comparison Between Early Appendicectomy and Delayed Appendicectomy in Treating Acute AppendicitisComparison Between Early Appendicectomy and Delayed Appendicectomy in Treating Acut... by Deaa Abdulkhalik Raheem m, Muqdad Fuad Abdulkareem, Humamalddin Edan Hussein

“…Results: Regarding the mean white blood cell count at the first postoperative day, it was lower for group B. than that for group A (p-value 0.0018). …”
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Inflammatory Pseudotumor of the Maxillary Sinus by Johann F. Castañeda, Jeffrey S. Concepcion, Ricardo L. Ramirez, Kirt Areis Delovino

“…In some patients, laboratory findings are normal; in others, there might be an elevated erythrocyte sedimentation rate and C-reactive protein level and sometimes a high white blood cell count3. However, none of the published reports on inflammatory pseudotumor have mentioned any presence of positive tumor markers. …”
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Correlation of Different Serum Biomarkers with Prediction of Early Pancreatic Graft Dysfunction Following Simultaneous Pancreas and Kidney Transplantation by Nora Jahn, Maria Theresa Voelker, Sven Laudi, Sebastian Stehr, Stefan Schneeberger, Gerald Brandacher, Elisabeth Sucher, Sebastian Rademacher, Daniel Seehofer, Robert Sucher, Hans Michael Hau

“…With regard to analyzing ePGD, serum levels of white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT), pancreatic lipase as well as neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) were measured preoperatively and at postoperative days (POD) 1, 2, 3 and 5. …”
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Childhood encephalitis in the Greater Mekong region (the SouthEast Asia Encephalitis Project): a multicentre prospective study by Jean David Pommier, MD, Chris Gorman, PhD, Yoann Crabol, MD, Kevin Bleakley, PhD, Heng Sothy, MD, Ky Santy, MD, Huong Thi Thu Tran, MD, Lam Van Nguyen, MD, Em Bunnakea, MD, Chaw Su Hlaing, MD, Aye Mya Min Aye, MD, Julien Cappelle, DVM, Magali Herrant, PhD, Patrice Piola, MD, Bruno Rosset, Veronique Chevalier, DVM, Arnaud Tarantola, MD, Mey Channa, MD, Jerome Honnorat, MD, Anne Laure Pinto, MSc, Sayaphet Rattanavong, MD, Manivanh Vongsouvath, MD, Mayfong Mayxay, MD, Sommanikhone Phangmanixay, MD, Khounthavy Phongsavath, MD, Ommar Swe Tin, MD, Latt Latt Kyaw, MD, Htay Htay Tin, MD, Kyaw Linn, MD, Thi Mai Hung Tran, MPH, Philippe Pérot, PhD, Nguyen Thi Thu Thuy, PhD, Nguyen Hien, MD, Phuc Huu Phan, MD, Philippe Buchy, MD, Philippe Dussart, PharmD, Denis Laurent, PharmD, Marc Eloit, DVM, Audrey Dubot-Pérès, PhD, Olivier Lortholary, MD, Xavier de Lamballerie, MD, Paul N Newton, FRCP, Marc Lecuit, Prof, Philippe Buchy, Em Bunnakea, Julien Cappelle, Mey Channa, Veronique Chevalier, Yoann Crabol, Xavier de Lamballerie, Audrey Dubot-Pérès, Philippe Dussart, Marc Eloit, Chris Gorman, Magali Herrant, Nguyen Hien, Chaw Su Hlaing, Jérôme Honnorat, Tran Thi Mai Hung, Tran Thi Thu Huong, Latt Latt Kyaw, Nguyen Van Lam, Denis Laurent, Marc Lecuit, Kyaw Linn, Olivier Lortholary, Mayfong Mayxay, Aye Mya Min Aye, Paul Newton, Philippe Perot, Sommanikhone Phangmanixay, Khounthavy Phongsavath, Phan Huu Phuc, Anne-Laurie Pinto, Patrice Piola, Jean-David Pommier, Sayaphet Rattanavong, Bruno Rosset, Ky Santy, Heng Sothy, Arnaud Tarantola, Nguyen Thi Thu Thuy, Htay Htay Tin, Ommar Swe Tin, Manivanh Vongsouvath, Pham Nhat An, Dang Duc Anh, Pascal Bonnet, Kimrong Bun, Danoy Chommanam, Viengmon Davong, Patrice Debré, Jean-François Delfraissy, Christian Devaux, Anousone Douangnouvong, Veasna Duong, Benoit Durand, Chanreaksmey Eng, Catherine Ferrant, Didier Fontenille, Lukas Hafner, Le Thanh Hai, Do Thu Huong, Marc Jouan, May July, Magali Lago, Jean-Paul Moatti, Bernadette Murgue, Khin Yi Oo, MengHeng Oum, Khansoudaphone Phakhounthong, Anh Tuan Pham, Do Quyen, Malee Seephonelee, Maud Seguy, Bountoy Sibounheunang, Kanarith Sim, Luong Minh Tan, Cho Thair, Win Thein, Phung Bich Thuy, Hervé Tissot-Dupont, Malavanh Vongsouvath

“…Methods: In this multicentre, observational, prospective study of childhood encephalitis, four referral hospitals in Cambodia, Vietnam, Laos, and Myanmar recruited children (aged 28 days to 16 years) who presented with altered mental status lasting more than 24 h and two of the following minor criteria: fever (within the 72 h before or after presentation), one or more generalised or partial seizures (excluding febrile seizures), a new-onset focal neurological deficit, cerebrospinal fluid (CSF) white blood cell count of 5 per mL or higher, or brain imaging (CT or MRI) suggestive of lesions of encephalitis. …”
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AK112, a novel PD-1/VEGF bispecific antibody, in combination with chemotherapy in patients with advanced non-small cell lung cancer (NSCLC): an open-label, multicenter, phase II tr... by Yuanyuan Zhao, Gang Chen, Jianhua Chen, Li Zhuang, Yingying Du, Qitao Yu, Wu Zhuang, Yanqiu Zhao, Ming Zhou, Weidong Zhang, Yu Zhang, Yixin Wan, Wenting Li, Weifeng Song, Zhongmin Maxwell Wang, Baiyong Li, Michelle Xia, Yunpeng Yang, Wenfeng Fang, Yan Huang, Li Zhang

“…The most common grade ≥3 treatment-related adverse events were decreased white blood cell count [7 (8.4%)], neutropenia [5 (6.0%)], thrombocytopenia [2 (2.4%)], anemia [4 (4.8%)], and myelosuppression [2 (2.4%)]. …”
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Cov-hep study: heparin in standard anticoagulation based on citrate for continuous veno-venous hemodialysis in patients with COVID-19: a structured summary of a study protocol for... by Paulo Ricardo Gessolo Lins, Claudia Coimbra César de Albuquerque, Camila Fernandes Assis, Bruna Cristine Duarte Rodrigues, Beatriz Pinto e Siqueira Campos, Eduardo de Oliveira Valle, Carla Paulina Sandoval Cabrera, Jeison de Oliveira Gois, Gabriela Cardoso Segura, Fernando Louzada Strufaldi, Lorena Catelan Mainardes, Rayra Gomes Ribeiro, Daniela Del Pilar Via Reque Cortes, Luciana Gil Lutf, Márcia Fernanda Arantes de Oliveira, Gabriel Teixeira Montezuma Sales, Igor Smolentzov, Bernardo Vergara Reichert, Lucia Andrade, Victor Faria Seabra, Camila Eleuterio Rodrigues

“…Physiological data collected by the day of CRRT start will be vital signs, the arterial oxygen tension/fraction of inspired oxygen (PaO2/FiO2) index, and serum creatinine, blood urea nitrogen, bilirubin, hemoglobin, hematocrit, platelets, white blood cell count levels and Peak D-dimer levels. …”
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Disitamab vedotin (RC48) plus toripalimab for HER2-expressing advanced gastric or gastroesophageal junction and other solid tumours: a multicentre, open label, dose escalation and... by Yakun Wang, Jifang Gong, Airong Wang, Jia Wei, Zhi Peng, Xicheng Wang, Jun Zhou, Changsong Qi, Dan Liu, Jian Li, Ming Lu, Zhihao Lu, Yanshuo Cao, Jiajia Yuan, Ruyan Zhang, Jianmin Fang, Xiaotian Zhang, Lin Shen

“…The most common grade 3 adverse events were a decreased neutrophil count (n = 13), and a decreased white blood cell count (n = 7). The efficacy assessment was completed for 52 patients. …”
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Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study by Victor Kande Betu Ku Mesu, DPH, Wilfried Mutombo Kalonji, MD, Clélia Bardonneau, MSc, Olaf Valverde Mordt, MSc, Digas Ngolo Tete, MPH, Séverine Blesson, MSc, François Simon, MSc, Sophie Delhomme, MSc, Sonja Bernhard, PhD, Hélène Mahenzi Mbembo, MD, Christian Mpia Moke, MD, Steven Lumeya Vuvu, MMed, Junior Mudji E'kitiak, MD, Felix Akwaso Masa, MD, Melchias Mukendi Ilunga, MD, Dieudonné Mpoyi Muamba Nzambi, MD, Tim Mayala Malu, MD, Serge Kapongo Tshilumbwa, MD, Franck Botalema Bolengi, MD, Mathieu Nkieri Matsho, MD, Crispin Lumbala, MPH, Bruno Scherrer, PhD, Nathalie Strub-Wourgaft, MD, Antoine Tarral, MD

“…Patients were classified into stage 1 or early stage 2 g-HAT groups following evidence of trypanosomes in the blood, lymph, and absence in CSF, and using white-blood-cell count in CSF. Patients received 1800 mg fexinidazole once per day on days 1–4 then 1200 mg fexinidazole on days 5–10. …”
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Ebola Virus Disease – Global Scenario & Bangladesh by Md Rezwanur Rahman

“…Laboratory findings include low white blood cell and platelet counts and elevated liver enzymes.1 It can be difficult to distinguish EVD from other infectious diseases such as malaria, typhoid fever and meningitis and it is not easy to diagnose. …”
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A New Frontier in the Fight Against Cancer (That Is, for Those Who Can Afford It) by Jennifer Gumer

“…The manufacture of CAR T-cell treatments begins with the collection of T-cells, a type of white bloods cells, from a patient.[3] These cells are then genetically modified using a viral vector to express a protein known as chimeric antigen receptor (i.e., CAR).  …”
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Signatures of cellular immunity after vaccination and challenge that associate with clinical outcome of Salmonella Typhi infection by Cross, D

“…C-reactive protein (CRP) and white blood cell count (WBC) are commonly used as prognostic indicators of patient condition, however, measures such as CRP are not always available in resource limited settings. …”

Thrombosis-related circulating miR-16-5p is associated with disease severity in patients hospitalised for COVID-19 by Ceren Eyileten, Zofia Wicik, Sérgio N. Simões, David C. Martins-Jr, Krzysztof Klos, Wojciech Wlodarczyk, Alice Assinger, Dariusz Soldacki, Andrzej Chcialowski, Jolanta M. Siller-Matula, Marek Postula

“…In this study we identified and validated miRNAs which could serve as novel, thrombosis-related predictive biomarkers of the COVID-19 complications, and can be used for early stratification of patients and prediction of severity of infection development in an individual.Abbreviations: ACE2, angiotensin-converting enzyme 2AF, atrial fibrillationAPP, Amyloid Beta Precursor ProteinaPTT, activated partial thromboplastin timeAUC, Area under the curveAβ, amyloid betaBMI, body mass indexCAD, coronary artery diseaseCALM1, Calmodulin 1 geneCaM, calmodulinCCND1, Cyclin D1CI, confidence intervalCOPD, chronic obstructive pulmonary diseaseCOVID-19, Coronavirus disease 2019CRP, C-reactive proteinCV, CardiovascularCVDs, cardiovascular diseasesDE, differentially expressedDM, diabetes mellitusEGFR, Epithelial growth factor receptorELAVL1, ELAV Like RNA Binding Protein 1FLNA, Filamin AFN1, Fibronectin 1GEO, Gene Expression OmnibushiPSC-CMs, Human induced pluripotent stem cell-derived cardiomyocytesHSP90AA1, Heat Shock Protein 90 Alpha Family Class A Member 1Hsp90α, heat shock protein 90αICU, intensive care unitIL, interleukinIQR, interquartile rangelncRNAs, long non-coding RNAsMI, myocardial infarctionMiRNA, MiR, microRNAmRNA, messenger RNAncRNA, non-coding RNANERI, network-medicine based integrative approachNF-kB, nuclear factor kappa-light-chain-enhancer of activated B cellsNPV, negative predictive valueNXF, nuclear export factorPBMCs, Peripheral blood mononuclear cellsPCT, procalcitoninPPI, Protein-protein interactionsPPV, positive predictive valuePTEN, phosphatase and tensin homologqPCR, quantitative polymerase chain reactionROC, receiver operating characteristicSARS-CoV-2, severe acute respiratory syndrome coronavirus 2SD, standard deviationTLR4, Toll-like receptor 4TM, thrombomodulinTP53, Tumour protein P53UBC, Ubiquitin CWBC, white blood cells…”
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应激性高血糖比值与急性缺血性卒中患者临床预后的相关性研究Correlation between Stress Hyperglycemia Ratio and Clinical Prognosis of Patients with Acute Ischemic Stroke... by 张东, 李治璋, 马瑞楠, 岳蕴华

“…There were 923 cases (62.2%) in favorable prognosis group and 561 cases (37.8%) in unfavorable prognosis group. (2) Univariate analysis showed that the SHR in favorable prognosis group was significantly lower than that in unfavorable prognosis group [0.82 (0.72-0.95) vs . 0.86 (0.74-1.02), P =0.001]. (3) Multivariate logistic regression analysis showed that compared with the lowest quartile of SHR, the highest quartile was independently associated with the 90-day unfavorable prognosis (OR 2.22, 95%CI 1.26-3.91, P =0.006), which had statistical difference in non-diabetic group in subgroup analysis (OR 2.11, 95%CI 1.19-3.75, P =0.010), and no statistical difference in diabetic group (OR 1.53, 95%CI 0.69-3.42, P =0.298). (4) The area under the ROC curve (C-value) of SHR for predicting 90-day unfavorable prognosis was 0.552 (95%CI 0.526-0.578, P =0.001, the optimal cut-off value was 0.84, the sensitivity was 52.94%, and the specificity was 56.12%); and in non-diabetic subgroup, the C-value was 0.600 (95%CI 0.563-0.637, P <0.001, the optimal cut-off value was 0.87, the sensitivity was 52.48%, and the specificity was 64.97%). (5) Correlation analysis showed that SHR was positively correlated with the baseline NIHSS score (r =0.115, P <0.001), CRP (r =0.079, P =0.002), and white blood cell count (r =0.126, P <0.001), while negatively correlated with platelet count (r =-0.094, P <0.001). …”
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Serum sclerostin in acute kidney injury patients by Ahmed Fayed, Dina O. Abdulazim, Mohamed Amin, Samir Elhadidy, Hussien H. Samir, Mona M. Salem, Ibrahim M. Abd ElAzim, Khaled El Sayed El Hawary, Usama A. Sharaf El Din

“…Results: Serum sclerostin, PTH, FGF23, phosphorus, CRP, IL6, HOMA IR, creatinine, urea, uric acid, ALT, AST and white blood cell count (WBC) were significantly higher while serum calcium, 25 OH vit D, hemoglobin, platelet count and FMD were significantly lower in group I compared to group II (P < 0.001 in all). …”
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院内大血管闭塞性卒中血管内治疗患者的临床特征及预后因素分析 Clinical Characteristics and Prognostic Analysis of Patients with Endovascular Treatment for In-Hospital Large Vessel Occlusive Stroke... by 张莉1，刘志广1，2，傅新民1，2，张洋2，宗海亮3 (ZHANG Li1, LIU Zhiguang1,2, FU Xinmin1,2, ZHANG Yang2, ZONG Hailiang3 )

“…Compared with the out-of-hospital group, more patients in the in-hospital group had a combination of atrial fibrillation (53.3% vs. 19.0%, P＜0.001), malignant tumor (15.6% vs. 1.0%, P=0.002), other arterial thrombosis (15.6% vs. 1.0%, P=0.002), and perioperative period (51.1% vs. 1.0%, P＜0.001), and the NIHSS score at the onset of the disease was higher [21.0 (14.5-35.0) points vs. 18.0 (13.5-24.5) points, P=0.019]. The levels of white blood cell count (U=1385.000, P＜0.001), D-dimer (U=654.500, P＜0.001) and IL-6 (U=1376.000, P＜0.001) in the in-hospital group were higher than those in the out-of-hospital group, and the levels of hemoglobin (U=1758.000, P=0.035), systolic blood pressure (t=-2.766, P=0.006) and diastolic blood pressure (U=1317.500, P＜0.001) were lower than those in the out-of-hospital group, and the differences were all statistically significant. …”
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Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis: the EASI-SWITCH RCT by Vicky Coyle, Caroline Forde, Richard Adams, Ashley Agus, Rosemary Barnes, Ian Chau, Mike Clarke, Annmarie Doran, Margaret Grayson, Danny McAuley, Cliona McDowell, Glenn Phair, Ruth Plummer, Dawn Storey, Anne Thomas, Richard Wilson, Ronan McMullan

“…Plain language summary The background Neutropenic sepsis, or infection with a low white blood cell count, can occur following cancer treatment. …”
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