Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast? by Khurana, Vikram, Lindquist, Susan

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An adipose lncRAP2-Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs by Juan R. Alvarez-Dominguez, Sally Winther, Jacob B. Hansen, Harvey F. Lodish, Marko Knoll

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CD8+ T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2Kb-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection by Sharvan Sehrawat, Oktay Kirak, Paul-Albert Koenig, Marisa K. Isaacson, Sofia Marques, Gunes Bozkurt, J. Pedro Simas, Rudolph Jaenisch, Hidde L. Ploegh

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Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability by Mark R Sullivan, Laura V Danai, Caroline A Lewis, Sze Ham Chan, Dan Y Gui, Tenzin Kunchok, Emily A Dennstedt, Matthew G Vander Heiden, Alexander Muir

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Temporal and thermal profiling of the Toxoplasma proteome implicates parasite Protein Phosphatase 1 in the regulation of Ca2+-responsive pathways by Alice L Herneisen, Zhu-Hong Li, Alex W Chan, Silvia NJ Moreno, Sebastian Lourido

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Widespread Changes in the Posttranscriptional Landscape at the Drosophila Oocyte-to-Embryo Transition by Iva Kronja, Bingbing Yuan, Stephen W. Eichhorn, Kristina Dzeyk, Jeroen Krijgsveld, David P. Bartel, Terry L. Orr-Weaver

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High-Resolution Mapping of Transcription Initiation in the Asexual Stages of Toxoplasma gondii by Benedikt M. Markus, Benedikt M. Markus, Benjamin S. Waldman, Benjamin S. Waldman, Hernan A. Lorenzi, Sebastian Lourido, Sebastian Lourido

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Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation by Raghu Ram Edupuganti, Arigela Harikumar, Yair Aaronson, Alva Biran, Badi Sri Sailaja, Malka Nissim-Rafinia, Gajendra Kumar Azad, Malkiel A. Cohen, Jung Eun Park, Chikdu S. Shivalila, Styliani Markoulaki, Siu Kwan Sze, Rudolf Jaenisch, Eran Meshorer

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Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients by Lakshmi E Miller-Vedam, Bastian Bräuning, Katerina D Popova, Nicole T Schirle Oakdale, Jessica L Bonnar, Jesuraj R Prabu, Elizabeth A Boydston, Natalia Sevillano, Matthew J Shurtleff, Robert M Stroud, Charles S Craik, Brenda A Schulman, Adam Frost, Jonathan S Weissman

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Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition by Lucie Y. Guo, Praveen Kumar Allu, Levani Zandarashvili, Kara L. McKinley, Nikolina Sekulic, Jennine M. Dawicki-McKenna, Daniele Fachinetti, Glennis A. Logsdon, Ryan M. Jamiolkowski, Don W. Cleveland, Iain M. Cheeseman, Ben E. Black

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Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation by Masatoshi Hara, Boryana Petrova, Terry L Orr-Weaver

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Identification of cryptic subunits from an apicomplexan ATP synthase by Diego Huet, Esther Rajendran, Giel G van Dooren, Sebastian Lourido

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mTOR: from growth signal integration to cancer, diabetes and ageing by Zoncu, Roberto, Efeyan, Alejo, Sabatini, David

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mTOR Signaling in Growth Control and Disease by Laplante, Mathieu, Sabatini, David M., Sabatini, David

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Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors by Joseph M Replogle, Jessica L Bonnar, Angela N Pogson, Christina R Liem, Nolan K Maier, Yufang Ding, Baylee J Russell, Xingren Wang, Kun Leng, Alina Guna, Thomas M Norman, Ryan A Pak, Daniel M Ramos, Michael E Ward, Luke A Gilbert, Martin Kampmann, Jonathan S Weissman, Marco Jost

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A statistical approach for identifying primary substrates of ZSWIM8-mediated microRNA degradation in small-RNA sequencing data by Peter Y. Wang, David P. Bartel

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An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway by Grace Y. Liu, Patrick Jouandin, Raymond E. Bahng, Norbert Perrimon, David M. Sabatini

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Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish by Jasmine M. McCammon, Hazel Sive

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Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia by F Esra Demircioglu, Brian A Sosa, Jessica Ingram, Hidde L Ploegh, Thomas U Schwartz

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The molecular basis of coupling between poly(A)-tail length and translational efficiency by Kehui Xiang, David P Bartel

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