Study protocol for the management of impacted maxillary central incisors: a multicentre randomised clinical trial: the iMAC Trial by Jadbinder Seehra, Andrew T. DiBiase, Shruti Patel, Rachel Stephens, Simon J. Littlewood, Richard J. Spencer, Tom Frawley, Philip E. Benson, Anthony J. Ireland, Farnaz Parvizi, Nikki Atack, Giles Kidner, Gabriella Wojewodka, Christopher Ward, Spyridon N. Papageorgiou, Jonathon T. Newton, Martyn T. Cobourne

Get full text

Case Report: Malignant Primary Sellar Paraganglioma With Unusual Genetic and Imaging Features by Stefan Stojanoski, Stefan Stojanoski, Henning Bünsow Boldt, Henning Bünsow Boldt, Dusko Kozic, Dusko Kozic, Attila Patócs, Márta Korbonits, Márta Korbonits, Milica Medic-Stojanoska, Milica Medic-Stojanoska, Olivera Casar-Borota, Olivera Casar-Borota

Get full text

Letter to the editor on: Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions by Park e... by Huihui Luo, Emil K. Gustavsson, Hannah Macpherson, Natalia Dominik, Kristina Zhelcheska, Kylie Montgomery, Claire Anderson, Wai Yan Yau, Stephanie Efthymiou, Chris Turner, Michael DeTure, Dennis W. Dickson, Keith A. Josephs, Tamas Revesz, Tammaryn Lashley, Glenda Halliday, Dominic B. Rowe, Emily McCann, Ian Blair, Andrew J. Lees, Pentti J. Tienari, Anu Suomalainen, Laura Molina-Porcel, Gabor G. Kovacs, Ellen Gelpi, John Hardy, Matti J. Haltia, Arianna Tucci, Zane Jaunmuktane, Mina Ryten, Henry Houlden, Zhongbo Chen

Get full text

The oDGal Mouse: A Novel, Physiologically Relevant Rodent Model of Sporadic Alzheimer’s Disease by Wayne Chadwick, Stuart Maudsley, William Hull, Enes Havolli, Eugene Boshoff, Mark D. W. Hill, Pascal J. D. Goetghebeur, David C. Harrison, Sohaib Nizami, David C. Bedford, Gareth Coope, Katia Real, Christoph Thiemermann, Peter Maycox, Mark Carlton, Sarah L. Cole

Get full text

Neuromodulation of innate immunity by remote ischaemic conditioning in humans: Experimental cross-over study by Shaun M. May, Eric Chiang, Anna Reyes, Gladys Martir, Amour Patel, Shamir Karmali, Sanjiv Patel, Simeon West, Ana Gutierrez del Arroyo, Alexander V. Gourine, Gareth L. Ackland

Get full text

“A Step and a Ceiling”: mechanical properties of Ca2+ spark vasoregulation in resistance arteries by pressure‐induced oxidative activation of PKG by Viktoria Csato, Sharifah Z. S. A. Kadir, Kaivan Khavandi, Hayley Bennett, Sarah Sugden, Alison M. Gurney, Harry A. T. Pritchard, David Hill‐Eubanks, Philip Eaton, Mark T. Nelson, Adam S. Greenstein

Get full text

The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester by Zoe C. Johnston, Michelle Bellingham, Panagiotis Filis, Ugo Soffientini, Denise Hough, Siladitya Bhattacharya, Marc Simard, Geoffrey L. Hammond, Peter King, Peter J. O’Shaughnessy, Paul A. Fowler

Get full text

The development of a theory and evidence-based intervention to aid implementation of exercise into the prostate cancer care pathway with a focus on healthcare professional behaviou... by Rebecca R. Turner, Madelynne A. Arden, Sophie Reale, Eileen Sutton, Stephanie J. C. Taylor, Liam Bourke, Diana M. Greenfield, Dylan Morrissey, Janet Brown, Patrick Doherty, Derek J. Rosario, Liz Steed

Get full text

Reduction of autophagy and increase in apoptosis correlates with a favorable clinical outcome in patients with rheumatoid arthritis treated with anti-TNF drugs by M. Vomero, V. Manganelli, C. Barbati, T. Colasanti, A. Capozzi, A. Finucci, F. R. Spinelli, F. Ceccarelli, C. Perricone, S. Truglia, S. Morrone, R. Maggio, R. Misasi, M. Bombardieri, M. Di Franco, F. Conti, M. Sorice, G. Valesini, C. Alessandri

Get full text

Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3 by Rémi Porte, Rita Silva-Gomes, Charlotte Theroude, Raffaella Parente, Fatemeh Asgari, Marina Sironi, Fabio Pasqualini, Sonia Valentino, Rosanna Asselta, Camilla Recordati, Marta Noemi Monari, Andrea Doni, Antonio Inforzato, Carlos Rodriguez-Gallego, Ignacio Obando, Elena Colino, Barbara Bottazzi, Alberto Mantovani

Get full text

A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain by Julius E. Kieswich, Jianmin Chen, Samira Alliouachene, Paul W. Caton, Kieran McCafferty, Christoph Thiemermann, Muhammad M. Yaqoob

Get full text

Digital Health for Supporting Precision Medicine in Pediatric Endocrine Disorders: Opportunities for Improved Patient Care by Luis Fernandez-Luque, Abdullah Al Herbish, Riyad Al Shammari, Jesús Argente, Jesús Argente, Jesús Argente, Bassam Bin-Abbas, Asma Deeb, David Dixon, Nabil Zary, Ekaterina Koledova, Martin O. Savage

Get full text

Exercise-induced myocardial edema in master triathletes: Insights from cardiovascular magnetic resonance imaging by Fabrizio Ricci, Fabrizio Ricci, Giovanni Donato Aquaro, Carlo De Innocentiis, Serena Rossi, Cesare Mantini, Francesca Longo, Mohammed Y. Khanji, Mohammed Y. Khanji, Mohammed Y. Khanji, Sabina Gallina, Alessandro Pingitore

Get full text

Improved lung function and patient-reported outcomes with co-suspension delivery technology glycopyrrolate/formoterol fumarate metered dose inhaler in COPD: a randomized Phase III... by Lipworth BJ, Collier DJ, Gon Y, Zhong NS, Nishi K, Chen R, Arora S, Maes A, Siddiqui S, Reisner C, Martin UJ

“…Brian J Lipworth,1 David J Collier,2 Yasuhiro Gon,3 Nanshan Zhong,4 Koichi Nishi,5 Rongchang Chen,4 Samir Arora,6 Andrea Maes,7 Shahid Siddiqui,8 Colin Reisner,7,8 Ubaldo J Martin8 1Scottish Centre for Respiratory Research, Ninewells Hospital, University of Dundee, Dundee, Scotland, UK; 2William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK; 3Itabashi Hospital, Nihon University School of Medicine, Itabashi, Tokyo, Japan; 4Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 5Ishikawa Prefectural Central Hospital, Kanazawa, Ishikawa, Japan; 6Aventiv Research Inc., Columbus, OH, USA; 7Pearl – a member of the AstraZeneca group, Morristown, NJ, USA; 8AstraZeneca, Gaithersburg, MD, USA Background: COPD is a major global cause of mortality and morbidity. …”
Get full text

Epigenetic and post‐transcriptional regulation of somatostatin receptor subtype 5 (SST5) in pituitary and pancreatic neuroendocrine tumors by Sergio Pedraza‐Arevalo, Alejandro Ibáñez‐Costa, Ricardo Blázquez‐Encinas, Miguel R. Branco, Mari C. Vázquez‐Borrego, Aura D. Herrera‐Martínez, Eva Venegas‐Moreno, Raquel Serrano‐Blanch, Álvaro Arjona‐Sánchez, María A. Gálvez‐Moreno, Marta Korbonits, Alfonso Soto‐Moreno, Manuel D. Gahete, Marika Charalambous, Raúl M. Luque, Justo P. Castaño

Get full text

Soluble interleukin-1 receptor type 2 plasma levels in Parkinson’s disease: relationship with cardiac autonomic profile before and after peripheral mechanical somatosensory stimula... by Dana Shiffer, Dana Shiffer, Antonio Roberto Zamunér, Maura Minonzio, Mara Bulgheroni, Alberto Porta, Alberto Porta, Roberto Leone, Barbara Bottazzi, Cecilia Garlanda, Cecilia Garlanda, Francesco Colotta, Franca Barbic, Franca Barbic, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani, Raffaello Furlan, Raffaello Furlan

Get full text

Concomitance of 47,XXY, a balanced reciprocal translocation of t(4;17)(q12;q11.2) encompassing SPINK2 at 4q12 and NOS at 17q11.2 and an AZFa sY86 deletion in an infertile male by Fang-Tzu Wu, Chih-Ping Chen, Shin-Wen Chen, Schu-Rern Chern, Po-Tsang Chen, Chien-Ling Chiu, Chen-Chi Lee, Wen-Lin Chen, Wayseen Wang

Get full text

Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis by David C Llewellyn, Rajaventhan Srirajaskanthan, Royce P Vincent, Catherine Guy, Eftychia E Drakou, Simon J B Aylwin, Ashley B Grossman, John K Ramage, Georgios K Dimitriadis

Get full text

Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease by Cindy Barnig, Cindy Barnig, Tjitske Bezema, Philip C. Calder, Philip C. Calder, Anne Charloux, Anne Charloux, Nelly Frossard, Johan Garssen, Johan Garssen, Oliver Haworth, Ksenia Dilevskaya, Francesca Levi-Schaffer, Evelyne Lonsdorfer, Evelyne Lonsdorfer, Marca Wauben, Aletta D. Kraneveld, Aletta D. Kraneveld, Anje A. te Velde

Get full text

Proconvertase Furin Is Downregulated in Postural Orthostatic Tachycardia Syndrome by Jasmina Medic Spahic, Jasmina Medic Spahic, Fabrizio Ricci, Fabrizio Ricci, Nay Aung, Jonas Axelsson, Jonas Axelsson, Olle Melander, Olle Melander, Richard Sutton, Viktor Hamrefors, Viktor Hamrefors, Artur Fedorowski, Artur Fedorowski

Get full text