Cardiopulmonary Resuscitation and Defibrillator Use in Sports by Mafalda Carrington, Rui Providência, Rui Providência, Rui Providência, C. Anwar A. Chahal, C. Anwar A. Chahal, C. Anwar A. Chahal, C. Anwar A. Chahal, Flavio D'Ascenzi, Alberto Cipriani, Fabrizio Ricci, Fabrizio Ricci, Fabrizio Ricci, Mohammed Y. Khanji, Mohammed Y. Khanji, Mohammed Y. Khanji

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Challenges in the care of individuals with severe primary insulin-like growth factor-I deficiency (SPIGFD): an international, multi-stakeholder perspective by Philippe F. Backeljauw, Mary Andrews, Peter Bang, Leo Dalle Molle, Cheri L. Deal, Jamie Harvey, Shirley Langham, Elżbieta Petriczko, Michel Polak, Helen L. Storr, Mehul T. Dattani

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A randomized, open-label, single-visit crossover study simulating triple-drug delivery with Ellipta compared with dual inhaler combinations in patients with COPD by van der Palen J, Moeskops-van Beurden W, Dawson CM, James WY, Preece A, Midwinter D, Barnes N, Sharma R

“…Job van der Palen,1,2 Wendy Moeskops-van Beurden,1 Carolyn M Dawson,3 Wai-Yee James,3 Andrew Preece,4 Dawn Midwinter,4 Neil Barnes,5 Raj Sharma6 1Department of Pulmonology, Medisch Spectrum Twente, Enschede, the Netherlands; 2Department of Research Methodology, Measurement, and Data Analysis, University of Twente, Enschede, the Netherlands; 3William Harvey Heart Centre, St Bartholomew Hospital, London, UK; 4Respiratory Therapy Area Unit, GlaxoSmithKline, Stockley Park, UK; 5Medical Department, GlaxoSmithKline, Brentford, UK; 6Respiratory Medical Franchise, GlaxoSmithKline, Brentford, UK Background: Administering maintenance COPD therapy with a combination of multiple inhalers may increase inhaler errors. …”
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DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases by Matthias Wielscher, Pooja R. Mandaviya, Brigitte Kuehnel, Roby Joehanes, Rima Mustafa, Oliver Robinson, Yan Zhang, Barbara Bodinier, Esther Walton, Pashupati P. Mishra, Pascal Schlosser, Rory Wilson, Pei-Chien Tsai, Saranya Palaniswamy, Riccardo E. Marioni, Giovanni Fiorito, Giovanni Cugliari, Ville Karhunen, Mohsen Ghanbari, Bruce M. Psaty, Marie Loh, Joshua C. Bis, Benjamin Lehne, Nona Sotoodehnia, Ian J. Deary, Marc Chadeau-Hyam, Jennifer A. Brody, Alexia Cardona, Elizabeth Selvin, Alicia K. Smith, Andrew H. Miller, Mylin A. Torres, Eirini Marouli, Xin Gào, Joyce B. J. van Meurs, Johanna Graf-Schindler, Wolfgang Rathmann, Wolfgang Koenig, Annette Peters, Wolfgang Weninger, Matthias Farlik, Tao Zhang, Wei Chen, Yujing Xia, Alexander Teumer, Matthias Nauck, Hans J. Grabe, Macus Doerr, Terho Lehtimäki, Weihua Guan, Lili Milani, Toshiko Tanaka, Krista Fisher, Lindsay L. Waite, Silva Kasela, Paolo Vineis, Niek Verweij, Pim van der Harst, Licia Iacoviello, Carlotta Sacerdote, Salvatore Panico, Vittorio Krogh, Rosario Tumino, Evangelia Tzala, Giuseppe Matullo, Mikko A. Hurme, Olli T. Raitakari, Elena Colicino, Andrea A. Baccarelli, Mika Kähönen, Karl-Heinz Herzig, Shengxu Li, BIOS consortium, Karen N. Conneely, Jaspal S. Kooner, Anna Köttgen, Bastiaan T. Heijmans, Panos Deloukas, Caroline Relton, Ken K. Ong, Jordana T. Bell, Eric Boerwinkle, Paul Elliott, Hermann Brenner, Marian Beekman, Daniel Levy, Melanie Waldenberger, John C. Chambers, Abbas Dehghan, Marjo-Riitta Järvelin

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Benefits of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI) in improving lung function and reducing exacerbations in patients with moderate-to-very severe COPD: a... by Fernando J. Martinez, Brian J. Lipworth, Klaus F. Rabe, David J. Collier, Gary T. Ferguson, Sanjay Sethi, Gregory J. Feldman, Gerald O’Brien, Martin Jenkins, Colin Reisner

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The effect of optimised patient information materials on recruitment in a lung cancer screening trial: an embedded randomised recruitment trial by Adwoa Parker, Peter Knapp, Shaun Treweek, Vichithranie Madhurasinghe, Roberta Littleford, Stephanie Gallant, Frank Sullivan, Stuart Schembri, Jo Rick, Jonathan Graffy, David J. Collier, Sandra Eldridge, Anne Kennedy, Peter Bower

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Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases by Jason A. Chen, Zhongbo Chen, Hyejung Won, Alden Y. Huang, Jennifer K. Lowe, Kevin Wojta, Jennifer S. Yokoyama, Gilbert Bensimon, P. Nigel Leigh, Christine Payan, Aleksey Shatunov, Ashley R. Jones, Cathryn M. Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-Francois Dartigues, Albert Ludolph, Adam L. Boxer, Jeff M. Bronstein, Ammar Al-Chalabi, Daniel H. Geschwind, Giovanni Coppola

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Validation of 2D flow MRI for helical and vortical flows by Samer Alabed, Pankaj Garg, Steffen Erhard Petersen, Rui Li, Fabrizio Ricci, Andrew J Swift, Ciaran Grafton-Clarke, Nay Aung, João Cavalcante, Hosamadin Assadi, Liang Zhong, Vassilios S Vassiliou, Gareth Matthews, Xiaodan Zhao, Zia Mehmood, Bahman Kasmai, Rob J van der Geest, Rebekah Girling, Victoria Underwood

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Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo by Asif J Iqbal, Tessa J Barrett, Lewis Taylor, Eileen McNeill, Arun Manmadhan, Carlota Recio, Alfredo Carmineri, Maximillian H Brodermann, Gemma E White, Dianne Cooper, Joseph A DiDonato, Maryam Zamanian-Daryoush, Stanley L Hazen, Keith M Channon, David R Greaves, Edward A Fisher

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An acute increase in Left Atrial volume and left ventricular filling pressure during Adenosine administered myocardial hyperaemia: CMR First-Pass Perfusion Study by Pankaj Garg, Wasim Javed, Hosamadin Assadi, Samer Alabed, Ciaran Grafton-Clarke, Andrew J Swift, Gareth Williams, Abdallah Al-Mohammad, Chris Sawh, Vassilios S Vassiliou, Mohammed Y Khanji, Fabrizio Ricci, John P Greenwood, Sven Plein, Peter Swoboda

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Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury: Impact on Myocardial Integrity by Johanna Wall, Sriveena Naganathar, Banjerd Praditsuktavorn, Oscar F. Bugg, Simon McArthur, Christoph Thiemermann, Christoph Thiemermann, Jordi L. Tremoleda, Karim Brohi

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Monitoring blood potassium concentration in hemodialysis patients by quantifying T-wave morphology dynamics by Flavio Palmieri, Pedro Gomis, Dina Ferreira, José Esteban Ruiz, Beatriz Bergasa, Alba Martín-Yebra, Hassaan A. Bukhari, Esther Pueyo, Juan Pablo Martínez, Julia Ramírez, Pablo Laguna

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Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36[S] by Latisha Love-Gregory, Aldi T. Kraja, Fiona Allum, Stella Aslibekyan, Åsa K. Hedman, Yanan Duan, Ingrid B. Borecki, Donna K. Arnett, Mark I. McCarthy, Panos Deloukas, Jose M. Ordovas, Paul N. Hopkins, Elin Grundberg, Nada A. Abumrad

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Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen by Anne L. Robertson, Nikolay V. Ogryzko, Katherine M. Henry, Catherine A. Loynes, Matthew J. Foulkes, Marco M. Meloni, Xingang Wang, Christopher Ford, Malcolm Jackson, Philip W. Ingham, Heather L. Wilson, Stuart N. Farrow, Roberto Solari, Roderick J. Flower, Simon Jones, Moira K. B. Whyte, Stephen A. Renshaw

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Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury by Kai Zhou, Hua Chen, Xiao-yu Wang, Yan-mei Xu, Yu-feng Liao, Yuan-yuan Qin, Xue-wan Ge, Ting-ting Zhang, Zhong-lin Fang, Bei-bei Fu, Qing-Zhong Xiao, Feng-qin Zhu, Si-rui Chen, Xue-sheng Liu, Qi-chao Luo, Shan Gao

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The impact of high versus standard enteral protein provision on functional recovery following intensive care admission (PRECISE trial): study protocol for a randomized controlled,... by Rob J. J. van Gassel, Julia L. M. Bels, Katrien Tartaglia, Bas C. T. van Bussel, Sander M. J. van Kuijk, Adam M. Deane, Zudin Puthucheary, Peter J. M. Weijs, Lilian Vloet, Bert Beishuizen, Ashley De Bie Dekker, Vincent Fraipont, Stoffel Lamote, Didier Ledoux, Clarissa Scheeren, Elisabeth De Waele, Arthur R. H. van Zanten, Dieter Mesotten, Marcel C. G. van de Poll

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Paraneoplastic hypoglycaemia secondary to IGF-2 secretion from a metastatic gastrointestinal stromal tumour by Michael C. Onyema, Eftychia E. Drakou, Georgios Giovos, Bianca M. Leca, Christos Kosmas, Ratnadeep Ganguly, Narasimha Murthy, Ashley B. Grossman, Harpal S. Randeva, Georgios K. Dimitriadis

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Translating the potential of the urine steroid metabolome to stage NAFLD (TrUSt-NAFLD): study protocol for a multicentre, prospective validation study by David Sheridan, Jeremy F Cobbold, Jeremy W Tomlinson, William Alazawi, Richard Parker, Alice J Sitch, Fredrik Karpe, David Harman, Hamish Miller, Márta Korbonits, Philip N Newsome, Guruprasad Padur Aithal, Pinelopi Manousou, Wiebke Arlt, Matthew Neville, Michael Biehl

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Improved lifestyle is associated with improved depression, anxiety and well-being over time in UK healthcare professionals during the COVID-19 pandemic: insights from the CoPE-HCP... by Ajay Gupta, Vikas Kapil, Mohammed Y Khanji, Sher May Ng, George Collett, Thomas Godec, Carmela Maniero, Imrana Siddiqui, Jaya Gupta

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COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial by Chiara Agrati, Serena Di Cosimo, Daniela Fenoglio, Daniela Fenoglio, Giovanni Apolone, Fabio Ciceri, Gennaro Ciliberto, Fausto Baldanti, Massimo Costantini, Diana Giannarelli, Giuseppe Ippolito, Franco Locatelli, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani, Aldo Morrone, Fabrizio Tagliavini, Antonio Uccelli, Antonio Uccelli, Pier Luigi Zinzani, Pier Luigi Zinzani, Nicola Silvestris, Nicola Silvestris, Maria Rescigno, Maria Rescigno

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