Association of HLA-C*07:359 with HLA-A, -B, and -DRB1 alleles in Taiwanese by Kuo-Liang Yang, Py-Yu Lin

“…HLA-C*07:359 is a rarely observed allele in the HLA-C locus in the world populations. The objective of this study is to report the allele HLA-C*07:359 that is more frequently found in the Taiwanese population, especially in the Taiwanese indigenous people, to demonstrate that it has a close linkage with HLA-B*39:01 allele in the HLA-B locus and to show the plausible deduced HLA-A-C-B-DRB1-DQB1 haplotypes in association with HLA-C*07:359 in two families of Taiwanese indigenous unrelated individuals. …”
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Disease progression strikingly differs in research and real-world Parkinson’s populations by Brett K. Beaulieu-Jones, Francesca Frau, Sylvie Bozzi, Karen J. Chandross, M. Judith Peterschmitt, Caroline Cohen, Catherine Coulovrat, Dinesh Kumar, Mark J. Kruger, Scott L. Lipnick, Lane Fitzsimmons, Isaac S. Kohane, Clemens R. Scherzer

“…. >10, p < 0.001; mini-mental state exam median decline 0.28 vs. 0.11, p < 0.001; and clinically recognized cognitive decline, p = 0.001). In real-world populations, patients are diagnosed more than eleven years later (RWD mean of 72.2 vs. research mean of 60.4, p < 0.001). …”
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Paired associated SARS-CoV-2 spike variable positions: a network analysis approach to emerging variants by Yiannis Manoussopoulos, Cleo Anastassopoulou, John P. A. Ioannidis, Athanasios Tsakris

“…Cliques of different sizes represented theoretical combinations of changing residues in sequence space, allowing the identification of significant aminoacidic combinations in single sequences of real-world populations. Our analytic approach that links network structural aspects to mutational aminoacidic combinations in the spike sequence population offers a novel way to understand virus epidemiology and evolution.…”
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Climate change favours connectivity between virus-bearing pest and rice cultivations in sub-Saharan Africa, depressing local economies by Mattia Iannella, Walter De Simone, Paola D’Alessandro, Maurizio Biondi

“…Aims Rice is a staple food for many countries, being fundamental for a large part of the worlds’ population. In sub-Saharan Africa, its importance is currently high and is likely to become even more relevant, considering that the number of people and the per-capita consumption are both predicted to increase. …”
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Novel genetic association of the Furin gene polymorphism rs1981458 with COVID-19 severity among Indian populations by Rudra Kumar Pandey, Anshika Srivastava, Rahul Kumar Mishra, Prajjval Pratap Singh, Gyaneshwer Chaubey

“…Additionally, we examined the Furin gene using next-generation sequencing (NGS) data from 393 diverse global samples, with a particular emphasis on South Asia, to investigate its Phylogeographic structure among diverse world populations. We found a significant positive association for the SNP rs1981458 with COVID-19 CFR (p < 0.05) among diverse Indian populations at different timelines of the first and second waves. …”
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Long‐term immune responses and comparative effectiveness of one or two doses of 7‐valent pneumococcal conjugate vaccine (PCV7) in HIV‐positive adults in the era of combination anti... by Aristine Cheng, Sui‐Yuan Chang, Mao‐Song Tsai, Yi‐Ching Su, Wen‐Chun Liu, Hsin‐Yun Sun, Chien‐Ching Hung

“…Conclusions One or two doses of PCV7 achieve durable seroprotective responses in HIV‐treated participants; however, two doses may be more robust than one dose in a larger study population or in real‐world populations with less cART coverage.…”
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Swiss experience of atezolizumab for platinum-pretreated urinary tract carcinoma: the SAUL study in real-world practice by Richard Cathomas, Julian Schardt, Miklos Pless, Anna Llado, Nicolas Mach, Christian Riklin, Jenny Haefeli, Simon Fear, Frank Stenner

“…The global SAUL study evaluated atezolizumab in a broader patient population more representative of real-world populations. Among approximately 1000 patients treated in SAUL, 25 were treated in Swiss oncology centres. …”
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Parametric study of portable solar-powered heat exchanger using computational fluid dynamics by Tengku Ibrahim, Tengku Muhammad Fahmi

“…Its importance is highlighted by the United Nation as decade for clean water in the world populations suffer lack of portable water in stressed area such as Africa and South East Asia. …”
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Ancestry informative markers single nucleotide polymorphisms panel for ancestry estimation in the Malay population by Yahya, Padillah

“…The genetic structure of the Malay population can be differentiated from the other world populations used in this study using the 1250 and 2240 AIM-SNP panels selected by ipPCA-FST and 2000 AIM-SNP panels selected by In and PCAIM.…”
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A quantitative systems pharmacology model for certolizumab pegol treatment in moderate-to-severe psoriasis by Pablo Coto-Segura, Cristina Segú-Vergés, Cristina Segú-Vergés, Antonio Martorell, David Moreno-Ramírez, Guillem Jorba, Guillem Jorba, Valentin Junet, Valentin Junet, Filippo Guerri, Filippo Guerri, Xavier Daura, Xavier Daura, Xavier Daura, Baldomero Oliva, Carlos Cara, Olaya Suárez-Magdalena, Sonya Abraham, Sonya Abraham, José Manuel Mas

“…We applied different modelling approaches: (i) an algorithm to generate vPop according to reference population values and comorbidity frequencies in real-world populations; (ii) physiologically based pharmacokinetic (PBPK) models of CZP dosing schemes in each virtual patient; and (iii) systems biology-based models of the mechanism of action (MoA) of the drug.ResultsThe combination of our different modelling approaches yielded a vPop distribution and a PBPK model that aligned with existing literature. …”
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First report of Burkholderia gladioli causing bacterial panicle blight of rice in Malaysia by Md Zali, Adam Zafdri, Ja'afar, Yasmin, Paramisparan, Karthik, Ismail, Siti Izera, Saad, Norsazilawati, Mohd Hata, Erneeza, Md Hatta, Muhammad Asyraf, Ismail, Mohd Razi, Yusof, Mohd Termizi, Zulperi, Dzarifah

“…Rice (Oryza sativa) is a staple food for most of the world's populations, particularly in Asia (Gumma et al. 2011). …”

Seroprevalence and risk factors for hepatitis B virus infection among general population in Northern India Soroprevalência e fatores de risco para infecção pelo vírus da hepatite B... by Rachna Behal, Renu Jain, Krishan K. Behal, Ajay Bhagoliwal, Nakshatra Aggarwal, T. N. Dhole

“…Epidemiological data reveals that there are 360 million carriers of hepatitis-B virus throughout the globe and 78% of the world populations’ hail from Asia. Though several studies from Indian sub-continent have provided an estimate of the prevalence of this viral infection, there exist only few studies, which reflect the status in the general population. …”
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