HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy by Jian Wang, Michael Weller, Roland Martin, Holger Moch, Julia Velz, Luca Regli, Hans-Georg Rammensee, Linus Backert, Oliver Kohlbacher, Ana Marcu, Leon Bichmann, Leon Kuchenbecker, Daniel Johannes Kowalewski, Lena Katharina Freudenmann, Lena Mühlenbruch, András Szolek, Maren Lübke, Philipp Wagner, Tobias Engler, Sabine Matovina, Mathias Hauri-Hohl, Konstantina Kapolou, Juliane Sarah Walz, Manuela Silginer, Markus W. Löffler, Florian Erhard, Andreas Schlosser, Stefan Stevanović, Marian Christoph Neidert

“…The HLA allotypes are representative for the world population. We observe that immunopeptidomes differ considerably between tissues and individuals on source protein and HLA-ligand level. …”
Get full text

The Association between Circulating microRNAs and the Risk of Active Disease Development from Latent Tuberculosis Infection: a Nested Case-Control Study by Henan Xin, Xuefang Cao, Ying Du, Jiaoxia Yan, Rui He, Zisen Liu, Haoran Zhang, Yijun He, Bin Zhang, Dakuan Wang, Ling Guan, Fei Shen, Boxuan Feng, Zhusheng Quan, Yongpeng He, Jianmin Liu, Qi Jin, Shouguo Pan, Lei Gao

“…IMPORTANCE Approximately a quarter of the world population are infected with M. tuberculosis and about 5% to 10% of these might develop active disease in their lifetime. …”
Get full text

Evaluation of humoral and cellular response to four vaccines against COVID-19 in different age groups: A longitudinal study by Giorgio Fedele, Filippo Trentini, Filippo Trentini, Ilaria Schiavoni, Sergio Abrignani, Sergio Abrignani, Guido Antonelli, Vincenzo Baldo, Tatjana Baldovin, Alessandra Bandera, Alessandra Bandera, Filippa Bonura, Pierangelo Clerici, Massimo De Paschale, Francesca Fortunato, Andrea Gori, Andrea Gori, Renata Grifantini, Giancarlo Icardi, Tiziana Lazzarotto, Tiziana Lazzarotto, Vittorio Lodi, Claudio Maria Mastroianni, Andrea Orsi, Rosa Prato, Vincenzo Restivo, Rita Carsetti, Eva Piano Mortari, Pasqualina Leone, Eleonora Olivetta, Stefano Fiore, Angela Di Martino, Silvio Brusaferro, Stefano Merler, Anna Teresa Palamara, Paola Stefanelli

“…To date there has been limited head-to-head evaluation of immune responses to different types of COVID-19 vaccines. A real-world population-based longitudinal study was designed with the aim to define the magnitude and duration of immunity induced by each of four different COVID-19 vaccines available in Italy at the time of this study. …”
Get full text

Studies of the effectiveness of transport sector interventions in low‐ and middle‐income countries: An evidence and gap map by Suchi Kapoor Malhotra, Howard White, Nina Ashley O. Dela Cruz, Ashrita Saran, John Eyers, Denny John, Ella Beveridge, Nina Blöndal

“…Lucas et al. suggest that up to 90% of the world's population are transport poor when defined as meeting at least one of the following criteria: (1) lack of available suitable transport, (2) lack of transport to necessary destinations, (3) cost of necessary transport puts household below the income poverty line, (4) excessive travel time, or (5) unsafe or unhealthy travel conditions. …”
Get full text

THE EARLY AND EFFECTIVE TREATMENT FOR SEVERE MENTAL ILLNESS (SMI) IN LOW AND MIDDLE INCOME (LAMI) COUNTRIES: A PUBLIC HEALTH CHALLENGE by saeed Farooq

“…Considering that almost one third of the world's population live in conflict-affected low-income countries, providing effective care for those suffering from psychosis is a huge challenge.7   This is ironic considering that effective treatments are available for most of these psychiatric disorders. …”
Get full text

Real Life Clinical Management and Survival in Advanced Cutaneous Melanoma: The Italian Clinical National Melanoma Registry Experience by Anna Crispo, Maria Teresa Corradin, Erika Giulioni, Antonella Vecchiato, Paolo Del Fiore, Paola Queirolo, Paola Queirolo, Francesco Spagnolo, Vito Vanella, Corrado Caracò, Giulio Tosti, Elisabetta Pennacchioli, Giuseppe Giudice, Eleonora Nacchiero, Pietro Quaglino, Simone Ribero, Monica Giordano, Desire Marussi, Stefania Barruscotti, Michele Guida, Vincenzo De Giorgi, Marcella Occelli, Federica Grosso, Giuseppe Cairo, Alessandro Gatti, Daniela Massa, Laura Atzori, Nicola Calvani, Tommaso Fabrizio, Giuseppe Mastrangelo, Federica Toffolutti, Egidio Celentano, Mario Budroni, Sara Gandini, Carlo Riccardo Rossi, Carlo Riccardo Rossi, Alessandro Testori, Giuseppe Palmieri, Paolo A. Ascierto, the Clinical National Melanoma Registry Study Group at the Italian Melanoma Intergroup, Maddalena Cespa, Rosachiara Forcignanò, Gianmichele Moise, Maria Concetta Fargnoli, Caterina Ferreli, Maria Grimaldi, Guido Zannetti, Saverio Cinieri, Giusto Trevisan, Ignazio Stanganelli, Giovanna Moretti, Francesca Bruder, Luca Bianchi, Maria Teresa Fierro, Luigi Mascheroni, Salvatore Asero, Caterina Catricalà, Stefania Staibano, Gaetana Rinaldi, Riccardo Pellicano, Laura Milesi, Marilena Visini, Franco Di Filippo, Leonardo Zichichi, Maria Antonietta Pizzichetta, Carmelo Iacono, Massimo Guidoboni, Giovanni Sanna, Michele Maio, Lucia Lospalluti, Rosanna Barbati, Leonardi Vita, Annamaria Pollio, Carlo Riberti

“…All types of immunotherapy showed a significant improved survival compared with all other therapies (p=0.001). 75% was the highest reduction of death reached by anti-PD-1 (HR=0.25), globally immunotherapy was significantly associated with improved survival, either for anti-CTLA4 monotherapy or combined with anti-PD-1 (HR=0.47 and 0.26, respectively) and BRAFI+MEKI (HR=0.62).ConclusionsThe nivolumab/pembrolizumab in combination of ipilimumab and the addition of ant-MEK to the BRAFi can be considered the best therapies to improve survival in a real-world-population. The CNMR can complement clinical registries with the intent of improving cancer management and standardizing cancer treatment.…”
Get full text

Evaluation of the Effects of Artificial Light on Some Plant Characteristics in the Design and Construction of a Small-scale Plant Factory by P. Shamsi Roodbarsar, S. R. Mousavi Seyedi, D. Kalantari, K. Ghasemi

“…IntroductionIt is predicted that the world population will grow to 9.3 billion by 2050 and the urban population will increase by 73%, growing from 3.6 billion to 6.3 billion. …”
Get full text

CMOS multimodal sensor based lab-on-a-chip system for personalized bio-imaging diagnosis by Huang, Xiwei

“…The world population is rapidly ageing with proportion of people aged 60-year-old and over, growing faster than any other age groups. …”
Get full text

Improving rice yield (Oryza sativa L.) and selected soil physicochemical properties using organic amendments under water-saving irrigation by Haque, Ahmad Numery Ashfaqul

“…Rice provides calories to more than half of the world's population, but consumes excessive water compared to other staple crops. …”
Get full text

Mass clonal propagation of selected bamboo genotype for construction purposes in Malaysia by Lee, Pay Chiann

“…Malaysia is one of the leading exporters of tropical timber products in the world, to fulfil the market demand for construction materials as world population is expected to reach 9.7 billion in year 2050, natural forest stand will not be sufficient. …”
Get full text

O-17 Are macroeconomic and health expenditure indicators correlated with the capacity for liver transplantation in Latin American Countries? THE ALEH Special Interest Group, intern... by Rodrigo Zapata, Graciela Castro, Josefina Pages, Fernando Cairo, Oscar Imventarza, Alejandra Villamil, Paulo Bittencourt, Leonardo Schiavon, J.R. Alfeu de Medeiros Fleck, Ricardo Villarroel, Oscar Varas, Juan Carlos Restrepo, Adriana Varon, Daniela Hernandez, Pablo Coste, Marcia Samada, Antonio Enamorado, Chong Ricardo, Byron Abad, Alvaro Urzúa, Rodrigo Wolff, Mario Uribe, Regina Ligorrea, Edgard Aguilera, Eira Cerda, Sergio Lopez, Marcos Girala, Martin Padilla, Marlene Perez, Victoria Mainardi, Solange Gerona

“…Introduction: Latin America (LA), is a geographical region with 20 countries homing 652 million people (10% world population), with a huge cultural, economic and developmental diversity. …”
Get full text

Tendência da mortalidade por câncer nas capitais e interior do Brasil entre 1980 e 2006 Tendencia de la mortalidad por cáncer en las capitales e interior de Brasil entre 1980 y 200... by Gulnar Azevedo e Silva, Carmen Justina Gamarra, Vania Reis Girianelli, Joaquim Gonçalves Valente

“…The rates of overall cancer mortality and major types were corrected by proportionally redistributing 50% of ill-defined causes of death and standardizing them by age according to the standard world population. Trend curves for Brazil and its major regions were calculated for state capitals and other municipalities according to sex, and were evaluated by means of simple linear regression. …”
Get full text

A 12-month follow-up of the immune response to SARS-CoV-2 primary vaccination: evidence from a real-world study by Giorgio Fedele, Ilaria Schiavoni, Filippo Trentini, Filippo Trentini, Pasqualina Leone, Eleonora Olivetta, Alessandra Fallucca, Stefano Fiore, Angela Di Martino, Sergio Abrignani, Sergio Abrignani, Vincenzo Baldo, Tatjana Baldovin, Alessandra Bandera, Alessandra Bandera, Pierangelo Clerici, Massimo De Paschale, Fabiana Diaco, Alexander Domnich, Francesca Fortunato, Irene Giberti, Andrea Gori, Andrea Gori, Renata Grifantini, Tiziana Lazzarotto, Tiziana Lazzarotto, Vittorio Lodi, Claudio Maria Mastroianni, Rosa Prato, Vincenzo Restivo, Francesco Vitale, Silvio Brusaferro, Stefano Merler, Anna Teresa Palamara, Paola Stefanelli, the Study Group for the Immunological Monitoring post Covid19 vaccination

“…A real-world population-based longitudinal study, aimed at determining the magnitude and duration of immunity induced by different types of vaccines against COVID-19, started in 2021 by enrolling a cohort of 2,497 individuals at time of their first vaccination. …”
Get full text

Transição epidemiológica da mortalidade por doenças circulatórias no Brasil Transición epidemiológica de la mortalidad por enfermedades circulatorias en Brasil Epidemiologic transi... by Antonio de Padua Mansur, Adriano Ibrahim A. Lopes, Desidério Favarato, Solange Desirée Avakian, Luíz Antonio M. César, José Antonio F. Ramires

“…The risk of death was adjusted by direct method by using 1960 world population as the standard population. RESULTS: It was observed that the risk of death from IHD and CVD increased exponentially as age advanced. …”
Get full text

Enzymatic Extraction and Modification, and Frying Stability of Moringa Oleifera Seed Oil. by Mohammed, Abdulkarim Sabo

“…Consumption of edible oils has grown with the increase in world population. The increasing health awareness and consciousness amongst consumers made the food industry more discriminating in the types of oil they use for food applications. …”
Get full text

Plant Biosystems Design Research Roadmap 1.0 by Xiaohan Yang, June I. Medford, Kasey Markel, Patrick M. Shih, Henrique C. De Paoli, Cong T. Trinh, Alistair J. McCormick, Raphael Ployet, Steven G. Hussey, Alexander A. Myburg, Poul Erik Jensen, Md Mahmudul Hassan, Jin Zhang, Wellington Muchero, Udaya C. Kalluri, Hengfu Yin, Renying Zhuo, Paul E. Abraham, Jin-Gui Chen, David J. Weston, Yinong Yang, Degao Liu, Yi Li, Jessy Labbe, Bing Yang, Jun Hyung Lee, Robert W. Cottingham, Stanton Martin, Mengzhu Lu, Timothy J. Tschaplinski, Guoliang Yuan, Haiwei Lu, Priya Ranjan, Julie C. Mitchell, Stan D. Wullschleger, Gerald A. Tuskan

“…Various plants have been genetically improved mostly through breeding, along with limited modification via genetic engineering, yet they are still not able to meet the ever-increasing needs, in terms of both quantity and quality, resulting from the rapid increase in world population and expected standards of living. A step change that may address these challenges would be to expand the potential of plants using biosystems design approaches. …”
Get full text

Efficacy of bendamustine and rituximab in unfit patients with previously untreated chronic lymphocytic leukemia. Indirect comparison with ibrutinib in a real‐world setting. A GIMEM... by Antonio Cuneo, Anthony R. Mato, Gian Matteo Rigolin, Alfonso Piciocchi, Massimo Gentile, Luca Laurenti, John N. Allan, John M. Pagel, Danielle M. Brander, Brian T. Hill, Allison Winter, Nicole Lamanna, Constantine S. Tam, Ryan Jacobs, Frederick Lansigan, Paul M. Barr, Mazyar Shadman, Alan P. Skarbnik, Jeffrey J. Pu, Alison R. Sehgal, Stephen J. Schuster, Nirav N. Shah, Chaitra S. Ujjani, Lindsey Roeker, Ester Maria Orlandi, Atto Billio, Livio Trentin, Martin Spacek, Monia Marchetti, Alessandra Tedeschi, Fiorella Ilariucci, Gianluca Gaidano, Michael Doubek, Lucia Farina, Stefano Molica, Francesco Di Raimondo, Marta Coscia, Francesca Romana Mauro, Javier de la Serna, Angeles Medina Perez, Isacco Ferrarini, Giuseppe Cimino, Maurizio Cavallari, Rosalba Cucci, Marco Vignetti, Robin Foà, Paolo Ghia, the GIMEMA, European Research Initiative (ERIC) on CLL, US study group

“…We arrived at the following conclusions: (a) BR is a relatively effective first‐line regimen in a real‐world population of unfit patients without TP53 disruption, (b) ibrutinib provided longer disease control than BR in patients with advanced disease stage.…”
Get full text

Carcass and meat lamb and kid quality and development of consumer acceptability Calidad de la canal y de la carne ovina y caprina y los gustos de los consumidores Qualidade da carc... by Carlos Sañudo Astiz

“…But, recent changes in consumer attitudes, together with the increment in artificial fibre industries and human world population, some crisis related with the international wool market and some increments in lamb prices, have provoked that lamb meat has increased its relative importance inside the global sheep income. …”
Get full text

Internal fixation implants for intracapsular hip fractures in older adults by Lewis, SR, Macey, R, Eardley, WGP, Dixon, JR, Cook, J, Griffin, XL

“…The increased proportion of older adults in the world population means that the absolute number of hip fractures is rising rapidly across the globe. …”

Analyzing social support regarding the lived experience of mothers with autistic children by Somayeh Shafiei, Maryam Shafiei

“…According to the US Centre for Disease Control and Prevention, one percent of the world's population has autism spectrum disorder. Based on this, it seems that the issue of mothering children with special needs should be studied to introduce their challenges and problems as well as opportunities. …”
Get full text