Abundance profiling of specific gene groups using precomputed gut metagenomes yields novel biological hypotheses. by Konstantin Yarygin, Alexander Tyakht, Andrey Larin, Elena Kostryukova, Sergei Kolchenko, Vilgelm Bitner, Dmitry Alexeev

“…Profiling of the genes belonging to crAssphage showed that its abundance varied across the world populations and was not associated with clinical status. …”
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Large-scale real-world data analysis identifies comorbidity patterns in schizophrenia by Chenyue Lu, Di Jin, Nathan Palmer, Kathe Fox, Isaac S. Kohane, Jordan W. Smoller, Kun-Hsing Yu

“…However, its comorbidity patterns have not been systematically characterized in real-world populations. To address this gap, we conducted an observational study using a cohort of 86 million patients in a nationwide health insurance dataset. …”
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Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations by Omberg Larsson, Salit Jacqueline, Hackett Neil, Fuller Jennifer, Matthew Rebecca, Chouchane Lotfi, Rodriguez-Flores Juan L, Bustamante Carlos, Crystal Ronald G, Mezey Jason G

“…</p> <p>Conclusions</p> <p>By simultaneously using the 55 world populations from the Human Genome Diversity Panel, SupportMix was able to extract the fine-scale ancestry of the Qatar population, providing many new observations concerning the ancestry of the region. …”
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Tracking invasion histories in the sea: facing complex scenarios using multilocus data. by Marc Rius, Xavier Turon, Víctor Ordóñez, Marta Pascual

“…We revealed the most likely invasion history for world populations of M. squamiger, which is broadly characterized by the presence of multiple ancestral sources and non-independent introductions within the introduced range. …”
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Characterization of the relationship between APOBEC3B deletion and ACE Alu insertion. by Kang Wang, Yuanyuan Li, Chunyan Dai, Kaishi Wang, Jinghua Yu, Yiran Tan, Wenyan Zhang, Xiao-Fang Yu

“…APOBEC3B (A3B), a member of the cytidine deaminase family APOBEC3s, also exhibits a variable gene insertion/deletion polymorphism across world populations. Using data available from published reports, we examined the global geographic distribution of ACE and A3B genotypes. …”
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VARIASI DELESI 30 bp GEN LMP1 C-TERMINUS EBV PADA PENDERITA KARSINOMA NASOFARING by , dr. Nur Signa Aini Gumilas, , Prof. dr. Sofia Mubarika Haryana, M.Med.Sc., Ph.D

“…Epstein-Barr Virus (EBV) is one of the causes of nasopharyngeal carcinoma (NPC), which more than 90% the world populations are infected with EBV. LMP1 expression caused by EBV infection, in which LMP1 is oncogenic, because it can cause the transformation of normal cells to become cancerous. …”

Iron controls the adaptive immune response by Frost, J

“…Overall, these findings reveal an unexpected sensitivity of adaptive immunity to serum iron availability and may have implications for control of infections and vaccination programmes in developing-world populations where iron deficiency is highly prevalent and the infectious burden is considerable.…”

<i>HR</i> Gene Variants Identified in Mexican Patients with Alopecia Areata by Andrés Ortiz-Ramírez, María Cristina Hernández-Jiménez, Iliana Berenice Guardiola-Avila, Erick de Jesús De Luna-Santillana, Amanda Alejandra Oliva-Hernández, María Lourdes Altamirano-García, Karina Janett Juárez-Rendón

“…(Gln250Gln) and c.3215T > A (Val1072AGlu) have not been described in other world populations. Both non-synonymous variants proved to be significant (<i>p</i> ≤ 0.05). …”
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The Footprint of Type 1 Diabetes on Red Blood Cells: A Metabolomic and Lipidomic Study by José Raul Herance, Andreea Ciudin, Rubén Lamas-Domingo, Carolina Aparicio-Gómez, Cristina Hernández, Rafael Simó, Martina Palomino-Schätzlein

“…The prevalence of diabetes type 1 (T1D) in the world populations is continuously growing. Although treatment methods are improving, the diagnostic is still symptom-based and sometimes far after onset of the disease. …”
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Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution by Juyong Brian Kim, Mary Prunicki, Francois Haddad, Christopher Dant, Vanitha Sampath, Rushali Patel, Eric Smith, Cezmi Akdis, John Balmes, Michael P. Snyder, Joseph C. Wu, Kari C. Nadeau

“…This serious and growing health threat is attributed to increasing urbanization of the world's populations with consequent exposure to polluted air. …”
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Gene of folate cycle MTHFR and nutrition by K. D. Ievleva, T. A. Bairova, O. V. Kalyuzhnaya, O. A. Pervushina, L. V. Rychkova, L. I. Kolesnikova, S. I. Kolesnikov

“…But a few studies are about causes of prevalence differences of gene polymorphisms of folate cycle in the world's populations. The main objective was to explore 677C>T mutation MTHFR gene among Russian and Buryat to compare it with ones in other populations. …”
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Irritable bowel syndrome dietary modifications - what to forbid and what to recommend? by Agnieszka Kaczyńska, Małgorzata Wieteska, Paweł Stanicki, Julita Szarpak

“…<p><span>Irritable bowel syndrom is a gastrointestinal disorder, that affects about 10 % of worlds population. The etiology remains unclear, however studies show, that bad dietary habits may aggravate the symptoms. …”
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Relevance of <i>CYP2D6</i> Gene Variants in Population Genetic Differentiation by Anita Stojanović Marković, Matea Zajc Petranović, Tatjana Škarić-Jurić, Željka Celinšćak, Maja Šetinc, Željka Tomas, Marijana Peričić Salihović

“…Linkage disequilibrium showed that all African populations have three or more haplotype blocks within the <i>CYP2D6</i> gene, while other world populations have one, except for Chinese Dai and Punjabi in Pakistan populations, which have two.…”
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Regulatory variants of APOBEC3 genes potentially associate with COVID-19 severity in populations with African ancestry by Ke Zhang, Fang Chen, Hu-Yan Shen, Ping-Ping Zhang, Han Gao, Hong Peng, Yu-Si Luo, Zhong-Shan Cheng

“…Abstract Since November 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused the worldwide pandemic of the coronavirus disease 2019 (COVID-19), the impact of which is huge to the lives of world populations. Many studies suggested that such situation will continue due to the endless mutations in SARS-CoV-2 genome that result in complexity of the efforts for the control of SARS-CoV-2, since the special enrichment of nucleotide substitution C>U in SARS-CoV-2 sequences were discovered mainly due to the editing by human host factors APOBEC3 genes. …”
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Physiologically based toxicokinetic modelling of Tri(2-chloroethyl) phosphate (TCEP) in mice accounting for multiple exposure routes by Jiaqi Ding, Wanyu He, Wanxiao Sha, Guoqiang Shan, Lingyan Zhu, Lin Zhu, Jianfeng Feng

“…We performed a health risk assessment for world populations based on human PBTK model. The risk of TCEP in dust is greater through mouth than through skin. …”
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Allele Frequencies of Apolipoprotein E in a South Western Nigerian population on HAART by Olabisi Titilayo BAMIDELE, Olatunde Olayanju, Martin Ehizode Emuze, Joel Olufunminiyi Akande, Nonso Nduka, Bola Joyce Eseile, Olanrewaju Olasehinde, Modupe Akinrele Kuti

“…Conclusions: Allelic frequency seen is similar to that described in other studied populations and the frequency of genotypes observed was also similar to those described among world populations with a higher observation of ApoE4 allele as seen in people of African descent. …”
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The First Chemically-Synthesised, Highly Immunogenic Anti-SARS-CoV-2 Peptides in DNA Genotyped Aotus Monkeys for Human Use by Manuel E. Patarroyo, Manuel E. Patarroyo, Manuel A. Patarroyo, Martha P. Alba, Laura Pabon, María T. Rugeles, Wbeimar Aguilar-Jimenez, Lizdany Florez, Adriana Bermudez, Ashok K. Rout, Christian Griesinger, Carlos F. Suarez, Jorge Aza-Conde, César Reyes, Catalina Avendaño, Catalina Avendaño, Jhoan Samacá, Anny Camargo, Yolanda Silva, Martha Forero, Edgardo Gonzalez

“…Peptides were analysed with serum samples from patients suffering mild or severe SARS-CoV-2 infection, thereby increasing chemically-synthesised peptides’ potential coverage for the world populations up to 62.9%. These peptides’ 3D structural analysis (by 1H-NMR acquired at 600 to 900 MHz) suggested structural-functional immunological association. …”
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How Genetics Might Explain the Unusual Link Between Malaria and COVID-19 by Marta Rusmini, Marta Rusmini, Paolo Uva, Paolo Uva, Antonio Amoroso, Manlio Tolomeo, Andrea Cavalli, Andrea Cavalli

“…To verify this scientific hypothesis, we here use public data from whole-genome sequencing (WGS) experiments to extrapolate the genetic information of 46 world populations with matched COVID-19 data. In particular, we focus on 47 genes, including ACE2 and genes which have previously been reported to play a role in malaria. …”
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Contemporary HCV pangenotypic DAA treatment protocols are exclusionary to real world HIV-HCV co-infected patients by A. Maughan, K. Sadigh, V. Angulo-Diaz, C. Mandimika, M. Villanueva, J. K. Lim, O. Ogbuagu

“…However, there is some concern that stringent inclusion and exclusion criteria in the trials may lead to results that are not achievable in real-world populations. Methods Our study evaluated a real-world HIV-HCV coinfected population and compared them to the eligibility criteria for trials of two of the most recent approved HCV agents; sofosbuvir/velpatasvir and glecaprevir/pibrentasvir. …”
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Real-World Analysis of Durvalumab after Chemoradiation in Stage III Non-Small-Cell Lung Cancer by Beatrice T. B. Preti, Michael S. Sanatani, Daniel Breadner, Suganija Lakkunarajah, Carolyn Scott, Caroline Esmonde-White, Eric McArthur, George Rodrigues, Mitali Chaudhary, Adam Mutsaers, Robin Sachdeva, Mark D. Vincent

“…However, carefully selected clinical trial populations can differ significantly from real-world populations, which can have implications on treatment toxicities and outcomes, making it difficult to accurately counsel patients. …”
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