An Epidemiological Study of Thiopurinemethyltransferase Variants in a Croatian Inflammatory Bowel Disease Patient Cohort by Agata Ladić, Nada Božina, Vladimir Borzan, Marko Brinar, Boris Vucelić, Silvija Čuković-Čavka

“…Our aim was to investigate the frequencies of variant alleles, i.e. genotypes in inflammatory bowel disease (IBD) patients and healthy individuals and to compare these frequencies with selected world populations. The most common variant alleles TPMT*2, TPMT*3A, TPMT*3B and TPMT*3C were analyzed with polymerase chain reactionbased assays and allele-specific polymerase chain reaction-based assays in 685 participants including 459 IBD patients and 226 healthy volunteers. …”
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Mapping the use of Group-Based Trajectory Modelling in medication adherence research: A scoping review protocol [version 2; peer review: 3 approved] by Caroline A. Walsh, Sara Mucherino, Valentina Orlando, Kathleen E. Bennett, Enrica Menditto, Caitriona Cahir

“…Researchers are adopting enhanced methods to analyse and visualise dynamic behaviours, such as medication adherence, within ‘real-world’ populations. Application of GBTM based on longitudinal adherence behaviour allows for the identification of adherence trajectories or groups.  …”
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Thromboembolic Events in Users of Warfarin Treated with Different Skeletal Muscle Relaxants by Charles E. Leonard, Colleen M. Brensinger, Warren B. Bilker, Samantha E. Soprano, Neil Dhopeshwarkar, Todd E. H. Hecht, Scott E. Kasner, Edith A. Nutescu, Anne Holbrook, Matthew Carr, Darren M. Ashcroft, Cheng Chen, Sean Hennessy

“…Despite international calls to minimize patient harm arising from anticoagulant drug interactions, scant data exist on clinical outcomes in real-world populations. We examined effects of concomitant use of warfarin and individual muscle relaxants on rates of hospitalization for thromboembolism among economically disadvantaged persons. …”
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Evaluating Prognostic Bias of Critical Illness Severity Scores Based on Age, Sex, and Primary Language in the United States: A Retrospective Multicenter Study by Xiaoli Liu, PhD, Max Shen, MD, Margaret Lie, MD, Zhongheng Zhang, MD, Chao Liu, MD, Deyu Li, PhD, Roger G. Mark, PhD, Zhengbo Zhang, PhD, Leo Anthony Celi, MD

“…Caution must be taken when using them for quality benchmarking and decision-making among diverse real-world populations.…”
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Analysis of disease comorbidity patterns in a large-scale China population by Mengfei Guo, Yanan Yu, Tiancai Wen, Xiaoping Zhang, Baoyan Liu, Jin Zhang, Runshun Zhang, Yanning Zhang, Xuezhong Zhou

“…Conclusions Our study indicates that disease comorbidity is significant and valuable to understand the disease incidences and their interactions in real-world populations, which will provide important insights for detection of the patterns of disease classification, diagnosis and prognosis.…”
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Mapping the use of Group-Based Trajectory Modelling in medication adherence research: A scoping review protocol [version 1; peer review: 3 approved] by Caroline A. Walsh, Sara Mucherino, Valentina Orlando, Kathleen E. Bennett, Enrica Menditto, Caitriona Cahir

“…Researchers are adopting enhanced methods to analyse and visualise dynamic behaviours, such as medication adherence, within ‘real-world’ populations. Application of GBTM based on longitudinal adherence behaviour allows for the identification of adherence trajectories or groups.  …”
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Strengthening user authentication for better protection of mobile application systems by Mohamed, Kartini, A. Jabar, Marzanah, Ishak, Iskandar, Salimin, Norahana, Salleh, Nor Safwan Amirul, Hamzah, Abdul Qaiyum, Jarno, Ahmad Dahari, Pauzi, Muhamad Faeez

“…This also means 97% of the human world populations are actually mobile phone users. Besides, more than 50% of the mobile phone users are using smarts phones which are capable of downloading a lot of mobile application systems (apps). …”
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Polymorphism of lipid exchange genes in some populations of South and East Siberia by L. E. Tabikhanova, L. P. Osipova, E. N. Voronina, A. O. Bragin, M. L. Filipenko

“…The objective of the presented study was to investigate the allele frequencies of lipid metabolism genes in indigenous populations of Siberia to identify the ethnic features of allele frequency distribution for polymorphic variants in genes CETP (G1264A, rs5882), LPL (C1791G, rs328) and FTO (C83401A, rs8050136) in the samples taken from Buryats, Teleuts and Russians of Eastern Siberia, and to compare them with data on world populations. Samples of the Eastern (N = 132) and Western (N = 278) Buryats, Teleuts (N = 120), Russians (N = 122) and persons of mixed Buryat-Russian origin (N = 56) were genotyped by real-time PCR using competitive TaqMan-probes. …”
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Association of Helicobacter Pylori Infection with Anemia: A Retrospective Study by Misbah Vaqar Patoli, Fasiha Sohail, Muhammad Fahad Zakir, Arfeen Azam Khan, Daara Jamali, Arzu Jadoon Khan

“…Background: Helicobacter pylori (Hpylori) infection affects around half of the worlds’ population. Anemia is considered a complication of Hpylori infection. …”
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The complete genome sequence BK polyomavirus study in kidney transplanted patients by Manoochehr Makvandi, Gholam Abbas Kaydani, Heshmatollah Shahbazian, Alireza Teimoori, Fakher Rahim, Sajjad Aslani

“…This virus has spread worldwide and up to 82% of the world populations are serologically positive. BK polyomavirus usually transmits through inhalation or fecal-oral way in childhood, as well as is likely to cause an asymptomatic disease. …”
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A new 500 kb haplotype associated with high CD8+ T-lymphocyte numbers predicts a less severe expression of hereditary hemochromatosis by Mascarenhas Cláudia, Krikler Samuel H, Whittington Chris, Cruz Eugénia, Lacerda Rosa, Vieira Jorge, Porto Graça

“…</p> <p>Conclusion</p> <p>These results may have important implications not only for approaching the question of the penetrance of the hemochromatosis gene in different world populations but also to further narrow the region of interest to find a candidate gene involved in the setting of CD8+ T-lymphocyte numbers in humans.…”
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Effectiveness of flour fortification with iron on anemia and iron deficiency: a systematic review by Jila Sadighi, Katayoun Jahangiri, Azita Goshtasebi, Rahele Rostami

“…Objective: Anemia is the most common health problem, which affects a considerable number of world populations. Iron deficiency is responsible for more than 50% of all cases of anemia. …”
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Gluten Degrading Enzymes for Treatment of Celiac Disease by Guoxian Wei, Eva J. Helmerhorst, Ghassan Darwish, Gabriel Blumenkranz, Detlef Schuppan

“…Celiac disease (CeD) affects about 1% of most world populations. It presents a wide spectrum of clinical manifestations, ranging from minor symptoms to mild or severe malabsorption, and it may be associated with a wide variety of autoimmune diseases. …”
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Machine learning and atherosclerotic cardiovascular disease risk prediction in a multi-ethnic population by Andrew Ward, Ashish Sarraju, Sukyung Chung, Jiang Li, Robert Harrington, Paul Heidenreich, Latha Palaniappan, David Scheinker, Fatima Rodriguez

“…It is unknown if machine learning (ML) models can improve ASCVD risk prediction across broader diverse, real-world populations. We developed ML models for ASCVD risk prediction for multi-ethnic patients using an electronic health record (EHR) database from Northern California. …”
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Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment. by Frédéric D Chevalier, Winka Le Clec'h, Marina McDew-White, Vinay Menon, Meghan A Guzman, Stephen P Holloway, Xiaohang Cao, Alexander B Taylor, Safari Kinung'hi, Anouk N Gouvras, Bonnie L Webster, Joanne P Webster, Aidan M Emery, David Rollinson, Amadou Garba Djirmay, Khalid M Al Mashikhi, Salem Al Yafae, Mohamed A Idris, Hélène Moné, Gabriel Mouahid, P John Hart, Philip T LoVerde, Timothy J C Anderson

“…Three aspects of the data are of particular interest: (i) segregating OXA-resistance alleles are widespread in Old World populations (4.29-14.91% frequency), despite minimal OXA usage, (ii) two OXA-resistance mutations (p.W120R, p.N171IfsX28) are particularly common (>5%) in East African and Middle-Eastern populations, (iii) the p.E142del allele has identical flanking SNPs in both West Africa and Puerto Rico, suggesting that parasites bearing this allele colonized the New World during the slave trade and therefore predate OXA deployment. …”
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Development and validation of a claims-based measure as an indicator for disease status in patients with multiple sclerosis treated with disease-modifying drugs by Michael Munsell, Molly Frean, Joseph Menzin, Amy L. Phillips

“…Abstract Background Administrative healthcare claims data provide a mechanism for assessing and monitoring multiple sclerosis (MS) disease status across large, clinically representative “real-world” populations. The estimation of MS disease status using administrative claims can be a challenge, however, due to a lack of detailed clinical information. …”
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A Situational Mapping Overview of Training Programmes for Community-Based Rehabilitation Workers in Southern Africa: Strategies for Strengthening Accessible Rural Rehabilitation Pr... by Lieketseng Ned, Ritika Tiwari, Lucia Hess-April, Theresa Lorenzo, Usuf Chikte

“…In 2018, the United Nations global report showed that people with disabilities, who make up 15% of the worlds' population, have poorer health and rehabilitation access (SDG 3). …”
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The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review by Haeusler, I, Chan, X, Guérin, P, White, N

“…While these findings provide further evidence of the rarity of serious cardiovascular events after treatment with these drugs, they also underscore the need for continued strengthening of pharmacovigilance systems for robust detection of rare drug adverse events in real-world populations. A standardised approach to measurement and reporting of ECG data in malaria trials is also needed.…”

Seasonal influenza vaccination policies in the 194 WHO Member States: The evolution of global influenza pandemic preparedness and the challenge of sustaining equitable vaccine acce... by Kathleen F. Morales, David W. Brown, Laure Dumolard, Claudia Steulet, Alba Vilajeliu, Alba Maria Ropero Alvarez, Ann Moen, Martin Friede, Philipp Lambach

“…Low and low-middle income countries, representing 40% of the worlds’ population, accounted for 52/61 (85%) of countries with no evidence of a policy in either year. …”
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Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program by Frank R. Wendt, Gita A. Pathak, Jacqueline Vahey, Xuejun Qin, Dora Koller, Brenda Cabrera-Mendoza, Angela Haeny, Kelly M. Harrington, Nallakkandi Rajeevan, Linh M. Duong, Daniel F. Levey, Flavio De Angelis, Antonella De Lillo, Tim B. Bigdeli, Saiju Pyarajan, VA Million Veteran Program, John Michael Gaziano, Joel Gelernter, Mihaela Aslan, Dawn Provenzale, Drew A. Helmer, Elizabeth R. Hauser, Renato Polimanti, Department of Veteran Affairs Cooperative Study Program (#2006)

“…Results Ancestry groups were defined by (i) HARE (harmonized ancestry and race/ethnicity) and (ii) a random-forest clustering approach using the 1000 Genomes Project and the Human Genome Diversity Project (1kGP + HGDP) reference panels (77 world populations representing six continental groups). …”
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