466 Combined inhibition of KRAS G12C and PD-1 boosts the therapeutic efficacy via conditioning of tumor microenvironment in pre-clinical humanized NSCLC mouse models by Panpan Wang, Jingjing Wang, Yawen Zhang, Xiangnan Qiang, Qingyang Gu, Ting Ni, Tongxin Huo, Huacheng He, Wenting Shi

Development of a DNA-encoded library screening method “DEL Zipper” to empower the study of RNA-targeted chemical matter by Zhongyao Ma, Bin Zou, Jiannan Zhao, Rui Zhang, Qiaoqiao Zhu, Xiaofeng Wang, Linan Xu, Xiang Gao, Xinyue Hu, Wei Feng, Wen Luo, Min Wang, Yunyun He, Zhifeng Yu, Weiren Cui, Qi Zhang, Letian Kuai, Wenji Su

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452 Braicitinib treatment reduced the expansion of CD8+ T cells in C3H mice with skin grafts-induced alopecia areata by Chunhui He, Nan Xie, Ruiqing Yan, Xiangnan Qiang, Hao Yi, Xiao Jian, Yaxin Cai, Yanping Yuan

Assessment of AI-Based Protein Structure Prediction for the NLRP3 Target by Jian Yin, Junkun Lei, Jialin Yu, Weiren Cui, Alexander L. Satz, Yifan Zhou, Hua Feng, Jason Deng, Wenji Su, Letian Kuai

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59 Preclinical platform for nucleic acid drug evaluation: siRNA and mRNA therapeutics by Dong Wang, Xiangnan Qiang, Zhixiang Zhang, Qingyang Gu

1162 Upregulation of metabolism enzymes mediatesADC resistance in a HER2-positive cancer cell line by Dong Wang, Xiangnan Qiang, Zhixiang Zhang, Qingyang Gu

Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection by Rui Ge, Zuyuan Shen, Jian Yin, Wenhua Chen, Qi Zhang, Yulong An, Dewei Tang, Alexander L. Satz, Wenji Su, Letian Kuai

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294 Comparison of preclinical efficacy between CD19 CAR-T and CD3×CD19 bispecific antibody (blinatumomab) by Jun Huang, Ronghua Zhang, Xiangnan Qiang, Zhixiang Zhang, Ting Ni, Chenhui He, Zhifeng Zhao, Jingwei Huang, Xiangyi Wang

446 The administration of JAK and TYK2 inhibitor successfully ameliorated the severity of T cell transfer-induced colitis in mice by Juan Wang, Chunhui He, Nan Xie, Ruiqing Yan, Xiangnan Qiang, Yanping Yuan, Dongye Jia

A new wave of innovations within the DNA damage response by Qi Li, Wenyuan Qian, Yang Zhang, Lihong Hu, Shuhui Chen, Yuanfeng Xia

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Solution-Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering by Ke Li, Xiaohong Liu, Sixiu Liu, Yulong An, Yanfang Shen, Qingxia Sun, Xiaodong Shi, Wenji Su, Weiren Cui, Zhiqiang Duan, Letian Kuai, Hongfang Yang, Alexander L. Satz, Kaixian Chen, Hualiang Jiang, Mingyue Zheng, Xuanjia Peng, Xiaojie Lu

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A Practical and Economical Route to (S)-Glycidyl Pivalate by Jeffrey M. Noble, Le Chang, Dan Chen, Binglin Wang, Raymond N. Dominey, Daniel W. Cook, Justina M. Burns, Rodger W. Stringham, Flavio S. P. Cardoso, David R. Snead

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Anti-hypertensive effect of a novel angiotensin II receptor neprilysin inhibitor (ARNi) -S086 in DSS rat model by Jingchao Sun, Jingchao Sun, Ying Xiao, Wenjie Xu, Wei Xing, Frank Du, Maozhi Tian, Danqi Xu, Yihua Ren, Xin Fang

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Targeting FAK improves the tumor uptake of antibody-drug conjugates to strengthen the anti-cancer responses by Baoyuan Zhang, Zhixiang Zhang, Jiaming Gao, Shiqiang Lu, Ran Pang, Dongfang Li, Xun Huang, Natasha Qin, Leo Liu, Zaiqi Wang

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Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity by Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, Tao Guo, Karen Akinsanya, David Madge, Kristian K. Jensen

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Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation by Rong-Rong Xiao, Lei Jin, Nan Xie, Piaopiao Luo, Wenjie Gao, Pengfei Tu, Xiaoni Ai

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Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi by Zhiwei Kong, Xin Zhang, Feng Zhou, Liu Tang, Yitong Chen, Saijie Li, Xiaokang Zhang, Letian Kuai, Wenji Su, Weiren Cui, Jiaxi Cai, Yuli Wang, Jun Yang, You-Liang Peng, Dongli Wang, Junfeng Liu

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The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection—suramin inhibits EV71 infection in vitro and in vivo by Peijun Ren, Gang Zou, Benjamin Bailly, Shanshan Xu, Mei Zeng, Xinsheng Chen, Liang Shen, Ying Zhang, Patrice Guillon, Fernando Arenzana-Seisdedos, Philippe Buchy, Jian Li, Mark von Itzstein, Qihan Li, Ralf Altmeyer

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Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase... by Yuqin Yao, Zhuowei Liu, Manyu Zhao, Zhengxia Chen, Peng Li, Yang Zhang, Yuxi Wang, Chengjian Zhao, Chaofeng Long, Xiaoxin Chen, Jinliang Yang

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Editorial: The boulder peptide symposium 2021 scientific update by Yvonne Angell, Yvonne Angell, John Mayer, John Mayer, Rebecca Nofsinger, Rebecca Nofsinger, Waleed Danho

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