Chemo‐Selective Single‐Cell Metabolomics Reveals the Spatiotemporal Behavior of Exogenous Pollutants During Xenopus Laevis Embryogenesis by Pengfei Li, Song Gao, Wanting Qu, Ying Li, Zhen Liu

“…Herein, a zero‐sample‐loss micro‐biopsy‐based mass spectrometric platform is presented for quantitative, chemo‐selective, high‐coverage, and minimal‐destructive profiling of development‐associated cis‐diol metabolites, which are critical for signal transduction and epigenome regulation, at both cellular level and tissue level of Xenopus laevis. Using this platform, three extraordinary findings that are otherwise hard to achieve are revealed: 1) there are characteristically different cis‐diol metabolic signatures among oocytes, anterior and posterior part of tailbud‐stage embryos; 2) halogenated cis‐diols heavily accumulate at the posterior part of tailbud‐stage embryos of Xenopus laevis; 3) dimethachlon, a kind of exogenous fungicide that is widely used as pesticide, may be bio‐transformed and accumulated in vertebrate animals in environment. …”
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Abnormal left-right organizer and laterality defects in Xenopus embryos after formin inhibitor SMIFH2 treatment. by Natalia Petri, Rhea Nordbrink, Nikoloz Tsikolia, Stanislav Kremnyov

“…However, it has been argued that prior to emergence of leftward flow an additional mechanism operates during early cleavage stages in Xenopus embryo which is based on cytoskeletal processes. …”
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Tissue-specific expression of carbohydrate sulfotransferases drives keratan sulfate biosynthesis in the notochord and otic vesicles of Xenopus embryos by Yuuri Yasuoka, Yuuri Yasuoka

“…Here, I surveyed developmental expression patterns of genes related to HSKS biosynthesis in Xenopus embryos. Of these genes, the KS chain-synthesizing glycosyltransferase genes, beta-1,3-N-acetylglucosaminyltransferase (b3gnt7) and beta-1,4-galactosyltransferase (b4galt4), are strongly expressed in the notochord and otic vesicles, but also in other tissues. …”
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Adult and embryonic blood and endothelium derive from distinct precursor populations which are differentially programmed by BMP in Xenopus. by Walmsley, M, Ciau-Uitz, A, Patient, R

“…These results indicate that both adult and the anterior component of embryonic blood in Xenopus embryos derive from populations of progenitors that also give rise to endothelial cells. …”

Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development. by Lin, A, Tan, C, Lin, C, Strochlic, L, Huang, Y, Richter, J, Holt, C

“…RESULTS: We show that cytoplasmic polyadenylation is required in Xenopus retinal ganglion cell (RGC) growth cones for translation-dependent, but not translation-independent, chemotropic responses in vitro, and that inhibition of CPE binding through dominant-negative interference severely reduces axon outgrowth in vivo. …”

Evaluation of the developmental toxicity of 2-phenoxyethanol and clove oil anaesthetics using the Frog Embryo Teratogenesis Assay: Xenopus (FETAX) by D. Vrskova, H. Modra

“…The developmental toxicity of two anaesthetics, 2-phenoxyethanol and clove oil, used in aquaculture was evaluated using the Frog Embryo Teratogenesis Assay: Xenopus (FETAX) and the results were compared to outcomes in fish. …”
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Recognition of H2AK119ub plays an important role in RSF1-regulated early Xenopus development by Saeid Mohammad Parast, Deli Yu, Chunxu Chen, Chunxu Chen, Chunxu Chen, Amanda J. Dickinson, Chenbei Chang, Hengbin Wang, Hengbin Wang, Hengbin Wang

“…In addition, similar to knockdown of PRC1 components in Xenopus, the anterior-posterior neural patterning was affected in rsf1 knockdown embryos. …”
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M6A transcriptome-wide map of circRNAs identified in the testis of normal and AZ-treated Xenopus laevis by Xin Zhang, Linlin Sai, Weiliang Zhang, Xingzheng Kan, Qiang Jia, Cunxiang Bo, Wenhui Yin, Hua Shao, Mingming Han, Cheng Peng

“…In this study, we conducted m6A sequencing analysis to explore the m6A transcriptome-wide profile of circRNAs in testis tissues of Xenopus laevis (X. laevis) with and without treatment with 100 µg/L atrazine (AZ). …”
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Tetrabromobisphenol A Disturbs Brain Development in Both Thyroid Hormone-Dependent and -Independent Manners in <i>Xenopus laevis</i> by Mengqi Dong, Yuanyuan Li, Min Zhu, Jinbo Li, Zhanfen Qin

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Functional expression and ligand identification of homo- and heteromeric Drosophila melanogaster CO2 receptors in the Xenopus laevis oocyte system by Paul M. Ziemba, Alina Mueck, Günter Gisselmann, Klemens F. Stoertkuhl

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Physiological Functions of Thiol Peroxidases (Gpx1 and Prdx2) during <i>Xenopus laevis</i> Embryonic Development by Hongchan Lee, Na Young Lee, Youni Kim, Hong-Seok Choi, Tayaba Ismail, Hong-Yeoul Ryu, Dong-Hyung Cho, Zae Young Ryoo, Dong-Seok Lee, Taeg Kyu Kwon, Tae Joo Park, Taejoon Kwon, Hyun-Shik Lee

“…Currently, we investigated the functional roles of Gpx1 and Prdx2 during vertebrate embryogenesis using <i>Xenopus laevis</i> as a vertebrate model. Our investigations revealed the zygotic nature of <i>gpx1</i> having its localization in the eye region of developing embryos, whereas <i>prdx2</i> exhibited a maternal nature and were localized in embryonic ventral blood islands. …”
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Enhanced Loss of Retinoic Acid Network Genes in <i>Xenopus laevis</i> Achieves a Tighter Signal Regulation by Tali Abbou, Liat Bendelac-Kapon, Audeliah Sebag, Abraham Fainsod

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Crosstalk between Thyroid Hormone and Corticosteroid Signaling Targets Cell Proliferation in <i>Xenopus tropicalis</i> Tadpole Liver by Muriel Rigolet, Nicolas Buisine, Marylou Scharwatt, Evelyne Duvernois-Berthet, Daniel R. Buchholz, Laurent M. Sachs

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Injury-induced cooperation of InhibinβA and JunB is essential for cell proliferation in Xenopus tadpole tail regeneration by Makoto Nakamura, Tatsuya Kyoda, Hitoshi Yoshida, Kimiko Takebayashi-Suzuki, Ryota Koike, Eri Takahashi, Yuka Moriyama, Marcin Wlizla, Marko E. Horb, Atsushi Suzuki

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Cinnamic Acid and Caffeic Acid Effects on Gastric Tight Junction Proteins Analyzed in <i>Xenopus laevis</i> Oocytes by Marie-Luise Vollstädt, Laura Stein, Nora Brunner, Salah Amasheh

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Time-resolved quantitative proteomic analysis of the developing Xenopus otic vesicle reveals putative congenital hearing loss candidates by Aparna B. Baxi, Peter Nemes, Sally A. Moody

“…Our findings demonstrate the application of this Xenopus dataset to understanding the dynamic regulation of proteins during otic development and to discovery of additional candidates for human CHL.…”
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Identification of protein phosphatase 4 catalytic subunit as a Wnt promoting factor in pan-cancer and Xenopus early embryogenesis by YiLi Wang, WonHee Han, SeokMin Yun, JinKwan Han

“…Thus, we investigated the potential correlation between PPP4C and biological processes (BPs) and canonical Wnt signaling using pan-cancer analysis and Xenopus laevis (X. laevis) embryo model. Our results indicate that PPP4C is a potential biomarker for specific cancer types due to its high diagnostic accuracy and significant prognostic correlation. …”
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Early life exposure to perfluorooctanesulfonate (PFOS) impacts vital biological processes in Xenopus laevis: Integrated morphometric and transcriptomic analyses by Tayaba Ismail, Hyun-Kyung Lee, Hongchan Lee, Youni Kim, Eunjeong Kim, Jun-Yeong Lee, Kee-Beom Kim, Hong-Yeoul Ryu, Dong-Hyung Cho, Taeg Kyu Kwon, Tae Joo Park, Taejoon Kwon, Hyun-Shik Lee

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The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis. by Taylor, E, Cecillon, S, Bonis, A, Chapman, R, Povirk, L, Lindsay, H

“…Here we demonstrate that in Xenopus laevis egg extracts, the MRN complex is not required for classical DNA-PK-dependent NHEJ. …”

The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation. by Gribble, F, Tucker, S, Ashcroft, F

“…We have examined the mechanism by which nucleotides modulate the tolbutamide block of the beta-cell ATP-sensitive K+ channel (KATP channel), using wild-type and mutant KATP channels heterologously expressed in Xenopus oocytes. This channel is composed of sulphonylurea receptor (SUR1) and pore-forming (Kir6.2) subunits. 2. …”