The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens. by Sanduni V Hapuarachchi, Simon A Cobbold, Sarah H Shafik, Adelaide S M Dennis, Malcolm J McConville, Rowena E Martin, Kiaran Kirk, Adele M Lehane

“…Both compounds were shown to inhibit lactate transport across the parasite plasma membrane, and the transport of lactate by PfFNT expressed in Xenopus laevis oocytes. PfFNT inhibition caused accumulation of lactate in parasitised erythrocytes, and swelling of both the parasite and parasitised erythrocyte. …”
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Dissection of the Ovulatory Process Using ex vivo Approaches by Alexander A. Tokmakov, Vasily E. Stefanov, Ken-Ichi Sato

“…Here, we provide an overview of the major molecular and cytological events of ovulation observed in frogs, primarily in the African clawed frog Xenopus laevis, using mainly ex vivo approaches, with the focus on meiotic oocyte maturation and follicle rupture. …”
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Annexin A3 Regulates Early Blood Vessel Formation. by Stryder M Meadows, Ondine Cleaver

“…Our studies identify Anxa3 as a unique marker of the endothelial and myeloid cell lineages of Xenopus laevis during development. Anxa3 transcripts are also detected in endothelial cells (ECs) of zebrafish and mouse embryos, suggesting an important evolutionary function during formation of blood vessels. …”
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Replication, methylation, and expression of X laevis globin genes injected into fertilized Xenopus eggs. by Williams, J, Bendig, M, Patient, R, Banville, D, Greaves, D, Mahbubani, H

“…In the South African clawed toad, Xenopus laevis, the tadpole alpha-globin gene (alpha T1) and the major adult alpha- and beta-globin genes (alpha 1 and beta 1) are linked in the genome in the order alpha T1-alpha 1-beta 1. …”

Splice-variant- and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potency. by Jones, A, Buckingham, S, Papadaki, M, Yokota, M, Sattelle, B, Matsuda, K, Sattelle, D

“…We show that alternative splicing and RNA editing have a combined influence on the potency of the neurotransmitter GABA, and the editing isoforms detected in vivo span the entire functional range of potencies seen for all possible edit variants expressed in Xenopus laevis oocytes. The extent of RNA editing is developmentally regulated and can also be linked to the choice of alternative exons. …”

Studies on nucleocytoplasmic relationships during differentiation in vertebrates (1961) by Gurdon, J

“…Nuclear transplantation in Xenopus laevis is carried out by a similar method to that of Briggs and King for Rana pipiens. …”

Isolation of nanobodies against Xenopus embryonic antigens using immune and non-immune phage display libraries. by Keiji Itoh, Alice H Reis, Andrew Hayhurst, Sergei Y Sokol

“…The use of Xenopus laevis as a model for vertebrate developmental biology is limited by a lack of antibodies specific for embryonic antigens. …”
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An Inverse Relationship Links Temperature and Substrate Apparent Affinity in the Ion-Coupled Cotransporters rGAT1 and KAAT1 by Antonio Peres, Alessandra Vollero, Eleonora Margheritis, Francesca D'Antoni, Elena Bossi

“…The effects of temperature on the operation of two ion-coupled cotransporters of the SLC6A family, namely rat GAT1 (SLC6A1) and KAAT1 (SLC6A19) from Manduca sexta, have been studied by electrophysiological means in Xenopus laevis oocytes expressing these proteins. The maximal transport-associated current (Imax) and the apparent substrate affinity (K05) were measured. …”
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A dynamical model of oocyte maturation unveils precisely orchestrated meiotic decisions. by Benjamin Pfeuty, Jean-Francois Bodart, Ralf Blossey, Marc Lefranc

“…In this paper, we propose a dynamical model of the molecular network that orchestrates maturation of Xenopus laevis oocytes. Our model reproduces the core features of maturation progression, including the characteristic non-monotonous time course of cyclin-Cdks, and unveils the network design principles underlying a precise sequence of meiotic decisions, as captured by bifurcation and sensitivity analyses. …”
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Low frequency vibrations induce malformations in two aquatic species in a frequency-, waveform-, and direction-specific manner. by Laura N Vandenberg, Claire Stevenson, Michael Levin

“…We investigated the effects of low frequency vibrations on early embryonic development of two aquatic species, Xenopus laevis (frogs) and Danio rerio (zebrafish), specifically focusing on the effects of varying frequencies, waveforms, and applied direction. …”
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Thyroid Hormone Regulation of Adult Intestinal Stem Cell Development: Mechanisms and Evolutionary Conservations by Guihong Sun, Yun-Bo Shi

“…In amphibians such as <i>Xenopus laevis</i>, the process takes place during metamorphosis, which is totally dependent upon T3 and resembles postembryonic development in mammals when T3 levels are also high. …”
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Incomplete posttranslational prohormone modifications in hyperactive neuroendocrine cells by Martens Gerard JM, Strating Jeroen RPM

“…<p>Abstract</p> <p>Background</p> <p>In black-background-adapted <it>Xenopus laevis</it>, the intermediate pituitary melanotrope cells are hyperactive, producing large amounts of their major secretory cargo proopiomelanocortin (POMC, representing ~80% of all newly synthesised proteins), whereas in white-adapted frogs these cells are only basally active. …”
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Zinc protection of fertilized eggs is an ancient feature of sexual reproduction in animals. by Katherine L Wozniak, Rachel E Bainbridge, Dominique W Summerville, Maiwase Tembo, Wesley A Phelps, Monica L Sauer, Bennett W Wisner, Madelyn E Czekalski, Srikavya Pasumarthy, Meghan L Hanson, Melania B Linderman, Catherine H Luu, Madison E Boehm, Steven M Sanders, Katherine M Buckley, Daniel J Bain, Matthew L Nicotra, Miler T Lee, Anne E Carlson

“…Here, we demonstrate that eggs from amphibia and teleost fish also release zinc. Using Xenopus laevis as a model, we document that zinc reversibly blocks fertilization. …”
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Involvement of Histidine Residue His382 in pH Regulation of MCT4 Activity. by Shotaro Sasaki, Masaki Kobayashi, Yuya Futagi, Jiro Ogura, Hiroaki Yamaguchi, Ken Iseki

“…Transport of lactate via MCT4 was measured by using a Xenopus laevis oocyte expression system. MCT4-mediated lactate transport was inhibited by Zn2+ in a pH physiological condition but not in an acidic condition. …”
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Aquaporin expression in the alimentary canal of the honey bee Apis mellifera L. (Hymenoptera: Apidae) and functional characterization of Am_Eglp 1. by Débora Linhares Lino de Souza, Jose Eduardo Serrão, Immo Alex Hansen

“…We performed a functional characterization of Am_Eglp 1 using heterologous expression in Xenopus laevis oocyte followed by water uptake assays. …”
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Mitotic spindle scaling during Xenopus development by kif2a and importin α by Jeremy D Wilbur, Rebecca Heald

“…To identify mechanisms that scale the spindle during Xenopus laevis embryogenesis, we established an in vitro system using cytoplasmic extracts prepared from embryos that recapitulates in vivo spindle size differences between stage 3 (4 cells, 37 µm) and stage 8 (∼4000 cells, 18 µm). …”
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Functional clustering drives encoding improvement in a developing brain network during awake visual learning. by Kaspar Podgorski, Derek Dunfield, Kurt Haas

“…Using two-photon calcium imaging to monitor evoked activity in over 100 neurons simultaneously, we investigate network-level changes in the developing Xenopus laevis tectum during visual training with motion stimuli. …”
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Remodeling of the metabolome during early frog development. by Livia Vastag, Paul Jorgensen, Leonid Peshkin, Ru Wei, Joshua D Rabinowitz, Marc W Kirschner

“…A rapid series of synchronous cell divisions initiates embryogenesis in many animal species, including the frog Xenopus laevis. After many of these cleavage cycles, the nuclear to cytoplasmic ratio increases sufficiently to somehow cause cell cycles to elongate and become asynchronous at the mid-blastula transition (MBT). …”
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Mcm10 self-association is mediated by an N-terminal coiled-coil domain. by Wenyue Du, Ajeetha Josephrajan, Suraj Adhikary, Timothy Bowles, Anja-Katrin Bielinsky, Brandt F Eichman

“…Here, we show that self-association of Xenopus laevis Mcm10 is mediated by a conserved coiled-coil (CC) motif within the N-terminal domain (NTD). …”
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МИТОТИЧЕСКИЙ ЦИКЛ И ЕГО РЕГУЛЯЦИЯ

“…Многие важные данные получены в экспериментах с оплодотворенными ооцитами морского ежа Arbacia punctulata и лягушки Xenopus laevis, а также на клетках млекопитающих in vitro. …”
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