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    IL6R inhibits viability and apoptosis of pancreatic beta-cells in type 2 diabetes mellitus via regulation by miR-22 of the JAK/STAT signaling pathway by Wu X, Yu T, Ji N, Huang Y, Gao L, Shi W, Yan Y, Li H, Ma L, Wu K, Wu Z

    Published 2019-08-01
    “…Xinhua Wu,1 Tao Yu,1 Ning Ji,1 Yujie Huang,1 Lingcheng Gao,1 Wen Shi,1 Yan Yan,1 Hang Li,1 Liming Ma,1 Kede Wu,2 Zhen Wu31Department of Endocrinology, Huaian Hospital of Huaian District, Huaian, Jiangsu 223200, People’s Republic of China; 2Clinical Medicine, Medical College of Yangzhou University, Yangzhou, Jiangsu 225009, People’s Republic of China; 3Electric Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, People’s Republic of ChinaCorrespondence: Xinhua WuDepartment of Endocrinology, Huaian Hospital of Huaian District, 50 Meters North of Huaihe Road, Huaian 223200, People’s Republic of ChinaTel +865 178 593 9208Email wuxh8686@163.comBackground and aim: Type 2 diabetes mellitus (T2DM) is a common disease of harming to people’s health. …”
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    Canagliflozin Attenuates Hepatic Steatosis and Atherosclerosis Progression in Western Diet-Fed ApoE-Knockout Mice by Zuo Q, Zhang G, He L, Ma S, Ma H, Zhai J, Wang Z, Zhang T, Wang Y, Guo Y

    Published 2022-12-01
    “…Qingjuan Zuo,1,2 Guorui Zhang,1,3 Lili He,2 Sai Ma,4 Huijuan Ma,5 Jianlong Zhai,6 Zhongli Wang,7 Tingting Zhang,2 Yan Wang,2 Yifang Guo1,2 1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Department of Geriatric Cardiology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 3Department of Cardiology, the Third Hospital of Shijiazhuang City Affiliated to Hebei Medical University, Shijiazhuang, People’s Republic of China; 4Department of Internal Medicine, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 5Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 6Department of Cardiology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 7Department of Physical Examination Center, Hebei General Hospital, Shijiazhuang, People’s Republic of ChinaCorrespondence: Yifang Guo, Department of Geriatric Cardiology, Hebei General Hospital, No. 348, Heping West Road, Xinhua District, Shijiazhuang, Hebei, 050051, People’s Republic of China, Tel +86-15100189182, Email guoyifang@hotmail.comPurpose: To investigate the effect of canagliflozin (20 mg/kg) on hepatic steatosis and atherosclerosis, and further to explore its possible mechanism.Methods: Blood glucose, blood lipid, oxidative stress response and inflammatory cytokines were examined by intraperitoneal glucose tolerance test and ELISA assay. …”
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