Dietary replacement of inorganic trace minerals with lower levels of organic trace minerals leads to enhanced antioxidant capacity, nutrient digestibility, and reduced fecal minera... by Yunxia Xiong, Bailei Cui, Zhentao He, Shuai Liu, Qiwen Wu, Hongbo Yi, Fei Zhao, Zongyong Jiang, Shenglan Hu, Li Wang

“…This study aimed to investigate the effects of dietary replacement of 100% inorganic trace minerals (ITMs) with 30–60% organic trace minerals (OTMs) on the performance, meat quality, antioxidant capacity, nutrient digestibility, and fecal mineral excretion and to assess whether low-dose OTMs could replace whole ITMs in growing-finishing pigs' diets.MethodsA total of 72 growing-finishing pigs (Duroc × Landrace × Yorkshire) with an initial average body weight of 74.25 ± 0.41 kg were selected and divided into four groups with six replicates per group and three pigs per replicate. …”
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Prolonged warm ischemia time leads to severe renal dysfunction of donation-after-cardiac death kidney grafts by Peter Urbanellis, Laura Mazilescu, Dagmar Kollmann, Ivan Linares-Cervantes, J. Moritz Kaths, Sujani Ganesh, Fabiola Oquendo, Manraj Sharma, Toru Goto, Yuki Noguchi, Rohan John, Ana Konvalinka, Istvan Mucsi, Anand Ghanekar, Darius Bagli, Lisa A. Robinson, Markus Selzner

“…Here, we use a large animal renal transplantation model to study the effects of prolonged WI during procurement on post-transplantation renal function. Kidneys from 30 kg-Yorkshire pigs were procured following increasing WI times of 0 min (Heart-Beating Donor), 30 min, 60 min, 90 min, and 120 min (n = 3–6 per group) to mimic DCD. …”
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Point-of-care creatinine tests to assess kidney function for outpatients requiring contrast-enhanced CT imaging: systematic reviews and economic evaluation by Mark Corbett, Ana Duarte, Alexis Llewellyn, James Altunkaya, Melissa Harden, Martine Harris, Simon Walker, Stephen Palmer, Sofia Dias, Marta Soares

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The Responses of Lactobacillus reuteri LR1 or Antibiotic on Intestinal Barrier Function and Microbiota in the Cecum of Pigs by Bijing Yang, Bijing Yang, Chunyan Liu, Chunyan Liu, Yanna Huang, Qiwen Wu, Yunxia Xiong, Xuefen Yang, Shenglan Hu, Zongyong Jiang, Li Wang, Hongbo Yi

“…A total of 144 weaned pigs (Duroc × Landrace × Yorkshire, 21 days of age) were randomly assigned to the control group (CON, fed with a basal diet), the antibiotic group (AO, fed with basal diet plus 100 mg/kg olaquindox and 75 mg/kg aureomycin), and the L. reuteri group (LR, fed with the basal diet + 5 × 1010 CFU/kg L. reuteri LR1) throughout the 164-d experiment. …”
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Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability by Direnis Erdinc, Alejandro Rodríguez‐Luis, Mahmoud R Fassad, Sarah Mackenzie, Christopher M Watson, Sebastian Valenzuela, Xie Xie, Katja E Menger, Kate Sergeant, Kate Craig, Sila Hopton, Gavin Falkous, Genomics England Research Consortium, Joanna Poulton, Hector Garcia‐Moreno, Paola Giunti, Carlos A deMoura Aschoff, Jonas A Morales Saute, Amelia J Kirby, Camilo Toro, Lynne Wolfe, Danica Novacic, Lior Greenbaum, Aviva Eliyahu, Ortal Barel, Yair Anikster, Robert McFarland, Gráinne S Gorman, Andrew M Schaefer, Claes M Gustafsson, Robert W Taylor, Maria Falkenberg, Thomas J Nicholls

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Dietary butyrate, lauric acid and stearic acid improve gut morphology and epithelial cell turnover in weaned piglets by Xianglin Zeng, Yuan Yang, Junmin Wang, Zhaobin Wang, Jun Li, Yulong Yin, Huansheng Yang

“…Thirty-two weaned piglets (Duroc × Landrace × Yorkshire, BW = 7.81 ± 0.26 kg) were weaned at 21 d and randomly assigned to 1 of 4 experimental treatments: (1) a basal diet (control); (2) control + 0.3% butyrate (BT); (3) control + 0.3% lauric acid (LA); (4) control + 0.3% stearic acid (SA). …”
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Use of generic and condition-specific measures of health-related quality of life in NICE decision-making: a systematic review, statistical modelling and survey by Louise Longworth, Yaling Yang, Tracey Young, Brendan Mulhern, Mónica Hernández Alava, Clara Mukuria, Donna Rowen, Jonathan Tosh, Aki Tsuchiya, Pippa Evans, Anju Devianee Keetharuth, John Brazier

“…Participants: Two representative samples of the UK general population from Yorkshire (n = 600). Interventions: None. Main outcome measures: Comparisons of EQ-5D, SF-6D and HUI3 in four conditions with various generic and condition-specific measures. …”
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Managing with Learning Disability and Diabetes: OK-Diabetes – a case-finding study and feasibility randomised controlled trial by Allan House, Louise Bryant, Amy M Russell, Alexandra Wright-Hughes, Liz Graham, Rebecca Walwyn, Judy M Wright, Claire Hulme, John L O’Dwyer, Gary Latchford, Shaista Meer, Jacqueline C Birtwistle, Alison Stansfield, Ramzi Ajjan, Amanda Farrin

“…Setting: Three cities in West Yorkshire, UK. Participants: In the observational study: adults aged > 18 years with a mild or moderate learning disability, who have type 2 diabetes that is not being treated with insulin and who are living in the community. …”
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Effect of Niacin on Growth Performance, Intestinal Morphology, Mucosal Immunity and Microbiota Composition in Weaned Piglets by Shilong Liu, Xiaoping Zhu, Yueqin Qiu, Li Wang, Xiuguo Shang, Kaiguo Gao, Xuefen Yang, Zongyong Jiang

“…A total of 96 weaned piglets (Duroc × (Landrace × Yorkshire), 21-d old, 6.65 ± 0.02 kg body weight (BW)) were randomly allocated into 3 treatment groups (8 replicate pens per treatment, each pen containing 4 males; <i>n</i> = 32/treatment) for 14 d. …”
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Reduced dietary nitrogen with a high Lys:CP ratio restricted dietary N excretion without negatively affecting weaned piglets by Hongnan Liu, Li Wu, Hui Han, Yuying Li, Lijian Wang, Jie Yin, Wenjun Fan, Miaomiao Bai, Jiming Yao, Xingguo Huang, Tiejun Li

“…Two experiments (45 d each experiment) were performed on weaned piglets (Duroc × Landrace × Yorkshire, 28 d of age) to test this and to determine the optimal lysine to crude protein (Lys:CP) ratio in diet. …”
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The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHO... by Enya Daynes, Molly Baldwin, Neil J. Greening, Thomas Yates, Nicolette C. Bishop, George Mills, Matthew Roberts, Malik Hamrouni, Tatiana Plekhanova, Ioannis Vogiatzis, Carlos Echevarria, Rashmita Nathu, Hamish J. C. McAuley, Lorna Latimer, Jennifer Glennie, Francesca Chambers, Ruth Penfold, Emily Hume, Dimitrios Magaritis, Charikleia Alexiou, Sebastian Potthoff, Mitchell James Hogg, Catherine Haighton, Bethany Nichol, Olivia C. Leavy, Matthew Richardson, Omer Elneima, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Claire M. Nolan, Charlotte Bolton, Linzy Houchen-Wolloff, Ewen M. Harrison, Nazir Lone, Jennifer Quint, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Ramen, Louise V. Wain, Christopher Brightling, William D.-C. Man, Rachael Evans, Sally J. Singh

“…Ethics and dissemination Ethical approval was gained as part of the PHOSP-COVID study by Yorkshire and the Humber Leeds West Research NHS Ethics Committee, and the study was prospectively registered on the ISRCTN trial registry (ISRCTN13293865). …”
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The clinical effectiveness and cost-effectiveness of low-intensity psychological interventions for the secondary prevention of relapse after depression: a systematic review by M Rodgers, M Asaria, S Walker, D McMillan, M Lucock, M Harden, S Palmer, A Eastwood

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Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospectiv... by Richard Skone, Daniel White, Bethan Phillips, Jennifer Evans, Robert Andrews, Benjamin Saunders, Kerry Hood, Mallinath Chakraborty, Sarah Edkins, Barbara Paquete, Sian Foulkes, Anna Barrow, Siske Struik, Valerie O'Donnell, Sara Ali, Patrícia R S Rodrigues, Angela Strang, Summia Zaher, Simran Sharma, Luke C Davies, Linda Moet, James E McLaren, Gareth L Watson, Peter Ghazal, Edward Parkinson, Sivakumar Oruganti, William John Watkins, Selyf Shapey, Rim al Samsam, Malcolm Gajraj, Michelle Jardine, Jong Eun Song, Lloyd Abood, Sarah Joanne Kotecha, Awen Evans, Iona Buchanan, Susan Bowes, Begum Ali, Maya Gore, Rhian Thomas-Turner, Federico Liberatore, Thomas Woolley

“…This study received approval for deferred consent.Ethics and dissemination The study has received research ethics committee approval from the Yorkshire and Humber Leeds West Research Ethics Committee 2 (reference 20/YH/0214; IRAS reference 250612). …”
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Randomised controlled trial of Antiglucocorticoid augmentation (metyrapone) of antiDepressants in Depression (ADD Study) by I Nicol Ferrier, Ian M Anderson, Jane Barnes, Peter Gallagher, Heinz CR Grunze, Peter M Haddad, Allan O House, Tom Hughes, Adrian J Lloyd, Chrysovalanto Mamasoula, Elaine McColl, Simon Pearce, Najma Siddiqi, Baxi Sinha, Chris Speed, Nick Steen, June Wainwright, Stuart Watson, Fiona H Winter, R Hamish McAllister-Williams, the ADD Study Team

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The PMIP4 contribution to CMIP6 – Part 2: Two interglacials, scientific objective and experimental design for Holocene and Last Interglacial simulations by B. L. Otto-Bliesner, P. Braconnot, S. P. Harrison, D. J. Lunt, A. Abe-Ouchi, A. Abe-Ouchi, S. Albani, P. J. Bartlein, E. Capron, E. Capron, A. E. Carlson, A. Dutton, H. Fischer, H. Goelzer, H. Goelzer, A. Govin, A. Haywood, F. Joos, A. N. LeGrande, W. H. Lipscomb, G. Lohmann, N. Mahowald, C. Nehrbass-Ahles, F. S. R. Pausata, J.-Y. Peterschmitt, S. J. Phipps, H. Renssen, H. Renssen, Q. Zhang

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Identification of gut microbes associated with feed efficiency by daily-phase feeding strategy in growing-finishing pigs by Qin Jiang, Chunlin Xie, Lingli Chen, Hongli Xiao, Zhilian Xie, Xiaoyan Zhu, Libao Ma, Xianghua Yan

“…A total of 204 Landrace × Yorkshire pigs (75 d) were randomly assigned into 2 treatments. …”
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Effects of Different Supplemental Levels of Eucommia ulmoides Leaf Extract in the Diet on Carcass Traits and Lipid Metabolism in Growing–Finishing Pigs by Yuhuan Yang, Fengna Li, Fengna Li, Qiuping Guo, Wenlong Wang, Lingyu Zhang, Lingyu Zhang, Yunju Yin, Saiming Gong, Mengmeng Han, Mengmeng Han, Yulong Yin

“…A total of 144 crossbred (Duroc × Landrace × Yorkshire) piglets with an average initial weight of 10.11 ± 0.03 kg were randomly allotted to four treatment groups, each with six replicates and six piglets per replicate. …”
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Robotic-assisted surgery compared with laparoscopic resection surgery for rectal cancer: the ROLARR RCT by David Jayne, Alessio Pigazzi, Helen Marshall, Julie Croft, Neil Corrigan, Joanne Copeland, Philip Quirke, Nicholas West, Richard Edlin, Claire Hulme, Julia Brown

“…Philip Quirke and Nicholas West were supported by Yorkshire Cancer Research Campaign and the MRC Bioinformatics initiative. …”
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A framework and toolkit of interventions to enhance reflective learning among health-care professionals: the PEARL mixed-methods study by Julian Bion, Olivia Brookes, Celia Brown, Carolyn Tarrant, Julian Archer, Duncan Buckley, Lisa-Marie Buckley, Ian Clement, Felicity Evison, Fang Gao Smith, Chris Gibbins, Emma-Jo Hayton, Jennifer Jones, Richard Lilford, Randeep Mullhi, Greg Packer, Gavin D Perkins, Jonathan Shelton, Catherine Snelson, Paul Sullivan, Ivo Vlaev, Daniel Wolstenholme, Stephen Wright, the PEARL collaboration

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Information Literacy Skills: Teacher and Student Viewpoints by Julie Stephens

“…Setting – Ripon Grammar School, Yorkshire, United Kingdom (high school/co-educational). …”
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