A protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients – ZAP2 by Dawn Aitken, Laura L. Laslett, Guoqi Cai, Catherine Hill, Lyn March, Anita E. Wluka, Yuanyuan Wang, Leigh Blizzard, Flavia Cicuttini, Graeme Jones

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AP2σ mutations impair calcium-sensing receptor trafficking and signaling, and reveal an endosomal pathway that spatially-directs G-protein selectivity by Gorvin, C, Rogers, A, Hastoy, B, Tarasov, A, Frost, M, Sposini, S, Inoue, A, Whyte, M, Rorsman, O, Hanyaloglu, A, Breitwieser, G, Thakker, R

Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2 by Hannan, FM, Stevenson, M, Bayliss, AL, Stokes, VJ, Stewart, M, Kooblall, KG, Gorvin, CM, Codner, G, Teboul, L, Wells, S, Thakker, RV