Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins by Elisabeth Braun, Dominik Hotter, Lennart Koepke, Fabian Zech, Rüdiger Groß, Konstantin M.J. Sparrer, Janis A. Müller, Christian K. Pfaller, Elena Heusinger, Rebecka Wombacher, Kathrin Sutter, Ulf Dittmer, Michael Winkler, Graham Simmons, Martin R. Jakobsen, Karl-Klaus Conzelmann, Stefan Pöhlmann, Jan Münch, Oliver T. Fackler, Frank Kirchhoff, Daniel Sauter

“…Keywords: GBPs, restriction factor, furin, HIV, influenza A virus, measles virus, Zika virus, viral envelope proteins…”
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The Antiviral Effect of Novel Steroidal Derivatives on Flaviviruses by Luping Zhang, Luping Zhang, Luping Zhang, Dengyuan Zhou, Dengyuan Zhou, Dengyuan Zhou, Qiuyan Li, Qiuyan Li, Qiuyan Li, Shuo Zhu, Shuo Zhu, Shuo Zhu, Muhammad Imran, Muhammad Imran, Muhammad Imran, Hongyu Duan, Hongyu Duan, Hongyu Duan, Shengbo Cao, Shengbo Cao, Shengbo Cao, Shaoyong Ke, Jing Ye, Jing Ye, Jing Ye

“…In the present study, the antiviral effect of steroidal dehydroepiandrosterone (DHEA) and 23 synthetic derivatives against flaviviruses such as Japanese encephalitis virus (JEV), Zika virus (ZIKV), and Dengue virus (DENV) were appraised by examining the characteristics of virus infection both in vitro and in vivo. …”
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Mutations in the Methyltransferase Motifs of L Protein Attenuate Newcastle Disease Virus by Regulating Viral Translation and Cell-to-Cell Spread by Xiao Li, Lu Sun, Jing Zhao, Kaihang Tu, Jia Xue, Xin Guo, Guozhong Zhang

“…In addition to the (G)-G-G-D and K-D-K-E motifs of many nonsegmented, negative-stranded RNA viruses, similar motifs have been found in dengue virus, Zika virus, Japanese encephalitis virus (JEV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). …”
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Prevalence of arboviruses and other infectious causes of skin rash in patients treated at a tertiary health unit in the Brazilian Amazon by Luiz Henrique Gonçalves Maciel, Cosmo Vieira da Rocha Neto, Yasmin Ferreira Martins, Francielen de Azevedo Furtado, Pâmela Cunha Teixeira, Maianne Yasmin Oliveira Dias, Yanka Karolinna Batista Rodrigues, Isa Cristina Ribeiro Piauilino, Sérgio Damasceno Pinto, Aline Cristiane Côrte Alencar, João Bosco de Lima Gimaque, Maria Paula Gomes Mourão, Marcus Vinicius Guimarães Lacerda, Márcia da Costa Castilho, Camila Bôtto-Menezes

“…Individuals of either gender, aged over 18 years, were invited to participate voluntarily. Infection by Zika virus (ZIKV), dengue virus (DENV), chikungunya virus (CHIKV), Mayaro virus (MAYV), Oropouche virus (OROV) and measles was evaluated using RT-qPCR (real-time polymerase chain reaction). …”
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Development of a PROTAC-Based Targeting Strategy Provides a Mechanistically Unique Mode of Anti-Cytomegalovirus Activity by Friedrich Hahn, Stuart T. Hamilton, Christina Wangen, Markus Wild, Jintawee Kicuntod, Nadine Brückner, Jasmine E. L. Follett, Lars Herrmann, Ahmed Kheimar, Benedikt B. Kaufer, William D. Rawlinson, Svetlana B. Tsogoeva, Manfred Marschall

“…In addition, further antiviral activities were demonstrated, such as the inhibition of SARS-CoV-2 replication, whereas other investigated human viruses (i.e., varicella zoster virus, adenovirus type 2, and Zika virus) were found insensitive. Combined, the antiviral quality of this approach is seen in its (i) mechanistic uniqueness; (ii) future options of combinatorial drug treatment; (iii) potential broad-spectrum activity; and (iv) applicability in clinically relevant antiviral models. …”
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Bidirectional Interactions between Arboviruses and the Bacterial and Viral Microbiota in Aedes aegypti and Culex quinquefasciatus by Chenyan Shi, Leen Beller, Lanjiao Wang, Ana Rosales Rosas, Lander De Coninck, Lyza Héry, Laurence Mousson, Nonito Pagès, Jeroen Raes, Leen Delang, Anubis Vega-Rúa, Anna-bella Failloux, Jelle Matthijnssens

“…In this study, we compared the bacteriome and virome (both eukaryotic viruses and bacteriophages) of female adult Aedes aegypti and Culex quinquefasciatus mosquitoes fed with sucrose/water, blood, or blood spiked with Zika virus (ZIKV) or West Nile virus (WNV), respectively. …”
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High Seroprevalence of IgG Antibodies to Multiple Arboviruses in People Living with HIV (PLWHIV) in Madagascar by Fetra Angelot Rakotomalala, Julie Bouillin, Santatriniaina Dauphin Randriarimanana, Guillaume Thaurignac, Luca Maharavo, Mihaja Raberahona, Lucien Razafindrakoto, Jasmina Rasoanarivo, Mala Rakoto-Andrianarivelo, Danielle Aurore Doll Rakoto, François Xavier Babin, Tahinamandranto Rasamoelina, Eric Delaporte, Luc Hervé Samison, Martine Peeters, Eric Nerrienet, Ahidjo Ayouba

“…We used a Luminex-based serological assay to detect IgG antibodies against antigens from Dengue virus serotypes 1–4 (DENV1–4), Zika virus (ZIKV), West Nile virus (WNV), Usutu virus (USUV), Chikungunya virus (CHIKV), and O’nyong nyong virus (ONNV). …”
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New Antibacterial Peptides from the Freshwater Mollusk <i>Pomacea poeyana</i> (Pilsbry, 1927) by Melaine González García, Armando Rodríguez, Annia Alba, Antonio A. Vázquez, Fidel E. Morales Vicente, Julio Pérez-Erviti, Barbara Spellerberg, Steffen Stenger, Mark Grieshober, Carina Conzelmann, Jan Münch, Heinz Raber, Dennis Kubiczek, Frank Rosenau, Sebastian Wiese, Ludger Ständker, Anselmo Otero-González

“…Pom-1 moderately inhibits Zika Virus infection but slightly enhances HIV-1 infectivion in vitro. …”
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PREVALÊNCIA DE INFECÇÕES CONGÊNITAS EM RECÉM-NASCIDOS PREMATUROS INTERNADOS EM UNIDADE DE TERAPIA INTENSIVA NEONATAL by Fernanda Prohmann Villas Boas, Matheus Gomes Reis Costa, Raquel Moreira Borges, Camilla da Cruz Martins, Giovanna Oliveira Stopa, Tatiana de Oliveira Vieira, Graciete Oliveira Vieira, Heli Vieira Brandão

“…Resultados: Dos 156 binômios mãe-filho, 41 (26,3%) mães apresentaram infecções durante o período gestacional e dentre elas, 11 (26,82%) RNs apresentaram infecção congênita do grupo TORCHS, sendo toxoplasmose 45,5% (n = 5), sífilis 27,27% (n = 3), zika vírus 9,09% (n = 1), co-infecção de sífilis/toxoplasmose 9,09% (n = 1), co-infecção toxoplasmose/citomegalovírus 9,09% (n = 1). …”
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Impact of deltamethrin-resistance in Aedes albopictus on its fitness cost and vector competence. by Jielin Deng, Yijia Guo, Xinghua Su, Shuang Liu, Wenqiang Yang, Yang Wu, Kun Wu, Guiyun Yan, Xiao-Guang Chen

“…<h4>Background</h4>Aedes albopictus is one of the most invasive species in the world as well as the important vector for mosquito-borne diseases such as dengue fever, chikungunya fever and zika virus disease. Chemical control of mosquitoes is an effective method to control mosquito-borne diseases, however, the wide and improper application of insecticides for vector control has led to serious resistance problems. …”
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Contraception and post abortion services: qualitative analysis of users’ perspectives and experiences following Zika epidemic in Honduras by Maria Belizan, Edna Maradiaga, Javier Roberti, Maricela Casco-Aguilar, Alison F. Ortez, Juan C. Avila-Flores, Gloria González, Carolina Bustillo, Alejandra Calderón, Harry Bock, María L. Cafferata, Adriano B. Tavares, Jackeline Alger, Moazzam Ali

“…Abstract Background Zika virus (ZIKV) infection during pregnancy has severe consequences on the new-born. …”
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Integrated Analysis Reveals the Characteristics and Effects of SARS-CoV-2 Maternal–Fetal Transmission by Ziliang Huang, Shuting Xia, Shiqiang Mei, Yanzi Wen, Jialiu Liu, Chengzhi Dong, Wenxin Chen, Peijie Yu, Lianghu Qu, Yanmin Luo, Lingling Zheng

“…Our results showed that the abundance of cytomegalovirus (CMV) and Zika virus (ZIKV) infection-associated factors in the placenta were higher than their primarily infected tissues, while the expression levels of SARS-CoV-2 binding receptor angiotensin-converting enzyme II (ACE2) were similar between lung and placenta. …”
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INTERVENÇÃO COM VETORES GENETICAMENTE MODIFICADOS: IMPACTO NA DISSEMINAÇÃO DE DENGUE EM UM MUNICÍPIO PAULISTA by Verônica Silva Furlani, Bianca Missio Morgan, João Paulo Galvão Nascimento, Isabelly Costa de Lima, Maria Fernanda Campelo Apolonis, Jean Rodrigo Santos, Márcio Fabrício Falcão de Paula Filho, Emerson Carraro

“…Introdução/objetivo: Arboviroses são enfermidades cujo vetor Aedes aegypti contribui nas epidemias emergentes de dengue, otmailsto e zika vírus. A dengue é sazonal, com pico nos meses de outubro a maio, sendo estratégia epidemiológica o controle do vetor. …”
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Development of a direct reverse-transcription quantitative PCR (dirRT-qPCR) assay for clinical Zika diagnosis by Lang Li, Jian-an He, Wei Wang, Yun Xia, Li Song, Ze-han Chen, Hang-zhi Zuo, Xuan-Ping Tan, Aaron Ho-Pui Ho, Siu-Kai Kong, Jacky Fong-Chuen Loo, Hua-wen Li, Dayong Gu

“…Objective: The nucleic acid-based polymerase chain reaction (PCR) assay is commonly applied to detect infection with Zika virus (ZIKV). However, the time- and labor-intensive sample pretreatment required to remove inhibitors that cause false-negative results in clinical samples is impractical for use in resource-limited areas. …”
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Ex vivo gut cultures of Aedes aegypti are efficiently infected by mosquito-borne alpha- and flaviviruses by Ana Lucia Rosales Rosas, Lanjiao Wang, Sara Goossens, Arno Cuvry, Li-Hsin Li, Nanci Santos-Ferreira, Alina Soto, Kai Dallmeier, Joana Rocha-Pereira, Leen Delang

“…ABSTRACT Aedes aegypti mosquitoes can transmit several arboviruses, including chikungunya virus (CHIKV), dengue virus (DENV), and Zika virus (ZIKV). When blood-feeding on a virus-infected human, the mosquito ingests the virus into the midgut (stomach), where it replicates and must overcome the midgut barrier to disseminate to other organs and ultimately be transmitted via the saliva. …”
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Identification and RNAi Profile of a Novel Iflavirus Infecting Senegalese <i>Aedes vexans arabiensis</i> Mosquitoes by Rhys Parry, Fanny Naccache, El Hadji Ndiaye, Gamou Fall, Ilaria Castelli, Renke Lühken, Jolyon Medlock, Benjamin Cull, Jenny C. Hesson, Fabrizio Montarsi, Anna-Bella Failloux, Alain Kohl, Esther Schnettler, Mawlouth Diallo, Sassan Asgari, Isabelle Dietrich, Stefanie C. Becker

“…The inland floodwater mosquito <i>Aedes vexans</i> (Meigen, 1830) is a competent vector of numerous arthropod-borne viruses such as Rift Valley fever virus (<i>Phenuiviridae</i>) and Zika virus (<i>Flaviviridae</i>). <i>Aedes vexans</i> spp. have widespread Afrotropical distribution and are common European cosmopolitan mosquitoes. …”
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Host-Viral Interactions at the Maternal-Fetal Interface. What We Know and What We Need to Know by James H. Girsch, James H. Girsch, Maria C. Mejia Plazas, Amanda Olivier, Mohamed Farah, Dawn Littlefield, Supriya Behl, Sohan Punia, Reona Sakemura, Jack R. Hemsath, Andrew Norgan, Elizabeth A. L. Enninga, Elizabeth A. L. Enninga, Erica L. Johnson, Rana Chakraborty, Rana Chakraborty, Rana Chakraborty

“…In this review, we characterize decidual and placental immunity during maternal viral (co)-infection with HIV-1, human cytomegalovirus (HCMV), and Zika virus. We discuss placental immunology, clinical presentation, and epidemiology, before characterizing host susceptibility and cellular tropism, and how the three viruses gain access into specific placental target cells. …”
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The <named-content content-type="genus-species">Aedes aegypti</named-content> Domino Ortholog p400 Regulates Antiviral Exogenous Small Interfering RNA Pathway Activity and <italic... by Melanie McFarlane, Floriane Almire, Joy Kean, Claire L. Donald, Alma McDonald, Bryan Wee, Mathilde Lauréti, Margus Varjak, Sandra Terry, Marie Vazeille, Rommel J. Gestuveo, Isabelle Dietrich, Colin Loney, Anna-Bella Failloux, Esther Schnettler, Emilie Pondeville, Alain Kohl

“…Antiviral activity of p400 was also demonstrated against chikungunya virus (Togaviridae) and Bunyamwera virus (Peribunyaviridae) but not Zika virus (Flaviviridae). p400 was found to be expressed across mosquito tissues and regulated ago-2 but not dcr-2 transcript levels in A. aegypti mosquitoes. …”
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Fortieth week by Sérgio Cavalheiro

“…The same was not achieved when we encountered the Zika virus epidemic, during which it took us a considerable time to correlate microcephaly with congenital viral infection. …”
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Fogarty International Center collaborative networks in infectious disease modeling: Lessons learnt in research and capacity building by Martha I. Nelson, James O. Lloyd-Smith, Lone Simonsen, Andrew Rambaut, Edward C. Holmes, Gerardo Chowell, Mark A. Miller, David J. Spiro, Bryan Grenfell, Cécile Viboud

“…These activities have provided evidence-based recommendations for disease control, including during large-scale outbreaks of pandemic influenza, Ebola and Zika virus. Together, these programs have coordinated international collaborative networks to advance the study of emerging disease threats and the field of computational epidemic modeling. …”
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