Characterization of dengue cases among patients with an acute illness, Central Department, Paraguay by Alejandra Rojas, Fátima Cardozo, César Cantero, Victoria Stittleburg, Sanny López, Cynthia Bernal, Francisco Eugenio Gimenez Acosta, Laura Mendoza, Benjamin A. Pinsky, Ivalena Arévalo de Guillén, Malvina Páez, Jesse Waggoner

“…Acute-phase specimens (≤8 days after symptom onset) were tested using rRT-PCR, a rapid diagnostic test for DENV nonstructural protein 1 (NS1) and anti-DENV IgM and IgG, and ELISA for IgG against NS1 from Zika virus (ZIKV). Results A total of 231 patients were enrolled (95.2% adults) at two sites: emergency care and an outpatient clinical site. …”
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Bibliometric and visual analysis of Chinese-language scholarly journal papers published by China provincial centers for disease control and prevention from 2011 to 2020：based on CS... by Jiao CHEN, Xiaoyu WANG, Yuan WANG, Jinyu DING

“…The keyword emergence results suggested that the frontiers of research had gradually shifted from infectious diseases such as enterovirus, hantavirus, and Zika virus to food-borne diseases and chronic non-communicable diseases such as tumors and senile diseases over time.ConclusionThe number of papers issued by the provincial CDCs in China in the past ten years has shown an overall steady and rising trend. …”
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Different epidemiological profiles in patients with Zika and dengue infection in Tapachula, Chiapas in Mexico (2016–2018): an observational, prospective cohort study by Pablo F. Belaunzarán-Zamudio, Héctor Armando Rincón León, Sandra Caballero Sosa, Emilia Ruiz, José Gabriel Nájera Cancino, Paul Rodriguez de La Rosa, María de Lourdes Guerrero Almeida, John H. Powers, John H. Beigel, Sally Hunsberger, Karina Trujillo, Pilar Ramos, Fernando J. Arteaga-Cabello, Alexander López-Roblero, Raydel Valdés-Salgado, Hugo Arroyo-Figueroa, Eli Becerril, Guillermo Ruiz-Palacios, for the Mexican Emerging Infectious Diseases Clinical Research Network (La Red)

“…Methods Prospective, observational cohort evaluating the natural history of Zika virus infection in the Mexico-Guatemala border area. …”
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An Integrated Molecular Approach to Untangling Host–Vector–Pathogen Interactions in Mosquitoes (Diptera: Culicidae) From Sylvan Communities in Mexico by Luis M. Hernández-Triana, Javier A. Garza-Hernández, Aldo I. Ortega Morales, Sean W. J. Prosser, Paul D. N. Hebert, Nadya I. Nikolova, Elsa Barrero, Erick de J. de Luna-Santillana, Vicente H. González-Alvarez, Ramón Mendez-López, Rahuel J. Chan-Chable, Anthony R. Fooks, Mario A. Rodríguez-Pérez

“…There are ~240 species of Culicidae in Mexico, of which some are vectors of arthropod-borne viruses such as Zika virus, dengue virus, chikungunya virus, and West Nile virus. …”
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Severity and Outcomes of Dengue in Hospitalized Jamaican Children in 2018–2019 During an Epidemic Surge in the Americas by Aileen May Lue, Aileen May Lue, Michelle-Ann Elizabeth Hue Richards-Dawson, Georgiana Marie Gordon-Strachan, Georgiana Marie Gordon-Strachan, Syed Matthew Kodilinye, Jacqueline Anne Theresa Dunkley-Thompson, Tracia Dahlia James-Powell, Curtis Alphonso Pryce, Chadwic De'sean Mears, Joshua James Anzinger, Joshua James Anzinger, Joshua James Anzinger, Karen Webster-Kerr, Karen Webster-Kerr, Celia Dana Claire Christie, Celia Dana Claire Christie, Celia Dana Claire Christie

“…Simultaneously, Jamaica reported its largest dengue outbreak in 40 years, following Chikungunya and Zika virus epidemics, in 2014 and 2016–2017, respectively. …”
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Structural and functional characterization of flavivirus non-structural protein 3 (NS3) in solution and atomic and enzymatic insights of vancomysin resistant enterococcus faecalis... by Pan, Ankita

“…This thesis focuses on the non-structural protein 3 (NS3) of two flaviviral pathogens, the Dengue (DENV; DENV-2) and Zika virus (ZIKV), that have emerged as a major health concern in Singapore and world-wide. …”
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Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children by Jessica Badolato-Corrêa, Fabiana Rabe Carvalho, Iury Amancio Paiva, Débora Familiar-Macedo, Helver Gonçalves Dias, Alex Pauvolid-Corrêa, Alex Pauvolid-Corrêa, Caroline Fernandes-Santos, Monique da Rocha Queiroz Lima, Mariana Gandini, Andréa Alice Silva, Silvia Maria Baeta Cavalcanti, Solange Artimos de Oliveira, Renata Artimos de Oliveira Vianna, Elzinandes Leal de Azeredo, Claudete Aparecida Araújo Cardoso, Claudete Aparecida Araújo Cardoso, Alba Grifoni, Alessandro Sette, Alessandro Sette, Daniela Weiskopf, Luzia Maria de-Oliveira-Pinto

“…Background: Zika virus (ZIKV) infection causes for mild and self-limiting disease in healthy adults. …”
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A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses by Kara M. Pryke, Jinu Abraham, Tina M. Sali, Bryan J. Gall, Iris Archer, Andrew Liu, Shelly Bambina, Jason Baird, Michael Gough, Marita Chakhtoura, Elias K. Haddad, Ilsa T. Kirby, Aaron Nilsen, Daniel N. Streblow, Alec J. Hirsch, Jessica L. Smith, Victor R. DeFilippis

“…Here, we characterize a novel small molecule that artificially activates this response and in so doing generates a cellular state antagonistic to growth of currently emerging viruses: Zika virus, Chikungunya virus, and dengue virus. We also show that this molecule is capable of eliciting cellular responses that are predictive of establishment of adaptive immunity. …”
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New strains of Japanese encephalitis virus circulating in Shanghai, China after a ten-year hiatus in local mosquito surveillance by Yuan Fang, Yi Zhang, Zheng-Bin Zhou, Shang Xia, Wen-Qi Shi, Jing-Bo Xue, Yuan-Yuan Li, Jia-Tong Wu

“…Several mosquito species acting as vectors of Japanese encephalitis virus (JEV), dengue virus, Zika virus, malaria parasites and other pathogens are primary mosquito species in Shanghai, China. …”
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Antigenic Characterization of New Lineage II Insect-Specific Flaviviruses in Australian Mosquitoes and Identification of Host Restriction Factors by Jessica J. Harrison, Jody Hobson-Peters, Agathe M. G. Colmant, Joanna Koh, Natalee D. Newton, David Warrilow, Helle Bielefeldt-Ohmann, Thisun B. H. Piyasena, Caitlin A. O’Brien, Laura J. Vet, Devina Paramitha, James R. Potter, Steven S. Davis, Cheryl A. Johansen, Yin Xiang Setoh, Alexander A. Khromykh, Roy A. Hall

“…IMPORTANCE The globally important flavivirus pathogens West Nile virus, Zika virus, dengue viruses, and yellow fever virus can infect mosquito vectors and be transmitted to humans and other vertebrate species in which they cause significant levels of disease and mortality. …”
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Determining dengue virus serostatus by indirect IgG ELISA compared with focus reduction neutralisation test in children in Cebu, Philippines: a prospective population-based study by Anna Lena Lopez, MD, Cameron Adams, BS, Michelle Ylade, MD, Ramesh Jadi, PhD, Jedas Veronica Daag, BS, Caitlyn T Molloy, BS, Kristal An Agrupis, MD, Deok Ryun Kim, PhD, Maria Wilda Silva, MD, In-Kyu Yoon, MD, Laura White, PhD, Jacqueline Deen, MD, Aravinda M de Silva, ProfPhD

“…Of the 11 sera that were false positive with ELISA, seven samples (63·6%) were seropositive for Zika virus or Japanese encephalitis virus with FRNT. …”
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Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2 by Rui Xiong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, Weijuan Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Yu Chen, Yingle Liu, Gang Zou, Dimitri Lavillete, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, Ke Lan, Honglin Li, Ke Xu

“…Herein, we identified two potent inhibitors of human DHODH, S312 and S416, with favorable drug-likeness and pharmacokinetic profiles, which all showed broad-spectrum antiviral effects against various RNA viruses, including influenza A virus, Zika virus, Ebola virus, and particularly against SARS-CoV-2. …”
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Mosquito-Borne Viral Pathogens Detected in Zambia: A Systematic Review by Rachel Milomba Velu, Geoffrey Kwenda, Liyali Libonda, Caroline Cleopatra Chisenga, Bumbangi Nsoni Flavien, Obvious Nchimunya Chilyabanyama, Michelo Simunyandi, Samuel Bosomprah, Nicholus Chintu Sande, Katendi Changula, Walter Muleya, Monicah Mirai Mburu, Benjamin Mubemba, Simbarashe Chitanga, John Tembo, Matthew Bates, Nathan Kapata, Yasuko Orba, Masahiro Kajihara, Ayato Takada, Hirofumi Sawa, Roma Chilengi, Edgar Simulundu

“…Three viruses (Chikungunya virus, Mayaro virus, Mwinilunga virus) were reported among the togaviruses whilst four (dengue virus, West Nile virus, yellow fever virus, Zika virus) were among the flavivirus and only one virus, Rift Valley fever virus, was reported in the <i>Phenuiviridae</i> family. …”
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ZIKV Disrupts Placental Ultrastructure and Drug Transporter Expression in Mice by Cherley Borba Vieira Andrade, Victoria Regina de Siqueira Monteiro, Sharton Vinicius Antunes Coelho, Hanailly Ribeiro Gomes, Ronny Paiva Campos Sousa, Veronica Muller de Oliveira Nascimento, Flavia Fonseca Bloise, Stephen Giles Matthews, Stephen Giles Matthews, Stephen Giles Matthews, Stephen Giles Matthews, Enrrico Bloise, Luciana Barros Arruda, Tania Maria Ortiga-Carvalho

“…Congenital Zika virus (ZIKV) infection can induce fetal brain abnormalities. …”
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A Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways by Ana Carolina Carvalho-Silva, Ana Carolina Carvalho-Silva, Almir Ribeiro Da Silva Junior, Almir Ribeiro Da Silva Junior, Almir Ribeiro Da Silva Junior, Vagner Oliveira-Carvalho Rigaud, Waleska Kerllen Martins, Waleska Kerllen Martins, Verônica Coelho, Verônica Coelho, Verônica Coelho, Irmtraut Araci Hoffmann Pfrimer, Jorge Kalil, Jorge Kalil, Jorge Kalil, Simone Gonçalves Fonseca, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto, Ludmila Rodrigues Pinto Ferreira, Ludmila Rodrigues Pinto Ferreira

“…Zika virus (ZIKV) is an arbovirus mainly transmitted by mosquitos of the genus Aedes. …”
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Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas by Laise de Moraes, Moyra M. Portilho, Bram Vrancken, Frederik Van den Broeck, Luciane Amorim Santos, Marina Cucco, Laura B. Tauro, Mariana Kikuti, Monaise M. O. Silva, Gúbio S. Campos, Mitermayer G. Reis, Aldina Barral, Manoel Barral-Netto, Viviane Sampaio Boaventura, Anne-Mieke Vandamme, Kristof Theys, Philippe Lemey, Guilherme S. Ribeiro, Ricardo Khouri

“…The Americas, particularly Brazil, were greatly impacted by the widespread Zika virus (ZIKV) outbreak in 2015 and 2016. Efforts were made to implement genomic surveillance of ZIKV as part of the public health responses. …”
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Mosquito-Borne Arboviruses Occurrence and Distribution in the Last Three Decades in Central Africa: A Systematic Literature Review by Natacha Poungou, Silas Lendzele Sevidzem, Aubin Armel Koumba, Christophe Roland Zinga Koumba, Phillipe Mbehang, Richard Onanga, Julien Zahouli Bi Zahouli, Gael Darren Maganga, Luc Salako Djogbénou, Steffen Borrmann, Ayola Akim Adegnika, Stefanie C. Becker, Jacques François Mavoungou, Rodrigue Mintsa Nguéma

“…Of the six arboviruses (dengue virus (DENV), chikungunya virus (CHIKV), yellow fever virus (YFV), Zika virus (ZIKV), Rift Valley fever virus (RVFV), and West Nile virus (WNV)) of public health concern studied, the most frequently reported were chikungunya and dengue. …”
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Glycyrrhizic Acid Derivatives Bearing Amino Acid Residues in the Carbohydrate Part as Dengue Virus E Protein Inhibitors: Synthesis and Antiviral Activity by Mann-Jen Hour, Yeh Chen, Chen-Sheng Lin, Lidia A. Baltina, Ju-Ying Kan, Yan-Ting Tsai, Yan-Tung Kiu, Hsueh-Chou Lai, Lia A. Baltina, Svetlana F. Petrova, Cheng-Wen Lin

“…Dengue virus (DENV) is one of the most geographically distributed mosquito-borne flaviviruses, like Japanese encephalitis virus (JEV), and Zika virus (ZIKV). In this study, a library of the known and novel Glycyrrhizic acid (GL) derivatives bearing amino acid residues or their methyl/ethyl esters in the carbohydrate part were synthesized and studied as DENV inhibitors in vitro using the cytopathic effect (CPE), viral infectivity and virus yield assays with DENV1 and DENV-2 in Vero E6 and A549 cells. …”
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Antibody cross-reactivity and evidence of susceptibility to emerging Flaviviruses in the dengue-endemic Brazilian Amazon by Barbara Batista Salgado, Fábio Carmona de Jesus Maués, Maele Jordão, Renato Lemos Pereira, Daniel A. Toledo-Teixeira, Pierina L. Parise, Fabiana Granja, Higo Fernando Santos Souza, Marcio Massao Yamamoto, Jannifer Oliveira Chiang, Livia Caricio Martins, Silvia Beatriz Boscardin, Jaila Dias Borges Lalwani, Pedro Fernando C Vasconcelos, José Luiz Proença-Modena, Pritesh Lalwani

“…About 93% had antiyellow fever virus 17D-reactive antibodies, whereas 80.5% reacted to wild-type yellow fever virus. Zika virus (ZIKV) had the lowest seropositivity percentage (52.6%) compared with other Flaviviruses. …”
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Antiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates by Romain Marlin, Delphine Desjardins, Vanessa Contreras, Guillaume Lingas, Caroline Solas, Pierre Roques, Thibaut Naninck, Quentin Pascal, Sylvie Behillil, Pauline Maisonnasse, Julien Lemaitre, Nidhal Kahlaoui, Benoit Delache, Andrés Pizzorno, Antoine Nougairede, Camille Ludot, Olivier Terrier, Nathalie Dereuddre-Bosquet, Francis Relouzat, Catherine Chapon, Raphael Ho Tsong Fang, Sylvie van der Werf, Manuel Rosa Calatrava, Denis Malvy, Xavier de Lamballerie, Jeremie Guedj, Roger Le Grand

“…Here, the authors explore the antiviral activity of favipiravir against Zika virus and SARS-CoV-2 in cynomolgus macaques, in order to support future clinical investigations into this RNA polymerase inhibitor.…”
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