Animal models for the risk assessment of viral pandemic potential by Mee Sook Park, Jin Il Kim, Joon-Yong Bae, Man-Seong Park

“…Focusing on the pandemic potential of viral infectious diseases, we suggest what should be assessed to prevent global catastrophes from influenza virus, Middle East respiratory syndrome coronavirus, dengue and Zika viruses.…”
Get full text

History of Mosquitoborne Diseases in the United States and Implications for New Pathogens by Max J. Moreno-Madriñán, Michael Turell

“…The introduction and spread of West Nile virus and the recent introduction of chikungunya and Zika viruses into the Americas have raised concern about the potential for various tropical pathogens to become established in North America. …”
Get full text

Tetraspanins as Potential Therapeutic Candidates for Targeting Flaviviruses by Waqas Ahmed, Girish Neelakanta, Girish Neelakanta, Hameeda Sultana, Hameeda Sultana

“…Studies in the identification of novel therapeutic candidates and strategies to target West Nile virus, dengue and Zika viruses are highly warranted due to the failure in development of vaccines. …”
Get full text

Virus infection and direct-acting antivirals in pregnancy by Xuan Huang, Jing Tang

“…Mechanism: We conducted literature research to summarize the available evidence on the use of direct-acting antivirals during pregnancy for infections due to influenza, hepatitis B and C, human immunodeficiency, herpes simplex virus, cytomegalovirus, varicella-zoster virus, Ebola, and Zika viruses, and human coronavirus. Findings in brief: To support further the rational use of antivirals during pregnancy, the discussion includes the influence of pregnancy on pharmacokinetics, safety, and transplacental permeability, and the protection of mothers and children from vertical transmission. …”
Get full text

Anopheles mosquitoes may drive invasion and transmission of Mayaro virus across geographically diverse regions. by Marco Brustolin, Sujit Pujhari, Cory A Henderson, Jason L Rasgon

“…Imported MAYV cases are on the rise, leading to invasion concerns similar to Chikungunya and Zika viruses. Little is known about the range of mosquito species that are competent MAYV vectors. …”
Get full text

Understanding Immune Responses to Viruses—Do Underlying Th1/Th2 Cell Biases Predict Outcome? by Faith H. N. Howard, Amy Kwan, Natalie Winder, Amina Mughal, Cristal Collado-Rojas, Munitta Muthana

“…Examples include the current COVID-19 pandemic and the recent epidemics of the Chikungunya, Ebola, and Zika viruses. Immune responses to viruses have been well-characterised within the innate and adaptive immunity pathways with the outcome following viral infection predominantly attributed to properties of the virus and circumstances of the infection. …”
Get full text

Similar Neural Pathways Control Foraging in Mosquitoes and Worms by Jogender Singh, Alejandro Aballay

“…ABSTRACT Female Aedes aegypti mosquitoes bite human hosts to obtain a blood meal and, in the process, act as vectors for many disease-causing viruses, including the dengue, chikungunya, yellow fever, and Zika viruses. After a complete meal, the female mosquitoes lose attraction to their hosts for several days. …”
Get full text

Intensified Short Symptom Screening Program for Dengue Infection during Pregnancy, India by Shilpa Naik, Matthew L. Robinson, Mallika Alexander, Ajay Chandanwale, Pradip Sambarey, Aarti Kinikar, Renu Bharadwaj, Gajanan N. Sapkal, Puja Chebrolu, Prasad Deshpande, Vandana Kulkarni, Smita Nimkar, Vidya Mave, Amita Gupta, Jyoti Mathad

“…Of 5,843 pregnant women screened, 52 were enrolled and tested for dengue, chikungunya, and Zika viruses by using a Trioplex real-time reverse transcription PCR. …”
Get full text

Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes by Ahmed M. E. Elrefaey, Philippa Hollinghurst, Christine M. Reitmayer, Luke Alphey, Kevin Maringer

“…For example, dengue, Japanese encephalitis, West Nile, yellow fever, and Zika viruses are transmitted by infected mosquitoes and cause severe and fatal diseases in humans. …”
Get full text

Congenital Zika syndrome is associated with maternal protein malnutrition. by Barbeito-Andrés, J, Pezzuto, P, Higa, LM, Dias, AA, Vasconcelos, JM, Santos, TMP, Ferreira, JCCG, Ferreira, RO, Dutra, FF, Rossi, AD, Barbosa, RV, Amorim, CKN, De Souza, MPC, Chimelli, L, Aguiar, RS, Gonzalez, PN, Lara, FA, Castro, MC, Molnár, Z, Lopes, RT, Bozza, MT, Vianez, JLSG, Barbeito, CG, Cuervo, P, Bellio, M, Tanuri, A, Garcez, PP

“…Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). …”

Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus by Kraemer, M, Messina, J, Faria, N, Pybus, O, Wint, W, al, e

“…Global surveillance and control efforts that aim to mitigate the spread of chikungunya, dengue, yellow fever and Zika viruses must consider the so far unabated spread of these mosquitos. …”

Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa by Panayiota Kotsakiozi, Benjamin R. Evans, Andrea Gloria‐Soria, Basile Kamgang, Martin Mayanja, Julius Lutwama, Gilbert Le Goff, Diego Ayala, Christophe Paupy, Athanase Badolo, Joao Pinto, Carla A. Sousa, Arlete D. Troco, Jeffrey R. Powell

“…Abstract Aedes aegypti, the major vector of dengue, yellow fever, chikungunya, and Zika viruses, remains of great medical and public health concern. …”
Get full text

Multifaceted contributions of Dicer2 to arbovirus transmission by Aedes aegypti by Sarah Hélène Merkling, Anna Beth Crist, Annabelle Henrion-Lacritick, Lionel Frangeul, Elodie Couderc, Valérie Gausson, Hervé Blanc, Alexander Bergman, Artem Baidaliuk, Ottavia Romoli, Maria-Carla Saleh, Louis Lambrechts

“…The loss of Dicer2 enhances early viral replication and systemic viral dissemination of four medically significant arboviruses (chikungunya, Mayaro, dengue, and Zika viruses) representing two viral families. However, Dicer2 mutants and wild-type mosquitoes display overall similar levels of vector competence. …”
Get full text

Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses by Mohammad Shoushtari, Farzin Roohvand, Mostafa Salehi-Vaziri, Arash Arashkia, Hasan Bakhshi, Kayhan Azadmanesh

“…Surprisingly, there are no effective vaccine for many other hazardous flaviviruses, including West Nile and Zika viruses. Furthermore, in spite of approved vaccines for some flaviviruses, for example DENV, alternative prophylactic vaccines seem to be still needed for the protection of a broader population, and it originates from the unsatisfying safety, and the efficacy of vaccines that have been introduced. …”
Get full text

Development of a dengue virus serotype-specific non-structural protein 1 capture immunochromatography method by Poltep, K, Nakayama, EE, Sasaki, T, Kurosu, T, Takashima, Y, Phadungsombat, J, Kosoltanapiwat, N, Hanboonkunupakarn, B, Suwanpakdee, S, Imad, HA, Srimark, N, Kitamura, C, Yamanaka, A, Okubo, A, Shioda, T, Leaungwutiwong, P

“…We also confirmed that there was no cross-reaction with chikungunya, Japanese encephalitis, Sindbis, and Zika viruses. Evaluation of these systems using serum from DENV-infected individuals indicated a serotype specificity of almost 100%. …”

Visual threats reduce blood-feeding and trigger escape responses in Aedes aegypti mosquitoes by Nicole E. Wynne, Karthikeyan Chandrasegaran, Lauren Fryzlewicz, Clément Vinauger

“…Abstract The diurnal mosquitoes Aedes aegypti are vectors of several arboviruses, including dengue, yellow fever, and Zika viruses. To find a host to feed on, they rely on the sophisticated integration of olfactory, visual, thermal, and gustatory cues emitted by the hosts. …”
Get full text

Nurses’ Perception of Safety on Hospital Interior Environments and Infectious Diseases: An Exploratory Study by Suyeon Bae, Abimbola O. Asojo

“…From the 2003 outbreaks of Severe Acute Respiratory Syndrome to the recent concerns about the Ebola and Zika viruses, interest in the role of healthcare environment fomites in spreading infectious diseases has increased. …”
Get full text

Serological Cross-Reactivity in Zoonotic Flaviviral Infections of Medical Importance by Priscilla Gomes da Silva, José Augusto Seixas dos Reis, Marcio Nogueira Rodrigues, Quézia da Silva Ardaya, João Rodrigo Mesquita

“…Flaviviruses are enveloped RNA viruses from the family Flaviviridae that comprise many important human pathogenic arboviruses such as Yellow Fever, Dengue, and Zika viruses. Because they belong to the same genus, these viruses show sequence and structural homology among them, which results in serological cross-reactivity. …”
Get full text

Current Progress on Host Antiviral Factor IFITMs by Linzhu Ren, Shouwen Du, Wang Xu, Tiyuan Li, Shipin Wu, Ningyi Jin, Ningyi Jin, Chang Li

“…Since the first demonstration of their natural ability to resist viral infection in 1996, IFITMs have been reported to limit a variety of viral infections, including some major pathogens that seriously endanger human health and social stability, such as influenza A, Ebol, severe acute respiratory syndrome, AIDS, and Zika viruses, etc. Studies show that IFITMs mainly exert antiviral activity during virus entry, specifically interfering with the fusion of the envelope and the endosome membrane or forming fusion micropores to block the virus from entering the cytoplasm. …”
Get full text

Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil by João Silveira Moledo Gesto, Gabriel Sylvestre Ribeiro, Marcele Neves Rocha, Fernando Braga Stehling Dias, Julia Peixoto, Fabiano Duarte Carvalho, Thiago Nunes Pereira, Luciano Andrade Moreira

“…We have also demonstrated that refractoriness to dengue and Zika viruses, either thorough oral-feeding or intra-thoracic saliva challenging assays, was maintained over the adaptation to the natural environment of Southeastern Brazil. …”
Get full text