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3401
Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
Published 2018“…Zika virus (ZIKV) emerged on a global scale and no licensed vaccine ensures long-lasting anti-ZIKV immunity. …”
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3402
CRISPR/Cas9 knockout of female-biased genes AeAct-4 or myo-fem in Ae. aegypti results in a flightless phenotype in female, but not male mosquitoes.
Published 2020-12-01“…Aedes aegypti is a vector of dengue, chikungunya, and Zika viruses. Current vector control strategies such as community engagement, source reduction, and insecticides have not been sufficient to prevent viral outbreaks. …”
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3403
The Wolbachia strain wAu provides highly efficient virus transmission blocking in Aedes aegypti.
Published 2018-01-01“…The wAu strain also reached high densities in Ae. aegypti, and provided highly efficient transmission blocking of dengue and Zika viruses. Both wAu and wAlbA were less susceptible than wMel to density reduction/incomplete maternal transmission resulting from elevated larval rearing temperatures. …”
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3404
Multifaceted functional implications of an endogenously expressed tRNA fragment in the vector mosquito Aedes aegypti.
Published 2018-01-01“…The mosquito Aedes aegypti is the primary vector of human arboviral diseases caused by dengue, chikungunya and Zika viruses. Many studies have shown the potential roles of small RNA molecules such as microRNA, small interfering RNA and PIWI-interacting RNA in vector mosquitoes. …”
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3405
Reproduction numbers of infectious disease models
Published 2017-08-01“…Keywords: Basic reproduction number, Disease control, West Nile virus, Cholera, Anthrax, Zika virus…”
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3406
Ebola Virus Glycoprotein Domains Associated with Protective Efficacy
Published 2021-06-01“…Due to its favorable immune cell targeting, this vaccine has also been used as a base vector for the development of second generation VSV-based vaccines against Influenza, Nipah, and Zika viruses. However, in these situations, it may be beneficial if the immunogenicity against EBOV GP is minimized to induce a better protective immune response against the other foreign immunogen. …”
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3407
Development of a Dengue Virus Serotype-Specific Non-Structural Protein 1 Capture Immunochromatography Method
Published 2021-11-01“…We also confirmed that there was no cross-reaction with chikungunya, Japanese encephalitis, Sindbis, and Zika viruses. Evaluation of these systems using serum from DENV-infected individuals indicated a serotype specificity of almost 100%. …”
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3408
Phenotypic Response of <i>Wolbachia pipientis</i> in a Cell-Free Medium
Published 2020-07-01“…<i>Wolbachia</i>, an obligate intracellular bacterium estimated to infect millions of arthropod species worldwide, is currently being utilized in novel control strategies to limit the transmission of Dengue and Zika viruses. A limitation for <i>Wolbachia</i>-based control approaches is the difficulty of transferring <i>Wolbachia</i> to novel hosts and the lack of tools for the genetic transformation of <i>Wolbachia</i> due to the inability to culture <i>Wolbachia</i> outside the insect host cell in an axenic media. …”
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3409
Targeting the Achilles heel of mosquito-borne viruses for antiviral therapy
Published 2021“…Mosquito-borne viruses encompass a wide range of pathogens, such as dengue and Zika viruses, that often cocirculate geographically. …”
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Journal Article -
3410
Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells
Published 2022“…Zika virus (ZIKV) can infect human developing brain (HDB) progenitors resulting in epidemic microcephaly, whereas analogous cellular tropism offers treatment potential for the adult brain cancer, glioblastoma (GBM). …”
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3411
Vector-Transmitted Flaviviruses: An Antiviral Molecules Overview
Published 2023-09-01“…In particular, the Yellow Fever, dengue, West Nile, and Zika viruses have high morbidity and mortality—about an estimated 20,000 deaths per year. …”
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3412
Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases
Published 2019-01-01“…Whilst effective drugs have been developed against the hepacivirus HCV, no antiviral therapy is currently available for any other viruses, including the flaviviruses dengue (DENV), West Nile and Zika viruses. The RNA-dependent RNA polymerase (RdRp) is responsible for viral replication and represents an excellent therapeutic target with no homologue found in mammals. …”
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3413
Insecticide Susceptibility Status of Aedes albopictus in Dengue Hotspot Areas in Malaysia
Published 2021-04-01“…Aedes albopictus (Skuse, 1894) is the most dominant species contributing as a vector of dengue, Chikungunya and Zika viruses in Malaysia. Knowledge of the current insecticide resistance of Ae. albopictus is essential for the success of vector control program. …”
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3414
Potential for the Invasive Species Aedes Albopictus and Arboviral Transmission through the Chabahar Port in Iran
Published 2018-07-01“…Background: Dengue, chikungunya, and Zika viruses are emerging infectious disease threats wherever suitable vectors, hosts, and habitat are present. …”
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3415
Genetic Diversity and Phylogeny of Aedes aegypti, the Main Arbovirus Vector in the Pacific.
Published 2016-01-01“…Ae. aegypti is the major vector of arboviruses (dengue, chikungunya and Zika viruses) in the region. The intense circulation of these viruses in the Pacific during the last decade led to an increase of vector control measures by local health authorities. …”
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3416
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection
Published 2021“…While influenza and Zika viruses induce ISGylation, SARS-CoV-2 triggers deISGylation instead to generate free ISG15. …”
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3417
West Nile virus infections are here! Are we prepared to face another flavivirus epidemic?
Published 2019-03-01“…Abstract Emerging arthropod-borne viruses (arboviruses), such as chikungunya and Zika viruses, are a major threat to public health in countries like Brazil where biodiversity is high and medical care is sometimes precarious. …”
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3418
C-Type Lectin-20 Interacts with ALP1 Receptor to Reduce Cry Toxicity in Aedes aegypti
Published 2018-09-01“…Aedes aegypti is a crucial vector for human diseases, such as yellow fever, dengue, chikungunya, and Zika viruses. Today, a major challenge throughout the globe is the insufficient availability of antiviral drugs and vaccines against arboviruses, and toxins produced by Bacillus thuringiensis (Bt) are still used as biological agents for mosquito control. …”
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3419
Susceptibility to endemic Aedes‐borne viruses among pregnant women in Risaralda, Colombia
Published 2022-09-01“…Recent epidemics of chikungunya and Zika viruses (ZIKV) highlight that preparedness for future epidemics requires assessment of susceptibility, particularly among high-risk groups. …”
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3420
Humoral cross-reactivity between Zika and dengue viruses: implications for protection and pathology
Published 2017-01-01“…Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that has recently caused extensive outbreaks in Central and South America and the Caribbean. …”
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