Estimating Hemodynamic Significant Deformations of Brachiocephalic Arteries Using CT Perfusion by Vladimir V. Krylov, Elena V. Grigorieva, Natalia P. Polunina, Viktor V. Lukyanchikov, Vagan A. Dalibaldyan

“…In 6 patients, the acetazolamide challenge test was used to evaluate the autoregulatory disturbances. …”
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Cloning, expression and purification of the α-carbonic anhydrase from the mantle of the Mediterranean mussel, Mytilus galloprovincialis by Rosa Perfetto, Sonia Del Prete, Daniela Vullo, Vincenzo Carginale, Giovanni Sansone, Carmela M. A. Barone, Mosè Rossi, Fatmah A. S. Alasmary, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran, Clemente Capasso

“…Curiously, the rec-MgaCA showed a very similar kinetic and acetazolamide inhibition features when compared to those of the native enzyme (MgaCA), which has a molecular weight of 50 kDa. …”
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Quantification of cerebral vascular hemodynamics using MRI by Zhao, Y

“…CVR, ATT, and blood flow velocity were estimated before and after acetazolamide administration in healthy volunteers. Regional differences of CVR were found between the two ASL methods. …”

Quantification of cerebral perfusion and cerebrovascular reserve using Turbo‐QUASAR arterial spin labeling MRI by Zhao, M, Václavů, L, Petersen, E, Biemond, B, Sokolska, M, Suzuki, Y, Thomas, D, Nederveen, A, Chappell, M

“…Data from an in vivo experiment conducted on a healthy cohort were retrospectively analyzed to compare the CBF and CVR (induced by acetazolamide) measurement from Turbo‐QUASAR and PCASL on the basis of global and regional differences. …”

Idiopathic Intracranial Hypertension: Current Neuroophthalmologic Points by A. V. Petrayevsky, K. S. Trishkin, I. A. Gndoyan

“…Drug therapy: long-term oral use of carbonic anhydrase inhibitors (acetazolamide, topiramate). High doses of steroids (methylprednisone) are used for short-term treatment of patients with fulminant disease type before surgery. …”
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Brain volume measured by synthetic magnetic resonance imaging in adult moyamoya disease correlates with cerebral blood flow and brain function by Kazufumi Kikuchi, Osamu Togao, Koji Yamashita, Takuro Isoda, Ataru Nishimura, Koichi Arimura, Akira Nakamizo, Koji Yoshimoto, Kousei Ishigami

“…Cerebrovascular reactivity (CVR) to acetazolamide challenge was also evaluated. Brain function was measured using the Wechsler Adult Intelligence Scales (WAIS)-III/IV and the WAIS-R tests. …”
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Moyamoya disease associated with ankylosing spondylitis in a 9-year-old child: a case report by Fan Yang, Peicong Ge, Xun Ye

“…Due to the bad cerebral blood flow on acetazolamide computed tomography perfusion and poor clinical manifestation, he underwent a right encephalo-duroarterio-synangiosis. …”
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Synthesis, Molecular Docking Analysis, ADMET and Drug Likeness Prediction of a Benzenesulfonamide Derivative Analogue of SLC-0111 by Yousra Ouafa Bouone, Abdeslem Bouzina, Nour-Eddine Aouf

“…The most well-known compounds that inhibit CAs are sulfonamide-containing molecules, including valdecoxib, acetazolamide and the antitumor agent recently introduced to phase II clinical trials: the SLC-0111. …”
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HIPERTENSION INTRACRANEAL IDIOPATICA, CASO CLINICO: HALLAZGOS EN RM Y REVISION DE LA LITERATURA by Paloma García I, Francisco Javier De Castro G, José Francisco Asensio C, Juan Carlos Paniagua E, Andrés Framiñán de Miguel

“…Management include administration of acetazolamide, repeated lumbar punctures and weight loss. …”
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Exploring the multi-target enzyme inhibition potential of new sulfonamido-thiazoline derivatives; synthesis and computational studies by Imran Shafique, Aamer Saeed, Atteeque Ahmed, Ghulam Shabir, Anwar Ul-Hamıd, Ajmal Khan, Burak Tüzün, Mahinur Kirici, Parham Taslimi, Muhammad Latif

“…Most of the synthesized molecules were more effective than standard inhibitors tacrine, and acetazolamide against AchE, BchE and against CA I and CA II respectively. …”
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Pharmacological Modulation of Rate-Dependent Depression of the Spinal H-Reflex Predicts Therapeutic Efficacy against Painful Diabetic Neuropathy by Corinne A. Lee-Kubli, XiaJun Zhou, Corinne G. Jolivalt, Nigel A. Calcutt

“…Administration of the GABA_B receptor agonist baclofen restored RDD and alleviated indices of neuropathic pain in diabetic rats, as did spinal delivery of the carbonic anhydrase inhibitor acetazolamide. Pharmacological manipulation of RDD can be used to identify potential therapies that act against neuropathic pain arising from spinal disinhibition.…”
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Intraocular pressure screening during high-volume cataract surgery outreach in Ethiopia by Ian J. McClain, David M. Rooney, Geoffrey C. Tabin

“…A total of 17 patients received oral acetazolamide prior to surgery to acutely lower IOP. …”
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Bis-pharmacophore of cinnamaldehyde-clubbed thiosemicarbazones as potent carbonic anhydrase-II inhibitors by Asif Rasool, Zahra Batool, Majid Khan, Sobia Ahsan Halim, Zahid Shafiq, Ahmed Temirak, Mohamed A. Salem, Tarik E. Ali, Ajmal Khan, Ahmed Al-Harrasi

“…Among all the synthesized derivatives, compound 3n (IC50 = 10.3 ± 0.62 µM), 3g (IC50 = 12.1 ± 1.01 µM), and 3h (IC50 = 13.4 ± 0.52 µM) showed higher inhibitory activity as compared to the standard inhibitor, acetazolamide. Furthermore, molecular docking of all the active compounds was carried out to predict their behavior of molecular binding. …”
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Fit for high altitude: are hypoxic challenge tests useful? by Matthys Heinrich

“…The increasing numbers of drugs to treat acute pulmonary hypertension due to altitude exposure (acetazolamide, dexamethasone, nifedipine, sildenafil) or to other etiologies (anticoagulants, prostanoids, phosphodiesterase-5-inhibitors, endothelin receptor antagonists) including mechanical aids to reduce periodical or insufficient ventilation during altitude exposure (added dead space, continuous or bilevel positive airway pressure, non-invasive ventilation) call for further randomized controlled trials of combined applications.…”
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Antiepileptic Drugs and Their Dual Mechanism of Action on Carbonic Anhydrase by Calin Magheru, Sorina Magheru, Marcela Coltau, Anica Hoza, Corina Moldovan, Liliana Sachelarie, Irina Gradinaru, Loredana Liliana Hurjui, Felicia Marc, Dorina Maria Farcas

“…(1) Background: The benefit of using inhibitors of carbonic anhydrase (CA), such as acetazolamide, in the treatment of epilepsy has previously been described. (2) Methods: In this paper, the effect on CA of the most well-known antiepileptic drugs was studied in vitro and in vivo. …”
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Formation of morpholine-acetamide derivatives as potent anti-tumor drug candidates: Pharmacological evaluation and molecular docking studies by Ahmed Sadiq Sheikh, Reem Altaf, Humaira Nadeem, Muhammad Tariq Khan, Babar Murtaza

“…Interestingly, the carbonic anhydrase inhibitory activity of compound 1h was comparable with that of standard acetazolamide (IC50 7.51 μM). The compounds 1h and 1i significantly inhibited the proliferation of ovarian cancer cell line ID8 with IC50 of 9.40, and 11.2 μM, respectively while the standard cisplatin exhibited an IC50 8.50 μM. …”
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Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity by Davide Moi, Alessandro Deplano, Andrea Angeli, Gianfranco Balboni, Claudiu T. Supuran, Valentina Onnis

“…The synthesized compounds were evaluated against isoforms hCA I, II, IX and XII using acetazolamide (AAZ) as standard inhibitor. Several urea and thiourea derivatives showed inhibitory activity at low nanomolar levels with selectivity against the cytosolic hCA II isoform, as well as the transmembrane, tumor-associated enzymes hCA IX and XII. …”
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Increased intracranial tension and cochleovestibular symptoms: an observational clinical study by Badr E. Mostafa, Hesham A. A. El-Sersy, Tarek A. Hamid

“…Patients with abnormal test results were shifted to acetazolamide+betahistine. Thirty patients had a dramatic response on both audiological and vestibular manifestations. …”
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GREATER AORTIC STIFFNESS IS ASSOCIATED WITH LOWER HIPPOCAMPAL CEREBROVASCULAR RESERVE BUT NOT CEREBRAL BLOOD FLOW OR AMYLOID IN MIDDLE-AGED AND OLDER ADULTS by Lyndsey E. DuBose, Laura L. Boles Ponto, David J. Moser, Gary L. Pierce

“…Hippocampal CVR was calculated as the percent (%) change in CBF in response to the pharmacological vasodilator, acetazolamide. Hippocampal amyloid burden was quantified using distribution volume ratio (DVR) from [11C]PIB PET imaging. …”
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HIGH-ALTITUDE ILLNESS by Dwitya Elvira

“…Acclimatization is one of the prevention that can be done before the climbing, in the addition of several treatment such as acetazolamide, dexamethasone, phospodiestrase inhibitor and gingko biloba.…”
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