Inhibitors of Mitochondrial Human Carbonic Anhydrases VA and VB as a Therapeutic Strategy against Paclitaxel-Induced Neuropathic Pain in Mice by Laura Micheli, Lara Testai, Andrea Angeli, Donatello Carrino, Alessandra Pacini, Francesco Margiotta, Lorenzo Flori, Claudiu T. Supuran, Vincenzo Calderone, Carla Ghelardini, Lorenzo Di Cesare Mannelli

“…In both experiments, acetazolamide (AAZ, 100 mg/kg, p.o.) used as the reference drug was partially active. …”
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<i>CACNA1A</i> Mutations Causing Early Onset Ataxia: Profiling Clinical, Dysmorphic and Structural-Functional Findings by Antonio F. Martínez-Monseny, Albert Edo, Dídac Casas-Alba, Mercè Izquierdo-Serra, Mercè Bolasell, David Conejo, Loreto Martorell, Jordi Muchart, Laura Carrera, Carlos I. Ortez, Andrés Nascimento, Baldo Oliva, José M. Fernández-Fernández, Mercedes Serrano

“…There was an improvement in cerebellar syndrome over time despite a cerebellar atrophy progression, inconsistent response to acetazolamide and positive response to methylphenidate. …”
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New Sulfamethoxazole Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, Cytotoxic Activity and Molecular Modeling by Mohamed A. Abdelgawad, Syed N. A. Bukhari, Arafa Musa, Mohammed Elmowafy, Mohammed H. Elkomy, AbdElAziz. A. Nayl, Ahmed H. El-Ghorab, Ibrahim Hotan Alsohaimi, Mohamed Sadek Abdel-Bakky, Ibrahim O. Althobaiti, Hamud A. Altaleb, Hany A. Omar, Ahmed H. Abdelazeem, Mohamed A. Zaki, Mohamed E. Shaker, Heba A. H. Elshemy

“…The active compounds were further evaluated against hCAs I and II inhibitory activity and compounds <b>S8</b>, <b>S9</b> and <b>S15</b> showed the least inhibitory effect compared to the reference standard, acetazolamide, indicating that their effect in normal cells is the lowest. …”
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Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation by Linh N. N. Le, Gregory J. Wheeler, Emily N. Holy, Corinne A. Donnay, Nicholas P. Blockley, Alan H. Yee, Kwan L. Ng, Audrey P. Fan, Audrey P. Fan

“…We hypothesized that OEF decreases in response to vasodilation with acetazolamide (ACZ) in healthy conditions, reflecting compensation in regions with increased cerebral blood flow (CBF), while cerebral metabolic rate of oxygen (CMRO2) remained unchanged. …”
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Design and search for prospective diuretics (CA II Inhibitors) among aroylhydrazones of esters quinone oxime using in silico and in vivo methodology by K.V. Sokolova, V.V. Stavytskyi, S.О. Konovalova, O.A. Podpletnya, S.I. Kovalenko, A.P. Avdeenko

“…It is important that the discovered new classes of inhibitors do not always contain the main “pharmacophoric” function (sulfamide), which is characteristic of “classic” drugs (Acetazolamide, Methazolamide, Ethoxzolamide, Dorzolamide and others), but are derivatives of phenols, polyamines, coumarins/thiocoumarins, ureas, thioureas, hydroxamates, etc. …”
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Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors by Mónica Martínez-Montiel, Laura L. Romero-Hernández, Simone Giovannuzzi, Paloma Begines, Adrián Puerta, Ana I. Ahuja-Casarín, Miguel X. Fernandes, Penélope Merino-Montiel, Sara Montiel-Smith, Alessio Nocentini, José M. Padrón, Claudiu T. Supuran, José G. Fernández-Bolaños, Óscar López

“…Regarding sulfonamido-based inhibitors, the best template turned out to be a <span style="font-variant: small-caps;">d</span>-<i>galacto</i>-configured carbohydrate residue, <i>meta</i>-substitution on the aryl moiety (<b>9b</b>), with <i>K</i>_i against CA XII within the low nM range (5.1 nM), and remarkable selectivity indexes (1531 for CA I and 181.9 for CA II); this provided an enhanced profile in terms of potency and selectivity compared to more flexible linear thioureas <b>1</b>–<b>4</b> and the drug acetazolamide (AAZ), used herein as a reference compound. …”
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Symptomatic Tarlov cysts: A case series and effectiveness of multimodal rehabilitation plus pharmacological treatment by Marcos Edgar Fernández-Cuadros, Luz María Martín-Martín, Olga Susana Pérez-Moro, María Jesús Albaladejo-Florín

“…Aims: We describe the management of a series of patients with symptomatic Tarlov cysts using a protocol that combines multimodal rehabilitation (biofeedback+posterior tibial nerve stimulation+INDIBA® radiofrequency) and pharmacological treatment (Tiobec Dol® dietary supplement and/or acetazolamide) and evaluate the effect of this programme on pain and pelvic floor muscle strength. …”
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